KR100709795B1 - 바이오칩 및 이의 제조방법 - Google Patents

바이오칩 및 이의 제조방법 Download PDF

Info

Publication number
KR100709795B1
KR100709795B1 KR1020017013634A KR20017013634A KR100709795B1 KR 100709795 B1 KR100709795 B1 KR 100709795B1 KR 1020017013634 A KR1020017013634 A KR 1020017013634A KR 20017013634 A KR20017013634 A KR 20017013634A KR 100709795 B1 KR100709795 B1 KR 100709795B1
Authority
KR
South Korea
Prior art keywords
hydrogel
prepolymer
delete delete
polymerization
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020017013634A
Other languages
English (en)
Korean (ko)
Other versions
KR20020026275A (ko
Inventor
한순갑
파그나니로베르토
칭버그페이블
Original Assignee
바이오셉트 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이오셉트 인코포레이티드 filed Critical 바이오셉트 인코포레이티드
Publication of KR20020026275A publication Critical patent/KR20020026275A/ko
Application granted granted Critical
Publication of KR100709795B1 publication Critical patent/KR100709795B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545Synthetic resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020017013634A 1999-04-26 2000-04-26 바이오칩 및 이의 제조방법 Expired - Fee Related KR100709795B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/299,831 1999-04-26
US09/299,831 US6174683B1 (en) 1999-04-26 1999-04-26 Method of making biochips and the biochips resulting therefrom
PCT/US2000/011282 WO2000065097A1 (en) 1999-04-26 2000-04-26 Biochip and method for making it

Publications (2)

Publication Number Publication Date
KR20020026275A KR20020026275A (ko) 2002-04-09
KR100709795B1 true KR100709795B1 (ko) 2007-04-23

Family

ID=23156484

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017013634A Expired - Fee Related KR100709795B1 (ko) 1999-04-26 2000-04-26 바이오칩 및 이의 제조방법

Country Status (8)

Country Link
US (1) US6174683B1 (enExample)
EP (1) EP1173620B1 (enExample)
JP (1) JP2002543398A (enExample)
KR (1) KR100709795B1 (enExample)
AT (1) ATE344840T1 (enExample)
AU (1) AU4669000A (enExample)
DE (1) DE60031772T2 (enExample)
WO (1) WO2000065097A1 (enExample)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638464B2 (en) * 1999-04-26 2009-12-29 Biocept, Inc. Three dimensional format biochips
EP1214594B1 (en) 1999-05-14 2006-08-02 Iris BioTechnologies, Inc. Reversible immobilization of ligands onto metal surfaces, their preparation and use in biochemical applications
JP3957118B2 (ja) * 1999-05-18 2007-08-15 富士フイルム株式会社 試験片およびこの試験片からの画像情報読取装置
US6372813B1 (en) * 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6358557B1 (en) * 1999-09-10 2002-03-19 Sts Biopolymers, Inc. Graft polymerization of substrate surfaces
US6692952B1 (en) * 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US7270954B1 (en) * 2000-06-30 2007-09-18 Iris Biotechnologies, Inc. Hybridization of target DNA with immobilized nucleic acid analogs
JP2002058478A (ja) * 2000-08-22 2002-02-26 Hitachi Ltd チップ、ゲノム薬剤処方支援システム、チップ情報提供システム、チップ供給システム及び記録媒体
US20050100951A1 (en) * 2000-10-26 2005-05-12 Biocept, Inc. 3D format biochips and method of use
JP2004518138A (ja) * 2000-10-26 2004-06-17 バイオセプト インコーポレイテッド 3次元型バイオチップ
EP2295971B1 (en) * 2001-03-09 2016-09-07 TrovaGene, Inc. Conjugate probes and optical detection of analytes
US20020142304A1 (en) * 2001-03-09 2002-10-03 Anderson Daniel G. Uses and methods of making microarrays of polymeric biomaterials
AU2002303176A1 (en) * 2001-03-27 2002-10-15 University Of Delaware Genomics applications for modified oligonucleotides
EP1245272A1 (en) * 2001-03-30 2002-10-02 Ucb S.A. Substrates, preparation and use
EP1373472B1 (en) * 2001-04-03 2007-06-27 Biocept, Inc. Methods and gel compositions for encapsulating living cells and organic molecules
US20040253634A1 (en) * 2001-04-10 2004-12-16 Denong Wang Novel microarrays and methods of use thereof
US20060073610A1 (en) * 2001-07-06 2006-04-06 Millpore Corporation Patterned composite membrane and stenciling method for the manufacture thereof
WO2003056293A2 (en) * 2001-07-10 2003-07-10 Whitehead Institute For Biomedical Research Small molecule microarrays
AU2002322458A1 (en) * 2001-07-13 2003-01-29 Nanosphere, Inc. Method for immobilizing molecules onto surfaces
US7297553B2 (en) 2002-05-28 2007-11-20 Nanosphere, Inc. Method for attachment of silylated molecules to glass surfaces
CA2563510A1 (en) * 2001-07-13 2005-11-17 Nanosphere, Inc. Method for preparing substrates having immobilized molecules and substrates
CA2455923A1 (en) * 2001-07-30 2003-10-09 Sts Biopolymers, Inc. Graft polymer matrices
US6656725B2 (en) * 2001-08-15 2003-12-02 The University Of Chicago Method of fabrication of microarray of gel-immobilized compounds on a chip by copolymerization
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
KR100450822B1 (ko) * 2001-09-01 2004-10-01 삼성전자주식회사 에폭시기를 갖는 방사형 폴리에틸렌글리콜 유도체를이용한 하이드로 젤 바이오칩의 제조방법
CN1217009C (zh) * 2001-09-01 2005-08-31 三星电子株式会社 利用具有环氧基的星状聚乙二醇衍生物制备水凝胶生物芯片的方法
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
FR2831275B1 (fr) * 2001-10-18 2004-01-30 Commissariat Energie Atomique Substrat revetu d'un film organique transparent et procede de fabrication
WO2003038131A1 (en) * 2001-11-01 2003-05-08 Rensselaer Polytechnic Institute Biocatalytic solgel microarrays
US7842498B2 (en) * 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
WO2003046144A2 (en) * 2001-11-26 2003-06-05 Molecular Reflections, Inc. Microscale immobilization of molecules using a hydrogel and methods of use thereof
WO2003050276A1 (en) * 2001-12-05 2003-06-19 Dow Global Technologies Inc. Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
US20050221283A1 (en) * 2001-12-11 2005-10-06 Mahant Vijay K Biochip
US20040033546A1 (en) 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
AU2003265769A1 (en) * 2002-05-02 2003-11-17 Ciphergen Biosystems, Inc. Biochips with surfaces coated with polysaccharide based hydrogels
AU2003249200B2 (en) * 2002-07-12 2009-08-13 Iscience Interventional Corporation Ultrasound interfacing device for tissue imaging
US20040028804A1 (en) * 2002-08-07 2004-02-12 Anderson Daniel G. Production of polymeric microarrays
US20050233473A1 (en) * 2002-08-16 2005-10-20 Zyomyx, Inc. Methods and reagents for surface functionalization
CN100412203C (zh) * 2002-09-13 2008-08-20 株式会社Lg生命科学 在芯片基板上凝胶化制备的生物芯片
JP2006501449A (ja) * 2002-09-27 2006-01-12 ザ ジェネラル ホスピタル コーポレーション 細胞分離のためのマイクロ流体デバイスおよびその使用
DE10259821B4 (de) 2002-12-19 2006-03-09 Siemens Ag Bio-Chip
AU2003300168A1 (en) * 2002-12-31 2004-07-29 Rodi Pharma, Inc. Bindingzyme arrays and high-throughput proteomic methods
US7534621B2 (en) * 2003-02-07 2009-05-19 Canon Kabuhsiki Kashia Method of producing probe medium and method of immobilizing probe using probe medium
US20040171091A1 (en) * 2003-02-27 2004-09-02 Cell Work, Inc. Standardized evaluation of therapeutic efficacy based on cellular biomarkers
AU2004250131A1 (en) * 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
US20040265883A1 (en) * 2003-06-27 2004-12-30 Biocept, Inc. mRNA expression analysis
DE10332849A1 (de) * 2003-07-18 2005-02-17 Sustech Gmbh & Co. Kg Arrays immobilisierter Biomoleküle auf Hydrogel-bildenden Oberflächen, deren Herstellung und deren Verwendung
US20050136536A1 (en) * 2003-09-15 2005-06-23 Anderson Daniel G. Embryonic epithelial cells
US20050112650A1 (en) * 2003-10-20 2005-05-26 Ciphergen Biosystems, Inc. Reactive polyurethane-based polymers
DE102004062281A1 (de) * 2003-12-29 2005-07-28 Siemens Ag Verfahren und Spotting-Lösung zum Herstellen von Microarrays
US20060065528A1 (en) * 2004-02-03 2006-03-30 Gabriel Lopez Nanostructured devices for separation and analysis
US20060040377A1 (en) * 2004-08-17 2006-02-23 Biocept, Inc. Protein microarrays
US7258990B2 (en) * 2004-08-19 2007-08-21 Biocept, Inc. Alleviation of non-specific binding in microarray assays
US7595157B2 (en) * 2004-08-19 2009-09-29 Biocept, Inc. Microarrays utilizing hydrogels
JP4939019B2 (ja) * 2004-09-14 2012-05-23 三菱化学株式会社 生体物質が固定化された固相担体、及び生体物質が固定化された固相担体の製造方法、生体物質固定化キット並びにセンサーチップ
CN101019027B (zh) 2004-09-14 2012-09-26 三菱化学美迪恩斯株式会社 生物材料结构体、其制造方法及应用
US8298290B2 (en) * 2004-09-20 2012-10-30 Davol, Inc. Implantable prosthesis for soft tissue repair
US8663225B2 (en) * 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US7439062B2 (en) 2004-12-23 2008-10-21 Biocept, Inc. Beads for capturing target cells from bodily fluid
US20080003599A1 (en) * 2004-12-28 2008-01-03 Dary Ekaterina L Biological Microchip for Multiple Parallel Immunoassay of Compounds and Immunoassay Metods Using Said Microchip
KR101159071B1 (ko) * 2005-01-14 2012-06-26 삼성전자주식회사 신규한 히드로겔 공중합체, 상기 공중합체가 코팅되어있는 기판, 상기 공중합체를 이용하여 마이크로어레이를제조하는 방법 및 그에 의하여 제조된 마이크로어레이
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20100240028A1 (en) * 2005-08-23 2010-09-23 The University Of Chicago Method to improve quality of microarrays by controlling evaporation
US7598037B2 (en) * 2005-09-27 2009-10-06 U Chicago Argonne, Llc Method for implementing non-destructive quality control of substrates and printed biological microarrays
WO2007121276A2 (en) * 2006-04-12 2007-10-25 Biocept, Inc. Enrichment of circulating fetal dna
US7829644B2 (en) * 2006-04-19 2010-11-09 Uchicago Argonne, Llc Gel-forming reagents and uses thereof for preparing microarrays
US7923054B2 (en) 2006-04-19 2011-04-12 Gore Enterprise Holdings, Inc. Functional porous substrates for attaching biomolecules
US20080132429A1 (en) * 2006-05-23 2008-06-05 Uchicago Argonne Biological microarrays with enhanced signal yield
EP2201094A4 (en) * 2007-09-17 2010-10-06 Twof Inc METHOD FOR EXTENDING HYDROGEL-MARKED PRIMERS FOR MICROARRAY
US20100240054A1 (en) * 2008-09-22 2010-09-23 Biocept, Inc. Identification and isolation of fetal cells and nucleic acid
US8187979B2 (en) * 2009-12-23 2012-05-29 Varian Semiconductor Equipment Associates, Inc. Workpiece patterning with plasma sheath modulation
EP2541250A1 (en) * 2011-06-30 2013-01-02 Koninklijke Philips Electronics N.V. Molecular architecture on magnetic particles for affinity assays with low non-specific binding
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
EP2739587B1 (en) 2011-08-01 2020-05-27 Denovo Sciences Cell capture system
US10379107B2 (en) 2011-09-12 2019-08-13 Ecole Polytechnique Federale de Lausanna (EPFL) Method for preparing topographically structured microarrays
WO2013115476A1 (ko) 2012-01-31 2013-08-08 국립암센터 검체 시료의 응집용 조성물, 이를 이용한 파라핀 블록의 제작방법 및 상기 파라핀 블록을 이용한 세포 마이크로어레이용 세포군집 표본의 제조방법
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
CN104849114A (zh) * 2015-05-13 2015-08-19 安徽农业大学 彗星实验专用载片
KR101754774B1 (ko) * 2015-12-29 2017-07-06 주식회사 스칼라팍스트롯 바이오 칩 및 바이오 칩의 제조 방법
WO2017116078A1 (ko) * 2015-12-29 2017-07-06 주식회사 스칼라팍스트롯 바이오 칩 및 바이오 칩의 제조 방법
KR102478639B1 (ko) 2016-02-23 2022-12-19 노을 주식회사 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치
KR20170099739A (ko) 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법
US10371610B2 (en) * 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
US10429387B2 (en) * 2016-07-27 2019-10-01 Universiteit Tweate Simple and affordable method for immuophenotyping using a microfluidic chip sample preparation with image cytometry
AU2018323449B2 (en) 2017-08-29 2020-09-03 Bio-Rad Laboratories, Inc. System and method for isolating and analyzing cells
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
SG11202112151UA (en) 2019-05-07 2021-12-30 Bio Rad Laboratories System and method for automated single cell processing
KR20250084977A (ko) 2019-06-14 2025-06-11 바이오 래드 래버러토리스 인코오포레이티드 자동화된 단일 세포 처리 및 분석을 위한 시스템 및 방법
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
CN111521601B (zh) * 2020-04-22 2022-01-25 中国科学院宁波材料技术与工程研究所 一种比率型荧光高分子水凝胶在海鲜新鲜度检测中的应用
CN113244973B (zh) * 2021-07-15 2021-10-08 成都博奥晶芯生物科技有限公司 凝胶基质点样液及空白点样液、三维凝胶芯片及制备方法
CN118369438A (zh) 2021-12-10 2024-07-19 伯乐实验室有限公司 用形态可调节功能化颗粒进行样品处理的组合物、方法和系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0481740A2 (en) * 1990-10-16 1992-04-22 Puritan-Bennett Corporation Optical fiber PH microsensor and method of manufacture
WO1994009125A1 (en) * 1992-10-13 1994-04-28 Idaho Research Foundation, Inc. Dynamic bed reactor

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3939123A (en) 1974-06-18 1976-02-17 Union Carbide Corporation Lightly cross-linked polyurethane hydrogels based on poly(alkylene ether) polyols
US4098645A (en) * 1976-02-24 1978-07-04 W. R. Grace & Co. Immobilization of proteins with polyurethane polymers
US4110286A (en) 1977-02-07 1978-08-29 Alcolac Inc. Stable polyurethane latices, emulsifiable prepolymers therefor and methods of making the same
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
CA2003942A1 (en) * 1989-09-26 1991-03-26 Julie Lia Rudolph Solid assay support systems
EP0453621A1 (en) * 1990-04-28 1991-10-30 W.R. Grace & Co.-Conn. Polymer-modified drugs having enhanced biological and pharmacological activities
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
CA2107683C (en) * 1992-02-13 2004-07-20 Dale G. Swan Immobilization of chemical species in crosslinked matrices
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
RU2041261C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
RU2041262C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
US5736257A (en) 1995-04-25 1998-04-07 Us Navy Photoactivatable polymers for producing patterned biomolecular assemblies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0481740A2 (en) * 1990-10-16 1992-04-22 Puritan-Bennett Corporation Optical fiber PH microsensor and method of manufacture
WO1994009125A1 (en) * 1992-10-13 1994-04-28 Idaho Research Foundation, Inc. Dynamic bed reactor

Also Published As

Publication number Publication date
WO2000065097A1 (en) 2000-11-02
DE60031772T2 (de) 2007-09-06
DE60031772D1 (de) 2006-12-21
US6174683B1 (en) 2001-01-16
KR20020026275A (ko) 2002-04-09
EP1173620A1 (en) 2002-01-23
ATE344840T1 (de) 2006-11-15
EP1173620B1 (en) 2006-11-08
JP2002543398A (ja) 2002-12-17
AU4669000A (en) 2000-11-10

Similar Documents

Publication Publication Date Title
KR100709795B1 (ko) 바이오칩 및 이의 제조방법
US7638464B2 (en) Three dimensional format biochips
EP1787120B1 (en) Alleviation of non-specific binding in microarray assays
EP1373472B1 (en) Methods and gel compositions for encapsulating living cells and organic molecules
EP0710666B1 (en) Material used for immobilization of biologically active substance and method for immobilization of said substance using said material
US7595157B2 (en) Microarrays utilizing hydrogels
EP1328810B1 (en) Three dimensional format biochip
JPH07191008A (ja) 生体適合性をもつた低蛋白質吸着性のアフイニテイー・マトリツクス
US20050100951A1 (en) 3D format biochips and method of use
EP1779114A1 (en) Protein microarrays
AU2002246918B8 (en) Three dimensional biochip
AU2002246918B2 (en) Three dimensional biochip
RU2456314C2 (ru) Материал для получения биочипа
AU2002246918A1 (en) Three dimensional biochip
HK1113197A (en) Microarrays utilizing hydrogels
HK1107400A (en) Alleviation of non-specific binding in microarray assays

Legal Events

Date Code Title Description
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R17-X000 Change to representative recorded

St.27 status event code: A-5-5-R10-R17-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20110328

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20120414

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20120414

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000