KR100503443B1 - 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 - Google Patents

광학적으로 활성인 세티리진 또는 그의 염의 제조방법 Download PDF

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Publication number
KR100503443B1
KR100503443B1 KR1020040006608A KR20040006608A KR100503443B1 KR 100503443 B1 KR100503443 B1 KR 100503443B1 KR 1020040006608 A KR1020040006608 A KR 1020040006608A KR 20040006608 A KR20040006608 A KR 20040006608A KR 100503443 B1 KR100503443 B1 KR 100503443B1
Authority
KR
South Korea
Prior art keywords
formula
optically active
compound
cetirizine
chlorophenyl
Prior art date
Application number
KR1020040006608A
Other languages
English (en)
Korean (ko)
Inventor
김재신
박용균
하문천
Original Assignee
한림제약(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한림제약(주) filed Critical 한림제약(주)
Priority to KR1020040006608A priority Critical patent/KR100503443B1/ko
Priority to PCT/KR2005/000231 priority patent/WO2005073207A1/en
Priority to EP05726293A priority patent/EP1718627A4/de
Application granted granted Critical
Publication of KR100503443B1 publication Critical patent/KR100503443B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020040006608A 2004-02-02 2004-02-02 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 KR100503443B1 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020040006608A KR100503443B1 (ko) 2004-02-02 2004-02-02 광학적으로 활성인 세티리진 또는 그의 염의 제조방법
PCT/KR2005/000231 WO2005073207A1 (en) 2004-02-02 2005-01-27 Process for preparing optically active cetirizine or its salt
EP05726293A EP1718627A4 (de) 2004-02-02 2005-01-27 Verfahren zur herstellung von optisch aktivem cetirizin oder dessen salz

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020040006608A KR100503443B1 (ko) 2004-02-02 2004-02-02 광학적으로 활성인 세티리진 또는 그의 염의 제조방법

Publications (1)

Publication Number Publication Date
KR100503443B1 true KR100503443B1 (ko) 2005-07-22

Family

ID=34825062

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020040006608A KR100503443B1 (ko) 2004-02-02 2004-02-02 광학적으로 활성인 세티리진 또는 그의 염의 제조방법

Country Status (3)

Country Link
EP (1) EP1718627A4 (de)
KR (1) KR100503443B1 (de)
WO (1) WO2005073207A1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009078627A2 (en) * 2007-12-17 2009-06-25 Hanmi Pharm. Co., Ltd. Method for preparing (r)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
KR20220099201A (ko) * 2021-01-05 2022-07-13 ㈜분자와물질 광학분할에 의한 새로운 레보세티리진의 제조방법

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2599498C (en) * 2005-03-03 2011-06-21 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
GB8827391D0 (en) 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6265579B1 (en) * 1999-10-29 2001-07-24 Salsbury Chemicals, Inc. Process for preparing piperazine-substituted aliphatic carboxylates

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009078627A2 (en) * 2007-12-17 2009-06-25 Hanmi Pharm. Co., Ltd. Method for preparing (r)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine
WO2009078627A3 (en) * 2007-12-17 2009-09-03 Hanmi Pharm. Co., Ltd. Method for preparing (r)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine
KR100998067B1 (ko) 2008-09-08 2010-12-03 주식회사 삼오제약 비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
KR20220099201A (ko) * 2021-01-05 2022-07-13 ㈜분자와물질 광학분할에 의한 새로운 레보세티리진의 제조방법
KR102491445B1 (ko) 2021-01-05 2023-01-25 (주)분자와물질 광학분할에 의한 새로운 레보세티리진의 제조방법

Also Published As

Publication number Publication date
EP1718627A4 (de) 2007-04-18
EP1718627A1 (de) 2006-11-08
WO2005073207A1 (en) 2005-08-11

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