JP5302893B2 - Mriで使用される分極試料ための方法およびデバイス - Google Patents
Mriで使用される分極試料ための方法およびデバイス Download PDFInfo
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- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/31—Temperature control thereof
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- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B25/00—Machines, plants or systems, using a combination of modes of operation covered by two or more of the groups F25B1/00 - F25B23/00
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B9/00—Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point
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- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B2309/00—Gas cycle refrigeration machines
- F25B2309/003—Gas cycle refrigeration machines characterised by construction or composition of the regenerator
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B9/00—Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point
- F25B9/02—Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point using Joule-Thompson effect; using vortex effect
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B9/00—Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point
- F25B9/14—Compression machines, plants or systems, in which the refrigerant is air or other gas of low boiling point characterised by the cycle used, e.g. Stirling cycle
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/38—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field
- G01R33/381—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using electromagnets
- G01R33/3815—Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field using electromagnets with superconducting coils, e.g. power supply therefor
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- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
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- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Description
2 クライオスタット
3 分極手段
3a マイクロ波室
3b 導波管
3c マイクロ波源
4 光ファイバ
5 超伝導磁石
6 中心開口部
7 試料輸送管
9 試料保持カップ
10 He注入管
11 抽出管
14、23、27 弁
15 溶解分極材料用ユニット
16 中空体
17 撹拌手段
19 ブレード
20 永久磁石
21 溶媒
25 出口
28 コンピュータ
100 分極サブシステム、抽出システム
110 容器
120 材料搬送ライン
130 スキャナ
140 被験者
150 システム
200 クライオスタット構造
210 冷却デバイス、コールドフィンガ
220 第1の冷却ステージ、予冷ステージ
230 第2の冷却ステージ
240 冷却板
250 中間冷却リンク
260 磁石冷却システム
Claims (13)
- 核磁気共鳴(NMR)システム用の過分極サンプルを製造する装置であって、
選択された材料サンプルの分極に用いるクライオスタット構造(200)であって、
排気されて真空領域を生成するように適合された中心開口部(6)と、
前記中心開口部に挿入されて、前記サンプルを選択した温度に維持する冷却デバイス(210)と、
前記試料の段階的冷却を行うための第1の冷却ステージ(220)および第2の冷却ステージ(230)と
を備え、
前記第1の冷却ステージ(220)が前記第2の冷却ステージ(230)に保持される前記サンプルの予冷を行い、
前記第1の冷却ステージ(220)が前記NMRシステムの冷却器(260)を備えることを特徴とする過分極サンプル製造装置。 - 前記第2の冷却ステージ(230)に保持された前記サンプルを分極する磁場を提供する磁石(5)と、
前記中心開口部(6)内に配置された試料輸送管(7)と、
前記試料輸送管(7)に導入された前記サンプルを保持する試料保持カップ(9)と、
前記中心開口部(6)内に配置された抽出管(11)と、
前記抽出管(11)に結合し、前記試料保持カップ(9)から前記サンプルを抽出する抽出システム(100)と、
を備え、
前記第2の冷却ステージが、
冷却板(240)と、
MRIシステムの磁石冷却システムへの冷却リンク(250)、
とを備え、
前記冷却板および冷却リンクが前記選択された材料を所望の温度にするための追加の冷却を行うことを特徴とする請求項1記載の装置。 - 前記中心開口部(6)内に配置された試料輸送管(7)と、
前記試料輸送管(7)に導入された前記サンプルを保持する複数の試料保持カップ(9)と、
前記複数の試料保持カップ(9)の前記サンプルが順次に分極され、順次融解されるように前記複数の試料保持カップ(9)を移動する手段と、
を備える請求項1または2に記載の装置。 - 前記サンプルが導入されたイメージング対象にNMR分光法を実施するNMR機器に、過分極サンプルを製造する前記装置が設けられ、
前記装置の低温空間が前記NMR機器の磁石クライオスタットに統合される、請求項1乃至3のいずれかに記載の装置。 - 核磁気共鳴(NMR)システムのうちの1つで使用される過分極サンプルを製造する方法であって、
選択された材料の固体サンプルの分極用のクライオスタット構造(100)であって、
分極サブシステム(110)を含み、真空領域を生成するように構成された中心開口部(6)と、
前記中心開口部(6)内にまたは前記中心開口部に隣接するように挿入されて、前記サンプルを選択された温度に維持する前記NMRシステムの冷却デバイス(210)と、
とを備える前記クライオスタット構造を提供する工程を具備し、
前記クライオスタット構造がさらに、
前記試料の段階的冷却を行うための第1の冷却ステージ(220)および第2の冷却ステージ(230)と、
前記第2の冷却ステージ(230)に保持された前記サンプルを分極する磁場を提供する磁石(5)と、
前記中心開口部(6)内に配置された試料輸送管(7)と、
前記試料輸送管(7)に導入された前記サンプルを保持する試料保持カップ(9)と、
前記中心開口部(6)内に配置された抽出管(11)と、
前記抽出管(11)に結合し、前記試料保持カップ(9)から前記サンプルを抽出する抽出システム(100)と、を備え、前記磁石(5)が前記分極システム内に選択された磁場を維持するように構成されることを特徴とする方法。 - 前記冷却デバイスが、蓄冷材で構築されたデバイスを含み、
前記蓄冷材は1.2K未満に冷却可能であるように選択された材料で構築され、
前記蓄冷材が、磁性蓄冷材、酸化物セラミックス蓄冷材、セラミック型高cp材、およびその組み合わせからなるグループから選択されることを特徴とする請求項5記載の方法。 - 前記冷却デバイスがGd1.5Al0.5O3で構築された冷却器であることを特徴とする請求項5または6に記載の方法。
- 前記中心開口部を排気し、シールして、前記真空領域を生成するステップをさらに含むことを特徴とする請求項5乃至7のいずれかに記載の方法。
- 前記サンプルが導入されたイメージング対象に核磁気共鳴(NMR)分光法を実施するNMR分析デバイスに、前記クライオスタット構造(100)が設けられ、
前記クライオスタット構造(100)の低温空間が前記NMR分析デバイスの磁石クライオスタットに統合され、
前記NMR分析デバイスを使用して前記サンプルを分析するステップをさらに含むことを特徴とする請求項5乃至8のいずれかに記載の方法。 - 前記第1の冷却ステージが、前記NMRシステムの超導電磁石を取り囲む熱シールドを冷却し、前記冷却デバイスを予冷するための前記NMRシステムの冷却器を備えることを特徴とする請求項5乃至9のいずれかに記載の方法。
- 前記第2の冷却ステージが前記超導電磁石を冷却するための前記NMRシステムの冷却器を備えることを特徴とする請求項10記載の方法。
- 前記試料保持カップ(9)の前記サンプルを分極するステップと、
分極された前記サンプルを融解するステップと、
融解された前記サンプルを抽出するステップと、
を備えることを特徴とする請求項5乃至11のいずれかに記載の方法。 - 前記複数の試料保持カップ(9)の前記サンプルを順次分極するステップと、
分極された前記サンプルを順次融解するステップと、
を備えることを特徴とする請求項5乃至11のいずれかに記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/591,846 US7631507B2 (en) | 2006-11-02 | 2006-11-02 | Methods and devices for polarized samples for use in MRI |
US11/591,846 | 2006-11-02 | ||
PCT/US2007/081736 WO2008060803A2 (en) | 2006-11-02 | 2007-10-18 | Method and apparatus for producing hyperpolarized samples for use in magnetic resonance |
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Publication Number | Publication Date |
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JP2010508908A JP2010508908A (ja) | 2010-03-25 |
JP2010508908A5 JP2010508908A5 (ja) | 2011-01-06 |
JP5302893B2 true JP5302893B2 (ja) | 2013-10-02 |
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US (1) | US7631507B2 (ja) |
JP (1) | JP5302893B2 (ja) |
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GB0605031D0 (en) * | 2006-03-13 | 2006-04-19 | Oxford Instr Molecular Biotool | NMR inspection apparatus |
JP4468388B2 (ja) * | 2007-02-05 | 2010-05-26 | 株式会社日立製作所 | 磁場発生器 |
EP2028505A3 (en) * | 2007-08-24 | 2010-03-17 | Oxford Instruments Molecular Biotools Ltd. | Coolant assembly of a DNP apparatus |
US8575932B2 (en) * | 2008-01-08 | 2013-11-05 | The University Of Georgia Research Foundation, Inc. | Upper stack for a nuclear magnetic resonance spectrometer aaparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus |
US8516834B2 (en) * | 2008-08-14 | 2013-08-27 | S2 Corporation | Apparatus and methods for improving vibration isolation, thermal dampening, and optical access in cryogenic refrigerators |
WO2010020776A2 (en) * | 2008-08-19 | 2010-02-25 | Oxford Instruments Molecular Biotools Limited | Dynamic nuclear polarisation system |
CA2772190A1 (en) * | 2009-08-31 | 2011-03-03 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
US8427161B2 (en) * | 2009-12-18 | 2013-04-23 | General Electric Company | Method and apparatus for generating hyperpolarized materials |
EP2343568A1 (en) * | 2009-12-30 | 2011-07-13 | Koninklijke Philips Electronics N.V. | Dynamic nuclear polarization apparatus with sample transport system |
US9234691B2 (en) * | 2010-03-11 | 2016-01-12 | Quantum Design International, Inc. | Method and apparatus for controlling temperature in a cryocooled cryostat using static and moving gas |
US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
DE102010017568B4 (de) * | 2010-06-24 | 2012-09-13 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Hyperpolarisationseinrichtung und Verfahren zur Verabreichung eines hyperpolarisierten flüssigen Kontrastmittels |
JP2013542036A (ja) * | 2010-11-16 | 2013-11-21 | アスペクト イメージング リミテッド | 非侵襲的に過分極した画像を生成するシステム及び方法 |
WO2013092996A1 (en) * | 2011-12-23 | 2013-06-27 | Stichting Katholieke Universiteit | Rapid cycle dynamic nuclear polarization magnetic resonance apparatus |
US9329246B2 (en) * | 2012-10-03 | 2016-05-03 | Bruker Biospin Ag | Method for hyperpolarization transfer in the liquid state |
US9642924B2 (en) | 2013-08-29 | 2017-05-09 | Duke University | Contrast agents based on long-lived nuclear singlet states and related methods |
DE102013219453B8 (de) * | 2013-09-26 | 2014-10-02 | Bruker Biospin Ag | DNP-Vorrichtung |
US10088536B2 (en) * | 2015-03-27 | 2018-10-02 | Bruker Biospin Corporation | Sample introduction system and method for polarization |
US10481222B2 (en) | 2017-07-24 | 2019-11-19 | General Electric Company | Fluid path insert for a cryogenic cooling system |
US10520561B2 (en) * | 2017-09-27 | 2019-12-31 | General Electric Company | System and method for hyperpolarizing a substance and quenching radicals therein |
US11035807B2 (en) * | 2018-03-07 | 2021-06-15 | General Electric Company | Thermal interposer for a cryogenic cooling system |
GB2576185B (en) * | 2018-08-08 | 2022-07-20 | Oxford Instruments Nanotechnology Tools Ltd | Noise reduction method for a cryogenic cooling system |
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US4827736A (en) * | 1988-07-06 | 1989-05-09 | Daikin Industries, Ltd. | Cryogenic refrigeration system for cooling a specimen |
JPH0334404A (ja) | 1989-06-30 | 1991-02-14 | Mitsubishi Electric Corp | 極低温冷凍装置 |
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FR2768568B1 (fr) * | 1997-09-17 | 2000-02-25 | Centre Nat Rech Scient | Procede et equipement pour la preparation d'un gaz d'helium hyperpolarise a forte pression, application dudit procede |
US6278893B1 (en) | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
US6125654A (en) | 1998-10-16 | 2000-10-03 | Syracuse University | Bulk production and usage of hyperpolarized 129 Xenon |
BR0115124B1 (pt) | 2000-11-03 | 2012-12-25 | dispositivo para fundir uma amostra hiperpolarizada sàlida, mÉtodo para produzir uma amostra hiperpolarizada fundida, e, uso de um dispositivo ou mÉtodo. | |
US20040049108A1 (en) | 2000-11-03 | 2004-03-11 | Ardenkjaer-Larsen Jan Henrik | Methods and devices for polarised nmr samples |
DE60122361T2 (de) | 2000-11-03 | 2007-06-21 | Ge Healthcare As | Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen |
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DE102004060832B3 (de) * | 2004-12-17 | 2006-06-14 | Bruker Biospin Gmbh | NMR-Spektrometer mit gemeinsamen Refrigerator zum Kühlen von NMR-Probenkopf und Kryostat |
US7415830B2 (en) * | 2005-08-31 | 2008-08-26 | Raytheon Company | Method and system for cryogenic cooling |
JP2009527768A (ja) * | 2006-02-21 | 2009-07-30 | ベルザー,アブラム | 超偏極方法、システムおよび組成物 |
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US7631507B2 (en) | 2009-12-15 |
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GB2456097A (en) | 2009-07-08 |
DE112007002589T5 (de) | 2009-09-10 |
US20080104966A1 (en) | 2008-05-08 |
GB2456097B (en) | 2010-04-28 |
JP2010508908A (ja) | 2010-03-25 |
DE112007002589B4 (de) | 2017-12-28 |
WO2008060803A3 (en) | 2008-08-21 |
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