KR100991975B1 - 핵산을 기본으로 하는 화합물 및 이의 사용방법 - Google Patents

핵산을 기본으로 하는 화합물 및 이의 사용방법 Download PDF

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Publication number
KR100991975B1
KR100991975B1 KR1020097009006A KR20097009006A KR100991975B1 KR 100991975 B1 KR100991975 B1 KR 100991975B1 KR 1020097009006 A KR1020097009006 A KR 1020097009006A KR 20097009006 A KR20097009006 A KR 20097009006A KR 100991975 B1 KR100991975 B1 KR 100991975B1
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KR
South Korea
Prior art keywords
compounds
present
compound
hepatitis
virus
Prior art date
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Expired - Fee Related
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KR1020097009006A
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English (en)
Korean (ko)
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KR20090048658A (ko
Inventor
라드하크리쉬난 피. 이예르
이 진
아를렝 롤랑
원창 저우
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미게닉스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020097009006A 2001-05-16 2002-05-15 핵산을 기본으로 하는 화합물 및 이의 사용방법 Expired - Fee Related KR100991975B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29147101P 2001-05-16 2001-05-16
US60/291,471 2001-05-16

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7014856A Division KR20040074594A (ko) 2001-05-16 2002-05-15 핵산을 기본으로 하는 화합물 및 이의 사용방법

Publications (2)

Publication Number Publication Date
KR20090048658A KR20090048658A (ko) 2009-05-14
KR100991975B1 true KR100991975B1 (ko) 2010-11-04

Family

ID=23120429

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097009006A Expired - Fee Related KR100991975B1 (ko) 2001-05-16 2002-05-15 핵산을 기본으로 하는 화합물 및 이의 사용방법
KR10-2003-7014856A Ceased KR20040074594A (ko) 2001-05-16 2002-05-15 핵산을 기본으로 하는 화합물 및 이의 사용방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR10-2003-7014856A Ceased KR20040074594A (ko) 2001-05-16 2002-05-15 핵산을 기본으로 하는 화합물 및 이의 사용방법

Country Status (7)

Country Link
US (3) US6881831B2 (https=)
JP (5) JP2005525991A (https=)
KR (2) KR100991975B1 (https=)
CN (2) CN101113160A (https=)
AU (1) AU2002316118A1 (https=)
GB (1) GB2392157B (https=)
WO (1) WO2002092006A2 (https=)

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DE60208400T2 (de) * 2001-10-03 2006-07-06 Bioniche Life Sciences Inc., Belleville Therapeutisch verwendbare triethylenglykol-cholesteryl-oligonukleotide
US20090280567A1 (en) * 2004-02-06 2009-11-12 Dharmacon, Inc. Stabilized sirnas as transfection controls and silencing reagents
EP2123759B1 (en) * 2004-02-06 2014-01-15 Thermo Fisher Scientific Biosciences Inc. Stabilized RNAS as transfection controls and silencing reagents
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
US20060166234A1 (en) * 2004-11-22 2006-07-27 Barbara Robertson Apparatus and system having dry control gene silencing compositions
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
US7935811B2 (en) * 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US20060223777A1 (en) * 2005-03-29 2006-10-05 Dharmacon, Inc. Highly functional short hairpin RNA
US8076303B2 (en) 2005-12-13 2011-12-13 Spring Bank Pharmaceuticals, Inc. Nucleotide and oligonucleotide prodrugs
WO2008036841A2 (en) * 2006-09-22 2008-03-27 Dharmacon, Inc. Tripartite oligonucleotide complexes and methods for gene silencing by rna interference
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
GB2471806B (en) * 2008-04-03 2012-12-19 Spring Bank Pharmaceuticals Inc Compositions and methods for treating viral infections
KR101926419B1 (ko) 2010-08-30 2018-12-10 스프링 뱅크 파마슈티칼스, 인크. 치료제로서 올리고뉴클레오타이드 유사체의 설계
BR112013005872A2 (pt) 2010-09-22 2019-09-24 Alios Biopharma Inc compostos, composição farmacêutica e respectivos usos
EP2794630A4 (en) 2011-12-22 2015-04-01 Alios Biopharma Inc SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE
WO2013142124A1 (en) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Solid forms of a thiophosphoramidate nucleotide prodrug
US9012427B2 (en) 2012-03-22 2015-04-21 Alios Biopharma, Inc. Pharmaceutical combinations comprising a thionucleotide analog
AU2014250762A1 (en) 2013-04-12 2015-10-29 Achillion Pharmaceuticals, Inc. Highly active nucleoside derivative for the treatment of HCV
JP7170535B2 (ja) 2015-10-20 2022-11-14 ソレント・セラピューティクス・インコーポレイテッド 細胞内送達化合物
EP3752511A4 (en) 2018-01-10 2021-12-29 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
CN111918870B (zh) * 2018-05-18 2022-07-08 正大天晴药业集团股份有限公司 氘代的低聚核苷酸及前体药物
CN113164506B (zh) * 2018-12-06 2023-12-08 正大天晴药业集团股份有限公司 二核苷酸化合物及其前体药物
CN111484541B (zh) * 2019-01-25 2023-06-02 博瑞生物医药（苏州）股份有限公司 双核苷酸前体药物及其制备方法
CN114206896B (zh) 2019-07-17 2024-12-17 纽科利制药公司 环状脱氧核糖核苷酸化合物
US12552820B2 (en) 2020-04-21 2026-02-17 Ligand Pharmaceuticals Incorporated Benzyloxy phosph(on)ate compounds

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Also Published As

Publication number Publication date
HK1077503A1 (zh) 2006-02-17
KR20090048658A (ko) 2009-05-14
US7709449B2 (en) 2010-05-04
CN1610553A (zh) 2005-04-27
JP2015091891A (ja) 2015-05-14
AU2002316118A1 (en) 2002-11-25
CN100400045C (zh) 2008-07-09
US20030109471A1 (en) 2003-06-12
JP2013177453A (ja) 2013-09-09
US7256179B2 (en) 2007-08-14
CN101113160A (zh) 2008-01-30
JP2017119712A (ja) 2017-07-06
WO2002092006A3 (en) 2004-08-19
GB2392157B (en) 2005-12-21
HK1060736A1 (en) 2004-08-20
JP2009242439A (ja) 2009-10-22
GB0327057D0 (en) 2003-12-24
WO2002092006A2 (en) 2002-11-21
US6881831B2 (en) 2005-04-19
US20070270359A1 (en) 2007-11-22
US20050143337A1 (en) 2005-06-30
GB2392157A (en) 2004-02-25
KR20040074594A (ko) 2004-08-25
JP2005525991A (ja) 2005-09-02

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