KR100934785B1 - (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트의신규한 결정형 및 그의 제조방법 - Google Patents
(1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트의신규한 결정형 및 그의 제조방법 Download PDFInfo
- Publication number
- KR100934785B1 KR100934785B1 KR1020070124602A KR20070124602A KR100934785B1 KR 100934785 B1 KR100934785 B1 KR 100934785B1 KR 1020070124602 A KR1020070124602 A KR 1020070124602A KR 20070124602 A KR20070124602 A KR 20070124602A KR 100934785 B1 KR100934785 B1 KR 100934785B1
- Authority
- KR
- South Korea
- Prior art keywords
- map
- solution
- cooling
- methyl
- crystalline form
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 10
- 238000001816 cooling Methods 0.000 claims abstract description 43
- 238000000034 method Methods 0.000 claims abstract description 37
- 238000004519 manufacturing process Methods 0.000 claims abstract description 10
- -1 diphenylphosphoryloxy Chemical group 0.000 claims abstract description 9
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 54
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 36
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 25
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 24
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 18
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 8
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims description 8
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 6
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Natural products CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- GWESVXSMPKAFAS-UHFFFAOYSA-N Isopropylcyclohexane Natural products CC(C)C1CCCCC1 GWESVXSMPKAFAS-UHFFFAOYSA-N 0.000 claims description 2
- 239000002904 solvent Substances 0.000 abstract description 21
- 238000002425 crystallisation Methods 0.000 abstract description 13
- 230000008025 crystallization Effects 0.000 abstract description 13
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical class C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 abstract description 8
- 206010013647 Drowning Diseases 0.000 abstract description 4
- 239000012296 anti-solvent Substances 0.000 abstract description 2
- SOVAZWBKYILMFE-AKGZTFGVSA-N (5s)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound CC1C=C(C(O)=O)N2C(=O)C[C@@H]12 SOVAZWBKYILMFE-AKGZTFGVSA-N 0.000 abstract 1
- 238000009448 modified atmosphere packaging Methods 0.000 description 57
- 239000013078 crystal Substances 0.000 description 37
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 33
- 230000015572 biosynthetic process Effects 0.000 description 12
- 238000001914 filtration Methods 0.000 description 12
- 238000004611 spectroscopical analysis Methods 0.000 description 10
- 238000001228 spectrum Methods 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- 238000010791 quenching Methods 0.000 description 6
- 230000000171 quenching effect Effects 0.000 description 6
- 238000002441 X-ray diffraction Methods 0.000 description 5
- 239000000543 intermediate Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
- 125000006503 p-nitrobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1[N+]([O-])=O)C([H])([H])* 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 2
- 230000002528 anti-freeze Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 229960002182 imipenem Drugs 0.000 description 2
- ZSKVGTPCRGIANV-ZXFLCMHBSA-N imipenem Chemical compound C1C(SCC\N=C\N)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 ZSKVGTPCRGIANV-ZXFLCMHBSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 1
- ONVDWPOQKDMJBN-UHFFFAOYSA-N [bromo(phenoxy)phosphoryl]oxybenzene Chemical compound C=1C=CC=CC=1OP(=O)(Br)OC1=CC=CC=C1 ONVDWPOQKDMJBN-UHFFFAOYSA-N 0.000 description 1
- BHIIGRBMZRSDRI-UHFFFAOYSA-N [chloro(phenoxy)phosphoryl]oxybenzene Chemical compound C=1C=CC=CC=1OP(=O)(Cl)OC1=CC=CC=C1 BHIIGRBMZRSDRI-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- DHSUYTOATWAVLW-WFVMDLQDSA-N cilastatin Chemical compound CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O DHSUYTOATWAVLW-WFVMDLQDSA-N 0.000 description 1
- 229960004912 cilastatin Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940043279 diisopropylamine Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000019837 monoammonium phosphate Nutrition 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (17)
- X-선 분말회절분석에서 5.680, 6.980, 10.240, 10.620, 11.160, 15.020, 15.500, 16.720, 20.200, 20.720, 21.260, 22.200, 22.660, 25.060, 25.640, 26.020, 26.380, 28.000, 29.980, 31.060, 35.400, 36.800, 39.420, 45.260, 45.800 및 49.040의 2θ 회절각을 갖는, (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트(MAP)의 결정형 II.
- 결정형 I의 (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트(MAP)를 에틸아세테이트, 아세톤 또는 이소프로필알콜에 용해시킨 후, 이 용액을 0.1 내지 30K/분의 속도로 냉각시키는 것을 포함하는, 제 1 항의 MAP의 결정형 II의 제조방법.
- 제 2 항에 있어서,상기 에틸아세테이트, 아세톤 또는 이소프로필알콜을 MAP의 2 내지 12배 중량의 양으로 사용하는 것을 특징으로 하는, MAP의 결정형 II의 제조방법.
- 제 2 항에 있어서,상기 MAP를 에틸아세테이트에 용해시키고, 이때 MAP의 용해를 65 내지 75℃에서, 용액의 냉각을 5 내지 35℃에서 수행하고, 용액의 냉각시 용액을 250 내지 350rpm 의 속도로 교반하는 것을 특징으로 하는, MAP의 결정형 II의 제조방법.
- 제 2 항에 있어서,상기 MAP를 아세톤에 용해시키고, 이때 MAP의 용해를 30 내지 45℃에서, 용액의 냉각을 0 내지 -30℃에서 수행하고 용액의 냉각시 용액을 400 내지 500rpm의 속도로 교반하는 것을 특징으로 하는, MAP의 결정형 II의 제조방법.
- 제 2 항에 있어서,상기 MAP를 이소프로필알콜에 용해시킨 후 용액의 냉각에 앞서 용액에 용액의 0.3 내지 1배 중량의 물을 추가로 첨가하는 것을 특징으로 하는, MAP의 결정형 II의 제조방법.
- 제 6 항에 있어서,상기 MAP의 용해를 70 내지 80℃에서, 용액의 냉각을 -10 내지 10℃에서 수행하고, 용액의 냉각시 용액을 교반하지 않는 것을 특징으로 하는, MAP의 결정형 II의 제조방법.
- X-선 분말회절분석에서 5.660, 6.920, 10.660, 13.800, 15.500, 16.660, 20.700, 21.240, 25.060, 26.020, 27.560, 29.920, 31.080, 32.000, 36.820, 37.680 및 41.120의 2θ 회절각을 갖는, (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6- [(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트(MAP)의 결정형 III.
- 결정형 I의 (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트(MAP)를 메틸에틸케톤 또는 메틸아테세이트에 용해시킨 후, 이 용액을 0.1 내지 15K/분의 속도로 냉각시키는 것을 포함하는, 제 8 항의 MAP의 결정형 III의 제조방법.
- 제 9 항에 있어서,상기 메틸에틸케톤 또는 메틸아세테이트를 MAP의 3 내지 7배 중량의 양으로 사용하는 것을 특징으로 하는, MAP의 결정형 III의 제조방법.
- 제 9 항에 있어서,상기 MAP를 메틸에틸케톤에 용해시키고, 이때 MAP의 용해를 40 내지 55℃에서, 용액의 냉각을 0 내지 -30℃에서 수행하고, 용액의 냉각시 용액을 100 내지 300rpm으로 교반하는 것을 특징으로 하는, MAP의 결정형 III의 제조방법.
- 제 9 항에 있어서,상기 MAP를 메틸아세테이트에 용해시키고, 이때 MAP의 용해를 40 내지 55℃에서, 용액의 냉각을 0 내지 -30℃에서 수행하고, 용액의 냉각시 용액을 교반하지 않는 것을 특징으로 하는, MAP의 결정형 III의 제조방법.
- X-선 분말회절분석에서 3 내지 30의 범위 내에서 5.600, 6.860, 10.580, 13.280, 14.040, 15.480, 15.960, 16.640, 17.680, 17.960, 18.320, 20.840, 21.200, 21.820, 22.720, 24.960, 25.640, 26.300 및 30.000의 2θ 회절각을 갖는, (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트(MAP)의 무정형-함유 결정형.
- 제 13 항에 있어서,상기 결정형이 무정형을 75 내지 85%의 부피로 함유하는 것을 특징으로 하는, MAP의 무정형-함유 결정형.
- 결정형 I의 (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트(MAP)를 이소프로필알콜에 용해시킨 후, 이 용액과 사이클로헥산을 혼합하여 0.1 내지 15K/분의 속도로 냉각시키는 것을 포함하는, 제 13 항의 MAP의 무정형-함유 결정형의 제조방법.
- 제 15 항에 있어서,상기 MAP, 이소프로필알콜 및 사이클로헥산을 1:8~15:8~15의 중량비로 사용하는 것을 특징으로 하는, MAP의 무정형-함유 결정형의 제조방법.
- 제 15 항에 있어서,상기 MAP의 용해를 70 내지 80℃에서, 용액의 냉각을 0 내지 40℃에서 수행하고, 용액의 냉각시 용액을 100 내지 300rpm으로 교반하는 것을 특징으로 하는, MAP의 무정형-함유 결정형의 제조방법.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070124602A KR100934785B1 (ko) | 2007-12-03 | 2007-12-03 | (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트의신규한 결정형 및 그의 제조방법 |
JP2008308764A JP4588087B2 (ja) | 2007-12-03 | 2008-12-03 | (1R,5R,6S)−p−ニトロベンジル−2−(ジフェニルホスホリルオキシ)−6−[(R)−1−ヒドロキシエチル]−1−メチル−カルバペネム−3−カルボキシレートの新規な結晶形及びその製造方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020070124602A KR100934785B1 (ko) | 2007-12-03 | 2007-12-03 | (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트의신규한 결정형 및 그의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20090057843A KR20090057843A (ko) | 2009-06-08 |
KR100934785B1 true KR100934785B1 (ko) | 2009-12-31 |
Family
ID=40868950
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020070124602A KR100934785B1 (ko) | 2007-12-03 | 2007-12-03 | (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트의신규한 결정형 및 그의 제조방법 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP4588087B2 (ko) |
KR (1) | KR100934785B1 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103374037B (zh) * | 2012-04-12 | 2016-08-31 | 浙江九洲药业股份有限公司 | 碳青霉烯类化合物中间体的结晶纯化方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3080417B2 (ja) * | 1991-02-28 | 2000-08-28 | 日本ワイスレダリー株式会社 | 結晶形態の1−メチル−2−ジフエニルホスホリルオキシ−カルバペネム化合物 |
US6346617B1 (en) * | 1997-08-26 | 2002-02-12 | Merck & Co., Inc. | Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof |
JP3684339B2 (ja) * | 2001-07-10 | 2005-08-17 | ワイス株式会社 | カルバペネム化合物の製造方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3479720B2 (ja) * | 1992-07-08 | 2003-12-15 | 武田薬品工業株式会社 | カルバペネム類の製造法 |
JP3834798B2 (ja) * | 1995-05-16 | 2006-10-18 | 日本曹達株式会社 | アゼチジノン化合物の製造方法 |
JP4028098B2 (ja) * | 1998-07-30 | 2007-12-26 | 株式会社カネカ | カルバペネム抗生物質中間体の製造方法 |
CN101432289B (zh) * | 2006-04-28 | 2013-07-10 | 株式会社钟化 | 碳青霉素烯抗生素中间体的改良结晶析出方法 |
-
2007
- 2007-12-03 KR KR1020070124602A patent/KR100934785B1/ko active IP Right Grant
-
2008
- 2008-12-03 JP JP2008308764A patent/JP4588087B2/ja not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3080417B2 (ja) * | 1991-02-28 | 2000-08-28 | 日本ワイスレダリー株式会社 | 結晶形態の1−メチル−2−ジフエニルホスホリルオキシ−カルバペネム化合物 |
US6346617B1 (en) * | 1997-08-26 | 2002-02-12 | Merck & Co., Inc. | Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof |
JP3684339B2 (ja) * | 2001-07-10 | 2005-08-17 | ワイス株式会社 | カルバペネム化合物の製造方法 |
Also Published As
Publication number | Publication date |
---|---|
KR20090057843A (ko) | 2009-06-08 |
JP4588087B2 (ja) | 2010-11-24 |
JP2009137959A (ja) | 2009-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2005508321A (ja) | 結晶形態のエルタペネムナトリウム | |
CA2956714A1 (en) | Coformer salts of (2s,3s)-methyl 7-fluoro-2-(4-fluorophenyl)-3-(1-methyl-1h-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tetrahydroquinoline-5-carboxylate and methods of preparing them | |
CA2855022A1 (en) | 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal | |
KR101785186B1 (ko) | 프라수그렐 염의 결정형 | |
JP4480396B2 (ja) | カルバペネム化合物の製造方法 | |
KR100934785B1 (ko) | (1R,5R,6S)-p-니트로벤질-2-(디페닐포스포릴옥시)-6-[(R)-1-히드록시에틸]-1-메틸-카바페넴-3-카복실레이트의신규한 결정형 및 그의 제조방법 | |
US9000150B2 (en) | Process for the preparation of pure meropenem trihydrate | |
CN108358979B (zh) | 泰万菌素的纯化方法 | |
CN105646521B (zh) | 一种莫西克汀的结晶方法 | |
KR101299162B1 (ko) | 이미페넴 중간체의 제조방법 | |
KR20090007572A (ko) | 카르바페넴 항생 물질 중간체의 개량된 정석 방법 | |
KR101017944B1 (ko) | (1R, 5R, 6S)-p-나이트로벤질-2-(다이페닐포스포릴옥시)-6-[(R)-1-하이드록시에틸]-1-메틸-카바페넴-3-카복실레이트(MAP)결정형 Ⅱ의 제조방법 | |
KR102219563B1 (ko) | 페나진 유도체 제조를 위한 중간체 및 그의 제조방법 | |
US6225469B1 (en) | Process for the preparation of 7-alkoxyalkyl-1,2,4-triazolo[1,5-A] pyrimidine derivatives | |
CN115677697B (zh) | 粒度可调控且流动性好的b晶型阿维巴坦钠析晶方法 | |
CN109496215B (zh) | 一种福沙匹坦磷酸酯中间体及其制备方法 | |
KR101256692B1 (ko) | 결정 형태의 1β-메틸카르바페넴 중간체 | |
JP2015533142A (ja) | エルタペネム中間体の製造 | |
EP0985658B1 (en) | Process for producing l-valine benzyl ester p-toluenesulfonate | |
EP1637538B1 (en) | Crystalline carbapenem intermediate | |
CN106083859B (zh) | 一种亚胺培南一水合物晶体的制备方法 | |
Shiraiwa et al. | Optical Resolution by Preferential Crystallization of (RS)-Bromosuccinic Acid. | |
WO2008111018A2 (en) | Process for the preparation of crystals of prulifloxacin | |
KR20220044684A (ko) | 살리실아민 아세테이트 제조방법 | |
CN102633800A (zh) | 美罗培南中间体的晶体及其制备方法和应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20130327 Year of fee payment: 5 |
|
FPAY | Annual fee payment |
Payment date: 20140306 Year of fee payment: 6 |
|
FPAY | Annual fee payment |
Payment date: 20150306 Year of fee payment: 7 |
|
FPAY | Annual fee payment |
Payment date: 20160329 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20170403 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20180404 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20190402 Year of fee payment: 11 |