KR100851648B1 - 남성의 테스토스테론 결핍치료용 물질 - Google Patents
남성의 테스토스테론 결핍치료용 물질 Download PDFInfo
- Publication number
- KR100851648B1 KR100851648B1 KR1020047000258A KR20047000258A KR100851648B1 KR 100851648 B1 KR100851648 B1 KR 100851648B1 KR 1020047000258 A KR1020047000258 A KR 1020047000258A KR 20047000258 A KR20047000258 A KR 20047000258A KR 100851648 B1 KR100851648 B1 KR 100851648B1
- Authority
- KR
- South Korea
- Prior art keywords
- clomiphene
- testosterone
- trans
- treatment
- levels
- Prior art date
Links
- 0 *c(cc1)ccc1C(c1ccccc1)=C(c1ccccc1)Cl Chemical compound *c(cc1)ccc1C(c1ccccc1)=C(c1ccccc1)Cl 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Beans For Foods Or Fodder (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (8)
- 시스-클로미펜과 트랜스-클로미펜 또는 약학적으로 용인가능한 염류나 그것의 용매화합물과 선택적으로 하나 또는 그 이상의 약학적으로 용인가능한 희석액, 보조약, 기제나 첨가제를 포함하고, 상기 트랜스-클로미펜과 시스-클로미펜의 비가 71/29 w/w보다 큰 물질을 유효성분으로 포함하는 수컷 포유류에서 테스토스테론의 혈청수치를 증가시키는 치료를 위한 조성물.
- 제 1항에 있어서,상기 조성물은 필수적으로 트랜스-클로미펜 또는 약학적으로 효과적인 염류나 그것의 용매화합물과 선택적으로 하나 또는 그 이상의 약학적으로 용인가능한 희석액, 보조약, 기제 또는 첨가제의 효과적인 양으로 구성되는 것을 특징으로 하는 조성물.
- 삭제
- 삭제
- 제 1항 또는 제 2항에 있어서,상기 조성물은 필수적으로 트랜스-클로미펜 1에서 200mg 사이의 용량으로 구성되는 것을 특징으로 하는 조성물.
- 제 1항 또는 제 2항에 있어서,상기 조성물은 하루에 트랜스-클로미펜 1.5mg/kg의 용량으로 투여되는 것을 특징으로 하는 조성물.
- 제 1항 또는 제 2항에 있어서,상기 조성물은 경구적 사용을 위해 채워진 캡슐 형태인 것을 특징으로 하는 조성물.
- 제 1항 또는 제 2항에 있어서,상기 조성물은 1차 또는 2차 성선기능저하증, 발기부전, 정자 부족증, 무정자증, 진행성 근육 질량 감소, 피로, 우울감 또는 골다공증의 치료를 위해 사용되는 것을 특징으로 하는 조성물.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30431301P | 2001-07-09 | 2001-07-09 | |
US60/304,313 | 2001-07-09 | ||
PCT/US2002/021524 WO2003005954A2 (en) | 2001-07-09 | 2002-07-09 | Methods and materials for the treatment of testosterone deficiency in men |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040013131A KR20040013131A (ko) | 2004-02-11 |
KR100851648B1 true KR100851648B1 (ko) | 2008-08-13 |
Family
ID=23175972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020047000258A KR100851648B1 (ko) | 2001-07-09 | 2002-07-09 | 남성의 테스토스테론 결핍치료용 물질 |
Country Status (24)
Country | Link |
---|---|
US (6) | US7759360B2 (ko) |
EP (1) | EP1411916B1 (ko) |
JP (2) | JP4845165B2 (ko) |
KR (1) | KR100851648B1 (ko) |
CN (2) | CN1954807A (ko) |
AT (1) | ATE406153T1 (ko) |
AU (1) | AU2002318225B2 (ko) |
BR (1) | BR0211067A (ko) |
CA (2) | CA2777199A1 (ko) |
CL (1) | CL2004000026A1 (ko) |
CO (1) | CO5550428A2 (ko) |
CY (1) | CY1108563T1 (ko) |
DE (1) | DE60228583D1 (ko) |
DK (1) | DK1411916T3 (ko) |
EC (1) | ECSP044937A (ko) |
ES (1) | ES2312593T3 (ko) |
HK (1) | HK1071521A1 (ko) |
MX (1) | MXPA04000097A (ko) |
NZ (2) | NZ530491A (ko) |
PL (1) | PL211339B1 (ko) |
PT (1) | PT1411916E (ko) |
RU (1) | RU2297218C2 (ko) |
WO (1) | WO2003005954A2 (ko) |
ZA (1) | ZA200400142B (ko) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2777199A1 (en) | 2001-07-09 | 2003-01-23 | Repros Therapeutics Inc. | Methods and materials for the treatment of testosterone deficiency in men |
US7737185B2 (en) | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
US7173064B2 (en) | 2001-07-09 | 2007-02-06 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy |
MX2007000050A (es) * | 2004-07-14 | 2007-07-10 | Repros Therapeutics Inc | Trans-clomifeno para el tratamiento de hipertrofia de prostata benigna, cancer de prostata, hipogonadismo, trigliceridos elevados y colesterol elevado. |
KR20070100811A (ko) * | 2005-02-04 | 2007-10-11 | 레프로스 쎄라피우틱스 아이엔씨. | 남성불임의 치료를 위한 트랜스―클로미펜을 이용한 물질과치료방법 |
EP2392322A3 (en) * | 2005-03-22 | 2012-02-22 | Repros Therapeutics Inc. | Dosing regimes for trans-clomiphene |
WO2008157335A2 (en) * | 2007-06-13 | 2008-12-24 | Quatrx Pharmaceuticals Company | Methods for the treatment of erectile dysfunction using fispemifene |
US20110118355A1 (en) * | 2007-09-21 | 2011-05-19 | Harry Fisch | Treatment of migraine headaches using antiestrogens |
US20090105348A1 (en) * | 2007-10-18 | 2009-04-23 | Harry Fisch | Treatment of migraine headaches using antiestrogens |
CA2702710C (en) | 2007-10-16 | 2013-05-07 | Repros Therapeutics, Inc. | Trans-clomiphene for metabolic syndrome |
US20090215738A1 (en) * | 2008-02-26 | 2009-08-27 | Michael Charles Scally | Prevention and treatment of an increase in cardiovascular risk, adverse cardiovascular events, infertility, and adverse psychological effects after androgen or gnrh analogue intake |
TWI477276B (zh) | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | 抗黃體素給藥方案 |
RU2474424C2 (ru) * | 2010-09-24 | 2013-02-10 | Государственное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гиперэстрадиолемии и нормогонадотропного гипогонадизма у мужчин |
UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
US20140235601A1 (en) * | 2011-08-09 | 2014-08-21 | Kenneth W. Adams | Use of Aromatase Inhibitor Or Estrogen Blocker For Increasing Spermatogenesis Or Testosterone Levels In Males |
BR112014029131B1 (pt) | 2012-05-31 | 2021-03-09 | Allergan Pharmaceuticals International Limited | cápsula de mucoadesivo |
MX2015001912A (es) * | 2012-08-21 | 2015-06-05 | Repros Therapeutics Inc | Formulaciones de trans - clomifeno y usos de las mismas. |
CN104755087A (zh) | 2012-11-02 | 2015-07-01 | 利普生物药剂公司 | 治疗孕酮依赖性病况的方法和组合物 |
CA2889770A1 (en) | 2012-11-02 | 2014-05-08 | Repros Therapeutics Inc. | Trans-clomiphene for use in cancer therapy |
US9814687B2 (en) * | 2014-08-20 | 2017-11-14 | Professional Compounding Centers Of America | Transdermal pharmaceutical compositions including C-SERMs for low testosterone levels in men |
RU2586305C1 (ru) * | 2015-02-02 | 2016-06-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ лечения обструктивной азооспермии и криптозооспермии у пациентов с хроническим простатитом |
US10364212B2 (en) | 2016-04-22 | 2019-07-30 | F.I.S.—Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0430388A2 (en) * | 1989-11-20 | 1991-06-05 | Applied Research Systems ARS Holding N.V. | Use of clomiphene for treatment of infertility |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2914563A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Therapeutic composition |
IT951631B (it) | 1971-03-18 | 1973-07-10 | Richardson Merrell Spa | Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi |
US4061733A (en) * | 1976-10-15 | 1977-12-06 | Narayan Vishwanath Gunjikar | Veterinary compositions for inducing estrus in animals and method |
US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
ATE36312T1 (de) | 1985-06-08 | 1988-08-15 | Asta Pharma Ag | Neue derivate des 1,1,2,2-tetramethyl-1,2-bis-(2fluor-4-hydroxyphenyl)-ethans. |
US4820736A (en) * | 1987-03-20 | 1989-04-11 | Yale University | Use of clomiphene to predict fertility in a human female |
JPH04312522A (ja) | 1991-04-08 | 1992-11-04 | Yoshiaki Kawashima | 徐放性錠剤の製造方法 |
US5681585A (en) * | 1991-12-24 | 1997-10-28 | Euro-Celtique, S.A. | Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer |
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5650425A (en) * | 1994-04-04 | 1997-07-22 | Pharmos Corporation | Permanently ionic derivatives of steroid hormones and their antagonists |
JPH10501814A (ja) | 1994-06-17 | 1998-02-17 | ユニバーシティ・オブ・ネブラスカ・ボード・オブ・リージェンツ | 生物的作用物質用のイン・シツゲル形成デリバリービヒクルおよびその使用方法 |
DE4435368A1 (de) * | 1994-09-22 | 1996-03-28 | Schering Ag | Verwendung von Aromatasehemmern zur Herstellung eines Arzneimittels zur Behandlung eines relativen Androgenmangels beim Mann |
US6221399B1 (en) * | 1995-08-17 | 2001-04-24 | Csir | Method of making controlled release particles of complexed polymers |
US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
IL120262A (en) * | 1996-02-28 | 2001-01-28 | Pfizer | Droloxifene and derivatives thereof for use in increasing serum testosterone levels |
AU744156B2 (en) * | 1996-10-28 | 2002-02-14 | General Mills Inc. | Embedding and encapsulation of controlled release particles |
WO1998044021A1 (en) * | 1997-04-03 | 1998-10-08 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same |
US6653297B1 (en) | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
US6342250B1 (en) * | 1997-09-25 | 2002-01-29 | Gel-Del Technologies, Inc. | Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices |
US6413533B1 (en) | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
ES2281186T3 (es) * | 1998-08-07 | 2007-09-16 | Novartis Vaccines And Diagnostics, Inc. | Pirazoles como moduladores de receptores de estrogenos. |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
MXPA01012769A (es) * | 1999-06-11 | 2003-06-24 | Watson Pharmaceuticals Inc | Administracion de esteroides androgenicos no orales para mujeres. |
AU6132700A (en) * | 1999-09-30 | 2001-04-05 | Chienna B.V. | Polymers loaded with bioactive agents |
US6258802B1 (en) | 1999-10-06 | 2001-07-10 | Medical College Of Hampton Roads | Corticoid therapy |
US20020004065A1 (en) * | 2000-01-20 | 2002-01-10 | David Kanios | Compositions and methods to effect the release profile in the transdermal administration of active agents |
CA2409647C (en) | 2000-05-26 | 2012-07-03 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
US7067557B2 (en) | 2000-05-26 | 2006-06-27 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
US6511986B2 (en) * | 2000-08-11 | 2003-01-28 | Wyeth | Method of treating estrogen receptor positive carcinoma |
US6503894B1 (en) * | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US20040192598A1 (en) | 2000-10-11 | 2004-09-30 | Laura Kragie | Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase |
CA2431566A1 (en) * | 2000-12-11 | 2002-07-18 | Testocreme, Llc | Topical testosterone formulations and associated methods |
US7173064B2 (en) * | 2001-07-09 | 2007-02-06 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene for treating wasting and lipodystrophy |
CA2777199A1 (en) * | 2001-07-09 | 2003-01-23 | Repros Therapeutics Inc. | Methods and materials for the treatment of testosterone deficiency in men |
US6645974B2 (en) * | 2001-07-31 | 2003-11-11 | Merck & Co., Inc. | Androgen receptor modulators and methods for use thereof |
WO2003026568A2 (en) | 2001-09-21 | 2003-04-03 | Merck & Co., Inc. | Androstanes as androgen receptor modulators |
US6600110B1 (en) * | 2001-10-01 | 2003-07-29 | Gram Precision | Portable digital readout scale |
US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
US7105679B2 (en) * | 2001-12-19 | 2006-09-12 | Kanojia Ramesh M | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
JP4312522B2 (ja) | 2003-06-30 | 2009-08-12 | 株式会社リコー | 現像剤補給方法、現像剤補給装置、及び、画像形成装置 |
MX2007000050A (es) | 2004-07-14 | 2007-07-10 | Repros Therapeutics Inc | Trans-clomifeno para el tratamiento de hipertrofia de prostata benigna, cancer de prostata, hipogonadismo, trigliceridos elevados y colesterol elevado. |
KR20070100811A (ko) * | 2005-02-04 | 2007-10-11 | 레프로스 쎄라피우틱스 아이엔씨. | 남성불임의 치료를 위한 트랜스―클로미펜을 이용한 물질과치료방법 |
JP2008537538A (ja) * | 2005-02-11 | 2008-09-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Vegf拮抗剤及び降圧剤の治療的組み合わせ |
EP2392322A3 (en) | 2005-03-22 | 2012-02-22 | Repros Therapeutics Inc. | Dosing regimes for trans-clomiphene |
JP2009503096A (ja) | 2005-08-05 | 2009-01-29 | リプロス セラピューティクス インコーポレイテッド | クロミフェンを用いる女性不妊症を処置するための方法および組成物 |
EP1829534A1 (en) | 2006-03-02 | 2007-09-05 | Laboratorios Del Dr. Esteve, S.A. | Use of compounds binding to the sigma receptor for the treatment of metabolic syndrome |
CA2702710C (en) | 2007-10-16 | 2013-05-07 | Repros Therapeutics, Inc. | Trans-clomiphene for metabolic syndrome |
US20100111901A1 (en) * | 2008-11-03 | 2010-05-06 | Auspex Pharmaceuticals, Inc. | Triazole inhibitors of aromatase |
TW201500041A (zh) | 2008-11-07 | 2015-01-01 | Repros Therapeutics Inc | 用於代謝症候群與第2型糖尿病的反式氯米芬 |
US20100144687A1 (en) * | 2008-12-05 | 2010-06-10 | Glaser Rebecca L | Pharmaceutical compositions containing testosterone and an aromatase inhibitor |
US20140235601A1 (en) | 2011-08-09 | 2014-08-21 | Kenneth W. Adams | Use of Aromatase Inhibitor Or Estrogen Blocker For Increasing Spermatogenesis Or Testosterone Levels In Males |
-
2002
- 2002-07-09 CA CA2777199A patent/CA2777199A1/en not_active Abandoned
- 2002-07-09 NZ NZ530491A patent/NZ530491A/en not_active IP Right Cessation
- 2002-07-09 NZ NZ551013A patent/NZ551013A/en not_active IP Right Cessation
- 2002-07-09 AU AU2002318225A patent/AU2002318225B2/en not_active Expired
- 2002-07-09 JP JP2003511763A patent/JP4845165B2/ja not_active Expired - Fee Related
- 2002-07-09 CN CNA2006101356235A patent/CN1954807A/zh active Pending
- 2002-07-09 RU RU2004100535/14A patent/RU2297218C2/ru active
- 2002-07-09 EP EP02748104A patent/EP1411916B1/en not_active Expired - Lifetime
- 2002-07-09 BR BRPI0211067-9A patent/BR0211067A/pt not_active Application Discontinuation
- 2002-07-09 KR KR1020047000258A patent/KR100851648B1/ko active IP Right Grant
- 2002-07-09 ES ES02748104T patent/ES2312593T3/es not_active Expired - Lifetime
- 2002-07-09 AT AT02748104T patent/ATE406153T1/de active
- 2002-07-09 PL PL374121A patent/PL211339B1/pl unknown
- 2002-07-09 WO PCT/US2002/021524 patent/WO2003005954A2/en active Application Filing
- 2002-07-09 DE DE60228583T patent/DE60228583D1/de not_active Expired - Lifetime
- 2002-07-09 CA CA2453337A patent/CA2453337C/en not_active Expired - Lifetime
- 2002-07-09 PT PT02748104T patent/PT1411916E/pt unknown
- 2002-07-09 CN CNB028174410A patent/CN1289075C/zh not_active Expired - Lifetime
- 2002-07-09 US US10/483,458 patent/US7759360B2/en not_active Expired - Fee Related
- 2002-07-09 MX MXPA04000097A patent/MXPA04000097A/es active IP Right Grant
- 2002-07-09 DK DK02748104T patent/DK1411916T3/da active
-
2003
- 2003-04-30 US US10/427,768 patent/US7368480B2/en not_active Expired - Lifetime
-
2004
- 2004-01-06 EC EC2004004937A patent/ECSP044937A/es unknown
- 2004-01-08 CL CL200400026A patent/CL2004000026A1/es unknown
- 2004-01-08 ZA ZA200400142A patent/ZA200400142B/en unknown
- 2004-01-09 CO CO04001222A patent/CO5550428A2/es not_active Application Discontinuation
-
2005
- 2005-05-25 HK HK05104390A patent/HK1071521A1/xx not_active IP Right Cessation
-
2008
- 2008-11-13 CY CY20081101298T patent/CY1108563T1/el unknown
-
2009
- 2009-09-03 JP JP2009204154A patent/JP2009280623A/ja not_active Withdrawn
-
2010
- 2010-07-16 US US12/838,036 patent/US8618176B2/en not_active Expired - Lifetime
-
2013
- 2013-12-03 US US14/095,494 patent/US20140093560A1/en not_active Abandoned
-
2015
- 2015-06-09 US US14/734,931 patent/US20150265553A1/en not_active Abandoned
-
2016
- 2016-08-17 US US15/239,394 patent/US10561624B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0430388A2 (en) * | 1989-11-20 | 1991-06-05 | Applied Research Systems ARS Holding N.V. | Use of clomiphene for treatment of infertility |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10561624B2 (en) | Methods and materials for the treatment of testosterone deficiency in men | |
US8519004B2 (en) | Dosing regimes for trans-clomiphene | |
AU2002318225A1 (en) | Methods and materials for the treatment of testosterone deficiency in men | |
CA2595363C (en) | Methods and materials with trans-clomiphene for the treatment of male infertility | |
US20080242726A1 (en) | Trans-Clomiphene for the Treatment of Benign Prostate Hypertrophy, Porstate Cancer, Hypogonadism Elevated Triglycerides and High Cholesterol | |
AU2008201142B2 (en) | Methods and materials for the treatment of testosterone deficiency in men |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E90F | Notification of reason for final refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20120724 Year of fee payment: 5 |
|
FPAY | Annual fee payment |
Payment date: 20130724 Year of fee payment: 6 |
|
FPAY | Annual fee payment |
Payment date: 20140724 Year of fee payment: 7 |
|
FPAY | Annual fee payment |
Payment date: 20150723 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20160722 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20170821 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20180727 Year of fee payment: 11 |
|
FPAY | Annual fee payment |
Payment date: 20190725 Year of fee payment: 12 |