KR100499812B1 - 아목시실린 및 클라불라네이트를 포함하는 약제학적 제형 - Google Patents

아목시실린 및 클라불라네이트를 포함하는 약제학적 제형 Download PDF

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Publication number
KR100499812B1
KR100499812B1 KR10-1999-7007362A KR19997007362A KR100499812B1 KR 100499812 B1 KR100499812 B1 KR 100499812B1 KR 19997007362 A KR19997007362 A KR 19997007362A KR 100499812 B1 KR100499812 B1 KR 100499812B1
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KR
South Korea
Prior art keywords
amoxicillin
clavulanate
granules
weight
tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR10-1999-7007362A
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English (en)
Korean (ko)
Other versions
KR20000071076A (ko
Inventor
자키 앙드레 기스타브 마셔
조세 루이스 산로마보르달로
케빈 스톰
Original Assignee
스미스클라인 비참 코포레이션
라보라뜨와르 글락소스미스클라인
스미쓰클라인 비참 에스.에이.
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Filing date
Publication date
Priority claimed from GBGB9703100.9A external-priority patent/GB9703100D0/en
Priority claimed from GBGB9703101.7A external-priority patent/GB9703101D0/en
Priority claimed from GBGB9703099.3A external-priority patent/GB9703099D0/en
Application filed by 스미스클라인 비참 코포레이션, 라보라뜨와르 글락소스미스클라인, 스미쓰클라인 비참 에스.에이. filed Critical 스미스클라인 비참 코포레이션
Publication of KR20000071076A publication Critical patent/KR20000071076A/ko
Application granted granted Critical
Publication of KR100499812B1 publication Critical patent/KR100499812B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
KR10-1999-7007362A 1997-02-14 1998-02-10 아목시실린 및 클라불라네이트를 포함하는 약제학적 제형 Expired - Fee Related KR100499812B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9703100.9A GB9703100D0 (en) 1997-02-14 1997-02-14 Formulations
GB9703099.3 1997-02-14
GBGB9703101.7A GB9703101D0 (en) 1997-02-14 1997-02-14 Formulations
GB9703100.9 1997-02-14
GBGB9703099.3A GB9703099D0 (en) 1997-02-14 1997-02-14 Formulations
GB9703101.7 1997-02-14
PCT/EP1998/000811 WO1998035672A1 (en) 1997-02-14 1998-02-10 Pharmaceutical formulations comprising amoxocyllin and clavulanate

Publications (2)

Publication Number Publication Date
KR20000071076A KR20000071076A (ko) 2000-11-25
KR100499812B1 true KR100499812B1 (ko) 2005-07-08

Family

ID=27268719

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-7007362A Expired - Fee Related KR100499812B1 (ko) 1997-02-14 1998-02-10 아목시실린 및 클라불라네이트를 포함하는 약제학적 제형

Country Status (25)

Country Link
EP (2) EP1142574A1 (https=)
JP (1) JP2001512451A (https=)
KR (1) KR100499812B1 (https=)
CN (1) CN1194687C (https=)
AP (1) AP1253A (https=)
AT (1) ATE243516T1 (https=)
AU (1) AU728526B2 (https=)
BG (1) BG103664A (https=)
BR (1) BR9807383A (https=)
CA (1) CA2280857A1 (https=)
DE (1) DE69815833T2 (https=)
DZ (1) DZ2420A1 (https=)
EA (1) EA002595B1 (https=)
ES (1) ES2201468T3 (https=)
HK (1) HK1043041A1 (https=)
ID (1) ID23673A (https=)
IL (1) IL131201A (https=)
MA (1) MA24473A1 (https=)
NO (1) NO993887L (https=)
NZ (1) NZ337043A (https=)
OA (1) OA11087A (https=)
PL (1) PL334976A1 (https=)
SK (1) SK110299A3 (https=)
TR (1) TR199901961T2 (https=)
WO (1) WO1998035672A1 (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9416600D0 (en) * 1994-08-17 1994-10-12 Smithkline Beecham Plc Pharmaceutical formulation
AR004510A1 (es) 1995-09-07 1998-12-16 Smithkline Beecham Plc Composiciones que comprenden amoxicilina y clavulanato, procedimientos para su preparacion y el uso de las composiciones para la fabricacion de unmedicamento
GB9815532D0 (en) * 1998-07-17 1998-09-16 Lek Pharmaceutical & Cvhemical Pharmaceutical suspension formulation
AU2869100A (en) * 1999-02-26 2000-09-14 Biovail International Ltd. Storage stable amoxycillin and clavulanate suspension composition
AP1806A (en) * 1999-04-13 2007-12-14 Beecham Pharmaceuticals Pte Ltd The use of a high dosage regimen of amoxycillin and potassium chavulate for the treatment of bacterial infections.
US7250176B1 (en) 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
FR2797588B1 (fr) * 1999-08-20 2003-08-01 Smithkline Beecham Lab Formulation pharmaceutique a base d'amoxycilline et de clavulanate
WO2001013883A1 (en) * 1999-08-20 2001-03-01 Smithkline Beecham Laboratoires Pharmaceutiques S.A.S. Pharmaceutical formulation comprising amoxycillin and clavulanate
US6541025B1 (en) * 1999-12-30 2003-04-01 Shear/Kershman Laboratories, Inc. Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals
US6375982B1 (en) * 2000-07-05 2002-04-23 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and method of using same
WO2002030392A2 (en) 2000-10-12 2002-04-18 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
AT412344B (de) * 2001-04-12 2005-01-25 Sandoz Ag Hydrophobisierte teilchen von k-clavulanat
AT413983B (de) * 2001-04-12 2006-08-15 Sandoz Ag K-clavulanat in der form eines granulates
AU2003208358A1 (en) * 2002-02-01 2003-09-02 Sandoz Gmbh Demixing-stable granulate
JP4698950B2 (ja) * 2002-04-09 2011-06-08 フラメル・テクノロジー アモキシシリンの改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
WO2004006917A1 (en) * 2002-07-16 2004-01-22 Ranbaxy Laboratories Limited Dispersible tablets for oral administration
CA2529102A1 (en) * 2003-06-16 2004-12-23 Glaxo Group Limited Pharmaceutical formulations comprising amoxicillin and clavulanate
KR100676617B1 (ko) * 2004-06-18 2007-01-30 주식회사유한양행 아목시실린 및/또는 클라불란산 또는 이의 염을 함유하는경구용 현탁정제 조성물
SI21912A (sl) * 2004-12-24 2006-06-30 Lek Farmacevtska Druzba D.D. Stabilne farmacevtske oblike, ki vsebujejo amoksicilin in klavulansko kislino
DE102006007830A1 (de) * 2006-02-17 2007-08-30 Grünenthal GmbH Lagerstabile orale Darreichungsform von Amoxicillin und Clavulansäure
CN100464750C (zh) * 2006-02-23 2009-03-04 珠海联邦制药股份有限公司 一种制备含阿莫西林钠和克拉维酸钾的药物混合物的方法
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
FI20070521A7 (fi) 2006-11-10 2008-05-11 Atacama Labs Oy Rakeita, tabletteja ja rakeistusmenetelmä
FI20080352A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi korkean lääkepitoisuuden tabletin valmistamiseksi
FI20080351A0 (fi) * 2008-05-09 2008-05-09 Atacama Labs Oy Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi
WO2009135946A1 (en) 2008-05-09 2009-11-12 Atacama Labs Oy Method and apparatus for dry granulation
CN102861015B (zh) * 2011-07-05 2015-07-08 北京乐维生物技术有限公司 一种稳定的阿莫西林克拉维酸钾缓释制剂及其制备工艺
WO2014065769A1 (en) * 2012-10-22 2014-05-01 Bilgiç Mahmut Formulations for oral suspensions comprising antibiotics
CN105555261B (zh) * 2013-09-20 2020-02-11 灿盛制药有限公司荷兰公司 包含交聚维酮的片剂
US9254261B2 (en) * 2014-03-03 2016-02-09 Sandoz Ag Stable quick dissolving dosage form comprising amoxicillin and clavulanic acid
KR102002906B1 (ko) * 2016-10-18 2019-07-23 경동제약 주식회사 셀레콕시브를 포함하는 정제
CN114072493A (zh) 2019-07-05 2022-02-18 葛兰素史密斯克莱知识产权（第2 号）有限公司 棒状链霉菌
CN113274357B (zh) * 2021-05-28 2022-12-27 广州白云山医药集团股份有限公司白云山制药总厂 一种阿莫西林药物及其制备方法
CN114869884A (zh) * 2021-07-30 2022-08-09 江苏恒丰强生物技术有限公司 一种用于猪呼吸道疾病的复方阿莫西林粉及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019227A2 (en) * 1991-05-08 1992-11-12 Laboratorios Beecham Sa Pharmaceutical formulations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) * 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4140764A (en) * 1974-12-18 1979-02-20 Beecham Group Limited β-Lactamase inhibitors and process for their preparation
JO984B1 (en) * 1977-10-11 1979-12-01 بيتشام غروب ليمتد A dry pharmaceutical compound with a suitable dosage unit for oral administration
NZ198241A (en) * 1980-09-27 1983-12-16 Beecham Group Ltd Tablet containing amoxycillin and potassium clavulanate
AU5863894A (en) * 1993-01-22 1994-08-15 Smithkline Beecham Plc Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
IL109770A0 (en) * 1993-05-29 1994-11-28 Smithkline Beecham Corp Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby
GB9402203D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Pharmaceutical formulation
GB9405856D0 (en) * 1994-03-24 1994-05-11 Smithkline Beecham Plc Pharmaceutical formulation
GB9407386D0 (en) * 1994-04-14 1994-06-08 Smithkline Beecham Plc Pharmaceutical formulation
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
DZ1926A1 (fr) * 1994-09-03 2002-02-17 Smithkline Beckman P L C Formulations pharmaceutiques.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992019227A2 (en) * 1991-05-08 1992-11-12 Laboratorios Beecham Sa Pharmaceutical formulations

Also Published As

Publication number Publication date
NO993887D0 (no) 1999-08-12
WO1998035672A1 (en) 1998-08-20
EP0975342B1 (en) 2003-06-25
EP0975342A1 (en) 2000-02-02
CN1251990A (zh) 2000-05-03
ID23673A (id) 2000-05-11
EP1142574A1 (en) 2001-10-10
ES2201468T3 (es) 2004-03-16
MA24473A1 (fr) 1998-10-01
IL131201A0 (en) 2001-01-28
EA199900647A1 (ru) 2000-06-26
CN1194687C (zh) 2005-03-30
BR9807383A (pt) 2000-03-14
JP2001512451A (ja) 2001-08-21
ATE243516T1 (de) 2003-07-15
NZ337043A (en) 2001-02-23
NO993887L (no) 1999-08-12
AU6719698A (en) 1998-09-08
HK1043041A1 (en) 2002-09-06
OA11087A (en) 2003-03-13
TR199901961T2 (xx) 1999-11-22
DE69815833T2 (de) 2004-05-19
DZ2420A1 (fr) 2003-01-04
SK110299A3 (en) 2000-08-14
DE69815833D1 (de) 2003-07-31
AU728526B2 (en) 2001-01-11
AP9901623A0 (en) 1999-09-30
BG103664A (en) 2000-03-31
EA002595B1 (ru) 2002-06-27
AP1253A (en) 2004-03-17
KR20000071076A (ko) 2000-11-25
CA2280857A1 (en) 1998-08-20
PL334976A1 (en) 2000-03-27
IL131201A (en) 2005-06-19

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St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000