WO2000006769A3 - Human ccr-2 gene polymorphisms - Google Patents

Human ccr-2 gene polymorphisms Download PDF

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Publication number
WO2000006769A3
WO2000006769A3 PCT/GB1999/002341 GB9902341W WO0006769A3 WO 2000006769 A3 WO2000006769 A3 WO 2000006769A3 GB 9902341 W GB9902341 W GB 9902341W WO 0006769 A3 WO0006769 A3 WO 0006769A3
Authority
WO
WIPO (PCT)
Prior art keywords
ccr
gene
polymorphisms
gene polymorphisms
human ccr
Prior art date
Application number
PCT/GB1999/002341
Other languages
French (fr)
Other versions
WO2000006769A2 (en
Inventor
John Craig Smith
Rakesh Anand
John Edward Norris Morten
Original Assignee
Zeneca Ltd
John Craig Smith
Rakesh Anand
John Edward Norris Morten
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9816193.8A external-priority patent/GB9816193D0/en
Priority claimed from GBGB9901844.2A external-priority patent/GB9901844D0/en
Application filed by Zeneca Ltd, John Craig Smith, Rakesh Anand, John Edward Norris Morten filed Critical Zeneca Ltd
Priority to EP99934896A priority Critical patent/EP1100963A2/en
Priority to AU50529/99A priority patent/AU5052999A/en
Priority to JP2000562551A priority patent/JP2002521063A/en
Publication of WO2000006769A2 publication Critical patent/WO2000006769A2/en
Publication of WO2000006769A3 publication Critical patent/WO2000006769A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

This invention relates to polymorphisms in the human CCR-2 gene, in particular to the discovery of two polymorphisms in the coding sequence of the CCR-2 gene and 11 polymorphisms in the promoter sequence of the CCR-2 gene. The invention also relates to methods and materials for analysing allelic variation in the CCR-2 gene, and to the use of CCR-2 polymorphism in the diagnosis and treatment of CCR-2 ligand mediated diseases such as rheumatoid arthritis and other inflammatory diseases.
PCT/GB1999/002341 1998-07-25 1999-07-20 Human ccr-2 gene polymorphisms WO2000006769A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99934896A EP1100963A2 (en) 1998-07-25 1999-07-20 Human ccr-2 gene polymorphisms
AU50529/99A AU5052999A (en) 1998-07-25 1999-07-20 Human ccr-2 gene polymorphisms
JP2000562551A JP2002521063A (en) 1998-07-25 1999-07-20 Human CCR-2 gene polymorphism

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9816193.8A GB9816193D0 (en) 1998-07-25 1998-07-25 Chemical compounds
GB9816193.8 1999-01-28
GB9901844.2 1999-01-28
GBGB9901844.2A GB9901844D0 (en) 1999-01-28 1999-01-28 Chemical compounds

Publications (2)

Publication Number Publication Date
WO2000006769A2 WO2000006769A2 (en) 2000-02-10
WO2000006769A3 true WO2000006769A3 (en) 2000-05-11

Family

ID=26314110

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1999/002341 WO2000006769A2 (en) 1998-07-25 1999-07-20 Human ccr-2 gene polymorphisms

Country Status (4)

Country Link
EP (1) EP1100963A2 (en)
JP (1) JP2002521063A (en)
AU (1) AU5052999A (en)
WO (1) WO2000006769A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100890448B1 (en) 2001-03-30 2009-03-26 시오자와 순이찌 Genomic DNAS Participating in Rheumatoid Arthritis, Method of Diagnosing the Same, Method of Judging Onset Riks Thereof and Diagnostic Kit for Detecting the Same

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0004183D0 (en) * 2000-02-22 2000-04-12 Smithkline Beecham Plc New use
DE10049549A1 (en) 2000-10-06 2002-05-02 Markus Hecker Inhibitor of the transcription factor IFR-1, useful for treating e.g. transplant rejection and autoimmune disease, reduces expression of CD40
JP2009519001A (en) * 2002-12-20 2009-05-14 アプレラ コーポレイション Genetic polymorphism associated with stenosis, detection method and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09238688A (en) * 1996-03-11 1997-09-16 Takeda Chem Ind Ltd Production of human mcp-1 receptor protein and its use
WO1997040462A2 (en) * 1996-04-19 1997-10-30 Spectra Biomedical, Inc. Correlating polymorphic forms with multiple phenotypes
US5707815A (en) * 1994-01-13 1998-01-13 Regents Of The University Of California Mammalian monocyte chemoattractant protein receptors and assays using them

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707815A (en) * 1994-01-13 1998-01-13 Regents Of The University Of California Mammalian monocyte chemoattractant protein receptors and assays using them
JPH09238688A (en) * 1996-03-11 1997-09-16 Takeda Chem Ind Ltd Production of human mcp-1 receptor protein and its use
WO1997040462A2 (en) * 1996-04-19 1997-10-30 Spectra Biomedical, Inc. Correlating polymorphic forms with multiple phenotypes

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ANZALA A O ET AL.: "CCR2-64I allele and genotype association with delayed AIDS progression in african women", THE LANCET, vol. 351, 1998, pages 1632 - 1633, XP002121127 *
DATABASE GENBANK 1995, HILLIER L ET AL.: "The WashU-Merck EST project", XP002131229 *
DATABASE GENBANK 1997, WONG L M ET AL.: "Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene" *
KOSTRIKIS ET AL: "A chemokine receptor CCR2 allele delays HIV -1 disease progression is associated with a CCR5 promoter mutation", NATURE MEDICINE, vol. 4, no. 3, March 1998 (1998-03-01), pages 350 - 353, XP002099017, ISSN: 1078-8956 *
MUMMIDI S ET AL.: "Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression", NATURE MEDICINE, vol. 4, no. 7, 1998, pages 786 - 793, XP002121126 *
NEWTON C R ET AL: "ANALYSIS OF ANY POINT MUTATION IN DNA. THE AMPLIFICATION REFRACTORY MUTATION SYSTEM (ARMS)", NUCLEIC ACIDS RESEARCH, vol. 17, no. 7, 11 April 1989 (1989-04-11), pages 2503 - 2516, XP000141596, ISSN: 0305-1048 *
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 01 30 January 1998 (1998-01-30) *
RIZZARDI G P ET AL.: "CCR2 polymorphism and HIV disease", NATURE MEDICINE, vol. 4, no. 3, 1998, pages 252 - 253, XP002121128 *
SMITH ET AL: "Contrasting genetic influence of CCR2 and CCR5 variants on HIV -1 infection and disease progression", SCIENCE, vol. 277, 15 August 1997 (1997-08-15), pages 959 - 965, XP002099015, ISSN: 0036-8075 *
SOZZANI S ET AL: "MCP -1 and CCR2 in HIV infection: regulation of agonist and receptor expression", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 62, July 1997 (1997-07-01), pages 30 - 33, XP002099019, ISSN: 0741-5400 *
WONG L-M ET AL.: "Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 2, 1997, pages 1038 - 1045, XP002121129 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100890448B1 (en) 2001-03-30 2009-03-26 시오자와 순이찌 Genomic DNAS Participating in Rheumatoid Arthritis, Method of Diagnosing the Same, Method of Judging Onset Riks Thereof and Diagnostic Kit for Detecting the Same

Also Published As

Publication number Publication date
WO2000006769A2 (en) 2000-02-10
JP2002521063A (en) 2002-07-16
EP1100963A2 (en) 2001-05-23
AU5052999A (en) 2000-02-21

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