JP2002515883A - 親水性分子の脂質化のための方法および組成物 - Google Patents

親水性分子の脂質化のための方法および組成物

Info

Publication number
JP2002515883A
JP2002515883A JP51593398A JP51593398A JP2002515883A JP 2002515883 A JP2002515883 A JP 2002515883A JP 51593398 A JP51593398 A JP 51593398A JP 51593398 A JP51593398 A JP 51593398A JP 2002515883 A JP2002515883 A JP 2002515883A
Authority
JP
Japan
Prior art keywords
compound
disulfide
group
acid
bbi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP51593398A
Other languages
English (en)
Japanese (ja)
Inventor
シェン，ウェイ―チャン
ワン，ジンファ
Original Assignee
ユニバーシティ オブ サザン カリフォルニア
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニバーシティ オブ サザン カリフォルニア filed Critical ユニバーシティ オブ サザン カリフォルニア
Publication of JP2002515883A publication Critical patent/JP2002515883A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP51593398A 1996-09-26 1997-09-26 親水性分子の脂質化のための方法および組成物 Ceased JP2002515883A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72130696A 1996-09-26 1996-09-26
US4949997P 1997-06-13 1997-06-13
US08/721,306 1997-06-13
US60/049,499 1997-06-13
PCT/US1997/017282 WO1998013007A2 (fr) 1996-09-26 1997-09-26 Procedes et compositions pour la lipidation de molecules hydrophile

Publications (1)

Publication Number Publication Date
JP2002515883A true JP2002515883A (ja) 2002-05-28

Family

ID=26727231

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51593398A Ceased JP2002515883A (ja) 1996-09-26 1997-09-26 親水性分子の脂質化のための方法および組成物

Country Status (10)

Country Link
EP (1) EP1023316A4 (fr)
JP (1) JP2002515883A (fr)
KR (1) KR100691315B1 (fr)
CN (1) CN1127477C (fr)
AU (1) AU737865B2 (fr)
BR (1) BR9712128A (fr)
CA (1) CA2267179A1 (fr)
IL (1) IL129177A0 (fr)
NO (1) NO991465L (fr)
WO (1) WO1998013007A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505039A (ja) * 2003-09-08 2007-03-08 マイラス バイオ コーポレーション 薬物の易変性の疎水性修飾により改善された送達
JP2010520286A (ja) * 2007-03-05 2010-06-10 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Ｗｎｔ組成物およびその使用方法
JP2011513240A (ja) * 2008-02-21 2011-04-28 ダーマケア・ニューロサイエンス・インスティテュート Ｍｎｔｆペプチドの美容および皮膚科用製剤

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
TWI242000B (en) * 1998-12-10 2005-10-21 Univ Southern California Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
GB0103877D0 (en) * 2001-02-16 2001-04-04 King S College London Novel Drug Delivery system
WO2005065239A2 (fr) * 2003-12-31 2005-07-21 Centocor, Inc. Nouvelles proteines recombinees avec thiol libre n-terminal
WO2008057298A2 (fr) * 2006-10-27 2008-05-15 Wei-Chiang Shen Interféron lipidisé et ses utilisations
WO2014134445A1 (fr) * 2013-02-28 2014-09-04 Tufts Unversity Composés à base de disulfure pour l'administration d'agents pharmaceutiques
US20160082126A1 (en) * 2013-05-13 2016-03-24 Tufts University Nanocomplexes for delivery of saporin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5907030A (en) * 1995-01-25 1999-05-25 University Of Southern California Method and compositions for lipidization of hydrophilic molecules
JP4651753B2 (ja) * 1996-06-25 2011-03-16 ペプスキャン システムズ ベー．フェー． 不安定結合による担体結合抗原から成るワクチン

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007505039A (ja) * 2003-09-08 2007-03-08 マイラス バイオ コーポレーション 薬物の易変性の疎水性修飾により改善された送達
JP2010520286A (ja) * 2007-03-05 2010-06-10 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ Ｗｎｔ組成物およびその使用方法
JP2011513240A (ja) * 2008-02-21 2011-04-28 ダーマケア・ニューロサイエンス・インスティテュート Ｍｎｔｆペプチドの美容および皮膚科用製剤
JP2014177464A (ja) * 2008-02-21 2014-09-25 Dermacare Neuroscience Institute Ｍｎｔｆペプチドの美容および皮膚科用製剤

Also Published As

Publication number Publication date
EP1023316A4 (fr) 2004-06-09
EP1023316A2 (fr) 2000-08-02
IL129177A0 (en) 2000-02-17
CN1127477C (zh) 2003-11-12
AU4596797A (en) 1998-04-17
WO1998013007A2 (fr) 1998-04-02
KR20000048608A (ko) 2000-07-25
NO991465L (no) 1999-05-10
AU737865B2 (en) 2001-09-06
KR100691315B1 (ko) 2007-03-12
NO991465D0 (no) 1999-03-25
CN1235594A (zh) 1999-11-17
CA2267179A1 (fr) 1998-04-02
BR9712128A (pt) 2000-12-12
WO1998013007A8 (fr) 1999-05-20

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