KR100742432B1 - 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법 - Google Patents

암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법 Download PDF

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Publication number
KR100742432B1
KR100742432B1 KR1020050130531A KR20050130531A KR100742432B1 KR 100742432 B1 KR100742432 B1 KR 100742432B1 KR 1020050130531 A KR1020050130531 A KR 1020050130531A KR 20050130531 A KR20050130531 A KR 20050130531A KR 100742432 B1 KR100742432 B1 KR 100742432B1
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South Korea
Prior art keywords
simvastatin
amlodipine
film layer
amlodipine camsylate
camsylate
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020050130531A
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English (en)
Korean (ko)
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KR20070068658A (ko
Inventor
우종수
지문혁
김용일
이홍기
Original Assignee
한미약품 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Priority to KR1020050130531A priority Critical patent/KR100742432B1/ko
Application filed by 한미약품 주식회사 filed Critical 한미약품 주식회사
Priority to BRPI0620790-1A priority patent/BRPI0620790A2/pt
Priority to PCT/KR2006/005658 priority patent/WO2007075009A1/en
Priority to CA002634639A priority patent/CA2634639A1/en
Priority to JP2008548399A priority patent/JP2009521526A/ja
Priority to EP06835362A priority patent/EP1978956A4/en
Priority to AU2006330199A priority patent/AU2006330199A1/en
Priority to US12/159,418 priority patent/US20090005425A1/en
Priority to CNA2006800492048A priority patent/CN101346140A/zh
Priority to RU2008130873/15A priority patent/RU2008130873A/ru
Publication of KR20070068658A publication Critical patent/KR20070068658A/ko
Application granted granted Critical
Publication of KR100742432B1 publication Critical patent/KR100742432B1/ko
Priority to IL192148A priority patent/IL192148A0/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020050130531A 2005-12-27 2005-12-27 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법 Expired - Fee Related KR100742432B1 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1020050130531A KR100742432B1 (ko) 2005-12-27 2005-12-27 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법
CNA2006800492048A CN101346140A (zh) 2005-12-27 2006-12-22 含有右旋樟脑磺酸氨氯地平和辛伐他汀的复合制剂及其制备方法
CA002634639A CA2634639A1 (en) 2005-12-27 2006-12-22 Complex formulation comprising amlodipine camsylate and simvastatin and method for preparation thereof
JP2008548399A JP2009521526A (ja) 2005-12-27 2006-12-22 カンシル酸アムロジピン及びシンバスタチンを含む複合製剤及びその製造方法
EP06835362A EP1978956A4 (en) 2005-12-27 2006-12-22 COMPLEX FORMULATION WITH AMLODIPINCAMSYLATE AND SIMVASTATIN AND METHOD OF MANUFACTURING THEREOF
AU2006330199A AU2006330199A1 (en) 2005-12-27 2006-12-22 Complex formulation comprising amlodipine camsylate and simvastatin and method for preparation thereof
BRPI0620790-1A BRPI0620790A2 (pt) 2005-12-27 2006-12-22 formulação complexa que compreende cansilato de amlodipina e sinvastatina e método para a sua preparação
PCT/KR2006/005658 WO2007075009A1 (en) 2005-12-27 2006-12-22 Complex formulation comprising amlodipine camsylate and simvastatin and method for preparation thereof
RU2008130873/15A RU2008130873A (ru) 2005-12-27 2006-12-22 Комбинированный состав, включающий амлодипина камсилат и симвастатин и способ его приготовления
US12/159,418 US20090005425A1 (en) 2005-12-27 2006-12-22 Complex Formulation Comprising Amlodipine Camsylate And Simvastatin and Method For Preparation Thereof
IL192148A IL192148A0 (en) 2005-12-27 2008-06-12 A complex formulation for oral administration containing amlodipine camsylate and simvastatin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020050130531A KR100742432B1 (ko) 2005-12-27 2005-12-27 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법

Publications (2)

Publication Number Publication Date
KR20070068658A KR20070068658A (ko) 2007-07-02
KR100742432B1 true KR100742432B1 (ko) 2007-07-24

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KR1020050130531A Expired - Fee Related KR100742432B1 (ko) 2005-12-27 2005-12-27 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법

Country Status (11)

Country Link
US (1) US20090005425A1 (enExample)
EP (1) EP1978956A4 (enExample)
JP (1) JP2009521526A (enExample)
KR (1) KR100742432B1 (enExample)
CN (1) CN101346140A (enExample)
AU (1) AU2006330199A1 (enExample)
BR (1) BRPI0620790A2 (enExample)
CA (1) CA2634639A1 (enExample)
IL (1) IL192148A0 (enExample)
RU (1) RU2008130873A (enExample)
WO (1) WO2007075009A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010085014A1 (en) * 2009-01-23 2010-07-29 Hanmi Pharm. Co., Ltd. Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same
JP6081058B2 (ja) * 2009-03-19 2017-02-15 第一三共株式会社 包装により安定保存された固形製剤
CN101836981B (zh) * 2009-12-01 2011-12-14 严洁 复方缬沙坦苯磺酸氨氯地平药物组合物及其制备方法
WO2011112993A2 (en) 2010-03-11 2011-09-15 University Of Louisville Research Foundation, Inc. Methods of predicting and decreasing the risk of pregnancy loss
KR20120068277A (ko) * 2010-12-17 2012-06-27 한미사이언스 주식회사 ＨＭＧ－ＣｏＡ 환원효소 억제제 및 아스피린을 포함하는 약제학적 복합제제
JP2014521738A (ja) * 2011-08-15 2014-08-28 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド コロールおよびスタチンの併用
TWI586353B (zh) * 2012-10-12 2017-06-11 Ea Pharma Co Ltd Pharmaceutical preparations containing calcium antagonists and angiotensin II receptor antagonists
KR20190043076A (ko) 2017-10-17 2019-04-25 한미약품 주식회사 암로디핀, 로자탄 및 로수바스타틴을 포함하는 당뇨병을 동반한 심혈관계 질환의 예방 또는 치료용 약학 조성물 및 이를 포함하는 복합제제
KR20200009101A (ko) 2017-10-17 2020-01-29 한미약품 주식회사 암로디핀, 로자탄 및 로수바스타틴을 포함하는 당뇨병을 동반한 심혈관계 질환의 예방 또는 치료용 약학 조성물 및 이를 포함하는 복합제제
KR102306888B1 (ko) 2019-11-25 2021-09-29 성균관대학교산학협력단 구멍쇠미역으로부터 분리된 신규 화합물을 유효성분으로 포함하는 동맥경화 예방 및 치료용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020025981A1 (en) 1997-08-29 2002-02-28 Pfizer Inc. Combination therapy
US20030092745A1 (en) 2000-02-25 2003-05-15 Pfizer Inc. Combination therapy
US20050053653A1 (en) 2003-09-05 2005-03-10 Argaw Kidane Osmotic delivery of therapeutic compounds by solubility enhancement
US20050059720A1 (en) 2000-08-30 2005-03-17 Sankyo Company, Limited Medicinal compositions for the prevention or treatment of cardiac failure

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10224612A1 (de) * 2002-06-04 2003-12-24 Lohmann Therapie Syst Lts Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung
KR100558505B1 (ko) * 2003-01-27 2006-03-07 한미약품 주식회사 안정한 무정형 암로디핀 캠실레이트, 이의 제조방법 및이를 포함하는 경구투여용 조성물
WO2006059217A1 (en) * 2004-12-01 2006-06-08 Ranbaxy Laboratories Limited Stable solid dosage forms of amlodipine besylate and processes for their preparation
KR100582347B1 (ko) * 2004-12-30 2006-05-22 한미약품 주식회사 3-하이드록시-3-메틸글루타릴 조효소 ａ 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020025981A1 (en) 1997-08-29 2002-02-28 Pfizer Inc. Combination therapy
US20030092745A1 (en) 2000-02-25 2003-05-15 Pfizer Inc. Combination therapy
US20050059720A1 (en) 2000-08-30 2005-03-17 Sankyo Company, Limited Medicinal compositions for the prevention or treatment of cardiac failure
US20050053653A1 (en) 2003-09-05 2005-03-10 Argaw Kidane Osmotic delivery of therapeutic compounds by solubility enhancement

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Publication number Publication date
EP1978956A1 (en) 2008-10-15
WO2007075009A1 (en) 2007-07-05
AU2006330199A1 (en) 2007-07-05
IL192148A0 (en) 2009-08-03
RU2008130873A (ru) 2010-02-10
KR20070068658A (ko) 2007-07-02
EP1978956A4 (en) 2009-08-19
CA2634639A1 (en) 2007-07-05
CN101346140A (zh) 2009-01-14
JP2009521526A (ja) 2009-06-04
BRPI0620790A2 (pt) 2011-11-22
US20090005425A1 (en) 2009-01-01

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