KR100850591B1 - 테트라졸 유도체 및 이를 사용한 대사 관련 장애의 치료방법 - Google Patents

테트라졸 유도체 및 이를 사용한 대사 관련 장애의 치료방법 Download PDF

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Publication number
KR100850591B1
KR100850591B1 KR1020067008311A KR20067008311A KR100850591B1 KR 100850591 B1 KR100850591 B1 KR 100850591B1 KR 1020067008311 A KR1020067008311 A KR 1020067008311A KR 20067008311 A KR20067008311 A KR 20067008311A KR 100850591 B1 KR100850591 B1 KR 100850591B1
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South Korea
Prior art keywords
compound
pharmaceutically acceptable
compounds
cyclopentapyrazole
acceptable salt
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Expired - Fee Related
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KR1020067008311A
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English (en)
Korean (ko)
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KR20060073974A (ko
Inventor
그램 셈플
토마스 슈레이더
필립 제이. 스키너
스티븐 엘. 콜레티
토피크 가르바오우이
제이슨 이. 임브리글리오
재규 정
루이 리앙
수브하레크하 라가반
다르비 슈미트
제임스 알. 타타
Original Assignee
아레나 파마슈티칼스, 인크.
머크 앤드 캄파니 인코포레이티드
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Application filed by 아레나 파마슈티칼스, 인크., 머크 앤드 캄파니 인코포레이티드 filed Critical 아레나 파마슈티칼스, 인크.
Publication of KR20060073974A publication Critical patent/KR20060073974A/ko
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Publication of KR100850591B1 publication Critical patent/KR100850591B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020067008311A 2003-10-31 2004-10-29 테트라졸 유도체 및 이를 사용한 대사 관련 장애의 치료방법 Expired - Fee Related KR100850591B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51623803P 2003-10-31 2003-10-31
US60/516,238 2003-10-31

Publications (2)

Publication Number Publication Date
KR20060073974A KR20060073974A (ko) 2006-06-29
KR100850591B1 true KR100850591B1 (ko) 2008-08-05

Family

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KR1020067008311A Expired - Fee Related KR100850591B1 (ko) 2003-10-31 2004-10-29 테트라졸 유도체 및 이를 사용한 대사 관련 장애의 치료방법

Country Status (37)

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US (2) US8637555B2 (cg-RX-API-DMAC7.html)
EP (2) EP1599469B1 (cg-RX-API-DMAC7.html)
JP (2) JP4533898B2 (cg-RX-API-DMAC7.html)
KR (1) KR100850591B1 (cg-RX-API-DMAC7.html)
CN (1) CN1867562B (cg-RX-API-DMAC7.html)
AR (1) AR046611A1 (cg-RX-API-DMAC7.html)
AT (1) ATE328880T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004287861B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415631A (cg-RX-API-DMAC7.html)
CA (1) CA2539985C (cg-RX-API-DMAC7.html)
CO (1) CO5690551A2 (cg-RX-API-DMAC7.html)
CR (1) CR8270A (cg-RX-API-DMAC7.html)
CY (1) CY1105479T1 (cg-RX-API-DMAC7.html)
DE (1) DE602004001134T2 (cg-RX-API-DMAC7.html)
DK (1) DK1599469T3 (cg-RX-API-DMAC7.html)
EA (1) EA011484B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP066529A (cg-RX-API-DMAC7.html)
ES (1) ES2267077T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20094801B (cg-RX-API-DMAC7.html)
HR (1) HRP20060286T3 (cg-RX-API-DMAC7.html)
IL (1) IL174042A0 (cg-RX-API-DMAC7.html)
IS (1) IS2372B (cg-RX-API-DMAC7.html)
MA (1) MA28171A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA06004556A (cg-RX-API-DMAC7.html)
MY (1) MY140410A (cg-RX-API-DMAC7.html)
NO (1) NO20062509L (cg-RX-API-DMAC7.html)
NZ (1) NZ546285A (cg-RX-API-DMAC7.html)
PE (1) PE20050483A1 (cg-RX-API-DMAC7.html)
PL (1) PL1599469T3 (cg-RX-API-DMAC7.html)
PT (1) PT1599469E (cg-RX-API-DMAC7.html)
RS (1) RS20060290A (cg-RX-API-DMAC7.html)
SI (1) SI1599469T1 (cg-RX-API-DMAC7.html)
TN (1) TNSN06150A1 (cg-RX-API-DMAC7.html)
TW (1) TWI258478B (cg-RX-API-DMAC7.html)
UA (1) UA86783C2 (cg-RX-API-DMAC7.html)
WO (1) WO2005044816A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA200603419B (cg-RX-API-DMAC7.html)

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ES2331521T3 (es) * 2003-11-21 2010-01-07 Arena Pharmaceuticals, Inc. Derivados de acido 4-oxo-4,5-dihidro-furan-2-carboxilico y procedimientos de tratamiento de trastornos metabolicos relacionados del mismo.
WO2006026273A2 (en) * 2004-08-25 2006-03-09 Merck & Co., Inc. Method of treating atherosclerosis, dyslipidemias and related conditions
EP1811996A1 (en) * 2004-11-05 2007-08-01 Arena Pharmaceuticals, Inc. Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists
PE20060949A1 (es) * 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles
AU2006261839B2 (en) 2005-06-28 2011-09-01 Merck Sharp & Dohme Corp. Niacin receptor agonists, compositions containing such compounds and methods of treatment
DE102006021733A1 (de) * 2006-05-09 2007-11-22 Bayer Healthcare Ag 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
DE102008063992A1 (de) 2008-12-19 2010-09-02 Lerner, Zinoviy, Dipl.-Ing. Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
JP2015522080A (ja) 2012-07-11 2015-08-03 エルセリクス セラピューティクス インコーポレイテッド スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物
EA201500852A1 (ru) 2013-02-21 2016-02-29 Адверио Фарма Гмбх Формы метил {4,6-диамино-2-[1-(2-фторбензил)-1н-пиразоло[3,4-в]пиридино-3-ил]пиримидино-5-ил}метил карбамата
WO2015012210A1 (ja) * 2013-07-23 2015-01-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ縮合環化合物
CN103755637A (zh) * 2013-12-26 2014-04-30 平湖优康药物研发有限公司 一种医药中间体1,4,5,6-四氢-3-环戊并吡唑甲腈的合成工艺
US12086719B2 (en) * 2019-10-11 2024-09-10 Royal Bank Of Canada System and method of machine learning using embedding networks

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0529854A2 (en) 1991-08-08 1993-03-03 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-COA reductase inhibitors

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Publication number Publication date
EP1599469B1 (en) 2006-06-07
AR046611A1 (es) 2005-12-14
ECSP066529A (es) 2006-10-10
IS2372B (is) 2008-06-15
TW200530221A (en) 2005-09-16
DE602004001134D1 (de) 2006-07-20
AU2004287861A1 (en) 2005-05-19
MXPA06004556A (es) 2006-07-06
UA86783C2 (ru) 2009-05-25
PT1599469E (pt) 2006-10-31
JP2007509181A (ja) 2007-04-12
EA011484B1 (ru) 2009-04-28
MY140410A (en) 2009-12-31
EA200600879A1 (ru) 2006-10-27
JP4533898B2 (ja) 2010-09-01
NO20062509L (no) 2006-06-26
CN1867562B (zh) 2011-07-13
HRP20060286T3 (en) 2007-03-31
EP1683794A1 (en) 2006-07-26
DE602004001134T2 (de) 2007-04-19
EP1599469A1 (en) 2005-11-30
TNSN06150A1 (en) 2007-11-15
TWI258478B (en) 2006-07-21
GEP20094801B (en) 2009-10-26
PE20050483A1 (es) 2005-08-25
BRPI0415631A (pt) 2006-12-12
CN1867562A (zh) 2006-11-22
CY1105479T1 (el) 2010-07-28
CR8270A (es) 2006-10-06
IS8481A (is) 2006-05-24
CO5690551A2 (es) 2006-10-31
NZ546285A (en) 2010-04-30
US8637555B2 (en) 2014-01-28
ZA200603419B (en) 2006-10-25
US20060217562A1 (en) 2006-09-28
IL174042A0 (en) 2006-08-01
DK1599469T3 (da) 2006-10-09
MA28171A1 (fr) 2006-09-01
SI1599469T1 (sl) 2006-10-31
ZA200606203B (en) 2007-04-25
PL1599469T3 (pl) 2006-10-31
ATE328880T1 (de) 2006-06-15
ES2267077T3 (es) 2007-03-01
AU2004287861B2 (en) 2008-08-14
CA2539985A1 (en) 2005-05-19
CA2539985C (en) 2010-02-16
US20070072924A1 (en) 2007-03-29
WO2005044816A1 (en) 2005-05-19
HK1076468A1 (en) 2006-01-20
KR20060073974A (ko) 2006-06-29
RS20060290A (sr) 2008-11-28
JP2010163448A (ja) 2010-07-29

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