JP4533898B2 - トリアゾール誘導体およびその代謝関連障害の処置方法 - Google Patents

トリアゾール誘導体およびその代謝関連障害の処置方法 Download PDF

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Publication number
JP4533898B2
JP4533898B2 JP2006536942A JP2006536942A JP4533898B2 JP 4533898 B2 JP4533898 B2 JP 4533898B2 JP 2006536942 A JP2006536942 A JP 2006536942A JP 2006536942 A JP2006536942 A JP 2006536942A JP 4533898 B2 JP4533898 B2 JP 4533898B2
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Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
compound
cyclopentapyrazole
ring
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Expired - Fee Related
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JP2006536942A
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English (en)
Japanese (ja)
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JP2007509181A (ja
JP2007509181A5 (cg-RX-API-DMAC7.html
Inventor
グレーム セムプル，
トーマス シュレーダー，
フィリップ ジェイ． スキナー，
スティーブン エル． コレッティー，
タウフィーク ガーバウイ，
ジェイソン イー． イムブリグリオ，
ジャエ−キュー ジュン，
ルイ リャン，
サブヘアカー ラグハバン，
ダービー シュミット，
ジェイムス アール． タタ，
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Merck and Co Inc
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Merck and Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2006536942A 2003-10-31 2004-10-29 トリアゾール誘導体およびその代謝関連障害の処置方法 Expired - Fee Related JP4533898B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51623803P 2003-10-31 2003-10-31
PCT/US2004/035927 WO2005044816A1 (en) 2003-10-31 2004-10-29 Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof

Related Child Applications (1)

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JP2010053852A Division JP2010163448A (ja) 2003-10-31 2010-03-10 トリアゾール誘導体およびその代謝関連障害の処置方法

Publications (3)

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JP2007509181A JP2007509181A (ja) 2007-04-12
JP2007509181A5 JP2007509181A5 (cg-RX-API-DMAC7.html) 2010-06-17
JP4533898B2 true JP4533898B2 (ja) 2010-09-01

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JP2006536942A Expired - Fee Related JP4533898B2 (ja) 2003-10-31 2004-10-29 トリアゾール誘導体およびその代謝関連障害の処置方法
JP2010053852A Pending JP2010163448A (ja) 2003-10-31 2010-03-10 トリアゾール誘導体およびその代謝関連障害の処置方法

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JP2015522080A (ja) 2012-07-11 2015-08-03 エルセリクス セラピューティクス インコーポレイテッド スタチン、ビグアナイド、およびさらなる薬剤を含む心血管代謝性リスクを減少させるための組成物
EA201500852A1 (ru) 2013-02-21 2016-02-29 Адверио Фарма Гмбх Формы метил {4,6-диамино-2-[1-(2-фторбензил)-1н-пиразоло[3,4-в]пиридино-3-ил]пиримидино-5-ил}метил карбамата
WO2015012210A1 (ja) * 2013-07-23 2015-01-29 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ縮合環化合物
CN103755637A (zh) * 2013-12-26 2014-04-30 平湖优康药物研发有限公司 一种医药中间体1,4,5,6-四氢-3-环戊并吡唑甲腈的合成工艺
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EP1599469B1 (en) 2006-06-07
AR046611A1 (es) 2005-12-14
ECSP066529A (es) 2006-10-10
IS2372B (is) 2008-06-15
TW200530221A (en) 2005-09-16
DE602004001134D1 (de) 2006-07-20
AU2004287861A1 (en) 2005-05-19
MXPA06004556A (es) 2006-07-06
UA86783C2 (ru) 2009-05-25
PT1599469E (pt) 2006-10-31
JP2007509181A (ja) 2007-04-12
EA011484B1 (ru) 2009-04-28
MY140410A (en) 2009-12-31
EA200600879A1 (ru) 2006-10-27
NO20062509L (no) 2006-06-26
CN1867562B (zh) 2011-07-13
HRP20060286T3 (en) 2007-03-31
EP1683794A1 (en) 2006-07-26
DE602004001134T2 (de) 2007-04-19
EP1599469A1 (en) 2005-11-30
TNSN06150A1 (en) 2007-11-15
TWI258478B (en) 2006-07-21
GEP20094801B (en) 2009-10-26
KR100850591B1 (ko) 2008-08-05
PE20050483A1 (es) 2005-08-25
BRPI0415631A (pt) 2006-12-12
CN1867562A (zh) 2006-11-22
CY1105479T1 (el) 2010-07-28
CR8270A (es) 2006-10-06
IS8481A (is) 2006-05-24
CO5690551A2 (es) 2006-10-31
NZ546285A (en) 2010-04-30
US8637555B2 (en) 2014-01-28
ZA200603419B (en) 2006-10-25
US20060217562A1 (en) 2006-09-28
IL174042A0 (en) 2006-08-01
DK1599469T3 (da) 2006-10-09
MA28171A1 (fr) 2006-09-01
SI1599469T1 (sl) 2006-10-31
ZA200606203B (en) 2007-04-25
PL1599469T3 (pl) 2006-10-31
ATE328880T1 (de) 2006-06-15
ES2267077T3 (es) 2007-03-01
AU2004287861B2 (en) 2008-08-14
CA2539985A1 (en) 2005-05-19
CA2539985C (en) 2010-02-16
US20070072924A1 (en) 2007-03-29
WO2005044816A1 (en) 2005-05-19
HK1076468A1 (en) 2006-01-20
KR20060073974A (ko) 2006-06-29
RS20060290A (sr) 2008-11-28
JP2010163448A (ja) 2010-07-29

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