KR100837186B1 - 항노화 효과를 나타내는 레티노익산 유도체 및 이의제조방법 - Google Patents
항노화 효과를 나타내는 레티노익산 유도체 및 이의제조방법 Download PDFInfo
- Publication number
- KR100837186B1 KR100837186B1 KR1020060095279A KR20060095279A KR100837186B1 KR 100837186 B1 KR100837186 B1 KR 100837186B1 KR 1020060095279 A KR1020060095279 A KR 1020060095279A KR 20060095279 A KR20060095279 A KR 20060095279A KR 100837186 B1 KR100837186 B1 KR 100837186B1
- Authority
- KR
- South Korea
- Prior art keywords
- retinoic acid
- formula
- acid derivative
- hydroxy
- alkyl
- Prior art date
Links
- PJLGMBDRJQBCHN-UHFFFAOYSA-N CC(C)(C)CC(OC=C1OC)=CC1=O Chemical compound CC(C)(C)CC(OC=C1OC)=CC1=O PJLGMBDRJQBCHN-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/21—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (8)
- 삭제
- 1) 레티노익산과 알킬클로로포메이트을 반응시켜 하기 화학식 2의 무수 화합 물을 제조하는 단계; 및2) 1) 단계에서 제조된 하기 화학식 2의 무수화합물을 하기 화학식 3의 아민 염산염과 반응시켜 화학식 1의 레티노익산 유도체를 제조하는 단계;로 이루어진 것을 특징으로 하는 레티노익산 유도체의 제조방법.[화학식 1][화학식 2][화학식 3][상기 식에서, R1은 수소, 직쇄 또는 분쇄의 (C1-C7)알킬 또는 (C3-C7)시클로알킬이고; R2는 히드록시, 1~4개의 히드록시기가 치환된 직쇄 또는 분쇄의 (C1-C7) 알킬 또는 히드록시피라논이 치환된 직쇄 또는 분쇄의 (C1-C5)알킬이고; R3는 (C1 -C7)알킬이다.]
- 제 1항, 제 2항 또는 제 4항 중 어느 한 항에 따른 레티노익산 유도체를 유효성분으로 함유하는 피부노화 방지용 피부외용제.
- 삭제
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020060095279A KR100837186B1 (ko) | 2006-09-29 | 2006-09-29 | 항노화 효과를 나타내는 레티노익산 유도체 및 이의제조방법 |
Applications Claiming Priority (1)
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KR1020060095279A KR100837186B1 (ko) | 2006-09-29 | 2006-09-29 | 항노화 효과를 나타내는 레티노익산 유도체 및 이의제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20080029342A KR20080029342A (ko) | 2008-04-03 |
KR100837186B1 true KR100837186B1 (ko) | 2008-06-13 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020060095279A KR100837186B1 (ko) | 2006-09-29 | 2006-09-29 | 항노화 효과를 나타내는 레티노익산 유도체 및 이의제조방법 |
Country Status (1)
Country | Link |
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KR (1) | KR100837186B1 (ko) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1283887A (en) * | 1970-02-02 | 1972-08-02 | Hoffmann La Roche | Acid amides |
EP0009776A1 (de) * | 1978-10-07 | 1980-04-16 | BASF Aktiengesellschaft | N-Monohydroxypropylamide, N-Dihydroxypropylamide und deren Acetonoide der all-E- und 13-Z-Retinsäure, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
-
2006
- 2006-09-29 KR KR1020060095279A patent/KR100837186B1/ko active IP Right Grant
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1283887A (en) * | 1970-02-02 | 1972-08-02 | Hoffmann La Roche | Acid amides |
EP0009776A1 (de) * | 1978-10-07 | 1980-04-16 | BASF Aktiengesellschaft | N-Monohydroxypropylamide, N-Dihydroxypropylamide und deren Acetonoide der all-E- und 13-Z-Retinsäure, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
Non-Patent Citations (3)
Title |
---|
Carcinogenesis, 6(4), 479-86(1985).* |
J. Pharm. Sci., 73(6), 745-751(1984).* |
Tetrahedron Letters, 46(31), 5113-5115(2005).* |
Also Published As
Publication number | Publication date |
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KR20080029342A (ko) | 2008-04-03 |
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