KR100794898B1 - 분극된 nmr 샘플을 위한 방법 및 장치 - Google Patents
분극된 nmr 샘플을 위한 방법 및 장치 Download PDFInfo
- Publication number
- KR100794898B1 KR100794898B1 KR1020037006099A KR20037006099A KR100794898B1 KR 100794898 B1 KR100794898 B1 KR 100794898B1 KR 1020037006099 A KR1020037006099 A KR 1020037006099A KR 20037006099 A KR20037006099 A KR 20037006099A KR 100794898 B1 KR100794898 B1 KR 100794898B1
- Authority
- KR
- South Korea
- Prior art keywords
- sample
- melting
- polarized
- polarization
- cryostat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Soft Magnetic Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Complex Calculations (AREA)
- Spectrometry And Color Measurement (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Polarising Elements (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004034-5 | 2000-11-03 | ||
| SE0004034A SE0004034D0 (sv) | 2000-11-03 | 2000-11-03 | Methods and devices for polarized material |
| US25697401P | 2001-01-05 | 2001-01-05 | |
| US60/256,974 | 2001-01-05 | ||
| PCT/EP2001/012737 WO2002036005A1 (en) | 2000-11-03 | 2001-11-02 | Methods and devices for polarised nmr samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20030066650A KR20030066650A (ko) | 2003-08-09 |
| KR100794898B1 true KR100794898B1 (ko) | 2008-01-14 |
Family
ID=26655292
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020037006099A Expired - Fee Related KR100794898B1 (ko) | 2000-11-03 | 2001-11-02 | 분극된 nmr 샘플을 위한 방법 및 장치 |
| KR1020037006098A Expired - Fee Related KR100656313B1 (ko) | 2000-11-03 | 2001-11-02 | Nmr 분석용 초분극된 고체 재료를 용해하기 위한 방법및 장치 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020037006098A Expired - Fee Related KR100656313B1 (ko) | 2000-11-03 | 2001-11-02 | Nmr 분석용 초분극된 고체 재료를 용해하기 위한 방법및 장치 |
Country Status (17)
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002037132A1 (en) * | 2000-11-03 | 2002-05-10 | Amersham Health As | Methods and devices for dissolving hyperpolarised solid material for nmr analyses |
| NO20031736D0 (no) * | 2003-04-15 | 2003-04-15 | Amersham Health As | Forbindelser |
| NO20035626D0 (no) * | 2003-12-17 | 2003-12-17 | Amersham Health As | Metode |
| US20050254998A1 (en) * | 2004-03-01 | 2005-11-17 | Ebara Corporation | Reactive detection chip and spotter suitable for manufacturing the chip |
| GB0411072D0 (en) | 2004-05-18 | 2004-06-23 | Oxford Instr Superconductivity | Apparatus and method for performing in-vitro dnp-nmr measurements |
| DE102004029632B4 (de) * | 2004-06-18 | 2011-06-09 | Bruker Biospin Gmbh | Verfahren und Vorrichtung zum Zuführen einer flüssigen Probe in ein NMR-Spektrometer |
| AU2005267668B2 (en) | 2004-07-30 | 2011-10-20 | Ge Healthcare As | Method of producing a composition, composition and its use |
| GB0424725D0 (en) * | 2004-11-09 | 2004-12-08 | Oxford Instr Superconductivity | Cryostat assembly |
| GB0507174D0 (en) * | 2005-04-08 | 2005-05-18 | Oxford Instr Molecular Biotool | Method of operating a dynamic nuclear polarization system |
| GB0514303D0 (en) * | 2005-07-12 | 2005-08-17 | Oxford Instr Molecular Biotool | Magnet assembly |
| JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Dnp過分極手段を備えた磁気共鳴イメージング装置 |
| ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
| EP1954321B1 (en) | 2005-12-01 | 2011-11-23 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
| JP2009519786A (ja) * | 2005-12-19 | 2009-05-21 | テックミン ピーティーワイ リミテッド | 誘導コイル検出 |
| US9207298B2 (en) | 2011-03-23 | 2015-12-08 | Millikelvin Technologies Llc | Techniques, systems and machine readable programs for magnetic resonance |
| US8703102B2 (en) * | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| AU2007254464B2 (en) | 2006-02-21 | 2013-02-21 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
| US7573268B2 (en) * | 2006-02-22 | 2009-08-11 | Los Alamos National Security, Llc | Direct imaging of neural currents using ultra-low field magnetic resonance techniques |
| JP5269791B2 (ja) | 2006-08-30 | 2013-08-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極(dnp)方法並びに該方法で使用するための化合物及び組成物 |
| US7631507B2 (en) | 2006-11-02 | 2009-12-15 | General Electric Company | Methods and devices for polarized samples for use in MRI |
| EP2117607A4 (en) | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | PICTURES AND METHOD FOR THEIR USE |
| US20080229928A1 (en) * | 2007-03-20 | 2008-09-25 | Urbahn John A | Sorption pump with integrated thermal switch |
| US20080240998A1 (en) * | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
| US8731640B2 (en) | 2007-03-28 | 2014-05-20 | General Electric Company | Fluid path system for dissolution and transport of a hyperpolarized material |
| US20080242974A1 (en) | 2007-04-02 | 2008-10-02 | Urbahn John A | Method and apparatus to hyperpolarize materials for enhanced mr techniques |
| US7519492B2 (en) * | 2007-05-02 | 2009-04-14 | General Electric Company | Apparatus and method for fully automated closed system quality control of a substance |
| WO2009027645A2 (en) * | 2007-08-24 | 2009-03-05 | The Universtiy Of Nottingham | Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri) |
| EP2028505A3 (en) | 2007-08-24 | 2010-03-17 | Oxford Instruments Molecular Biotools Ltd. | Coolant assembly of a DNP apparatus |
| KR101546208B1 (ko) * | 2007-08-28 | 2015-08-20 | 지이 헬쓰케어 리미티드 | 동적 핵 스핀 분극(dnp)을 위한 분극기를 위한 노즐 |
| DE102007044016B4 (de) * | 2007-09-14 | 2010-12-16 | Bruker Biospin Gmbh | Probenwechseleinrichtung mit auf mäanderförmiger Bahn geführten Probenaufnahmen, insbesondere für ein NMR-Spektrometer, und Kernspinresonanz-Spektrometer |
| WO2009046457A2 (en) * | 2007-10-05 | 2009-04-09 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
| EP2902041A1 (en) | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| WO2009089007A2 (en) * | 2008-01-08 | 2009-07-16 | The University Of Georgia Research Foundation, Inc. | Upper stack for a nuclear magnetic resonance spectrometer apparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus |
| JP4871311B2 (ja) * | 2008-02-26 | 2012-02-08 | 株式会社日立製作所 | 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置 |
| US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| WO2009133169A1 (en) | 2008-05-02 | 2009-11-05 | General Electric Company | Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate |
| DE102008033886B4 (de) * | 2008-07-18 | 2012-03-08 | Bruker Biospin Ag | Apparatur zur Durchführung von DNP-NMR Messungen mit Kompensationsanordnung |
| WO2010020776A2 (en) * | 2008-08-19 | 2010-02-25 | Oxford Instruments Molecular Biotools Limited | Dynamic nuclear polarisation system |
| US7633290B1 (en) * | 2008-09-09 | 2009-12-15 | General Electric Company | Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent |
| WO2010061191A1 (en) * | 2008-11-27 | 2010-06-03 | Oxford Instruments Molecular Biotools Limited | Apparatus for dynamic nuclear polarisation |
| DE102008063703B3 (de) * | 2008-12-19 | 2010-06-17 | Bruker Biospin Ag | Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe |
| BRPI1013677A2 (pt) | 2009-04-02 | 2016-04-26 | Ge Healthcare Ltd | método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. |
| US20100251732A1 (en) * | 2009-04-06 | 2010-10-07 | General Electric Company | Apparatus and method for introduction of a material into a cryogenic system |
| RU2526895C2 (ru) * | 2009-06-19 | 2014-08-27 | Конинклейке Филипс Электроникс Н.В. | Мрт с гиперполяризационным устройством, использующим фотоны с орбитальным угловым моментом |
| EP2443444A1 (en) * | 2009-06-19 | 2012-04-25 | Koninklijke Philips Electronics N.V. | Mri thermometry combined with hyperpolarisation device using photons with orbital angular momentum |
| SG178927A1 (en) * | 2009-08-31 | 2012-04-27 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| EP2476009A1 (en) | 2009-09-10 | 2012-07-18 | GE Healthcare UK Limited | 13c-mr detection using hyperpolarised 13c-fructose |
| US8427161B2 (en) * | 2009-12-18 | 2013-04-23 | General Electric Company | Method and apparatus for generating hyperpolarized materials |
| EP2348327B1 (en) * | 2010-01-18 | 2013-11-27 | Bruker BioSpin AG | Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals |
| BR112012020235A2 (pt) * | 2010-02-16 | 2017-11-07 | Koninl Philips Electronics Nv | "dispensador para a produção de um agente de contraste hiperpolarizado e sistema de exame de ressonância magnética" |
| JP5758982B2 (ja) * | 2010-04-08 | 2015-08-05 | ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. | 過分極基質の製造方法およびmriのための方法 |
| AU2011250012B2 (en) | 2010-05-03 | 2016-02-25 | Ge Healthcare Limited | Hyperpolarized lactate contrast agent for determination of LDH activity |
| KR101206727B1 (ko) * | 2011-01-03 | 2012-11-30 | 한국표준과학연구원 | 저자기장 핵자기공명 장치 및 저자기장 핵자기공명 방법 |
| US8786284B2 (en) * | 2011-01-11 | 2014-07-22 | Bridge12 Technologies, Inc. | Integrated high-frequency generator system utilizing the magnetic field of the target application |
| US9714995B2 (en) | 2011-03-23 | 2017-07-25 | Millikelvin Technologies Llc | Techniques, systems and machine readable programs for magnetic resonance |
| AU2012230778A1 (en) * | 2011-03-23 | 2013-10-10 | Millikelvin Technologies Llc | Improved techniques, systems and machine readable programs for magnetic resonance |
| US9110132B2 (en) * | 2011-08-05 | 2015-08-18 | Chris Chiodo | Electrical and fluid connection system for magnetic imaging |
| EP2766050B1 (en) | 2011-10-12 | 2018-09-05 | Bracco Imaging S.p.A | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
| US9693828B2 (en) | 2011-12-05 | 2017-07-04 | Bracco Imaging S.P.A. | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis |
| GB2498181A (en) | 2011-12-29 | 2013-07-10 | Bruker Biospin Gmbh | Device and method for rapid dynamic nuclear polarisation |
| EP2833924B1 (en) | 2012-04-02 | 2019-05-08 | Bracco Imaging S.p.A | Hyperpolarized amino acids |
| US9329245B2 (en) * | 2012-04-11 | 2016-05-03 | Bruker Biospin Ag | MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material |
| US20150133341A1 (en) | 2012-05-07 | 2015-05-14 | Albeda Innovations Aps | Intra-Operative Cancer Diagnosis Based on a Hyperpolarized Marker |
| CA2878010A1 (en) * | 2012-07-02 | 2014-01-09 | Millikelvin Technologies Llc | Improved techniques, systems and machine readable programs for magnetic resonance |
| US9329246B2 (en) | 2012-10-03 | 2016-05-03 | Bruker Biospin Ag | Method for hyperpolarization transfer in the liquid state |
| US9404984B2 (en) | 2012-11-06 | 2016-08-02 | Bruker Uk Limited | Method of hyperpolarization applying brute force using particulate acceleration agents |
| US9874622B2 (en) | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
| DE102013219453B8 (de) * | 2013-09-26 | 2014-10-02 | Bruker Biospin Ag | DNP-Vorrichtung |
| US20150198681A1 (en) * | 2014-01-15 | 2015-07-16 | Prudhvi Raju Chintalapati | Method for transporting an NMR sample spaced horizontally and vertically from a cryo-magnetic system using a vibration isolated motorized curvilinear Transport Carrier with dual end-effector and method for telescoping the Carrier to different cryo-magnetic systems at different heights |
| GB2540729B (en) * | 2015-05-01 | 2018-03-21 | Oxford Instruments Nanotechnology Tools Ltd | Superconducting magnet |
| DE102016203891B4 (de) * | 2016-03-09 | 2019-07-11 | Numares Ag | Verfahren zur Durchführung einer NMR-Messung und NMR-Spektrometer-Anordnung |
| US10481222B2 (en) * | 2017-07-24 | 2019-11-19 | General Electric Company | Fluid path insert for a cryogenic cooling system |
| JP6789585B2 (ja) | 2017-08-23 | 2020-11-25 | 国立大学法人大阪大学 | 原子核スピンの高偏極化方法及び高偏極化装置 |
| US10520561B2 (en) | 2017-09-27 | 2019-12-31 | General Electric Company | System and method for hyperpolarizing a substance and quenching radicals therein |
| WO2019159154A1 (en) * | 2018-02-19 | 2019-08-22 | Bruker France Sas | Nuclear spin hyperpolarization in a porous matrix |
| US10677874B2 (en) * | 2018-02-20 | 2020-06-09 | Wisconsin Alumni Research Foundation | System and method for control of hyperpolarized gas-phase contamination in spectroscopic magnetic resonance imaging |
| US11035807B2 (en) * | 2018-03-07 | 2021-06-15 | General Electric Company | Thermal interposer for a cryogenic cooling system |
| DE102019201071B4 (de) * | 2019-01-29 | 2020-11-05 | Bruker Biospin Gmbh | Vorrichtung zum schnellen Probenwechsel in einem NMR-Spektrometer mit Durchflusszelle |
| US10942237B2 (en) | 2019-05-07 | 2021-03-09 | GE Precision Healthcare LLC | System and method for hyperpolarizing a substance |
| US11925786B2 (en) | 2019-05-15 | 2024-03-12 | GE Precision Healthcare LLC | System and method for drawing a solution |
| EP3832333A1 (en) | 2019-12-02 | 2021-06-09 | Universität Wien | Method and device for delivering a liquid sample material to a spectrometer setup |
| WO2022092322A1 (ja) * | 2020-11-02 | 2022-05-05 | 国立大学法人大阪大学 | 原子核スピンの高偏極化方法、高偏極化試料の製造方法、高偏極化試料の製造装置及び高偏極化キット |
| DE102020214887B4 (de) | 2020-11-26 | 2022-08-04 | Bruker Switzerland Ag | Magnetsystem zur Durchführung von 2-Feld-NMR-Experimenten und zugehöriges Nachrüstverfahren |
| DE102021206392A1 (de) | 2021-06-22 | 2022-12-22 | Bruker Biospin Gmbh | Autonomes Herunterkühlen eines supraleitfähigen, trocken-gekühlten MR-Magnetspulensystems |
| GB202111734D0 (en) | 2021-08-16 | 2021-09-29 | Cambridge Entpr Ltd | Hyperpolarisation method and product |
| CN121656929B (zh) * | 2026-02-09 | 2026-05-29 | 中国科学院精密测量科学与技术创新研究院 | 用于稳定dDNP融溶转移路径磁场的分布式补偿装置及方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258710A (en) | 1992-03-27 | 1993-11-02 | General Electric Company | Cryogenic probe for NMR microscopy |
| WO1995006882A1 (en) * | 1993-08-30 | 1995-03-09 | Auburn International, Inc. | Nmr system for measuring polymer properties |
| US5617859A (en) | 1995-10-02 | 1997-04-08 | General Electric Company | Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures |
| WO2000023797A1 (en) * | 1998-10-16 | 2000-04-27 | Syracuse University | Bulk production and usage of hyperpolarized 129xenon |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3525928A (en) * | 1967-11-25 | 1970-08-25 | Nippon Electron Optics Lab | Temperature variable sample apparatus for nmr analysis |
| US4642206A (en) * | 1983-06-27 | 1987-02-10 | Syracuse University | Production of spin polarized fusion fuels |
| RU2186405C2 (ru) * | 1996-03-29 | 2002-07-27 | Лоренс Беркли Нэшнл Лэборэтори | Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов |
| CN1224502A (zh) * | 1996-03-29 | 1999-07-28 | 劳伦斯·伯克利国家实验室 | 利用超极化惰性气体对于核磁共振和磁共振成象质量的提高 |
| JP2002508687A (ja) * | 1997-06-19 | 2002-03-19 | ナイコムド イメージング エーエス | 磁気共鳴(mr)イメージング剤の生体外分極を含むオーバーハウザー磁気共鳴画像(ormi)法 |
| DE19742548C2 (de) * | 1997-09-26 | 1999-10-07 | Otten Ernst Wilhelm | Magneteinrichtung für Tansport und Aufbewahrung kernspinpolarisierter Gase und Verfahren zur Entnahme dieser Gase |
| US6278893B1 (en) | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| DE19937566C2 (de) * | 1999-08-09 | 2001-06-28 | Forschungszentrum Juelich Gmbh | Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators |
| GB0014463D0 (en) | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| WO2002037132A1 (en) * | 2000-11-03 | 2002-05-10 | Amersham Health As | Methods and devices for dissolving hyperpolarised solid material for nmr analyses |
| CA2427726C (en) * | 2000-11-03 | 2012-01-24 | Amersham Health As | Methods and devices for polarised nmr samples |
| US20040049108A1 (en) * | 2000-11-03 | 2004-03-11 | Ardenkjaer-Larsen Jan Henrik | Methods and devices for polarised nmr samples |
| US6515260B1 (en) * | 2001-11-07 | 2003-02-04 | Varian, Inc. | Method and apparatus for rapid heating of NMR samples |
-
2001
- 2001-11-02 WO PCT/EP2001/012736 patent/WO2002037132A1/en not_active Ceased
- 2001-11-02 ES ES01992900T patent/ES2269507T3/es not_active Expired - Lifetime
- 2001-11-02 DE DE60122361T patent/DE60122361T2/de not_active Expired - Lifetime
- 2001-11-02 KR KR1020037006099A patent/KR100794898B1/ko not_active Expired - Fee Related
- 2001-11-02 AU AU1600402A patent/AU1600402A/xx active Pending
- 2001-11-02 RU RU2003112008/28A patent/RU2281526C2/ru active
- 2001-11-02 HU HU0302425A patent/HUP0302425A3/hu unknown
- 2001-11-02 JP JP2002538821A patent/JP4061192B2/ja not_active Expired - Fee Related
- 2001-11-02 US US10/415,968 patent/US7372274B2/en not_active Expired - Lifetime
- 2001-11-02 AU AU2002216004A patent/AU2002216004B2/en not_active Expired
- 2001-11-02 CA CA002427732A patent/CA2427732C/en not_active Expired - Lifetime
- 2001-11-02 DK DK01992900T patent/DK1330659T3/da active
- 2001-11-02 PT PT01992900T patent/PT1330659E/pt unknown
- 2001-11-02 KR KR1020037006098A patent/KR100656313B1/ko not_active Expired - Fee Related
- 2001-11-02 BR BRPI0115126-6A patent/BR0115126B1/pt not_active IP Right Cessation
- 2001-11-02 AT AT01992900T patent/ATE336727T1/de active
- 2001-11-02 HU HU0303091A patent/HU227603B1/hu not_active IP Right Cessation
- 2001-11-02 EP EP01992900A patent/EP1330659B1/en not_active Expired - Lifetime
- 2001-11-02 EP EP09009604A patent/EP2204662A1/en not_active Withdrawn
- 2001-11-02 JP JP2002539834A patent/JP3682044B2/ja not_active Expired - Lifetime
- 2001-11-02 IL IL15547601A patent/IL155476A0/xx unknown
- 2001-11-02 AU AU2002214039A patent/AU2002214039B2/en not_active Ceased
- 2001-11-02 EP EP01982459.8A patent/EP1330182B1/en not_active Expired - Lifetime
- 2001-11-02 CN CNB018217435A patent/CN100392422C/zh not_active Expired - Lifetime
-
2003
- 2003-04-15 IL IL155475A patent/IL155475A/en not_active IP Right Cessation
- 2003-04-15 IL IL155476A patent/IL155476A/en active IP Right Grant
-
2006
- 2006-04-11 RU RU2006111607/28A patent/RU2386140C2/ru active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5258710A (en) | 1992-03-27 | 1993-11-02 | General Electric Company | Cryogenic probe for NMR microscopy |
| WO1995006882A1 (en) * | 1993-08-30 | 1995-03-09 | Auburn International, Inc. | Nmr system for measuring polymer properties |
| US5617859A (en) | 1995-10-02 | 1997-04-08 | General Electric Company | Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures |
| WO2000023797A1 (en) * | 1998-10-16 | 2000-04-27 | Syracuse University | Bulk production and usage of hyperpolarized 129xenon |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7102354B2 (en) | Methods and devices for hyperpolarising and melting NMR samples in a cryostat | |
| KR20030066650A (ko) | 분극된 nmr 샘플을 위한 방법 및 장치 | |
| AU2002214039A1 (en) | Methods and devices for polarised NMR samples | |
| US20040049108A1 (en) | Methods and devices for polarised nmr samples | |
| AU2002216004A1 (en) | Methods and devices for dissolving hyperpolarised solid material for NMR analyses | |
| JP5302893B2 (ja) | Mriで使用される分極試料ための方法およびデバイス | |
| JP4266216B2 (ja) | Nmr・esrアンテナ及びそれを用いた分析装置 | |
| RU2281527C2 (ru) | Способ и устройство для плавления поляризованных ямр-образцов | |
| van Kesteren et al. | A 75 GHz spectrometer for microwave-induced optical nuclear polarisation | |
| ES2545255T3 (es) | Dispositivo y procedimiento para producir una muestra de RMN hiperpolarizada |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P18-X000 | Priority claim added or amended |
St.27 status event code: A-2-2-P10-P18-nap-X000 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| FPAY | Annual fee payment |
Payment date: 20121226 Year of fee payment: 6 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 6 |
|
| FPAY | Annual fee payment |
Payment date: 20131224 Year of fee payment: 7 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 7 |
|
| FPAY | Annual fee payment |
Payment date: 20141223 Year of fee payment: 8 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 8 |
|
| FPAY | Annual fee payment |
Payment date: 20151224 Year of fee payment: 9 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 9 |
|
| FPAY | Annual fee payment |
Payment date: 20161229 Year of fee payment: 10 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 10 |
|
| FPAY | Annual fee payment |
Payment date: 20171227 Year of fee payment: 11 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 11 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |
|
| FPAY | Annual fee payment |
Payment date: 20190102 Year of fee payment: 12 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 12 |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20200109 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20200109 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |