KR100440645B1 - 결합조직부착의치료및치유를위한방법및조성물 - Google Patents

결합조직부착의치료및치유를위한방법및조성물 Download PDF

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KR100440645B1
KR100440645B1 KR1019970708278A KR19970708278A KR100440645B1 KR 100440645 B1 KR100440645 B1 KR 100440645B1 KR 1019970708278 A KR1019970708278 A KR 1019970708278A KR 19970708278 A KR19970708278 A KR 19970708278A KR 100440645 B1 KR100440645 B1 KR 100440645B1
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South Korea
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bmp
bone
tendon
connective tissue
methods
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Expired - Lifetime
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KR1019970708278A
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Korean (ko)
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KR19990014932A (ko
Inventor
존 엠 우즈니
러셀 에프 워렌
스콧 에이 로데오
조 에이 하나핀
Original Assignee
뉴욕 쏘사이어티 포 더 릴리프 어브 더 럽쳐드 앤드 크리플드 메인테이닝 더 하스피틀 포 스페셜 설져리
제네틱스 인스티튜트, 엘엘씨
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Application filed by 뉴욕 쏘사이어티 포 더 릴리프 어브 더 럽쳐드 앤드 크리플드 메인테이닝 더 하스피틀 포 스페셜 설져리, 제네틱스 인스티튜트, 엘엘씨 filed Critical 뉴욕 쏘사이어티 포 더 릴리프 어브 더 럽쳐드 앤드 크리플드 메인테이닝 더 하스피틀 포 스페셜 설져리
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Dental Preparations (AREA)
KR1019970708278A 1995-06-05 1996-05-21 결합조직부착의치료및치유를위한방법및조성물 Expired - Lifetime KR100440645B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46249795A 1995-06-05 1995-06-05
US08/462497 1995-06-05
US8/462,497 1995-06-05

Publications (2)

Publication Number Publication Date
KR19990014932A KR19990014932A (ko) 1999-02-25
KR100440645B1 true KR100440645B1 (ko) 2004-09-18

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KR1019970708278A Expired - Lifetime KR100440645B1 (ko) 1995-06-05 1996-05-21 결합조직부착의치료및치유를위한방법및조성물

Country Status (17)

Country Link
US (1) US6187742B1 (enExample)
EP (3) EP1364656B1 (enExample)
JP (1) JPH11507032A (enExample)
KR (1) KR100440645B1 (enExample)
CN (1) CN1133462C (enExample)
AT (1) ATE245996T1 (enExample)
AU (1) AU699918B2 (enExample)
CA (1) CA2220555C (enExample)
DE (1) DE69629294T2 (enExample)
DK (2) DK1364656T3 (enExample)
ES (2) ES2203701T3 (enExample)
FI (1) FI116511B (enExample)
HU (1) HU222664B1 (enExample)
OA (1) OA10547A (enExample)
PT (1) PT831884E (enExample)
TW (1) TW449478B (enExample)
WO (1) WO1996039169A1 (enExample)

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EP1364656A2 (en) 2003-11-26
EP1364656A3 (en) 2003-12-10
FI116511B (fi) 2005-12-15
US6187742B1 (en) 2001-02-13
KR19990014932A (ko) 1999-02-25
HU222664B1 (hu) 2003-09-29
ES2203701T3 (es) 2004-04-16
ATE245996T1 (de) 2003-08-15
PT831884E (pt) 2003-11-28
EP1364656B1 (en) 2013-11-20
FI974395A0 (fi) 1997-12-02
DK1364656T3 (da) 2013-12-16
AU699918B2 (en) 1998-12-17
HK1017841A1 (en) 1999-12-03
TW449478B (en) 2001-08-11
FI974395L (fi) 1997-12-02
ES2440441T3 (es) 2014-01-29
EP2289536A1 (en) 2011-03-02
AU5923496A (en) 1996-12-24
CN1186438A (zh) 1998-07-01
EP0831884B1 (en) 2003-07-30
DE69629294T2 (de) 2004-04-29
CA2220555C (en) 2011-07-19
DE69629294D1 (de) 2003-09-04
HUP9802556A1 (hu) 1999-03-29
JPH11507032A (ja) 1999-06-22
EP0831884A1 (en) 1998-04-01
DK0831884T3 (da) 2003-11-03
WO1996039169A1 (en) 1996-12-12
OA10547A (en) 2002-05-31
HUP9802556A3 (en) 1999-04-28
CA2220555A1 (en) 1996-12-12
CN1133462C (zh) 2004-01-07

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