KR100649058B1 - 유기 아지드화물의 제조 방법 - Google Patents
유기 아지드화물의 제조 방법 Download PDFInfo
- Publication number
- KR100649058B1 KR100649058B1 KR1020000007790A KR20000007790A KR100649058B1 KR 100649058 B1 KR100649058 B1 KR 100649058B1 KR 1020000007790 A KR1020000007790 A KR 1020000007790A KR 20000007790 A KR20000007790 A KR 20000007790A KR 100649058 B1 KR100649058 B1 KR 100649058B1
- Authority
- KR
- South Korea
- Prior art keywords
- azide
- reaction
- organic compound
- derivative
- solvent
- Prior art date
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
위치 | δ | 다중도 |
H1 | 5.47 | S |
H2 | 3.23 | D |
H3 | 3.88-3.92 | Ddd |
H4 | 3.38 | M |
H5 | 4.62 | Dd |
H6 | 3.70 | Dd |
H6' | 3.94 | Dd |
벤질의 CH2 | 4.70 | D |
방향족 양성자 | 7.29-7.40 | M |
OH | 2.43 | D |
Claims (11)
- 유기 화합물의 에폭시드 유도체와 알칼리 금속 아지드화물 염을 용매 내에서 반응시켜 유기 화합물의 아지드 유도체를 형성함으로써 아지드 작용기를 유기 화합물에 첨가하는 방법으로서, 반응 전, 반응 동안, 또는 반응 전과 반응 동안에, 비점이 반응 온도 이상인 (1-6C)알킬-(2-4C)카르복실산 에스테르를 상기 에폭시드 유도체에 대해 0.9 내지 1.1 범위 이내의 비율로 반응 혼합물에 첨가하는 것을 특징으로 하는 방법.
- 제1항에 있어서, 상기 유기 화합물의 에폭시드 유도체는 산화스티렌, 2,3-에폭시부탄, 산화인덴 및 탄수화물의 에폭시 유도체 중에서 선택되는 것을 특징으로 하는 방법.
- 제2항에 있어서, 상기 유기 화합물의 에폭시드 유도체는 탄수화물의 에폭시 유도체인 것을 특징으로 하는 방법.
- 제3항에 있어서, 상기 탄수화물의 에폭시드 유도체는 1,6:2,3-디안히드로-4-O-페닐메틸-β-D-만노피라노스 또는 1,6:2,3-디안히드로-4-O-[2,3-비스-O-페닐메틸 -4,6-O-페닐메틸리덴-β-D-글루코피라노실]-β-D-만노피라노스 또는 1,6:2,3-디안히드로-4-O-[2,3-비스-O-페닐메틸-4,6-O-(1-메틸에틸리덴)-β-D-글루코피라노실]-β-D-만노피라노스인 것을 특징으로 하는 방법.
- 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 반응 온도는 60 내지 120℃인 것을 특징으로 하는 방법.
- 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 에스테르는 부틸아세테이트인 것을 특징으로 하는 방법.
- 제5항에 있어서, 상기 에스테르는 부틸아세테이트인 것을 특징으로 하는 방법.
- 제1항 내지 제4항 중 어느 한 항에 있어서, 상기 용매의 부피와 최대 동일한 양으로 물을 반응 혼합물에 첨가하는 것을 특징으로 하는 방법.
- 제5항에 있어서, 상기 용매의 부피와 최대 동일한 양으로 물을 반응 혼합물에 첨가하는 것을 특징으로 하는 방법.
- 제6항에 있어서, 상기 용매의 부피와 최대 동일한 양으로 물을 반응 혼합물에 첨가하는 것을 특징으로 하는 방법.
- 제7항에 있어서, 상기 용매의 부피와 최대 동일한 양으로 물을 반응 혼합물에 첨가하는 것을 특징으로 하는 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99200484 | 1999-02-19 | ||
EP99200484.6 | 1999-02-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20010029568A KR20010029568A (ko) | 2001-04-06 |
KR100649058B1 true KR100649058B1 (ko) | 2006-11-24 |
Family
ID=8239903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020000007790A KR100649058B1 (ko) | 1999-02-19 | 2000-02-18 | 유기 아지드화물의 제조 방법 |
Country Status (23)
Country | Link |
---|---|
US (1) | US6232451B1 (ko) |
EP (1) | EP1029867B1 (ko) |
JP (1) | JP4347488B2 (ko) |
KR (1) | KR100649058B1 (ko) |
CN (1) | CN1156483C (ko) |
AR (1) | AR022615A1 (ko) |
AT (1) | ATE265463T1 (ko) |
AU (1) | AU769027B2 (ko) |
BR (1) | BRPI0000481B8 (ko) |
CA (1) | CA2296902C (ko) |
CZ (1) | CZ298569B6 (ko) |
DE (1) | DE60010147T2 (ko) |
DK (1) | DK1029867T3 (ko) |
ES (1) | ES2216810T3 (ko) |
HU (1) | HUP0000740A3 (ko) |
IL (1) | IL134144A (ko) |
NO (1) | NO314265B1 (ko) |
NZ (1) | NZ502829A (ko) |
PL (1) | PL198390B1 (ko) |
PT (1) | PT1029867E (ko) |
RU (1) | RU2241714C2 (ko) |
TR (1) | TR200000441A2 (ko) |
ZA (1) | ZA200000578B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8242344B2 (en) * | 2002-06-26 | 2012-08-14 | Fingersteps, Inc. | Method and apparatus for composing and performing music |
FR2935976B1 (fr) * | 2008-09-16 | 2010-12-17 | Sanofi Aventis | Voie courte de synthese du 1,6:2,3-dianhydro-b-d- mannopyranose. |
FR2935975B1 (fr) * | 2008-09-16 | 2010-12-17 | Sanofi Aventis | Procede de preparation du 1,6:2,3-dianhydro-b-d- mannopyranose. |
CN103819357B (zh) * | 2014-01-28 | 2016-03-16 | 浙江大学 | (-)-有效霉醇叠氮四乙酸酯的制备方法 |
CN112334454B (zh) * | 2018-06-29 | 2024-04-30 | 佐治亚州立大学研究基金会公司 | 环保的烯烃水合反应 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3893997A (en) | 1974-07-01 | 1975-07-08 | Smithkline Corp | Pseudodisaccharide intermediates |
CS191047B1 (en) * | 1977-09-05 | 1979-06-29 | Alzbeta Krutosikova | Ethylesters of 3-/5-aryl-2-furyl/-2-azidoacrylic acids and method for their preparing |
US4582918A (en) * | 1984-09-19 | 1986-04-15 | Schering Corporation | Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols |
CS276874B6 (cs) * | 1990-09-11 | 1992-08-12 | Ustav Organicke Chemie A Bioch | l-(3-azido-2,3-dideoxy-Beta-D-allokofuranosylJthymin, způsob jeho přípravy a použití |
US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
JPH08332095A (ja) * | 1995-06-06 | 1996-12-17 | Chisso Corp | インデノールの製造法 |
-
2000
- 2000-01-20 IL IL13414400A patent/IL134144A/en not_active IP Right Cessation
- 2000-01-21 CA CA002296902A patent/CA2296902C/en not_active Expired - Lifetime
- 2000-02-08 ZA ZA200000578A patent/ZA200000578B/xx unknown
- 2000-02-08 AU AU14965/00A patent/AU769027B2/en not_active Expired
- 2000-02-08 US US09/499,685 patent/US6232451B1/en not_active Expired - Lifetime
- 2000-02-14 ES ES00200466T patent/ES2216810T3/es not_active Expired - Lifetime
- 2000-02-14 AT AT00200466T patent/ATE265463T1/de active
- 2000-02-14 EP EP00200466A patent/EP1029867B1/en not_active Expired - Lifetime
- 2000-02-14 DK DK00200466T patent/DK1029867T3/da active
- 2000-02-14 PT PT00200466T patent/PT1029867E/pt unknown
- 2000-02-14 DE DE60010147T patent/DE60010147T2/de not_active Expired - Lifetime
- 2000-02-14 NZ NZ502829A patent/NZ502829A/en not_active IP Right Cessation
- 2000-02-16 JP JP2000037510A patent/JP4347488B2/ja not_active Expired - Lifetime
- 2000-02-17 BR BRPI0000481A patent/BRPI0000481B8/pt not_active IP Right Cessation
- 2000-02-17 TR TR2000/00441A patent/TR200000441A2/xx unknown
- 2000-02-17 AR ARP000100667A patent/AR022615A1/es active IP Right Grant
- 2000-02-18 NO NO20000805A patent/NO314265B1/no not_active IP Right Cessation
- 2000-02-18 PL PL338501A patent/PL198390B1/pl unknown
- 2000-02-18 CZ CZ20000588A patent/CZ298569B6/cs not_active IP Right Cessation
- 2000-02-18 CN CNB001022385A patent/CN1156483C/zh not_active Expired - Lifetime
- 2000-02-18 RU RU2000104086/04A patent/RU2241714C2/ru active
- 2000-02-18 HU HU0000740A patent/HUP0000740A3/hu unknown
- 2000-02-18 KR KR1020000007790A patent/KR100649058B1/ko active IP Right Grant
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3725385A (en) | Process for the demethylation of 3-amino macrolides | |
KR20210005071A (ko) | (티오)니코틴아미드 리보푸라노사이드 염 및 이의 조성물, 제조 방법, 및 용도 | |
KR100649058B1 (ko) | 유기 아지드화물의 제조 방법 | |
US4156777A (en) | Process for producing glucopyranose-nitrosourea compounds and novel compounds included therein | |
EP0081305A1 (en) | Erythromycin A derivatives | |
EP0114486B1 (en) | Alkylation of oleandomycin | |
MXPA00001753A (en) | Process for the preparation of organic azides | |
CN114478659B (zh) | 一种二糖化合物的制备方法 | |
US4357466A (en) | Processes for the production of 3'-deoxykanamycin A and intermediates | |
US5315002A (en) | Saccharide mercaptals | |
US7919599B2 (en) | Production of L-iduronate containing polysaccharides | |
US3317509A (en) | Process for the production of methyl nacyl-2, 3, 4, 7-tetra-o-acyl-beta-thiolincosaminides | |
US6376662B1 (en) | Method for synthesizing C-glycosides of ulosonic acids | |
EP0132026B1 (en) | Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin a and intermediates therefor | |
Ac | anomeric configuration and conformation of iV-acetyl bis (2, 3í4-tri-0-acetyl-/3-L-rhamnopyranosyl) amine un-derivative IV was found to be identical with that of der the same reaction conditions as described with compound II [1, 3]. compound II (Scheme 2). The 13C NMR spectrum of iV-Acetyl-bis (2, 3, 4-tri-0-acetyl-iS-L-rhamnopyrano-compound V7 (CDC13, 25 C) disclosed only one a little syl) amine (VI) was synthesized by 7V-acetylation of broadened signal of the anomeric carbon at 6= 80.5 | |
KAJI et al. | Synthesis and Utility of 2-(Benzoyloxyimino)-2-deoxy-α-D-lyxo-hexopyranosyl Bromide as a Novel α-D-Talosaminide Building Block | |
Hatanaka et al. | Synthesis and Ring-Opening Reaction of 1, 6-Anhydro-6-deoxy-6-thio-2, 3, 4-tri-O-benzyl-b-D-glucopyranose | |
Bairamova et al. | Synthesis of the principal chain of the o-antigenic polysaccharides of Shigella flexneri. Communication 2. Synthesis of 4-o-benzoyl-1, 2-o-(1-(cyanoethylidene)-β-L-rhamnopyranose | |
JPH09249681A (ja) | 6−o−(2−アセトアミドエチルホスホニル)−d−マンノピラノシド誘導体、及びその製造法 | |
EP0106231A1 (en) | Process for the O-demethylation of aminoglycoside compounds | |
JPS6310740A (ja) | 新規イノソース誘導体 | |
AT506933A1 (de) | Regioselektive sulfatierung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
N231 | Notification of change of applicant | ||
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20121019 Year of fee payment: 7 |
|
FPAY | Annual fee payment |
Payment date: 20131017 Year of fee payment: 8 |
|
FPAY | Annual fee payment |
Payment date: 20141022 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20151016 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20161019 Year of fee payment: 11 |
|
FPAY | Annual fee payment |
Payment date: 20171018 Year of fee payment: 12 |
|
FPAY | Annual fee payment |
Payment date: 20181018 Year of fee payment: 13 |