KR100846676B1 - 효소적 방법에 의한 광학활성 2-할로-2-(엔-치환된페닐)아세트산 에스테르와 2-할로-2-(엔-치환된페닐)아세트산의 제조 방법 - Google Patents

효소적 방법에 의한 광학활성 2-할로-2-(엔-치환된페닐)아세트산 에스테르와 2-할로-2-(엔-치환된페닐)아세트산의 제조 방법 Download PDF

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Publication number
KR100846676B1
KR100846676B1 KR1020060038183A KR20060038183A KR100846676B1 KR 100846676 B1 KR100846676 B1 KR 100846676B1 KR 1020060038183 A KR1020060038183 A KR 1020060038183A KR 20060038183 A KR20060038183 A KR 20060038183A KR 100846676 B1 KR100846676 B1 KR 100846676B1
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KR
South Korea
Prior art keywords
acetic acid
halo
substituted phenyl
chlorophenyl
candida
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Application number
KR1020060038183A
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English (en)
Korean (ko)
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KR20070105681A (ko
Inventor
황순욱
정선호
Original Assignee
엔자이텍 주식회사
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Priority to KR1020060038183A priority Critical patent/KR100846676B1/ko
Priority to PCT/KR2007/002073 priority patent/WO2007126258A1/fr
Publication of KR20070105681A publication Critical patent/KR20070105681A/ko
Application granted granted Critical
Publication of KR100846676B1 publication Critical patent/KR100846676B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/54—Acetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/59—Biological synthesis; Biological purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/921—Candida
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/931—Mucor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/939—Rhizopus

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020060038183A 2006-04-27 2006-04-27 효소적 방법에 의한 광학활성 2-할로-2-(엔-치환된페닐)아세트산 에스테르와 2-할로-2-(엔-치환된페닐)아세트산의 제조 방법 KR100846676B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020060038183A KR100846676B1 (ko) 2006-04-27 2006-04-27 효소적 방법에 의한 광학활성 2-할로-2-(엔-치환된페닐)아세트산 에스테르와 2-할로-2-(엔-치환된페닐)아세트산의 제조 방법
PCT/KR2007/002073 WO2007126258A1 (fr) 2006-04-27 2007-04-27 Procédé de fabrication d'esters d'acides 2-halo-2-(n-substitué phényl)acétiques optiquement actifs et acides 2-halo-2-(n-substitué phényl)acétiques par méthode enzymatique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020060038183A KR100846676B1 (ko) 2006-04-27 2006-04-27 효소적 방법에 의한 광학활성 2-할로-2-(엔-치환된페닐)아세트산 에스테르와 2-할로-2-(엔-치환된페닐)아세트산의 제조 방법

Publications (2)

Publication Number Publication Date
KR20070105681A KR20070105681A (ko) 2007-10-31
KR100846676B1 true KR100846676B1 (ko) 2008-07-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020060038183A KR100846676B1 (ko) 2006-04-27 2006-04-27 효소적 방법에 의한 광학활성 2-할로-2-(엔-치환된페닐)아세트산 에스테르와 2-할로-2-(엔-치환된페닐)아세트산의 제조 방법

Country Status (2)

Country Link
KR (1) KR100846676B1 (fr)
WO (1) WO2007126258A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107796904A (zh) * 2016-08-31 2018-03-13 武汉武药制药有限公司 一种用hplc分离测定邻氯扁桃酸对映异构体的方法
CN108192932B (zh) * 2017-12-26 2020-09-29 上海皓元生物医药科技有限公司 一种手性醇的酶催化制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0227078A1 (fr) 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Procédé de préparation d'acides S-alpha-méthylarylacétiques
JPS62205797A (ja) 1986-03-05 1987-09-10 Daicel Chem Ind Ltd 光学活性化合物の製造法
US5302528A (en) 1991-04-26 1994-04-12 Ministero Dell `Universita` e Della Ricerca Scientifica e Technologica Process for the enzymatic separation of the optical isomers of alpha-substituted carboxylic acids using esterase from Brevibacterium imperiale

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95931C (fi) * 1988-09-02 1996-04-10 Tanabe Seiyaku Co Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi
CA2234412C (fr) * 1997-06-09 2008-09-02 Kyowa Hakko Kogyo Co., Ltd. Methode de production d'un compose optiquement actif
ATE309977T1 (de) * 2000-09-29 2005-12-15 Bristol Myers Squibb Co Dynamische trennung von isomeren und getrennte isomere

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0227078A1 (fr) 1985-12-20 1987-07-01 Wisconsin Alumni Research Foundation Procédé de préparation d'acides S-alpha-méthylarylacétiques
JPS62205797A (ja) 1986-03-05 1987-09-10 Daicel Chem Ind Ltd 光学活性化合物の製造法
US5302528A (en) 1991-04-26 1994-04-12 Ministero Dell `Universita` e Della Ricerca Scientifica e Technologica Process for the enzymatic separation of the optical isomers of alpha-substituted carboxylic acids using esterase from Brevibacterium imperiale

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Publication number Publication date
WO2007126258A1 (fr) 2007-11-08
KR20070105681A (ko) 2007-10-31

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