KR100854583B1 - 피라졸릴 피리미딘 - Google Patents

피라졸릴 피리미딘 Download PDF

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Publication number
KR100854583B1
KR100854583B1 KR1020037010576A KR20037010576A KR100854583B1 KR 100854583 B1 KR100854583 B1 KR 100854583B1 KR 1020037010576 A KR1020037010576 A KR 1020037010576A KR 20037010576 A KR20037010576 A KR 20037010576A KR 100854583 B1 KR100854583 B1 KR 100854583B1
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KR
South Korea
Prior art keywords
alkyl
general formula
spp
optionally
formula
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Expired - Fee Related
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KR1020037010576A
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English (en)
Korean (ko)
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KR20030075188A (ko
Inventor
피셔뤼디거
알릭베른트
브레트슈나이더토마스
에스-자에드마젠
에르델렌크리스토프
뢰젤페터
레크만우도
Original Assignee
바이엘 크롭사이언스 아게
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Publication of KR20030075188A publication Critical patent/KR20030075188A/ko
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Publication of KR100854583B1 publication Critical patent/KR100854583B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020037010576A 2001-02-22 2002-02-11 피라졸릴 피리미딘 Expired - Fee Related KR100854583B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10108480.3 2001-02-22
DE10108480A DE10108480A1 (de) 2001-02-22 2001-02-22 Pyrazolylpyrimidine
PCT/EP2002/001400 WO2002068413A1 (de) 2001-02-22 2002-02-11 Pyrazolylpyrimidine

Publications (2)

Publication Number Publication Date
KR20030075188A KR20030075188A (ko) 2003-09-22
KR100854583B1 true KR100854583B1 (ko) 2008-08-27

Family

ID=7675081

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037010576A Expired - Fee Related KR100854583B1 (ko) 2001-02-22 2002-02-11 피라졸릴 피리미딘

Country Status (13)

Country Link
US (1) US7087616B2 (https=)
EP (1) EP1363905A1 (https=)
JP (1) JP2004524315A (https=)
KR (1) KR100854583B1 (https=)
CN (1) CN1301992C (https=)
BR (1) BR0207509A (https=)
DE (1) DE10108480A1 (https=)
HU (1) HUP0303241A2 (https=)
IL (1) IL157298A0 (https=)
MX (1) MXPA03007433A (https=)
TW (1) TWI236475B (https=)
WO (1) WO2002068413A1 (https=)
ZA (1) ZA200306468B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11724982B2 (en) 2014-10-10 2023-08-15 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI372050B (en) * 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
EP1833819A1 (en) 2004-12-30 2007-09-19 Astex Therapeutics Limited Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases
DE102005058418A1 (de) * 2005-12-07 2007-06-21 Bayer Cropscience Gmbh Verfahren zur Herstellung von Haloalkyl(thio)vinimidiniumsalzen und 4-(Haloalkyl(thio))-pyrazolen und deren Umsetzung zu Pflanzenschutzmitteln
EP1968579A1 (en) * 2005-12-30 2008-09-17 Astex Therapeutics Limited Pharmaceutical compounds
WO2008001101A2 (en) * 2006-06-29 2008-01-03 Astex Therapeutics Limited Pharmaceutical combinations
EP2049119A2 (en) * 2006-06-29 2009-04-22 Astex Therapeutics Limited Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morphoolin-4-ylmethyl-1h-benzoimidazol-2-yl)-1h-1-pyrazol-4-yl]-urea
DE102007003036A1 (de) * 2006-12-20 2008-06-26 Bayer Cropscience Ag Pyrimidinylpyrazole
DE102007044032A1 (de) 2007-09-14 2009-03-19 Bayer Healthcare Ag Substituierte heterocyclische Verbindungen und ihre Verwendung
DE102007048447A1 (de) 2007-10-10 2009-04-16 Bayer Healthcare Ag Substituierte Dihydropyrazolthione und ihre Verwendung
EP2135865A1 (de) * 2008-06-17 2009-12-23 Bayer CropScience AG Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
CN102186809A (zh) * 2008-08-14 2011-09-14 拜尔农作物科学股份公司 杀虫性的4-苯基-1h-吡唑
KR20120027265A (ko) 2009-04-27 2012-03-21 다우 아그로사이언시즈 엘엘씨 살충성 피리딘 화합물
WO2011045224A1 (de) * 2009-10-12 2011-04-21 Bayer Cropscience Ag 1- (pyrid-3-yl) -pyrazole und 1- (pyrimid-5-yl) -pyrazole als schädlingsbekämpfungsmittel
AR078947A1 (es) 2009-11-11 2011-12-14 Bayer Cropscience Ag Compuestos de diazinil-pirazolilo y procesos de preparacion de los mismos
JP2012116796A (ja) * 2010-12-01 2012-06-21 Sumitomo Chemical Co Ltd ヘテロ芳香環化合物およびその有害生物防除用途
KR20140138293A (ko) 2012-03-16 2014-12-03 액시킨 파마수티컬스 인코포레이티드 3,5-다이아미노피라졸 키나아제 억제제
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
HRP20220522T1 (hr) 2014-08-04 2022-06-10 Nuevolution A/S Proizvoljno kondenzirani heterociklil-supstituirani derivati pirimidina koji su korisni za liječenje upalnih, metaboličkih, onkoloških i autoimunih bolesti
US9546163B2 (en) 2014-12-23 2017-01-17 Axikin Pharmaceuticals, Inc. 3,5-diaminopyrazole kinase inhibitors
US11685727B2 (en) 2019-12-20 2023-06-27 Nuevolution A/S Compounds active towards nuclear receptors
MX2022007265A (es) 2019-12-20 2022-09-09 Nuevolution As Compuestos activos frente a receptores nucleares.
CA3174176A1 (en) 2020-03-31 2021-10-07 Sanne Schroder Glad Compounds active towards nuclear receptors
EP4126874A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165448A2 (de) * 1984-05-23 1985-12-27 Bayer Ag 1-Heteroaryl-4-aryl-pyrozolin-5-one
EP0967212A1 (en) * 1996-12-16 1999-12-29 Sumitomo Chemical Company Limited Pyrazoline compounds and use as plant disease control agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910910A (en) * 1972-03-31 1975-10-07 American Home Prod (2-Pyrimidinylthio) alkanoic acids, esters, amides and hydrazides
EP0702670A1 (de) 1993-06-07 1996-03-27 Bayer Ag Iodpropargylcarbamate und ihre verwendung als biozide im pflanzen- und materialschutz
CN1153779A (zh) * 1995-09-28 1997-07-09 山道士有限公司 2-(4-吡唑基氧基-嘧啶-5-基)乙酸衍生物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165448A2 (de) * 1984-05-23 1985-12-27 Bayer Ag 1-Heteroaryl-4-aryl-pyrozolin-5-one
EP0967212A1 (en) * 1996-12-16 1999-12-29 Sumitomo Chemical Company Limited Pyrazoline compounds and use as plant disease control agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11724982B2 (en) 2014-10-10 2023-08-15 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

Also Published As

Publication number Publication date
TWI236475B (en) 2005-07-21
IL157298A0 (en) 2004-02-19
CN1492864A (zh) 2004-04-28
HUP0303241A2 (hu) 2004-01-28
DE10108480A1 (de) 2002-09-05
JP2004524315A (ja) 2004-08-12
EP1363905A1 (de) 2003-11-26
BR0207509A (pt) 2004-03-09
WO2002068413A1 (de) 2002-09-06
CN1301992C (zh) 2007-02-28
KR20030075188A (ko) 2003-09-22
US20040102465A1 (en) 2004-05-27
MXPA03007433A (es) 2003-11-18
ZA200306468B (en) 2005-02-04
US7087616B2 (en) 2006-08-08

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