CN1125068C - 嘌呤衍生物的制备方法 - Google Patents

嘌呤衍生物的制备方法 Download PDF

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Publication number
CN1125068C
CN1125068C CN99804402A CN99804402A CN1125068C CN 1125068 C CN1125068 C CN 1125068C CN 99804402 A CN99804402 A CN 99804402A CN 99804402 A CN99804402 A CN 99804402A CN 1125068 C CN1125068 C CN 1125068C
Authority
CN
China
Prior art keywords
alkyl
compound
general formula
aryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN99804402A
Other languages
English (en)
Chinese (zh)
Other versions
CN1294591A (zh
Inventor
G·R·格恩
A·C·沙雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis International Pharmaceutical Ltd
Original Assignee
Novartis International Pharmaceutical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis International Pharmaceutical Ltd filed Critical Novartis International Pharmaceutical Ltd
Publication of CN1294591A publication Critical patent/CN1294591A/zh
Application granted granted Critical
Publication of CN1125068C publication Critical patent/CN1125068C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN99804402A 1998-04-02 1999-03-30 嘌呤衍生物的制备方法 Expired - Fee Related CN1125068C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9807116.0 1998-04-02
GBGB9807116.0A GB9807116D0 (en) 1998-04-02 1998-04-02 Novel process

Publications (2)

Publication Number Publication Date
CN1294591A CN1294591A (zh) 2001-05-09
CN1125068C true CN1125068C (zh) 2003-10-22

Family

ID=10829765

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99804402A Expired - Fee Related CN1125068C (zh) 1998-04-02 1999-03-30 嘌呤衍生物的制备方法

Country Status (16)

Country Link
US (1) US6437125B1 (https=)
EP (1) EP1068210B1 (https=)
JP (1) JP4459439B2 (https=)
KR (1) KR100613812B1 (https=)
CN (1) CN1125068C (https=)
AT (1) ATE268332T1 (https=)
AU (1) AU3605199A (https=)
BR (1) BR9908959A (https=)
CA (1) CA2323965A1 (https=)
DE (1) DE69917765T2 (https=)
DK (1) DK1068210T3 (https=)
ES (1) ES2222702T3 (https=)
GB (1) GB9807116D0 (https=)
IL (1) IL138289A0 (https=)
PT (1) PT1068210E (https=)
WO (1) WO1999051604A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1288215B8 (en) 2001-08-30 2005-04-06 Ajinomoto Co., Inc. Production method of famciclovir and production and crystallization method of intermediate therefor
EP1532151A2 (en) * 2002-08-26 2005-05-25 Teva Pharmaceutical Industries Limited Crystalline solid famciclovir forms i, ii, iii and preparation thereof
KR20080091298A (ko) * 2004-05-18 2008-10-09 테바 파마슈티컬 인더스트리즈 리미티드 결정성 고체 팜시클로버의 제조를 위한 건조방법
GB2426247A (en) * 2005-05-20 2006-11-22 Arrow Int Ltd Methods of preparing purine derivatives such as famciclovir
CN110386935A (zh) * 2018-04-20 2019-10-29 重庆常捷医药有限公司 一种泛昔洛韦中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
EP0141927B1 (en) 1983-08-18 1991-10-30 Beecham Group Plc Antiviral guanine derivatives
EP0182024B1 (en) 1984-09-20 1991-04-03 Beecham Group Plc Purine derivatives and their pharmaceutical use
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
US5688948A (en) * 1991-09-18 1997-11-18 Ajinomoto Co., Inc. Process for isomerizing acyclic nucleosides and process for separating purine nucleosides
GB9407698D0 (en) 1994-04-19 1994-06-15 Smithkline Beecham Plc Pharmaceuticals
EP0827960A1 (en) * 1996-09-10 1998-03-11 Ajinomoto Co., Inc. Process for producing purine derivatives

Also Published As

Publication number Publication date
CA2323965A1 (en) 1999-10-14
US6437125B1 (en) 2002-08-20
ATE268332T1 (de) 2004-06-15
IL138289A0 (en) 2001-10-31
CN1294591A (zh) 2001-05-09
AU3605199A (en) 1999-10-25
WO1999051604A3 (en) 2000-02-17
HK1035896A1 (en) 2001-12-14
JP2002510692A (ja) 2002-04-09
PT1068210E (pt) 2004-10-29
EP1068210B1 (en) 2004-06-02
DK1068210T3 (da) 2004-09-20
EP1068210A2 (en) 2001-01-17
ES2222702T3 (es) 2005-02-01
GB9807116D0 (en) 1998-06-03
DE69917765T2 (de) 2005-07-14
BR9908959A (pt) 2000-12-05
WO1999051604A2 (en) 1999-10-14
KR100613812B1 (ko) 2006-08-18
KR20010034701A (ko) 2001-04-25
DE69917765D1 (de) 2004-07-08
JP4459439B2 (ja) 2010-04-28

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ASS Succession or assignment of patent right

Owner name: BELLSOS INTELLECTUAL PROPERTY CO., LTD.

Free format text: FORMER OWNER: SMITHKLINE BEECHAM PLC

Effective date: 20010809

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Effective date of registration: 20010809

Address after: Bermuda Hamilton

Applicant after: Novartis Int Pharm Ltd.

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Applicant before: Smithkline Beecham PLC

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