KR100691315B1 - 친수성 분자를 지질화시키기 위한 방법 및 조성물 - Google Patents

친수성 분자를 지질화시키기 위한 방법 및 조성물 Download PDF

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Publication number
KR100691315B1
KR100691315B1 KR1019997002543A KR19997002543A KR100691315B1 KR 100691315 B1 KR100691315 B1 KR 100691315B1 KR 1019997002543 A KR1019997002543 A KR 1019997002543A KR 19997002543 A KR19997002543 A KR 19997002543A KR 100691315 B1 KR100691315 B1 KR 100691315B1
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KR
South Korea
Prior art keywords
compound
group
disulfide
complex
bbi
Prior art date
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KR1019997002543A
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English (en)
Korean (ko)
Other versions
KR20000048608A (ko
Inventor
셴웨이-치앙
왕징구아
Original Assignee
유니버시티 오브 써던 캘리포니아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 유니버시티 오브 써던 캘리포니아 filed Critical 유니버시티 오브 써던 캘리포니아
Publication of KR20000048608A publication Critical patent/KR20000048608A/ko
Application granted granted Critical
Publication of KR100691315B1 publication Critical patent/KR100691315B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019997002543A 1996-09-26 1997-09-26 친수성 분자를 지질화시키기 위한 방법 및 조성물 KR100691315B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72130696A 1996-09-26 1996-09-26
US08/721,306 1996-09-26
US8/721,306 1996-09-26
US4949997P 1997-06-13 1997-06-13
US60/049,499 1997-06-13

Publications (2)

Publication Number Publication Date
KR20000048608A KR20000048608A (ko) 2000-07-25
KR100691315B1 true KR100691315B1 (ko) 2007-03-12

Family

ID=26727231

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997002543A KR100691315B1 (ko) 1996-09-26 1997-09-26 친수성 분자를 지질화시키기 위한 방법 및 조성물

Country Status (10)

Country Link
EP (1) EP1023316A4 (fr)
JP (1) JP2002515883A (fr)
KR (1) KR100691315B1 (fr)
CN (1) CN1127477C (fr)
AU (1) AU737865B2 (fr)
BR (1) BR9712128A (fr)
CA (1) CA2267179A1 (fr)
IL (1) IL129177A0 (fr)
NO (1) NO991465L (fr)
WO (1) WO1998013007A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
TWI242000B (en) 1998-12-10 2005-10-21 Univ Southern California Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
GB0103877D0 (en) * 2001-02-16 2001-04-04 King S College London Novel Drug Delivery system
US20050054612A1 (en) * 2003-09-08 2005-03-10 Monahan Sean D. Delivery by labile hydrophobic modification of drugs
CA2551131A1 (fr) * 2003-12-31 2005-07-21 Centocor, Inc. Nouvelles proteines recombinees avec thiol libre n-terminal
EP2083866A4 (fr) 2006-10-27 2011-12-28 Wei-Chiang Shen Interféron lipidisé et ses utilisations
WO2008109119A2 (fr) * 2007-03-05 2008-09-12 The Board Of Trustees Of The Leland Stanford Junior University Compositions de wnt et procédés pour leur utilisation
JP5576801B2 (ja) * 2008-02-21 2014-08-20 ダーマケア・ニューロサイエンス・インスティテュート Ｍｎｔｆペプチドの美容および皮膚科用製剤
JP6762094B2 (ja) * 2013-02-28 2020-09-30 タフツ ユニバーシティー 薬剤のデリバリーのためのジスルフィド化合物
WO2014186366A1 (fr) 2013-05-13 2014-11-20 Tufts University Nanocomplexes destinées à l'administration de saporine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022773A1 (fr) * 1995-01-25 1996-08-01 University Of Southern California Procedes et compositions de lipidisation de molecules hydrophiles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4651753B2 (ja) * 1996-06-25 2011-03-16 ペプスキャン システムズ ベー．フェー． 不安定結合による担体結合抗原から成るワクチン

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022773A1 (fr) * 1995-01-25 1996-08-01 University Of Southern California Procedes et compositions de lipidisation de molecules hydrophiles

Also Published As

Publication number Publication date
AU4596797A (en) 1998-04-17
NO991465L (no) 1999-05-10
KR20000048608A (ko) 2000-07-25
WO1998013007A8 (fr) 1999-05-20
NO991465D0 (no) 1999-03-25
EP1023316A4 (fr) 2004-06-09
CN1127477C (zh) 2003-11-12
WO1998013007A2 (fr) 1998-04-02
CN1235594A (zh) 1999-11-17
EP1023316A2 (fr) 2000-08-02
BR9712128A (pt) 2000-12-12
AU737865B2 (en) 2001-09-06
JP2002515883A (ja) 2002-05-28
IL129177A0 (en) 2000-02-17
CA2267179A1 (fr) 1998-04-02

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