DE60122361T2 - Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen - Google Patents
Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen Download PDFInfo
- Publication number
- DE60122361T2 DE60122361T2 DE60122361T DE60122361T DE60122361T2 DE 60122361 T2 DE60122361 T2 DE 60122361T2 DE 60122361 T DE60122361 T DE 60122361T DE 60122361 T DE60122361 T DE 60122361T DE 60122361 T2 DE60122361 T2 DE 60122361T2
- Authority
- DE
- Germany
- Prior art keywords
- sample
- polarized
- solid
- cryostat
- retaining container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Soft Magnetic Materials (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Complex Calculations (AREA)
- Spectrometry And Color Measurement (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Polarising Elements (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004034A SE0004034D0 (sv) | 2000-11-03 | 2000-11-03 | Methods and devices for polarized material |
| SE0004034 | 2000-11-03 | ||
| US25697401P | 2001-01-05 | 2001-01-05 | |
| US256974P | 2001-05-01 | ||
| PCT/EP2001/012736 WO2002037132A1 (en) | 2000-11-03 | 2001-11-02 | Methods and devices for dissolving hyperpolarised solid material for nmr analyses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60122361D1 DE60122361D1 (de) | 2006-09-28 |
| DE60122361T2 true DE60122361T2 (de) | 2007-06-21 |
Family
ID=26655292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60122361T Expired - Lifetime DE60122361T2 (de) | 2000-11-03 | 2001-11-02 | Verfahren und einrichtung zum lösen hyperpolarisierter feststoffe für nmr-analysen |
Country Status (17)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102021206392A1 (de) | 2021-06-22 | 2022-12-22 | Bruker Biospin Gmbh | Autonomes Herunterkühlen eines supraleitfähigen, trocken-gekühlten MR-Magnetspulensystems |
| DE102008015872B4 (de) | 2007-03-28 | 2024-05-16 | General Electric Co. | Strömungsmittelpfad-System zur Auflösung und zum Transport eines hyperpolarisierten Materials |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002037132A1 (en) * | 2000-11-03 | 2002-05-10 | Amersham Health As | Methods and devices for dissolving hyperpolarised solid material for nmr analyses |
| NO20031736D0 (no) * | 2003-04-15 | 2003-04-15 | Amersham Health As | Forbindelser |
| NO20035626D0 (no) * | 2003-12-17 | 2003-12-17 | Amersham Health As | Metode |
| US20050254998A1 (en) * | 2004-03-01 | 2005-11-17 | Ebara Corporation | Reactive detection chip and spotter suitable for manufacturing the chip |
| GB0411072D0 (en) | 2004-05-18 | 2004-06-23 | Oxford Instr Superconductivity | Apparatus and method for performing in-vitro dnp-nmr measurements |
| DE102004029632B4 (de) * | 2004-06-18 | 2011-06-09 | Bruker Biospin Gmbh | Verfahren und Vorrichtung zum Zuführen einer flüssigen Probe in ein NMR-Spektrometer |
| AU2005267668B2 (en) | 2004-07-30 | 2011-10-20 | Ge Healthcare As | Method of producing a composition, composition and its use |
| GB0424725D0 (en) * | 2004-11-09 | 2004-12-08 | Oxford Instr Superconductivity | Cryostat assembly |
| GB0507174D0 (en) * | 2005-04-08 | 2005-05-18 | Oxford Instr Molecular Biotool | Method of operating a dynamic nuclear polarization system |
| GB0514303D0 (en) * | 2005-07-12 | 2005-08-17 | Oxford Instr Molecular Biotool | Magnet assembly |
| JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Ｄｎｐ過分極手段を備えた磁気共鳴イメージング装置 |
| ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
| EP1954321B1 (en) | 2005-12-01 | 2011-11-23 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
| JP2009519786A (ja) * | 2005-12-19 | 2009-05-21 | テックミン ピーティーワイ リミテッド | 誘導コイル検出 |
| US9207298B2 (en) | 2011-03-23 | 2015-12-08 | Millikelvin Technologies Llc | Techniques, systems and machine readable programs for magnetic resonance |
| US8703102B2 (en) * | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| AU2007254464B2 (en) | 2006-02-21 | 2013-02-21 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
| US7573268B2 (en) * | 2006-02-22 | 2009-08-11 | Los Alamos National Security, Llc | Direct imaging of neural currents using ultra-low field magnetic resonance techniques |
| JP5269791B2 (ja) | 2006-08-30 | 2013-08-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物 |
| US7631507B2 (en) | 2006-11-02 | 2009-12-15 | General Electric Company | Methods and devices for polarized samples for use in MRI |
| EP2117607A4 (en) | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | PICTURES AND METHOD FOR THEIR USE |
| US20080229928A1 (en) * | 2007-03-20 | 2008-09-25 | Urbahn John A | Sorption pump with integrated thermal switch |
| US8731640B2 (en) | 2007-03-28 | 2014-05-20 | General Electric Company | Fluid path system for dissolution and transport of a hyperpolarized material |
| US20080242974A1 (en) | 2007-04-02 | 2008-10-02 | Urbahn John A | Method and apparatus to hyperpolarize materials for enhanced mr techniques |
| US7519492B2 (en) * | 2007-05-02 | 2009-04-14 | General Electric Company | Apparatus and method for fully automated closed system quality control of a substance |
| WO2009027645A2 (en) * | 2007-08-24 | 2009-03-05 | The Universtiy Of Nottingham | Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri) |
| EP2028505A3 (en) | 2007-08-24 | 2010-03-17 | Oxford Instruments Molecular Biotools Ltd. | Coolant assembly of a DNP apparatus |
| KR101546208B1 (ko) * | 2007-08-28 | 2015-08-20 | 지이 헬쓰케어 리미티드 | 동적 핵 스핀 분극（ｄｎｐ）을 위한 분극기를 위한 노즐 |
| DE102007044016B4 (de) * | 2007-09-14 | 2010-12-16 | Bruker Biospin Gmbh | Probenwechseleinrichtung mit auf mäanderförmiger Bahn geführten Probenaufnahmen, insbesondere für ein NMR-Spektrometer, und Kernspinresonanz-Spektrometer |
| WO2009046457A2 (en) * | 2007-10-05 | 2009-04-09 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
| EP2902041A1 (en) | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| WO2009089007A2 (en) * | 2008-01-08 | 2009-07-16 | The University Of Georgia Research Foundation, Inc. | Upper stack for a nuclear magnetic resonance spectrometer apparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus |
| JP4871311B2 (ja) * | 2008-02-26 | 2012-02-08 | 株式会社日立製作所 | 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置 |
| US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| WO2009133169A1 (en) | 2008-05-02 | 2009-11-05 | General Electric Company | Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate |
| DE102008033886B4 (de) * | 2008-07-18 | 2012-03-08 | Bruker Biospin Ag | Apparatur zur Durchführung von DNP-NMR Messungen mit Kompensationsanordnung |
| WO2010020776A2 (en) * | 2008-08-19 | 2010-02-25 | Oxford Instruments Molecular Biotools Limited | Dynamic nuclear polarisation system |
| US7633290B1 (en) * | 2008-09-09 | 2009-12-15 | General Electric Company | Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent |
| WO2010061191A1 (en) * | 2008-11-27 | 2010-06-03 | Oxford Instruments Molecular Biotools Limited | Apparatus for dynamic nuclear polarisation |
| DE102008063703B3 (de) * | 2008-12-19 | 2010-06-17 | Bruker Biospin Ag | Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe |
| BRPI1013677A2 (pt) | 2009-04-02 | 2016-04-26 | Ge Healthcare Ltd | método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. |
| US20100251732A1 (en) * | 2009-04-06 | 2010-10-07 | General Electric Company | Apparatus and method for introduction of a material into a cryogenic system |
| RU2526895C2 (ru) * | 2009-06-19 | 2014-08-27 | Конинклейке Филипс Электроникс Н.В. | Мрт с гиперполяризационным устройством, использующим фотоны с орбитальным угловым моментом |
| EP2443444A1 (en) * | 2009-06-19 | 2012-04-25 | Koninklijke Philips Electronics N.V. | Mri thermometry combined with hyperpolarisation device using photons with orbital angular momentum |
| SG178927A1 (en) * | 2009-08-31 | 2012-04-27 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| EP2476009A1 (en) | 2009-09-10 | 2012-07-18 | GE Healthcare UK Limited | 13c-mr detection using hyperpolarised 13c-fructose |
| US8427161B2 (en) * | 2009-12-18 | 2013-04-23 | General Electric Company | Method and apparatus for generating hyperpolarized materials |
| EP2348327B1 (en) * | 2010-01-18 | 2013-11-27 | Bruker BioSpin AG | Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals |
| BR112012020235A2 (pt) * | 2010-02-16 | 2017-11-07 | Koninl Philips Electronics Nv | "dispensador para a produção de um agente de contraste hiperpolarizado e sistema de exame de ressonância magnética" |
| JP5758982B2 (ja) * | 2010-04-08 | 2015-08-05 | ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． | 過分極基質の製造方法およびｍｒｉのための方法 |
| AU2011250012B2 (en) | 2010-05-03 | 2016-02-25 | Ge Healthcare Limited | Hyperpolarized lactate contrast agent for determination of LDH activity |
| KR101206727B1 (ko) * | 2011-01-03 | 2012-11-30 | 한국표준과학연구원 | 저자기장 핵자기공명 장치 및 저자기장 핵자기공명 방법 |
| US8786284B2 (en) * | 2011-01-11 | 2014-07-22 | Bridge12 Technologies, Inc. | Integrated high-frequency generator system utilizing the magnetic field of the target application |
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| DE102008015872B4 (de) | 2007-03-28 | 2024-05-16 | General Electric Co. | Strömungsmittelpfad-System zur Auflösung und zum Transport eines hyperpolarisierten Materials |
| DE102021206392A1 (de) | 2021-06-22 | 2022-12-22 | Bruker Biospin Gmbh | Autonomes Herunterkühlen eines supraleitfähigen, trocken-gekühlten MR-Magnetspulensystems |
| US12055608B2 (en) | 2021-06-22 | 2024-08-06 | Bruker Biospin Gmbh | Autonomous cooling of a superconductive dry-cooled MR magnetic coil system |
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