WO2009078627A3 - Method for preparing (r)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine - Google Patents

Method for preparing (r)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine Download PDF

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Publication number
WO2009078627A3
WO2009078627A3 PCT/KR2008/007376 KR2008007376W WO2009078627A3 WO 2009078627 A3 WO2009078627 A3 WO 2009078627A3 KR 2008007376 W KR2008007376 W KR 2008007376W WO 2009078627 A3 WO2009078627 A3 WO 2009078627A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparing
phenylmethyl
chlorophenyl
piperazine
levocetirizine
Prior art date
Application number
PCT/KR2008/007376
Other languages
French (fr)
Other versions
WO2009078627A2 (en
Inventor
Tae Hee Ha
Won Jeoung Kim
Jong Ouk Baek
Suk Man Jang
Jae Chul Lee
Yoon Ju Lee
Kwee Hyun Suh
Gwan Sun Lee
Original Assignee
Hanmi Pharm. Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm. Co., Ltd. filed Critical Hanmi Pharm. Co., Ltd.
Publication of WO2009078627A2 publication Critical patent/WO2009078627A2/en
Publication of WO2009078627A3 publication Critical patent/WO2009078627A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds

Abstract

The present invention relates to a novel method for preparing (R)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine of formula (I), which is useful as an intermediate for preparing an antihistamine, levocetirizine.
PCT/KR2008/007376 2007-12-17 2008-12-12 Method for preparing (r)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine WO2009078627A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070132466A KR100954755B1 (en) 2007-12-17 2007-12-17 Method for preparing r---1-[4-chloro-phenylphenyl-methyl]piperazine
KR10-2007-0132466 2007-12-17

Publications (2)

Publication Number Publication Date
WO2009078627A2 WO2009078627A2 (en) 2009-06-25
WO2009078627A3 true WO2009078627A3 (en) 2009-09-03

Family

ID=40796003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/007376 WO2009078627A2 (en) 2007-12-17 2008-12-12 Method for preparing (r)-(-)-1-[(4-chlorophenyl)phenylmethyl]piperazine

Country Status (2)

Country Link
KR (1) KR100954755B1 (en)
WO (1) WO2009078627A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102491445B1 (en) 2021-01-05 2023-01-25 (주)분자와물질 Method of manufacturing levocetirizine by optical resolution

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0971571A (en) * 1995-06-29 1997-03-18 Toray Ind Inc Optical resolving agent and production of optically active 2-piperazinecarboxylic acid derivative with the same
EP0617028B1 (en) * 1993-03-15 2000-06-14 Ucb, S.A. Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl] piperazine
KR100503443B1 (en) * 2004-02-02 2005-07-22 한림제약(주) Processes for preparing an optically active cetirizine or its salt
WO2006094648A1 (en) * 2005-03-03 2006-09-14 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002249487A (en) * 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd 4-(tert-butoxycarbonyl)piperazine derivative, optically active acid addition salt of the same, method for producing them and optically active 1-[(substituted phenyl)phenylmethylpiperazine which uses them
MXPA06014213A (en) * 2004-06-18 2007-03-12 Neurosearch As Novel alkyl substituted piperazine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617028B1 (en) * 1993-03-15 2000-06-14 Ucb, S.A. Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl] piperazine
JPH0971571A (en) * 1995-06-29 1997-03-18 Toray Ind Inc Optical resolving agent and production of optically active 2-piperazinecarboxylic acid derivative with the same
KR100503443B1 (en) * 2004-02-02 2005-07-22 한림제약(주) Processes for preparing an optically active cetirizine or its salt
WO2006094648A1 (en) * 2005-03-03 2006-09-14 Ucb Farchim Sa Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine

Also Published As

Publication number Publication date
WO2009078627A2 (en) 2009-06-25
KR100954755B1 (en) 2010-04-27
KR20090065042A (en) 2009-06-22

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