CA2267179A1 - Procedes et compositions pour la lipidation de molecules hydrophile - Google Patents

Procedes et compositions pour la lipidation de molecules hydrophile Download PDF

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Publication number
CA2267179A1
CA2267179A1 CA002267179A CA2267179A CA2267179A1 CA 2267179 A1 CA2267179 A1 CA 2267179A1 CA 002267179 A CA002267179 A CA 002267179A CA 2267179 A CA2267179 A CA 2267179A CA 2267179 A1 CA2267179 A1 CA 2267179A1
Authority
CA
Canada
Prior art keywords
compound
disulfide
group
fatty acid
bbi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002267179A
Other languages
English (en)
Inventor
Wei-Chiang Shen
Jinghua Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2267179A1 publication Critical patent/CA2267179A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention se rapporte à des dérivés acides gras de composés contenant du disulfure (par exemple des peptides ou des protéines contenant du disulfure), qui comprennent des produits modifiés par conjugaison avec des acides gras, présentant une liaison disulfure, ces dérivés étant utilisés pour administrer les composés à teneur en disulfure dans des cellules de mammifères. La modification ainsi apportée augmente considérablement l'absorption desdits composés par les cellules de mammifères par rapport à la vitesse d'absorption de tels composés non conjugués, et elle prolonge la rétention de ces composés dans le sang et les tissus. En outre, la liaison disulfure du conjugué est très labile in vivo et elle facilite par conséquent la libération intracellulaire ou extracellulaire des composés intacts à partir des fractions d'acides gras.
CA002267179A 1996-09-26 1997-09-26 Procedes et compositions pour la lipidation de molecules hydrophile Abandoned CA2267179A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72130696A 1996-09-26 1996-09-26
US4949997P 1997-06-13 1997-06-13
US08/721,306 1997-06-13
US60/049,499 1997-06-13
PCT/US1997/017282 WO1998013007A2 (fr) 1996-09-26 1997-09-26 Procedes et compositions pour la lipidation de molecules hydrophile

Publications (1)

Publication Number Publication Date
CA2267179A1 true CA2267179A1 (fr) 1998-04-02

Family

ID=26727231

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002267179A Abandoned CA2267179A1 (fr) 1996-09-26 1997-09-26 Procedes et compositions pour la lipidation de molecules hydrophile

Country Status (10)

Country Link
EP (1) EP1023316A4 (fr)
JP (1) JP2002515883A (fr)
KR (1) KR100691315B1 (fr)
CN (1) CN1127477C (fr)
AU (1) AU737865B2 (fr)
BR (1) BR9712128A (fr)
CA (1) CA2267179A1 (fr)
IL (1) IL129177A0 (fr)
NO (1) NO991465L (fr)
WO (1) WO1998013007A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
TWI242000B (en) * 1998-12-10 2005-10-21 Univ Southern California Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
GB0103877D0 (en) * 2001-02-16 2001-04-04 King S College London Novel Drug Delivery system
US20050054612A1 (en) * 2003-09-08 2005-03-10 Monahan Sean D. Delivery by labile hydrophobic modification of drugs
WO2005065239A2 (fr) * 2003-12-31 2005-07-21 Centocor, Inc. Nouvelles proteines recombinees avec thiol libre n-terminal
WO2008057298A2 (fr) * 2006-10-27 2008-05-15 Wei-Chiang Shen Interféron lipidisé et ses utilisations
EP2134352A4 (fr) * 2007-03-05 2011-05-25 Univ Leland Stanford Junior Compositions de wnt et procédés pour leur utilisation
JP5576801B2 (ja) * 2008-02-21 2014-08-20 ダーマケア・ニューロサイエンス・インスティテュート Ｍｎｔｆペプチドの美容および皮膚科用製剤
WO2014134445A1 (fr) * 2013-02-28 2014-09-04 Tufts Unversity Composés à base de disulfure pour l'administration d'agents pharmaceutiques
US20160082126A1 (en) * 2013-05-13 2016-03-24 Tufts University Nanocomplexes for delivery of saporin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5907030A (en) * 1995-01-25 1999-05-25 University Of Southern California Method and compositions for lipidization of hydrophilic molecules
JP4651753B2 (ja) * 1996-06-25 2011-03-16 ペプスキャン システムズ ベー．フェー． 不安定結合による担体結合抗原から成るワクチン

Also Published As

Publication number Publication date
EP1023316A4 (fr) 2004-06-09
EP1023316A2 (fr) 2000-08-02
IL129177A0 (en) 2000-02-17
CN1127477C (zh) 2003-11-12
AU4596797A (en) 1998-04-17
WO1998013007A2 (fr) 1998-04-02
KR20000048608A (ko) 2000-07-25
NO991465L (no) 1999-05-10
AU737865B2 (en) 2001-09-06
KR100691315B1 (ko) 2007-03-12
NO991465D0 (no) 1999-03-25
CN1235594A (zh) 1999-11-17
BR9712128A (pt) 2000-12-12
WO1998013007A8 (fr) 1999-05-20
JP2002515883A (ja) 2002-05-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued