KR100940432B1 - 엔도텔린 길항제로 유용한 신규한 알칸설폰아마이드 - Google Patents

엔도텔린 길항제로 유용한 신규한 알칸설폰아마이드 Download PDF

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Publication number
KR100940432B1
KR100940432B1 KR1020047010218A KR20047010218A KR100940432B1 KR 100940432 B1 KR100940432 B1 KR 100940432B1 KR 1020047010218 A KR1020047010218 A KR 1020047010218A KR 20047010218 A KR20047010218 A KR 20047010218A KR 100940432 B1 KR100940432 B1 KR 100940432B1
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Prior art keywords
pyrimidin
bromo
delete delete
ethoxy
amide
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KR1020047010218A
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Korean (ko)
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KR20040073525A (ko
Inventor
마틴 볼리
크리스토퍼 보스
마틴 클로젤
왈터 피스칠리
토마스 웰러
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액테리온 파마슈티칼 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P27/06—Antiglaucoma agents or miotics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020047010218A 2002-01-02 2002-12-10 엔도텔린 길항제로 유용한 신규한 알칸설폰아마이드 Expired - Fee Related KR100940432B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP0200002 2002-01-02
EPPCT/EP02/00002 2002-01-02
PCT/EP2002/013970 WO2003055863A1 (en) 2002-01-02 2002-12-10 Novel alkansulfonamides as endothelin antagonists

Publications (2)

Publication Number Publication Date
KR20040073525A KR20040073525A (ko) 2004-08-19
KR100940432B1 true KR100940432B1 (ko) 2010-02-10

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KR1020047010218A Expired - Fee Related KR100940432B1 (ko) 2002-01-02 2002-12-10 엔도텔린 길항제로 유용한 신규한 알칸설폰아마이드

Country Status (20)

Country Link
US (1) US7323465B2 (enExample)
JP (1) JP4769418B2 (enExample)
KR (1) KR100940432B1 (enExample)
CN (1) CN100537546C (enExample)
AR (1) AR037943A1 (enExample)
AT (1) ATE381545T1 (enExample)
AU (1) AU2002361033B8 (enExample)
BR (1) BR0215424A (enExample)
CA (1) CA2471220C (enExample)
DE (1) DE60224223T2 (enExample)
ES (1) ES2297040T3 (enExample)
HU (1) HUP0500082A2 (enExample)
IL (2) IL162534A0 (enExample)
MX (1) MXPA04006457A (enExample)
MY (1) MY138502A (enExample)
NO (1) NO327220B1 (enExample)
NZ (1) NZ533693A (enExample)
TW (1) TWI248436B (enExample)
WO (1) WO2003055863A1 (enExample)
ZA (1) ZA200404927B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010523540A (ja) * 2007-04-03 2010-07-15 ファイザー・インク スルホンアミドおよびその医薬組成物
IT1393136B1 (it) * 2009-03-11 2012-04-11 Sifa Vitor S R L Procedimento per la preparazione del bosentan
US20100256371A1 (en) * 2009-04-02 2010-10-07 Glenmark Processes for the preparation of bosentan and its intermediates thereof
AR077999A1 (es) * 2009-09-02 2011-10-05 Vifor Int Ag Antagonistas de pirimidin y triazin-hepcidina
EP2907811A1 (en) * 2014-02-14 2015-08-19 Actelion Pharmaceuticals Ltd. Process for manufacturing pyrimidine sulfamide derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0743307A1 (en) * 1995-05-16 1996-11-20 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
WO1998057938A1 (en) * 1997-06-19 1998-12-23 Yamanouchi Pharmaceutical Co., Ltd. Substituted lower alkanesulfonamide derivatives and pharmaceutical composition containing the same
EP1191026A1 (en) * 2000-09-20 2002-03-27 Pfizer Limited New pyridazine endothelin antagonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3013752B2 (ja) * 1995-05-16 2000-02-28 田辺製薬株式会社 スルホンアミド誘導体
AU703386B2 (en) * 1995-12-20 1999-03-25 Astellas Pharma Inc. Arylethenesulfonamide derivatives and drug composition containing the same
WO1998003488A1 (en) * 1996-07-23 1998-01-29 Shionogi & Co., Ltd. Novel pyrimidine compounds and drug compositions
JP3116347B2 (ja) * 1996-11-13 2000-12-11 田辺製薬株式会社 医薬組成物
AU775194B2 (en) * 1999-09-03 2004-07-22 Actelion Pharmaceuticals Ltd Bis-sulfonamides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0743307A1 (en) * 1995-05-16 1996-11-20 Tanabe Seiyaku Co., Ltd. Sulfonamide derivative and process for preparing the same
WO1998057938A1 (en) * 1997-06-19 1998-12-23 Yamanouchi Pharmaceutical Co., Ltd. Substituted lower alkanesulfonamide derivatives and pharmaceutical composition containing the same
EP1191026A1 (en) * 2000-09-20 2002-03-27 Pfizer Limited New pyridazine endothelin antagonists

Also Published As

Publication number Publication date
HUP0500082A2 (hu) 2005-04-28
WO2003055863A1 (en) 2003-07-10
KR20040073525A (ko) 2004-08-19
DE60224223D1 (de) 2008-01-31
CA2471220A1 (en) 2003-07-10
ATE381545T1 (de) 2008-01-15
JP2005513155A (ja) 2005-05-12
AU2002361033B8 (en) 2009-01-29
NO20043215L (no) 2004-07-29
CA2471220C (en) 2010-11-16
US7323465B2 (en) 2008-01-29
BR0215424A (pt) 2004-12-14
DE60224223T2 (de) 2008-12-04
CN100537546C (zh) 2009-09-09
ZA200404927B (en) 2005-11-30
ES2297040T3 (es) 2008-05-01
CN1612864A (zh) 2005-05-04
AU2002361033A1 (en) 2003-07-15
IL162534A0 (en) 2005-11-20
TW200404063A (en) 2004-03-16
JP4769418B2 (ja) 2011-09-07
AR037943A1 (es) 2004-12-22
TWI248436B (en) 2006-02-01
MY138502A (en) 2009-06-30
US20050085639A1 (en) 2005-04-21
NO327220B1 (no) 2009-05-18
MXPA04006457A (es) 2004-10-04
AU2002361033B2 (en) 2008-11-20
IL162534A (en) 2011-07-31
NZ533693A (en) 2007-02-23

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