KR100854583B1 - 피라졸릴 피리미딘 - Google Patents

피라졸릴 피리미딘 Download PDF

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Publication number
KR100854583B1
KR100854583B1 KR1020037010576A KR20037010576A KR100854583B1 KR 100854583 B1 KR100854583 B1 KR 100854583B1 KR 1020037010576 A KR1020037010576 A KR 1020037010576A KR 20037010576 A KR20037010576 A KR 20037010576A KR 100854583 B1 KR100854583 B1 KR 100854583B1
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KR
South Korea
Prior art keywords
alkyl
general formula
spp
optionally
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020037010576A
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English (en)
Korean (ko)
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KR20030075188A (ko
Inventor
피셔뤼디거
알릭베른트
브레트슈나이더토마스
에스-자에드마젠
에르델렌크리스토프
뢰젤페터
레크만우도
Original Assignee
바이엘 크롭사이언스 아게
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Publication of KR20030075188A publication Critical patent/KR20030075188A/ko
Application granted granted Critical
Publication of KR100854583B1 publication Critical patent/KR100854583B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020037010576A 2001-02-22 2002-02-11 피라졸릴 피리미딘 Expired - Fee Related KR100854583B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10108480.3 2001-02-22
DE10108480A DE10108480A1 (de) 2001-02-22 2001-02-22 Pyrazolylpyrimidine
PCT/EP2002/001400 WO2002068413A1 (de) 2001-02-22 2002-02-11 Pyrazolylpyrimidine

Publications (2)

Publication Number Publication Date
KR20030075188A KR20030075188A (ko) 2003-09-22
KR100854583B1 true KR100854583B1 (ko) 2008-08-27

Family

ID=7675081

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037010576A Expired - Fee Related KR100854583B1 (ko) 2001-02-22 2002-02-11 피라졸릴 피리미딘

Country Status (13)

Country Link
US (1) US7087616B2 (enExample)
EP (1) EP1363905A1 (enExample)
JP (1) JP2004524315A (enExample)
KR (1) KR100854583B1 (enExample)
CN (1) CN1301992C (enExample)
BR (1) BR0207509A (enExample)
DE (1) DE10108480A1 (enExample)
HU (1) HUP0303241A2 (enExample)
IL (1) IL157298A0 (enExample)
MX (1) MXPA03007433A (enExample)
TW (1) TWI236475B (enExample)
WO (1) WO2002068413A1 (enExample)
ZA (1) ZA200306468B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11724982B2 (en) 2014-10-10 2023-08-15 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI372050B (en) * 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
MX2007008008A (es) 2004-12-30 2007-11-12 Astex Therapeutics Ltd Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora.
DE102005058418A1 (de) * 2005-12-07 2007-06-21 Bayer Cropscience Gmbh Verfahren zur Herstellung von Haloalkyl(thio)vinimidiniumsalzen und 4-(Haloalkyl(thio))-pyrazolen und deren Umsetzung zu Pflanzenschutzmitteln
JP5474354B2 (ja) * 2005-12-30 2014-04-16 アステックス、セラピューティックス、リミテッド 医薬化合物
US8435970B2 (en) * 2006-06-29 2013-05-07 Astex Therapeutics Limited Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea
JP2009542608A (ja) * 2006-06-29 2009-12-03 アステックス・セラピューティクス・リミテッド 医薬組合せ剤
DE102007003036A1 (de) * 2006-12-20 2008-06-26 Bayer Cropscience Ag Pyrimidinylpyrazole
DE102007044032A1 (de) 2007-09-14 2009-03-19 Bayer Healthcare Ag Substituierte heterocyclische Verbindungen und ihre Verwendung
DE102007048447A1 (de) 2007-10-10 2009-04-16 Bayer Healthcare Ag Substituierte Dihydropyrazolthione und ihre Verwendung
EP2135865A1 (de) * 2008-06-17 2009-12-23 Bayer CropScience AG Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US20110190365A1 (en) * 2008-08-14 2011-08-04 Bayer Crop Science Ag Insecticidal 4-phenyl-1H-pyrazoles
DE112010001898T5 (de) * 2009-04-27 2012-08-02 Dow Agrosciences Llc Insektizide Pyridinverbindungen
CN102573478B (zh) * 2009-10-12 2015-12-16 拜尔农作物科学股份公司 作为杀虫剂的1-(吡啶-3-基)-吡唑和1-(嘧啶-5-基)-吡唑
AR078947A1 (es) 2009-11-11 2011-12-14 Bayer Cropscience Ag Compuestos de diazinil-pirazolilo y procesos de preparacion de los mismos
JP2012116796A (ja) * 2010-12-01 2012-06-21 Sumitomo Chemical Co Ltd ヘテロ芳香環化合物およびその有害生物防除用途
CN104302640A (zh) 2012-03-16 2015-01-21 埃克希金医药品有限公司 3,5-二氨基吡唑激酶抑制剂
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
MY195016A (en) 2014-08-04 2023-01-03 Nuevolution As Optionally Fused Heterocyclyl-Substituted Derivatives of Pyrimidine Useful for The Treatment of Inflammatory, Metabolic, Oncologic and Autoimmune Diseases
MY191736A (en) 2014-12-23 2022-07-13 Axikin Pharmaceuticals Inc 3,5-diaminopyrazole kinase inhibitors
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
BR112022012205A2 (pt) 2019-12-20 2022-09-13 Nuevolution As Compostos ativos para receptores nucleares
JP7713954B2 (ja) 2020-03-31 2025-07-28 ヌエヴォリューション・アクティーゼルスカブ 核内受容体に対して活性な化合物
CA3174252A1 (en) 2020-03-31 2021-10-07 Nuevolution A/S Compounds active towards nuclear receptors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165448A2 (de) * 1984-05-23 1985-12-27 Bayer Ag 1-Heteroaryl-4-aryl-pyrozolin-5-one
EP0967212A1 (en) * 1996-12-16 1999-12-29 Sumitomo Chemical Company Limited Pyrazoline compounds and use as plant disease control agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910910A (en) * 1972-03-31 1975-10-07 American Home Prod (2-Pyrimidinylthio) alkanoic acids, esters, amides and hydrazides
EP0702670A1 (de) 1993-06-07 1996-03-27 Bayer Ag Iodpropargylcarbamate und ihre verwendung als biozide im pflanzen- und materialschutz
CN1153779A (zh) * 1995-09-28 1997-07-09 山道士有限公司 2-(4-吡唑基氧基-嘧啶-5-基)乙酸衍生物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165448A2 (de) * 1984-05-23 1985-12-27 Bayer Ag 1-Heteroaryl-4-aryl-pyrozolin-5-one
EP0967212A1 (en) * 1996-12-16 1999-12-29 Sumitomo Chemical Company Limited Pyrazoline compounds and use as plant disease control agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11724982B2 (en) 2014-10-10 2023-08-15 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration

Also Published As

Publication number Publication date
IL157298A0 (en) 2004-02-19
JP2004524315A (ja) 2004-08-12
US7087616B2 (en) 2006-08-08
MXPA03007433A (es) 2003-11-18
HUP0303241A2 (hu) 2004-01-28
CN1492864A (zh) 2004-04-28
EP1363905A1 (de) 2003-11-26
DE10108480A1 (de) 2002-09-05
ZA200306468B (en) 2005-02-04
US20040102465A1 (en) 2004-05-27
CN1301992C (zh) 2007-02-28
TWI236475B (en) 2005-07-21
KR20030075188A (ko) 2003-09-22
WO2002068413A1 (de) 2002-09-06
BR0207509A (pt) 2004-03-09

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