CO5690551A2 - Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo - Google Patents

Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo

Info

Publication number
CO5690551A2
CO5690551A2 CO06031620A CO06031620A CO5690551A2 CO 5690551 A2 CO5690551 A2 CO 5690551A2 CO 06031620 A CO06031620 A CO 06031620A CO 06031620 A CO06031620 A CO 06031620A CO 5690551 A2 CO5690551 A2 CO 5690551A2
Authority
CO
Colombia
Prior art keywords
thioxy
haloalkylsulfinyl
haloalkylsulfonyl
alkylsulfinyl
haloalkoxy
Prior art date
Application number
CO06031620A
Other languages
English (en)
Spanish (es)
Inventor
Graeme Semple
Thomas O Schrader
Philip J Skinner
Steven L Colletti
Tawfik Gharbaoui
Jason Imbriglio
Jae-Kyu Jung
Rui Liang
Subharekha Raghavan
Darby Schmidt
James R Tata
Original Assignee
Arena Pharm Inc
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc, Merck & Co Inc filed Critical Arena Pharm Inc
Publication of CO5690551A2 publication Critical patent/CO5690551A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CO06031620A 2003-10-31 2006-03-30 Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo CO5690551A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51623803P 2003-10-31 2003-10-31

Publications (1)

Publication Number Publication Date
CO5690551A2 true CO5690551A2 (es) 2006-10-31

Family

ID=34572875

Family Applications (1)

Application Number Title Priority Date Filing Date
CO06031620A CO5690551A2 (es) 2003-10-31 2006-03-30 Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo

Country Status (37)

Country Link
US (2) US8637555B2 (cg-RX-API-DMAC7.html)
EP (2) EP1599469B1 (cg-RX-API-DMAC7.html)
JP (2) JP4533898B2 (cg-RX-API-DMAC7.html)
KR (1) KR100850591B1 (cg-RX-API-DMAC7.html)
CN (1) CN1867562B (cg-RX-API-DMAC7.html)
AR (1) AR046611A1 (cg-RX-API-DMAC7.html)
AT (1) ATE328880T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004287861B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0415631A (cg-RX-API-DMAC7.html)
CA (1) CA2539985C (cg-RX-API-DMAC7.html)
CO (1) CO5690551A2 (cg-RX-API-DMAC7.html)
CR (1) CR8270A (cg-RX-API-DMAC7.html)
CY (1) CY1105479T1 (cg-RX-API-DMAC7.html)
DE (1) DE602004001134T2 (cg-RX-API-DMAC7.html)
DK (1) DK1599469T3 (cg-RX-API-DMAC7.html)
EA (1) EA011484B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP066529A (cg-RX-API-DMAC7.html)
ES (1) ES2267077T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20094801B (cg-RX-API-DMAC7.html)
HR (1) HRP20060286T3 (cg-RX-API-DMAC7.html)
IL (1) IL174042A0 (cg-RX-API-DMAC7.html)
IS (1) IS2372B (cg-RX-API-DMAC7.html)
MA (1) MA28171A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA06004556A (cg-RX-API-DMAC7.html)
MY (1) MY140410A (cg-RX-API-DMAC7.html)
NO (1) NO20062509L (cg-RX-API-DMAC7.html)
NZ (1) NZ546285A (cg-RX-API-DMAC7.html)
PE (1) PE20050483A1 (cg-RX-API-DMAC7.html)
PL (1) PL1599469T3 (cg-RX-API-DMAC7.html)
PT (1) PT1599469E (cg-RX-API-DMAC7.html)
RS (1) RS20060290A (cg-RX-API-DMAC7.html)
SI (1) SI1599469T1 (cg-RX-API-DMAC7.html)
TN (1) TNSN06150A1 (cg-RX-API-DMAC7.html)
TW (1) TWI258478B (cg-RX-API-DMAC7.html)
UA (1) UA86783C2 (cg-RX-API-DMAC7.html)
WO (1) WO2005044816A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA200603419B (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094572B2 (en) 2003-03-14 2006-08-22 Bristol-Myers Squibb Polynucleotide encoding a novel human G-protein coupled receptor variant of HM74, HGPRBMY74
PE20050483A1 (es) 2003-10-31 2005-08-25 Arena Pharm Inc Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas
ES2331521T3 (es) * 2003-11-21 2010-01-07 Arena Pharmaceuticals, Inc. Derivados de acido 4-oxo-4,5-dihidro-furan-2-carboxilico y procedimientos de tratamiento de trastornos metabolicos relacionados del mismo.
WO2006026273A2 (en) * 2004-08-25 2006-03-09 Merck & Co., Inc. Method of treating atherosclerosis, dyslipidemias and related conditions
EP1811996A1 (en) * 2004-11-05 2007-08-01 Arena Pharmaceuticals, Inc. Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists
PE20060949A1 (es) * 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles
AU2006261839B2 (en) 2005-06-28 2011-09-01 Merck Sharp & Dohme Corp. Niacin receptor agonists, compositions containing such compounds and methods of treatment
DE102006021733A1 (de) * 2006-05-09 2007-11-22 Bayer Healthcare Ag 3-Tetrazolylindazole und 3-Tetrazolylpyrazolopyridine sowie ihre Verwendung
DE102006043443A1 (de) 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
DE102008063992A1 (de) 2008-12-19 2010-09-02 Lerner, Zinoviy, Dipl.-Ing. Neue aliphatisch substituierte Pyrazolopyridine und ihre Verwendung
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
JP2015522080A (ja) 2012-07-11 2015-08-03 エルセリクス セラピューティクス インコーポレイテッド スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物
EA201500852A1 (ru) 2013-02-21 2016-02-29 Адверио Фарма Гмбх Формы метил {4,6-диамино-2-[1-(2-фторбензил)-1н-пиразоло[3,4-в]пиридино-3-ил]пиримидино-5-ил}метил карбамата
WO2015012210A1 (ja) * 2013-07-23 2015-01-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ縮合環化合物
CN103755637A (zh) * 2013-12-26 2014-04-30 平湖优康药物研发有限公司 一种医药中间体1,4,5,6-四氢-3-环戊并吡唑甲腈的合成工艺
US12086719B2 (en) * 2019-10-11 2024-09-10 Royal Bank Of Canada System and method of machine learning using embedding networks

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02178263A (ja) * 1988-12-27 1990-07-11 Kaken Pharmaceut Co Ltd アザアズレン誘導体、その製造法およびそれを有効成分とする抗アレルギー剤および抗炎症剤
US5134155A (en) * 1991-08-08 1992-07-28 Ortho Pharmaceutical Corporation Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors
US5948786A (en) 1996-04-12 1999-09-07 Sumitomo Pharmaceuticals Company, Limited Piperidinylpyrimidine derivatives
CZ225699A3 (cs) 1996-12-23 2000-09-13 Du Pont Pharmaceuticals Company Dusíkaté heteroaromatické sloučeniny jako inhibitory faktoru Xa
DE69941777D1 (de) 1998-03-10 2010-01-21 Ono Pharmaceutical Co Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
HUP0301493A2 (hu) 2000-03-09 2003-08-28 Ono Pharmaceutical Co., Ltd. Indolszármazékok, eljárás előállításukra és alkalmazásuk
US20010047027A1 (en) 2000-04-12 2001-11-29 Marc Labelle Prostaglandin D2 receptor antagonists
SK862003A3 (en) 2000-06-28 2003-06-03 Teva Pharma Carvedilol
US7157466B2 (en) 2000-06-30 2007-01-02 Smithkline Beecham (Cork) Limited Quinazoline ditosylate salt compounds
US6410583B1 (en) 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
DE10057751A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Carbamat-substituierte Pyrazolopyridinderivate
DE60215000T2 (de) 2001-05-23 2007-08-09 Merck Frosst Canada & Co, Kirkland Dihydropyrroloil[1,2-a]indol- und Tetrahydropyridol[1,2-a]indol-Derivate als Prostaglandin-D2-Rezeptor-Antagonisten
DK1397351T3 (da) 2001-06-01 2010-01-18 Hoffmann La Roche Pyrimidin-, triazin- og pyrazinderivater som glutamatreceptorer
WO2003002544A1 (en) 2001-06-26 2003-01-09 Bristol-Myers Squibb Company N-heterocyclic inhibitors of tnf-alpha expression
US6884750B2 (en) 2001-06-27 2005-04-26 Rs Tech Corp. Chiral salen catalyst and methods for the preparation of chiral compounds from racemic epoxides by using new catalyst
EP1424335A4 (en) 2001-09-07 2005-11-16 Ono Pharmaceutical Co INDOLE DERIVATIVES
DE10148617A1 (de) 2001-09-25 2003-04-24 Schering Ag Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel
AR038136A1 (es) 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
ES2365985T3 (es) 2002-03-19 2011-10-14 Ono Pharmaceutical Co., Ltd. Compuestos de ácido carboxílico y fármacos que contienen los compuestos como ingrediente activo.
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
WO2004033431A2 (en) 2002-10-04 2004-04-22 Arena Pharmaceuticals, Inc. Hydroxypyrazoles for use against metabolic-related disorders
EP1551403B1 (en) 2002-10-10 2009-04-29 Arena Pharmaceuticals, Inc. 5-substituted 2h-pyrazone-3-carboxylic acid derivatives as antilipolytic agents for the treatment of metabolic-related disorders such as dyslipidemia
DE10261131A1 (de) 2002-12-20 2004-07-01 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AR041089A1 (es) 2003-05-15 2005-05-04 Merck & Co Inc Procedimiento y composiciones farmaceutiicas para tratar aterosclerosis, dislipidemias y afecciones relacionadas
US7232823B2 (en) 2003-06-09 2007-06-19 Pfizer, Inc. Cannabinoid receptor ligands and uses thereof
US20070032537A1 (en) 2003-06-13 2007-02-08 Arena Pharmaceuticals, Inc. 5-Substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the acid receptor rup25 for the treatment of dyslipidemia and related diseases
GB0319124D0 (en) 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
GB0319126D0 (en) 2003-08-14 2003-09-17 Smithkline Beecham Corp Chemical compounds
PE20050483A1 (es) 2003-10-31 2005-08-25 Arena Pharm Inc Derivados de tetrazol de formula (i), sus composiciones farmaceuticas y procesos para producir composiciones farmaceuticas
CA2556073C (en) 2004-02-14 2012-01-10 Smithkline Beecham Corporation 8-chloro-1,3-disubstituted xanthine derivatives as hm74a receptor modulators
WO2006026273A2 (en) 2004-08-25 2006-03-09 Merck & Co., Inc. Method of treating atherosclerosis, dyslipidemias and related conditions
EP1811996A1 (en) 2004-11-05 2007-08-01 Arena Pharmaceuticals, Inc. Compositions for treating flushing and lipid-associated disorders comprising niacin receptor partial agonists
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
US8168799B2 (en) 2005-04-28 2012-05-01 Merck Sharpe & Dohme Ltd. Process for the preparation of tetrazolytetrahydrocyclopentapyrazoles

Also Published As

Publication number Publication date
EP1599469B1 (en) 2006-06-07
AR046611A1 (es) 2005-12-14
ECSP066529A (es) 2006-10-10
IS2372B (is) 2008-06-15
TW200530221A (en) 2005-09-16
DE602004001134D1 (de) 2006-07-20
AU2004287861A1 (en) 2005-05-19
MXPA06004556A (es) 2006-07-06
UA86783C2 (ru) 2009-05-25
PT1599469E (pt) 2006-10-31
JP2007509181A (ja) 2007-04-12
EA011484B1 (ru) 2009-04-28
MY140410A (en) 2009-12-31
EA200600879A1 (ru) 2006-10-27
JP4533898B2 (ja) 2010-09-01
NO20062509L (no) 2006-06-26
CN1867562B (zh) 2011-07-13
HRP20060286T3 (en) 2007-03-31
EP1683794A1 (en) 2006-07-26
DE602004001134T2 (de) 2007-04-19
EP1599469A1 (en) 2005-11-30
TNSN06150A1 (en) 2007-11-15
TWI258478B (en) 2006-07-21
GEP20094801B (en) 2009-10-26
KR100850591B1 (ko) 2008-08-05
PE20050483A1 (es) 2005-08-25
BRPI0415631A (pt) 2006-12-12
CN1867562A (zh) 2006-11-22
CY1105479T1 (el) 2010-07-28
CR8270A (es) 2006-10-06
IS8481A (is) 2006-05-24
NZ546285A (en) 2010-04-30
US8637555B2 (en) 2014-01-28
ZA200603419B (en) 2006-10-25
US20060217562A1 (en) 2006-09-28
IL174042A0 (en) 2006-08-01
DK1599469T3 (da) 2006-10-09
MA28171A1 (fr) 2006-09-01
SI1599469T1 (sl) 2006-10-31
ZA200606203B (en) 2007-04-25
PL1599469T3 (pl) 2006-10-31
ATE328880T1 (de) 2006-06-15
ES2267077T3 (es) 2007-03-01
AU2004287861B2 (en) 2008-08-14
CA2539985A1 (en) 2005-05-19
CA2539985C (en) 2010-02-16
US20070072924A1 (en) 2007-03-29
WO2005044816A1 (en) 2005-05-19
HK1076468A1 (en) 2006-01-20
KR20060073974A (ko) 2006-06-29
RS20060290A (sr) 2008-11-28
JP2010163448A (ja) 2010-07-29

Similar Documents

Publication Publication Date Title
CO5690551A2 (es) Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo
PE20060570A1 (es) Compuestos de quinazolina e isoquinolina piperidilo sustituidos como inhibidores de fosfodiesterasa pde-10
CO5700824A2 (es) Nuevos compuestos heterociclicos utiles para el tratamiento de desordenes inflamatorios y alergicos: proceso para su preparacion y composiciones farmaceuticas que los contienen
EA200970461A1 (ru) ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 3-ИЗОБУТИЛ-9,10-ДИМЕТОКСИ-1,3,4,6,7,11b-ГЕКСАГИДРО-2Н-ПИРИДО[2,1-a]ИЗОХИНОЛИН-2-ОЛА И СВЯЗАННЫЕ С НИМИ СПОСОБЫ
SE0202463D0 (sv) Novel compounds
DK2314582T3 (da) Heterocykliske forbindelser som antivirusmidler
AR046779A1 (es) Derivados de pirazol, metodos para su preparacion y usos de los mismos en la fabricacion de composiciones farmaceuticas y medicamentos que los contienen con actividad inhibitoria de trk para el tratamiento o profilaxis del cancer.
UA87153C2 (ru) Энантиомерно чистые аминогетероарильные соединения как ингибиторы протеинкиназы
ATE402174T1 (de) Imidazopyridinderivate als kinaseinhibitoren
CY1107001T1 (el) Αζωτουχα ετεροκυκλικα παραγωγα καρβοξαμιδιου ή αλας αυτων ως αντιϊκοι παραγοντες
DE60316013D1 (de) Heteroaryl-pyrimidinderivate als jak-inhibitoren
EA200201179A1 (ru) Производные 2-аминокарбонил-9h-пурина
AR047076A1 (es) Compuestos de pirrolotriazina como inhibidores de tirosina quinasas, composiciones farmaceuticas
CY1107747T1 (el) Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης
WO2007146124A3 (en) Deuterated tadalafil derivatives
DE60230127D1 (de) Inhibitoren von integrin alpha-v-beta-6
AR043673A1 (es) Compuestos heterociclicos inhibidores no nucleosidos de la transcriptasa inversa i, preparacion de los mismos, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento del sida
AR063625A1 (es) COMPUESTOS HETEROCICLICOS eTILES COMO AGENTES ANTICANCEROSOS
ATE359791T1 (de) Pyrimidin-2,4-dion-derivate als matrix- metalloproteinase-hemmer
EA200970124A1 (ru) Производные 2-арилиндола в качестве ингибиторов npges-1
EA200600694A1 (ru) Дисульфидные, сульфидные, сульфоксидные и сульфоновые производные циклических сахаров и их применение
DE60336735D1 (de) Neue biologischaktive molekü le
MXPA05009282A (es) Derivados de anilina sustituidos.
TW200510320A (en) Aminoquinoline derivatives and their use as adenosine A3 ligands
AR049276A1 (es) Compuestos carboxamidos opiodes y composiciones farmaceuticas que los contienen

Legal Events

Date Code Title Description
FC Application refused