BR9712128A - Métodos e composições para lipidização de moléculas hidrofìlicas - Google Patents

Métodos e composições para lipidização de moléculas hidrofìlicas

Info

Publication number
BR9712128A
BR9712128A BR9712128-2A BR9712128A BR9712128A BR 9712128 A BR9712128 A BR 9712128A BR 9712128 A BR9712128 A BR 9712128A BR 9712128 A BR9712128 A BR 9712128A
Authority
BR
Brazil
Prior art keywords
compounds
lipidization
compositions
methods
disulfide
Prior art date
Application number
BR9712128-2A
Other languages
English (en)
Inventor
Wei-Chiang Shen
Jinghua Wang
Original Assignee
Univ Southern California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Southern California filed Critical Univ Southern California
Publication of BR9712128A publication Critical patent/BR9712128A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

''MéTODOS E COMPOSIçõES PARA LIPIDIZAçãO DE MOLéCULAS HIDROFìLICAS" Derivados de ácidos graxos de compostos contendo dissulfeto (por exemplo, peptídios ou proteínas contendo dissulfeto) que compreendem produtos conjugados a ácidos graxos com uma ligação dissulfeto são empregados para distribuição dos compostos a células mamíferas. Essa modificação aumenta acentuadamente a absorção dos compostos pelas células mamíferas com relação à taxa de absorção dos compostos conjugados, bem como prolonga a retenção no sangue e no tecido dos compostos. Além disso, a ligação dissulfeto no conjugado é bastante lábil in vivo e assim facilita a liberação intracelular e extracelular dos compostos intactos das metades de ácido graxo.
BR9712128-2A 1996-09-26 1997-09-26 Métodos e composições para lipidização de moléculas hidrofìlicas BR9712128A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72130696A 1996-09-26 1996-09-26
US4949997P 1997-06-13 1997-06-13
PCT/US1997/017282 WO1998013007A2 (en) 1996-09-26 1997-09-26 Methods and compositions for lipidization of hydrophilic molecules

Publications (1)

Publication Number Publication Date
BR9712128A true BR9712128A (pt) 2000-12-12

Family

ID=26727231

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712128-2A BR9712128A (pt) 1996-09-26 1997-09-26 Métodos e composições para lipidização de moléculas hidrofìlicas

Country Status (10)

Country Link
EP (1) EP1023316A4 (pt)
JP (1) JP2002515883A (pt)
KR (1) KR100691315B1 (pt)
CN (1) CN1127477C (pt)
AU (1) AU737865B2 (pt)
BR (1) BR9712128A (pt)
CA (1) CA2267179A1 (pt)
IL (1) IL129177A0 (pt)
NO (1) NO991465L (pt)
WO (1) WO1998013007A2 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169078B1 (en) 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
TWI242000B (en) * 1998-12-10 2005-10-21 Univ Southern California Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use
GB0103877D0 (en) * 2001-02-16 2001-04-04 King S College London Novel Drug Delivery system
US20050054612A1 (en) * 2003-09-08 2005-03-10 Monahan Sean D. Delivery by labile hydrophobic modification of drugs
WO2005065239A2 (en) * 2003-12-31 2005-07-21 Centocor, Inc. Novel recombinant proteins with n-terminal free thiol
WO2008057298A2 (en) * 2006-10-27 2008-05-15 Wei-Chiang Shen Lipidized interferon and uses thereof
EP2134352A4 (en) * 2007-03-05 2011-05-25 Univ Leland Stanford Junior WNT COMPOSITIONS AND METHODS FOR THEIR USE
CA2716255C (en) * 2008-02-21 2016-11-29 Dermacare Neuroscience Institute Cosmetic and dermatological formulations of mntf peptides
CN105283441B (zh) * 2013-02-28 2018-10-23 塔夫茨大学 用于递送药剂的二硫化合物
WO2014186366A1 (en) 2013-05-13 2014-11-20 Tufts University Nanocomplexes for delivery of saporin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5907030A (en) * 1995-01-25 1999-05-25 University Of Southern California Method and compositions for lipidization of hydrophilic molecules
NZ333562A (en) * 1996-06-25 2001-04-27 Stichting Inst Voor Dierhouder Vaccine comprising antigens bound by thioester or disulphide bonds to fatty acid carriers such palmitic acid, antigens bound in reversible and labile way

Also Published As

Publication number Publication date
KR100691315B1 (ko) 2007-03-12
CN1127477C (zh) 2003-11-12
NO991465D0 (no) 1999-03-25
AU4596797A (en) 1998-04-17
KR20000048608A (ko) 2000-07-25
NO991465L (no) 1999-05-10
IL129177A0 (en) 2000-02-17
WO1998013007A8 (en) 1999-05-20
EP1023316A4 (en) 2004-06-09
JP2002515883A (ja) 2002-05-28
EP1023316A2 (en) 2000-08-02
CA2267179A1 (en) 1998-04-02
WO1998013007A2 (en) 1998-04-02
CN1235594A (zh) 1999-11-17
AU737865B2 (en) 2001-09-06

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]
B15K Others concerning applications: alteration of classification

Ipc: A61K 47/54 (2017.01), A61K 9/127 (2006.0