KR100865059B1 - 단순망막증 또는 전증식망막증의 예방제/치료제/진전억제제 - Google Patents

단순망막증 또는 전증식망막증의 예방제/치료제/진전억제제 Download PDF

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Publication number
KR100865059B1
KR100865059B1 KR1020017013765A KR20017013765A KR100865059B1 KR 100865059 B1 KR100865059 B1 KR 100865059B1 KR 1020017013765 A KR1020017013765 A KR 1020017013765A KR 20017013765 A KR20017013765 A KR 20017013765A KR 100865059 B1 KR100865059 B1 KR 100865059B1
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South Korea
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group
compound
angiotensin
retinopathy
antagonistic activity
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Expired - Fee Related
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KR1020017013765A
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Korean (ko)
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KR20020015315A (ko
Inventor
나까가와시즈에
나기사야스따까
이께다히또시
Original Assignee
다케다 야쿠힌 고교 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020017013765A 1999-04-28 2000-04-27 단순망막증 또는 전증식망막증의 예방제/치료제/진전억제제 Expired - Fee Related KR100865059B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12149899 1999-04-28
JPJP-P-1999-00121498 1999-04-28
PCT/JP2000/002766 WO2000066161A1 (en) 1999-04-28 2000-04-27 Preventives / remedies / progression inhibitors for simplex retinopathy or preproliferating retinopathy

Publications (2)

Publication Number Publication Date
KR20020015315A KR20020015315A (ko) 2002-02-27
KR100865059B1 true KR100865059B1 (ko) 2008-10-23

Family

ID=14812676

Family Applications (1)

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KR1020017013765A Expired - Fee Related KR100865059B1 (ko) 1999-04-28 2000-04-27 단순망막증 또는 전증식망막증의 예방제/치료제/진전억제제

Country Status (23)

Country Link
US (2) US7064141B1 (enExample)
EP (1) EP1197223B1 (enExample)
KR (1) KR100865059B1 (enExample)
CN (1) CN1172719C (enExample)
AT (1) ATE289204T1 (enExample)
AU (1) AU774799B2 (enExample)
BR (1) BR0010084A (enExample)
CA (1) CA2371554C (enExample)
CZ (1) CZ301913B6 (enExample)
DE (1) DE60018186T2 (enExample)
DK (1) DK1197223T3 (enExample)
ES (1) ES2233362T3 (enExample)
HU (1) HU226948B1 (enExample)
MX (1) MXPA01010923A (enExample)
NO (1) NO327446B1 (enExample)
NZ (1) NZ514855A (enExample)
PL (1) PL196895B1 (enExample)
PT (1) PT1197223E (enExample)
RU (1) RU2239454C2 (enExample)
SI (1) SI1197223T1 (enExample)
SK (1) SK286859B6 (enExample)
WO (1) WO2000066161A1 (enExample)
ZA (1) ZA200108527B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1452176A4 (en) * 2001-12-03 2009-01-21 Takeda Pharmaceutical AGENTS FOR IMPROVING THE STATE OF RESISTANCE OF INSULIN
JP4484427B2 (ja) * 2001-12-03 2010-06-16 武田薬品工業株式会社 インスリン抵抗性改善剤
TW200304812A (en) * 2002-03-08 2003-10-16 Sankyo Co An eye drop containing a tetrazole derivative
US8980870B2 (en) 2002-09-24 2015-03-17 Boehringer Ingelheim International Gmbh Solid telmisartan pharmaceutical formulations
DE10335027A1 (de) * 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
KR101087519B1 (ko) * 2003-04-15 2011-11-28 상꾜 가부시키가이샤 안구 내 혈관 신생성 질환의 예방 또는 치료를 위한 의약
US20050038093A1 (en) * 2003-05-02 2005-02-17 Boehringer Ingelheim International Gmbh Treating diabetic retinopathy with angiotensin II receptor blockers
PT1784181E (pt) 2004-08-31 2013-08-26 Newsouth Innovations Pty Ltd Inibição do vegf
AU2005300787B2 (en) * 2004-11-05 2011-05-26 Boehringer Ingelheim International Gmbh Bilayer tablet comprising telmisartan and amlodipine
EP1872783B1 (en) * 2005-04-21 2011-12-28 Santen Pharmaceutical Co., Ltd. Therapeutic agent for corneal/conjunctival disorder
EP1958949A4 (en) * 2005-12-06 2010-04-28 Santen Pharmaceutical Co Ltd THERAPEUTIC AGENT AGAINST HORNHAUT / BINDEHAUT DISEASE
MX2009010167A (es) * 2007-03-28 2009-10-12 Takeda Pharmaceutical Composicion farmaceutica solida que comprende un derivado de bencimidazol-7-carboxilato y un agente para el control del ph.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010183A1 (en) * 1990-12-14 1992-06-25 Smithkline Beecham Plc Use of angiotensin ii receptor antagonists in the treatment of diabetic retinopathy
JPH09210183A (ja) * 1996-01-31 1997-08-12 Suzuki Motor Corp 動力伝達装置
WO1999001459A1 (en) * 1997-06-30 1999-01-14 Zambon Group S.P.A. Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4201554A1 (de) 1992-01-22 1993-07-29 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5591762A (en) 1991-02-06 1997-01-07 Dr. Karl Thomae Gmbh Benzimidazoles useful as angiotensin-11 antagonists
GB9110635D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
ZA931063B (en) * 1992-02-17 1993-09-23 Ciba Geigy Treatment of glaucoma.
GB9223860D0 (en) * 1992-11-13 1993-01-06 Glaxo Group Ltd Chemical compounds
CZ154994A3 (en) 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
JPH0789957A (ja) * 1993-09-22 1995-04-04 Nissan Chem Ind Ltd ビフェニルメチルアミン誘導体
ES2243933T3 (es) * 1994-02-08 2005-12-01 Novartis Ag Tratamiento de glaucoma normotensivo con antagonistas de angiotensina ii.
BR9708336A (pt) * 1996-03-29 1999-08-03 Smithkline Beecham Corp Diidrato de eprosartan e processo para sua produção e formulação
CZ297941B6 (cs) 1996-04-05 2007-05-02 Takeda Pharmaceutical Company Limited Farmaceutický prípravek obsahující slouceninu s antagonickým úcinkem k angiotensinu II
TW416953B (en) * 1996-09-25 2001-01-01 Takeda Chemical Industries Ltd Tricyclic compounds for eliciting a prostaglandin I2 receptor agonistic effect, their production and use
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2182334T3 (es) 1997-06-27 2003-03-01 Smithkline Beecham Corp Monohidrato de eprosartan.
TR200000350T2 (tr) * 1997-08-06 2000-12-21 Smithkline Beecham Corporation Eprosartan arginil yüklenmesini-nötrleştirme-kompleksi ve bunun üretim prosesi ve formülasyonu.
WO1999044590A1 (en) 1998-03-04 1999-09-10 Takeda Chemical Industries, Ltd. Sustained-release preparation for aii antagonist, production and use thereof
SI1096932T1 (sl) 1998-07-10 2008-04-30 Novartis Pharma Ag Antihipertenzivna kombinacija valsartana in zaviralca kalcijevih kanalov
FR2783422A1 (fr) * 1998-09-21 2000-03-24 Sanofi Sa Composition pharmaceutique contenant un antagoniste des recepteurs at1 de l'angiotensine ii et un antiagregant plaquettaire
JP2000159671A (ja) * 1998-12-01 2000-06-13 Takeda Chem Ind Ltd 血管新生阻害剤

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010183A1 (en) * 1990-12-14 1992-06-25 Smithkline Beecham Plc Use of angiotensin ii receptor antagonists in the treatment of diabetic retinopathy
JPH09210183A (ja) * 1996-01-31 1997-08-12 Suzuki Motor Corp 動力伝達装置
WO1999001459A1 (en) * 1997-06-30 1999-01-14 Zambon Group S.P.A. Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
국제공개특허 제92/10183호
국제공개특허 제99/01459호

Also Published As

Publication number Publication date
CA2371554C (en) 2009-06-09
KR20020015315A (ko) 2002-02-27
BR0010084A (pt) 2002-01-15
EP1197223A1 (en) 2002-04-17
ZA200108527B (en) 2002-10-17
PL196895B1 (pl) 2008-02-29
HU226948B1 (en) 2010-03-29
AU774799B2 (en) 2004-07-08
NZ514855A (en) 2004-01-30
CN1172719C (zh) 2004-10-27
RU2239454C2 (ru) 2004-11-10
US20060189669A1 (en) 2006-08-24
DK1197223T3 (da) 2005-05-30
AU4143400A (en) 2000-11-17
DE60018186D1 (de) 2005-03-24
WO2000066161A1 (en) 2000-11-09
DE60018186T2 (de) 2005-12-29
ATE289204T1 (de) 2005-03-15
EP1197223A4 (en) 2003-10-29
PL350554A1 (en) 2002-12-16
NO20015257L (no) 2001-10-26
HUP0200890A2 (hu) 2002-11-28
PT1197223E (pt) 2005-04-29
CN1348385A (zh) 2002-05-08
CZ20013804A3 (cs) 2002-04-17
SI1197223T1 (enExample) 2005-08-31
NO327446B1 (no) 2009-06-29
NO20015257D0 (no) 2001-10-26
ES2233362T3 (es) 2005-06-16
CA2371554A1 (en) 2000-11-09
MXPA01010923A (es) 2002-06-21
SK15452001A3 (sk) 2002-04-04
SK286859B6 (sk) 2009-06-05
CZ301913B6 (cs) 2010-07-28
HUP0200890A3 (en) 2002-12-28
US7064141B1 (en) 2006-06-20
EP1197223B1 (en) 2005-02-16

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