KR100613812B1 - 푸린 유도체를 제조하는 방법 - Google Patents

푸린 유도체를 제조하는 방법 Download PDF

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Publication number
KR100613812B1
KR100613812B1 KR1020007010706A KR20007010706A KR100613812B1 KR 100613812 B1 KR100613812 B1 KR 100613812B1 KR 1020007010706 A KR1020007010706 A KR 1020007010706A KR 20007010706 A KR20007010706 A KR 20007010706A KR 100613812 B1 KR100613812 B1 KR 100613812B1
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KR
South Korea
Prior art keywords
alkyl
formula
compound
aryl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020007010706A
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English (en)
Korean (ko)
Other versions
KR20010034701A (ko
Inventor
그레이암 리차드 기인
앤드류 콜린 쉐어
Original Assignee
노파르티스 인터내셔널 파마슈티칼 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 노파르티스 인터내셔널 파마슈티칼 리미티드 filed Critical 노파르티스 인터내셔널 파마슈티칼 리미티드
Publication of KR20010034701A publication Critical patent/KR20010034701A/ko
Application granted granted Critical
Publication of KR100613812B1 publication Critical patent/KR100613812B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020007010706A 1998-04-02 1999-03-30 푸린 유도체를 제조하는 방법 Expired - Fee Related KR100613812B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9807116.0A GB9807116D0 (en) 1998-04-02 1998-04-02 Novel process
GB9807116.0 1998-04-02

Publications (2)

Publication Number Publication Date
KR20010034701A KR20010034701A (ko) 2001-04-25
KR100613812B1 true KR100613812B1 (ko) 2006-08-18

Family

ID=10829765

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007010706A Expired - Fee Related KR100613812B1 (ko) 1998-04-02 1999-03-30 푸린 유도체를 제조하는 방법

Country Status (16)

Country Link
US (1) US6437125B1 (https=)
EP (1) EP1068210B1 (https=)
JP (1) JP4459439B2 (https=)
KR (1) KR100613812B1 (https=)
CN (1) CN1125068C (https=)
AT (1) ATE268332T1 (https=)
AU (1) AU3605199A (https=)
BR (1) BR9908959A (https=)
CA (1) CA2323965A1 (https=)
DE (1) DE69917765T2 (https=)
DK (1) DK1068210T3 (https=)
ES (1) ES2222702T3 (https=)
GB (1) GB9807116D0 (https=)
IL (1) IL138289A0 (https=)
PT (1) PT1068210E (https=)
WO (1) WO1999051604A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60202245T2 (de) 2001-08-30 2005-09-01 Ajinomoto Co., Inc. Herstellungsmethode von Famciclovir und Herstellungs- bzw. Kristallisationsmethode eines entsprechenden Intermediates
AU2003268213A1 (en) * 2002-08-26 2004-03-11 Teva Pharmaceutical Industries Ltd. Crystalline solid famciclovir forms i, ii, iii and preparation thereof
US7473780B2 (en) * 2004-05-18 2009-01-06 Teva Pharmeceutical Industries Ltd. Drying process for preparing crystalline solid famciclovir
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
CN110386935A (zh) * 2018-04-20 2019-10-29 重庆常捷医药有限公司 一种泛昔洛韦中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
EP0182024B1 (en) * 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
GB8817607D0 (en) 1988-07-23 1988-09-01 Beecham Group Plc Novel process
US5688948A (en) * 1991-09-18 1997-11-18 Ajinomoto Co., Inc. Process for isomerizing acyclic nucleosides and process for separating purine nucleosides
GB9407698D0 (en) * 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
EP0827960A1 (en) * 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Process for producing purine derivatives

Also Published As

Publication number Publication date
PT1068210E (pt) 2004-10-29
WO1999051604A3 (en) 2000-02-17
CN1125068C (zh) 2003-10-22
CN1294591A (zh) 2001-05-09
AU3605199A (en) 1999-10-25
JP2002510692A (ja) 2002-04-09
DE69917765D1 (de) 2004-07-08
HK1035896A1 (en) 2001-12-14
ATE268332T1 (de) 2004-06-15
EP1068210A2 (en) 2001-01-17
DK1068210T3 (da) 2004-09-20
KR20010034701A (ko) 2001-04-25
ES2222702T3 (es) 2005-02-01
JP4459439B2 (ja) 2010-04-28
IL138289A0 (en) 2001-10-31
WO1999051604A2 (en) 1999-10-14
GB9807116D0 (en) 1998-06-03
CA2323965A1 (en) 1999-10-14
BR9908959A (pt) 2000-12-05
US6437125B1 (en) 2002-08-20
EP1068210B1 (en) 2004-06-02
DE69917765T2 (de) 2005-07-14

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