BRPI0620790A2 - formulação complexa que compreende cansilato de amlodipina e sinvastatina e método para a sua preparação - Google Patents
formulação complexa que compreende cansilato de amlodipina e sinvastatina e método para a sua preparação Download PDFInfo
- Publication number
- BRPI0620790A2 BRPI0620790A2 BRPI0620790-1A BRPI0620790A BRPI0620790A2 BR PI0620790 A2 BRPI0620790 A2 BR PI0620790A2 BR PI0620790 A BRPI0620790 A BR PI0620790A BR PI0620790 A2 BRPI0620790 A2 BR PI0620790A2
- Authority
- BR
- Brazil
- Prior art keywords
- amlodipine
- complex formulation
- film layer
- cansilate
- simvastatin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 72
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title claims abstract description 69
- 229960000528 amlodipine Drugs 0.000 title claims abstract description 64
- 238000009472 formulation Methods 0.000 title claims abstract description 61
- 229960002855 simvastatin Drugs 0.000 title claims abstract description 32
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title claims abstract description 27
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title abstract description 10
- 239000003381 stabilizer Substances 0.000 claims abstract description 19
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- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 9
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 9
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 9
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 6
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 2
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- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 description 12
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
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- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
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- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050130531A KR100742432B1 (ko) | 2005-12-27 | 2005-12-27 | 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법 |
| KR10-2005-0130531 | 2005-12-27 | ||
| PCT/KR2006/005658 WO2007075009A1 (en) | 2005-12-27 | 2006-12-22 | Complex formulation comprising amlodipine camsylate and simvastatin and method for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0620790A2 true BRPI0620790A2 (pt) | 2011-11-22 |
Family
ID=38218207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0620790-1A BRPI0620790A2 (pt) | 2005-12-27 | 2006-12-22 | formulação complexa que compreende cansilato de amlodipina e sinvastatina e método para a sua preparação |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090005425A1 (enExample) |
| EP (1) | EP1978956A4 (enExample) |
| JP (1) | JP2009521526A (enExample) |
| KR (1) | KR100742432B1 (enExample) |
| CN (1) | CN101346140A (enExample) |
| AU (1) | AU2006330199A1 (enExample) |
| BR (1) | BRPI0620790A2 (enExample) |
| CA (1) | CA2634639A1 (enExample) |
| IL (1) | IL192148A0 (enExample) |
| RU (1) | RU2008130873A (enExample) |
| WO (1) | WO2007075009A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY173823A (en) * | 2009-01-23 | 2020-02-24 | Hanmi Science Co Ltd | Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same |
| WO2010107081A1 (ja) * | 2009-03-19 | 2010-09-23 | 第一三共株式会社 | 包装により安定保存された固形製剤 |
| CN101836981B (zh) * | 2009-12-01 | 2011-12-14 | 严洁 | 复方缬沙坦苯磺酸氨氯地平药物组合物及其制备方法 |
| WO2011112993A2 (en) | 2010-03-11 | 2011-09-15 | University Of Louisville Research Foundation, Inc. | Methods of predicting and decreasing the risk of pregnancy loss |
| KR20120068277A (ko) * | 2010-12-17 | 2012-06-27 | 한미사이언스 주식회사 | ＨＭＧ－ＣｏＡ 환원효소 억제제 및 아스피린을 포함하는 약제학적 복합제제 |
| BR112014003529A2 (pt) * | 2011-08-15 | 2017-03-14 | Technion Res & Dev Foundation | combinações de corroles e estatinas |
| WO2014058046A1 (ja) * | 2012-10-12 | 2014-04-17 | 味の素株式会社 | カルシウム拮抗薬／アンジオテンシンｉｉ受容体拮抗薬含有医薬製剤 |
| KR20200009101A (ko) | 2017-10-17 | 2020-01-29 | 한미약품 주식회사 | 암로디핀, 로자탄 및 로수바스타틴을 포함하는 당뇨병을 동반한 심혈관계 질환의 예방 또는 치료용 약학 조성물 및 이를 포함하는 복합제제 |
| KR20190043076A (ko) | 2017-10-17 | 2019-04-25 | 한미약품 주식회사 | 암로디핀, 로자탄 및 로수바스타틴을 포함하는 당뇨병을 동반한 심혈관계 질환의 예방 또는 치료용 약학 조성물 및 이를 포함하는 복합제제 |
| KR102306888B1 (ko) | 2019-11-25 | 2021-09-29 | 성균관대학교산학협력단 | 구멍쇠미역으로부터 분리된 신규 화합물을 유효성분으로 포함하는 동맥경화 예방 및 치료용 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ502283A (en) | 1997-08-29 | 2002-05-31 | Pfizer Prod Inc | Cardiovascular therapy comprising amlodipine and a statin compound in amounts that are synergistically effective |
| US20030092745A1 (en) | 2000-02-25 | 2003-05-15 | Pfizer Inc. | Combination therapy |
| EP1314425A4 (en) | 2000-08-30 | 2004-06-02 | Sankyo Co | MEDICINAL COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE |
| DE10224612A1 (de) * | 2002-06-04 | 2003-12-24 | Lohmann Therapie Syst Lts | Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung |
| BRPI0407038A (pt) | 2003-01-27 | 2006-01-17 | Hanmi Pharm Ind Co Ltd | Camsilato de amlodipina amorfo estável, processo para a preparação do mesmo e composição para administração oral deste |
| US7611728B2 (en) | 2003-09-05 | 2009-11-03 | Supernus Pharmaceuticals, Inc. | Osmotic delivery of therapeutic compounds by solubility enhancement |
| WO2006059217A1 (en) * | 2004-12-01 | 2006-06-08 | Ranbaxy Laboratories Limited | Stable solid dosage forms of amlodipine besylate and processes for their preparation |
| KR100582347B1 (ko) * | 2004-12-30 | 2006-05-22 | 한미약품 주식회사 | 3-하이드록시-3-메틸글루타릴 조효소 ａ 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법 |
-
2005
- 2005-12-27 KR KR1020050130531A patent/KR100742432B1/ko not_active Expired - Fee Related
-
2006
- 2006-12-22 EP EP06835362A patent/EP1978956A4/en not_active Withdrawn
- 2006-12-22 BR BRPI0620790-1A patent/BRPI0620790A2/pt not_active IP Right Cessation
- 2006-12-22 WO PCT/KR2006/005658 patent/WO2007075009A1/en not_active Ceased
- 2006-12-22 CA CA002634639A patent/CA2634639A1/en not_active Abandoned
- 2006-12-22 US US12/159,418 patent/US20090005425A1/en not_active Abandoned
- 2006-12-22 CN CNA2006800492048A patent/CN101346140A/zh active Pending
- 2006-12-22 RU RU2008130873/15A patent/RU2008130873A/ru not_active Application Discontinuation
- 2006-12-22 JP JP2008548399A patent/JP2009521526A/ja not_active Withdrawn
- 2006-12-22 AU AU2006330199A patent/AU2006330199A1/en not_active Abandoned
-
2008
- 2008-06-12 IL IL192148A patent/IL192148A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006330199A1 (en) | 2007-07-05 |
| CN101346140A (zh) | 2009-01-14 |
| US20090005425A1 (en) | 2009-01-01 |
| CA2634639A1 (en) | 2007-07-05 |
| RU2008130873A (ru) | 2010-02-10 |
| EP1978956A1 (en) | 2008-10-15 |
| KR100742432B1 (ko) | 2007-07-24 |
| WO2007075009A1 (en) | 2007-07-05 |
| KR20070068658A (ko) | 2007-07-02 |
| EP1978956A4 (en) | 2009-08-19 |
| IL192148A0 (en) | 2009-08-03 |
| JP2009521526A (ja) | 2009-06-04 |
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Legal Events
| Date | Code | Title | Description |
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| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2161 DE 05/06/2012. |