KR100672965B1 - 약제학적 화합물로 유용한 나알라다제 억제제 및 그의조성물 - Google Patents

약제학적 화합물로 유용한 나알라다제 억제제 및 그의조성물 Download PDF

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KR100672965B1
KR100672965B1 KR1020017000232A KR20017000232A KR100672965B1 KR 100672965 B1 KR100672965 B1 KR 100672965B1 KR 1020017000232 A KR1020017000232 A KR 1020017000232A KR 20017000232 A KR20017000232 A KR 20017000232A KR 100672965 B1 KR100672965 B1 KR 100672965B1
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formula
moiety
pentanedioic acid
compound
substituted
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KR20010099586A (ko
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폴에프 잭슨
케이트엠. 맥클린
에릭 왕
바르바라에스. 슬러셔
레나에스. 라피더스
파벨 메이저
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길포드 파마슈티컬스 인코포레이티드
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Priority claimed from US09/110,262 external-priority patent/US6395718B1/en
Priority claimed from US09/228,391 external-priority patent/US6265609B1/en
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    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
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    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C333/14—Dithiocarbamic acids; Derivatives thereof
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020017000232A 1998-07-06 1999-07-02 약제학적 화합물로 유용한 나알라다제 억제제 및 그의조성물 Expired - Fee Related KR100672965B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11018698A 1998-07-06 1998-07-06
US09/110,186 1998-07-06
US09/110,262 1998-07-06
US09/110,262 US6395718B1 (en) 1998-07-06 1998-07-06 Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
US09/228,391 US6265609B1 (en) 1998-07-06 1999-01-12 Thio-substituted pentanedioic acid derivatives
US09/228,391 1999-01-12

Publications (2)

Publication Number Publication Date
KR20010099586A KR20010099586A (ko) 2001-11-09
KR100672965B1 true KR100672965B1 (ko) 2007-02-28

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KR1020017000232A Expired - Fee Related KR100672965B1 (ko) 1998-07-06 1999-07-02 약제학적 화합물로 유용한 나알라다제 억제제 및 그의조성물

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US (2) US6458775B1 (https=)
EP (2) EP1093453B1 (https=)
JP (1) JP4503836B2 (https=)
KR (1) KR100672965B1 (https=)
CN (1) CN1314882A (https=)
AT (1) ATE305449T1 (https=)
AU (1) AU770258B2 (https=)
BR (1) BR9912516A (https=)
CA (1) CA2337797C (https=)
CZ (1) CZ200113A3 (https=)
DE (1) DE69927502T2 (https=)
ES (1) ES2251204T3 (https=)
HU (1) HUP0103382A3 (https=)
IL (1) IL140499A0 (https=)
MX (1) MXPA01000144A (https=)
NO (1) NO20010052L (https=)
NZ (1) NZ508978A (https=)
PL (1) PL346762A1 (https=)
TR (1) TR200100025T2 (https=)
WO (1) WO2000001668A2 (https=)

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US6953668B1 (en) 1992-11-05 2005-10-11 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
US7070782B1 (en) * 1992-11-05 2006-07-04 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen
US7105159B1 (en) * 1992-11-05 2006-09-12 Sloan-Kettering Institute For Cancer Research Antibodies to prostate-specific membrane antigen
US6569432B1 (en) 1995-02-24 2003-05-27 Sloan-Kettering Institute For Cancer Research Prostate-specific membrane antigen and uses thereof
ATE317435T1 (de) 1995-02-24 2006-02-15 Sloan Kettering Inst Cancer Prostataspezifisches membranes antigen und seine anwendungen
US20040253246A1 (en) * 1996-02-23 2004-12-16 Israeli Ron S. Prostate-specific membrane antigen and uses thereof
US6395718B1 (en) * 1998-07-06 2002-05-28 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
US6444657B1 (en) * 1998-12-31 2002-09-03 Guilford Pharmaceuticals Inc. Methods for treating certain diseases using naaladase inhibitors
US6228888B1 (en) * 1999-07-01 2001-05-08 Guilford Pharmaceuticals Inc. Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors
WO2001091738A2 (en) * 2000-05-30 2001-12-06 Guilford Pharmaceuticals Inc. Naaladase inhibitors for treating amyotrophic lateral sclerosis
WO2001092274A2 (en) * 2000-05-30 2001-12-06 Guilford Pharmaceuticals Inc. Naaladase inhibitors for treating retinal disorders and glaucoma
WO2001092273A2 (en) * 2000-05-30 2001-12-06 Guilford Pharmaceuticals Inc. Benzenedicarboxylic acid derivatives
US6586623B2 (en) 2001-01-17 2003-07-01 Guilford Pharmaceuticals Inc. Thiol-based NAALADase inhibitors
WO2002092553A1 (en) * 2001-05-11 2002-11-21 Guilford Pharmaceuticals Inc. Hydroxamic acids and acyl hydroxamines as naaladase inhibitors
AU2002310202B2 (en) * 2001-05-30 2008-05-15 Eisai Inc. Thiolalkyl benzoic acid derivatives
US20050215472A1 (en) 2001-10-23 2005-09-29 Psma Development Company, Llc PSMA formulations and uses thereof
WO2003034903A2 (en) 2001-10-23 2003-05-01 Psma Development Company, L.L.C. Psma antibodies and protein multimers
WO2003057670A2 (en) * 2001-12-28 2003-07-17 Guilford Pharmaceuticals Inc. Indoles as naaladase inhibitors
US20040186081A1 (en) * 2003-03-03 2004-09-23 Guilford Pharmaceuticals Inc. Naaladase inhibitors for treating opioid tolerance
JP4773951B2 (ja) * 2003-03-03 2011-09-14 エーザイ インコーポレーテッド チオラクトン

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SU548609A1 (ru) * 1975-04-19 1977-02-28 Предприятие П/Я Г-4236 СОЛИ БИС-(у-СУЛЬФОПРОПИОНАТПРОПИЛ-ИЛИ СУЛЬФОИЗОБУТИРАТПРОПИЛ)-ПОЛИДИМЕТИЛ-СИЛОКСАНА, ОБЛАДАЮЩИЕ ПОВЕРХНОСТНО-АКТИВНЫМИСВОЙСТВАМИ1Изобретение относитс к новым химическим соединени м, а именно к сол м бис-(у-сульфо-0нропионатпропил- или сульфонзобутиратпро- пил)-нолидиметилснлоксана общей формулыСНз СНзСН, \КОз5СН2СН(р.)С(о)о(СН2)з-31-0-[81-о]-81-((:Н5,)зО(о)ССН(к)СН2бОзМ\<т\сн, ш,сн3где R = H, СНз; M = Na, К, NH4;m = 4, 8, 12, 16, обладающим поверхност- 5 но-активными свойствами.Соли бис-(•у-сульфопроиионатпропил- н сульфоизобутиратиропил) - нолидиметнлсилок- сана указанной формулы, обладающие повы- щенной поверхностной активностью могут 10 примен тьс в качестве эффективных поверх- ностио-активных веществ (ПАВ).Р1звестны ПАВ на основе кремнийорганнче- ских сульфоэфиров ^[1], сульфатов [2] или сульфонатов [3], снижающие поверхностное 15 нат жение воды до 20—30 дин/см.Наиболее близкими по технической сущности к описываемым соединени м вл ютс Na, К или NH4 соли 1,3-бис-(сульфопропионатал- кил- или сульфоизобутираталкил-1,1,3,3-тетра- 20 метилдисилоксана [4].Однако указанные соединени имеют недостаточную активность на границах фаз: вода — воздух (снижают поверхностное нат жение с 72,5 до 25—30 дин/см) и вода — кремний — органическа жидкость (снижают межфазовое нат жение с 47 до 6—14 дин/см).Целью изобретени вл етс синтез соединений, обладающих высокой эффективностью действи в качестве ПАВ.Дл этого используемые в качестве ПАВ соли бис- (i'-сульфопропионатнроиил- или сульфоизобутнратпропил) - иолидиметилсил- оксана содержат в своем составе удлиненную силоксановую день.Введение солей указанной формулы в концентраци х 1-10~з — 5-10~2 моль/л приводит к резкому снижению поверхностного нат л<е- ни воды (с 72,5 до 17 дин/см) и межфазного нат жени на границе вода — полиднметил- силоксан (с 47,7 до 4,3 дин/см).Соли бис-(у-сульфоироинонатпропнл- и сульфонзобутиратиропил) - полидиметилсил-
US4151172A (en) 1977-08-11 1979-04-24 E. R. Squibb & Sons, Inc. Phosphonoacyl prolines and related compounds
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