KR100642592B1 - 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법 - Google Patents

갑상선 자극 호르몬의 변이체 및 이에 근거한 방법 Download PDF

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Publication number
KR100642592B1
KR100642592B1 KR1020057013108A KR20057013108A KR100642592B1 KR 100642592 B1 KR100642592 B1 KR 100642592B1 KR 1020057013108 A KR1020057013108 A KR 1020057013108A KR 20057013108 A KR20057013108 A KR 20057013108A KR 100642592 B1 KR100642592 B1 KR 100642592B1
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South Korea
Prior art keywords
subunit
mutant
stimulating hormone
thyroid stimulating
mutated
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020057013108A
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English (en)
Korean (ko)
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KR20050085970A (ko
Inventor
브루스 디 웨인트럽
마리우스 더블유 스즈쿠드린스키
Original Assignee
유니버시티 어브 메릴랜드, 발티모어
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Publication of KR20050085970A publication Critical patent/KR20050085970A/ko
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Publication of KR100642592B1 publication Critical patent/KR100642592B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020057013108A 1997-09-22 1998-09-22 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법 Expired - Fee Related KR100642592B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93947297A 1997-09-22 1997-09-22
US08/939,472 1997-09-22

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020007003012A Division KR100642602B1 (ko) 1997-09-22 1998-09-22 갑상선자극호르몬의 돌연변이 및 그에 근거한 방법

Publications (2)

Publication Number Publication Date
KR20050085970A KR20050085970A (ko) 2005-08-29
KR100642592B1 true KR100642592B1 (ko) 2006-11-13

Family

ID=25473237

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020057013108A Expired - Fee Related KR100642592B1 (ko) 1997-09-22 1998-09-22 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법
KR1020057013106A Expired - Fee Related KR100642599B1 (ko) 1997-09-22 1998-09-22 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법
KR1020057013107A Expired - Fee Related KR100642586B1 (ko) 1997-09-22 1998-09-22 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법
KR1020007003012A Expired - Fee Related KR100642602B1 (ko) 1997-09-22 1998-09-22 갑상선자극호르몬의 돌연변이 및 그에 근거한 방법

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020057013106A Expired - Fee Related KR100642599B1 (ko) 1997-09-22 1998-09-22 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법
KR1020057013107A Expired - Fee Related KR100642586B1 (ko) 1997-09-22 1998-09-22 갑상선 자극 호르몬의 변이체 및 이에 근거한 방법
KR1020007003012A Expired - Fee Related KR100642602B1 (ko) 1997-09-22 1998-09-22 갑상선자극호르몬의 돌연변이 및 그에 근거한 방법

Country Status (10)

Country Link
US (1) US20040266665A1 (https=)
EP (2) EP1017817B1 (https=)
JP (1) JP2001517445A (https=)
KR (4) KR100642592B1 (https=)
CN (1) CN1277633A (https=)
AT (1) ATE356209T1 (https=)
AU (1) AU758156B2 (https=)
CA (1) CA2302993A1 (https=)
DE (1) DE69837271T2 (https=)
WO (1) WO1999015665A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2344277A1 (en) * 1998-09-22 2000-03-30 University Of Maryland, Baltimore Cystine knot growth factor mutants
KR100423735B1 (ko) * 2000-11-13 2004-03-20 학교법인 포항공과대학교 그레이브스 질환에 길항작용을 하는 펩타이드 및 그의 용도
JP2007513191A (ja) * 2003-12-05 2007-05-24 ザイモジェネティクス，インコーポレイティド 甲状腺刺激ホルモンを用いての炎症の処理方法
RU2006138235A (ru) * 2004-03-31 2008-05-10 Трофоджен, Инк. (Us) Суперагонисты человеческих гликопротеиновых гормонов и способы их применения
DK1971361T3 (da) 2005-12-23 2014-09-08 James D Kelly Forbedrede glycoformer af thyroidstimulerende hormonreceptor-polypeptidagonist til behandling af metabolisk syndrom
DK2063909T3 (da) * 2006-09-19 2013-01-02 Genzyme Corp Formuleringer til terapeutisk administration af thyroid-stimuleringshormon (TSH)
GB0725201D0 (en) * 2007-12-24 2008-01-30 Asterion Ltd Peptide fusion proteins
GB0808402D0 (en) * 2008-05-09 2008-06-18 Asterion Ltd Tsh
US20110052591A1 (en) * 2009-08-28 2011-03-03 Board Of Regents Of The University Of Texas System Variants of Thyroid Stimulating Hormone Beta
US10358574B2 (en) 2016-07-01 2019-07-23 Hercules Llc Coating compositions containing lactam-functionalized polymer
US20230220026A1 (en) * 2022-01-12 2023-07-13 National Yang Ming Chiao Tung University Nucleic acid carrier for producing the single-chain vegf fusion protein with high physiological stability and dimeric efficiency, preparation method thereof, and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980286A (en) * 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
ES2098261T3 (es) * 1989-02-21 1997-05-01 Univ Washington Formas modificadas de hormonas reproductoras.
PT725795E (pt) * 1994-08-12 2004-05-31 Univ Washington Formas de cadeia simples do quarteto de hormonas glicoproteicas
US6361992B1 (en) * 1996-05-08 2002-03-26 The United States Of America As Represented By The Department Of Health And Human Services Thyroid stimulating hormone superagonists

Also Published As

Publication number Publication date
KR100642602B1 (ko) 2006-11-10
KR20050085970A (ko) 2005-08-29
EP1816199A1 (en) 2007-08-08
CA2302993A1 (en) 1999-04-01
EP1017817A2 (en) 2000-07-12
WO1999015665A2 (en) 1999-04-01
KR20010030661A (ko) 2001-04-16
KR20050085969A (ko) 2005-08-29
WO1999015665A3 (en) 1999-05-20
JP2001517445A (ja) 2001-10-09
DE69837271T2 (de) 2007-11-22
DE69837271D1 (de) 2007-04-19
KR20050085968A (ko) 2005-08-29
US20040266665A1 (en) 2004-12-30
EP1017817B1 (en) 2007-03-07
AU758156B2 (en) 2003-03-13
AU9499898A (en) 1999-04-12
CN1277633A (zh) 2000-12-20
KR100642586B1 (ko) 2006-11-10
KR100642599B1 (ko) 2006-11-10
ATE356209T1 (de) 2007-03-15

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