KR100890448B1 - 만성관절류머티즘에 관여하는 게놈dna, 그 진단방법,그 발증가능성의 판정방법, 및 이들의 검출용 진단키트 - Google Patents
만성관절류머티즘에 관여하는 게놈dna, 그 진단방법,그 발증가능성의 판정방법, 및 이들의 검출용 진단키트 Download PDFInfo
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- KR100890448B1 KR100890448B1 KR1020037012783A KR20037012783A KR100890448B1 KR 100890448 B1 KR100890448 B1 KR 100890448B1 KR 1020037012783 A KR1020037012783 A KR 1020037012783A KR 20037012783 A KR20037012783 A KR 20037012783A KR 100890448 B1 KR100890448 B1 KR 100890448B1
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- dna
- seq
- same
- rheumatoid arthritis
- diagnostic kit
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
Description
nt2522 +136 (A→G) | nt2522 +235 (A→G) | nt2522 +394 (C→T) | nt2522 +556 (A→G) | nt2522 +764 (G→A) | ||
RA환자 | 변이보유자수 | 14 | 15 | 1 | 15 | 15 |
n | 33 | 43 | 42 | 46 | 45 | |
빈도(%) | 42.42 | 34.88 | 2.38 | 32.61 | 33.33 | |
건강한 사람 | 변이보유자수 | 5 | 5 | 0 | 4 | 4 |
n | 15 | 18 | 19 | 18 | 18 | |
빈도(%) | 33.33 | 27.78 | 0 | 22.22 | 22.22 |
nt2632 +106 (T→G) | nt2632 +191 (T→A) | nt2632 +211 (A→C) | nt2745 +375 (A→G) | nt2745 +576 (G→A) | ||
RA환자 | 변이보유자수 | 19 | 0 | 19 | 0 | 20 |
n | 45 | 32 | 39 | 54 | 54 | |
빈도(%) | 42.32 | 0 | 48.72 | 0 | 37.04 | |
건강한 사람 | 변이보유자수 | 4 | 1 | 2 | 0 | 6 |
n | 17 | 12 | 14 | 24 | 24 | |
빈도(%) | 23.53 | 8.33 | 14.29 | 0 | 25 |
nt2745 +655 (A→G) | nt2745 +1368 (T→C) | nt2745 +1435 (T→C) | nt2745 +1527 (C→T) | nt2745 +1921 (A→G) | ||
RA환자 | 변이보유자수 | 2 | 14 | 10 | 14 | 13 |
n | 54 | 31 | 28 | 32 | 46 | |
빈도(%) | 3.7 | 45.16 | 35.71 | 43.75 | 28.26 | |
건강한 사람 | 변이보유자수 | 1 | 4 | 2 | 4 | 4 |
n | 26 | 10 | 8 | 11 | 23 | |
빈도(%) | 3.85 | 40 | 25 | 36.36 | 17.39 |
Claims (4)
- 배열번호 1의 염기배열로 이루어지는 게놈DNA에 있어서, 하기의 변이,(1) 위치 1987의 염기가 시토신(c)으로부터 티민(t)으로 치환,(2) 위치 3664의 염기가 티민(t)으로부터 구아닌(g)으로의 치환, 및(3) 위치 3769의 염기가 아데닌(a)으로부터 시토신(C)으로의 치환의 1이상을 갖는 것을 특징으로 하는 만성관절류머티즘에 관여하는 게놈DNA.
- 삭제
- 배열번호 2 및 3의 염기배열로 이루어지는 프라이머 세트, 제한효소 Hinf-I 및 DNA 합성효소를 포함하되, 제1항 기재의 위치 3664의 변이부위를 포함하는 상기 배열번호 2 및 3의 합성 올리고뉴클레오티드를 프라이머로 하여 DNA의 +스트랜드를 PCR 증폭하고, PCR 산물을 상기 제한효소 Hinf-I로 절단하여, 2단편화되는가의 여부를 판단하는 것을 특징으로 하는 만성관절류머티즘의 진단키트.
- 배열번호 2 및 3의 염기배열로 이루어지는 프라이머 세트, 제한효소 Hinf-I 및 DNA 합성효소를 포함하되, 제1항 기재의 위치 3664의 변이부위를 포함하는 상기 배열번호 2 및 3의 합성 올리고뉴클레오티드를 프라이머로 하여 DNA의 +스트랜드를 PCR 증폭하고, PCR 산물을 상기 제한효소 Hinf-I로 절단하여, 2단편화되는가의 여부를 판단하는 것을 특징으로 하는 만성관절류머티즘 발증가능성의 판정키트.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2001-00102006 | 2001-03-30 | ||
JP2001102006 | 2001-03-30 | ||
PCT/JP2002/003191 WO2002079466A1 (en) | 2001-03-30 | 2002-03-29 | Genomic dnas participating in rheumatoid arthritis, method of diagnosing the same, method of judging onset riks thereof and diagnostic kit for detecting the same |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20030093291A KR20030093291A (ko) | 2003-12-06 |
KR100890448B1 true KR100890448B1 (ko) | 2009-03-26 |
Family
ID=18955253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020037012783A KR100890448B1 (ko) | 2001-03-30 | 2002-03-29 | 만성관절류머티즘에 관여하는 게놈dna, 그 진단방법,그 발증가능성의 판정방법, 및 이들의 검출용 진단키트 |
Country Status (12)
Country | Link |
---|---|
US (1) | US7514211B2 (ko) |
EP (1) | EP1384777B1 (ko) |
JP (1) | JPWO2002079466A1 (ko) |
KR (1) | KR100890448B1 (ko) |
AT (1) | ATE432345T1 (ko) |
AU (1) | AU2002244949B2 (ko) |
CA (1) | CA2443146C (ko) |
DE (1) | DE60232442D1 (ko) |
DK (1) | DK1384777T3 (ko) |
ES (1) | ES2325807T3 (ko) |
PT (1) | PT1384777E (ko) |
WO (1) | WO2002079466A1 (ko) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000006769A2 (en) * | 1998-07-25 | 2000-02-10 | Astrazeneca | Human ccr-2 gene polymorphisms |
WO2000017394A1 (en) | 1998-09-19 | 2000-03-30 | Astrazeneca Ab | Polymorphisms in the human alpha4 integrin subunit gene, suitable for diagnosis and treatment of integrin ligand mediated diseases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
US6623924B1 (en) * | 1997-05-15 | 2003-09-23 | Shunichi Shiozawa | Method for determining susceptibility to rheumatoid arthritis |
ATE514779T1 (de) * | 1999-03-20 | 2011-07-15 | Shunichi Shiozawa | Rheumatische arthritis-gen und verfahren für die diagnose von rheumatischer arthritis |
-
2002
- 2002-03-29 AT AT02713262T patent/ATE432345T1/de active
- 2002-03-29 AU AU2002244949A patent/AU2002244949B2/en not_active Expired
- 2002-03-29 JP JP2002578468A patent/JPWO2002079466A1/ja active Pending
- 2002-03-29 CA CA2443146A patent/CA2443146C/en not_active Expired - Lifetime
- 2002-03-29 DK DK02713262T patent/DK1384777T3/da active
- 2002-03-29 PT PT02713262T patent/PT1384777E/pt unknown
- 2002-03-29 EP EP02713262A patent/EP1384777B1/en not_active Expired - Lifetime
- 2002-03-29 ES ES02713262T patent/ES2325807T3/es not_active Expired - Lifetime
- 2002-03-29 US US10/473,368 patent/US7514211B2/en not_active Expired - Lifetime
- 2002-03-29 DE DE60232442T patent/DE60232442D1/de not_active Expired - Lifetime
- 2002-03-29 KR KR1020037012783A patent/KR100890448B1/ko active IP Right Grant
- 2002-03-29 WO PCT/JP2002/003191 patent/WO2002079466A1/ja active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000006769A2 (en) * | 1998-07-25 | 2000-02-10 | Astrazeneca | Human ccr-2 gene polymorphisms |
WO2000006769A3 (en) | 1998-07-25 | 2000-05-11 | Zeneca Ltd | Human ccr-2 gene polymorphisms |
WO2000017394A1 (en) | 1998-09-19 | 2000-03-30 | Astrazeneca Ab | Polymorphisms in the human alpha4 integrin subunit gene, suitable for diagnosis and treatment of integrin ligand mediated diseases |
Also Published As
Publication number | Publication date |
---|---|
PT1384777E (pt) | 2009-06-12 |
ATE432345T1 (de) | 2009-06-15 |
US7514211B2 (en) | 2009-04-07 |
DE60232442D1 (de) | 2009-07-09 |
AU2002244949B2 (en) | 2007-08-30 |
EP1384777A1 (en) | 2004-01-28 |
JPWO2002079466A1 (ja) | 2004-07-22 |
ES2325807T3 (es) | 2009-09-18 |
CA2443146C (en) | 2011-03-29 |
EP1384777B1 (en) | 2009-05-27 |
KR20030093291A (ko) | 2003-12-06 |
EP1384777A4 (en) | 2005-06-01 |
CA2443146A1 (en) | 2002-10-10 |
US20040175706A1 (en) | 2004-09-09 |
DK1384777T3 (da) | 2009-09-07 |
WO2002079466A1 (en) | 2002-10-10 |
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