KR100371062B1 - 안정성이향상된주사가능한택솔조성물및이를제형화하는방법 - Google Patents

안정성이향상된주사가능한택솔조성물및이를제형화하는방법 Download PDF

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Publication number
KR100371062B1
KR100371062B1 KR1019940702575A KR19940702575A KR100371062B1 KR 100371062 B1 KR100371062 B1 KR 100371062B1 KR 1019940702575 A KR1019940702575 A KR 1019940702575A KR 19940702575 A KR19940702575 A KR 19940702575A KR 100371062 B1 KR100371062 B1 KR 100371062B1
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KR
South Korea
Prior art keywords
solution
acid
taxol
injectable
ethanol
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Expired - Fee Related
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KR1019940702575A
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English (en)
Korean (ko)
Inventor
로빈 루이스 엘리오트
그레고리 포울 핸드렉크
데이비드 카르베르
티모시 프로우트
헤르니타 에왈드
Original Assignee
에프.에이치.포울딩 앤드 컴퍼니 리미티드
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Publication of KR100371062B1 publication Critical patent/KR100371062B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019940702575A 1992-11-27 1993-11-25 안정성이향상된주사가능한택솔조성물및이를제형화하는방법 Expired - Fee Related KR100371062B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPL6074 1992-11-27
AUPL607492 1992-11-27

Publications (1)

Publication Number Publication Date
KR100371062B1 true KR100371062B1 (ko) 2003-04-21

Family

ID=3776561

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702575A Expired - Fee Related KR100371062B1 (ko) 1992-11-27 1993-11-25 안정성이향상된주사가능한택솔조성물및이를제형화하는방법

Country Status (8)

Country Link
KR (1) KR100371062B1 (enrdf_load_stackoverflow)
CN (2) CN1096673A (enrdf_load_stackoverflow)
AU (1) AU5553894A (enrdf_load_stackoverflow)
IL (2) IL107776A0 (enrdf_load_stackoverflow)
IN (1) IN176188B (enrdf_load_stackoverflow)
NZ (1) NZ258044A (enrdf_load_stackoverflow)
WO (1) WO1994012198A1 (enrdf_load_stackoverflow)
ZA (1) ZA938844B (enrdf_load_stackoverflow)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2149150C (en) * 1992-11-27 2000-08-01 David R. Carver Injectable taxol composition with improved stability
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
FR2710534B1 (fr) * 1994-09-28 1996-07-05 Bristol Myers Squibb Co Solvant de stabilisation, composition pharmaceutique le contenant, et son procédé de préparation.
NL9500340A (nl) * 1995-02-22 1996-10-01 Yew Tree Pharmaceuticals B V Gestabiliseerde paclitaxel-oplossing en farmaceutisch preparaat dat deze oplossing bevat.
US5686488A (en) * 1995-08-25 1997-11-11 Alcon Laboratories, Inc. Polyethoxylated castor oil products as anti-inflammatory agents
DE19536165A1 (de) * 1995-09-28 1997-04-03 Basf Ag Verfahren zur Reinigung von alkoxylierten Fetten
EP0876145A4 (en) * 1995-12-21 1999-04-21 Genelabs Tech Inc TAX COMPOSITION AND PROCEDURE
KR100191446B1 (ko) * 1996-05-02 1999-06-15 송영욱 파클리탁셀 함유 전신성 홍반성 낭창치료제
KR100330373B1 (ko) * 1996-05-28 2002-11-07 주식회사한국신약 탁솔을 함유한 주사용 약제 조성물
KR100358934B1 (ko) * 1996-09-13 2003-01-29 주식회사한국신약 탁솔을함유한주사용약제조성물
US6045808A (en) * 1997-01-31 2000-04-04 Pharmacia & Upjohn Company Method for removing high boiling solvents from drug formulations by vacuum drying
CN1101677C (zh) * 1997-05-30 2003-02-19 韩万愚 含有紫杉醇的药用注射溶液
ATE226070T1 (de) * 1997-05-30 2002-11-15 Man Woo Han Taxol enthaltende pharmazeutische injektionslösung
BE1011216A3 (fr) * 1997-06-13 1999-06-01 Thissen En Abrege L T B Lab Forme pharmaceutique pour l'administration de paclitaxel, procede de preparation d'une composition de paclitaxel prete a l'emploi et utilisation de cette composition.
US6071952A (en) * 1998-12-02 2000-06-06 Mylan Pharmaceuticals, Inc. Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents
AU2002239282A1 (en) 2000-11-28 2002-06-11 Transform Pharmaceuticals, Inc. Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
KR100774366B1 (ko) * 2001-09-10 2007-11-08 주식회사 중외제약 파클리탁셀 주사제 조성물
CZ294371B6 (cs) * 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
HUE031505T2 (en) * 2002-06-26 2017-07-28 Syncore Biotechnology Co Ltd A method of producing a cationic liposomal composition comprising a lipophilic compound
EP2308467A3 (en) * 2005-06-17 2011-06-22 Hospira Australia Pty Ltd Liquid pharmaceutical formulations of docetaxel
DK3311805T3 (da) 2005-08-31 2020-04-14 Abraxis Bioscience Llc Sammensætninger, der omfatter svært vandopløselige farmaceutiske midler og antimikrobielle midler
CN101396354B (zh) * 2007-09-30 2010-12-01 江苏恒瑞医药股份有限公司 一种稳定的塔三烷类化合物液体组合物及其制备方法和其应用
CN101829051B (zh) * 2010-05-31 2012-09-12 南昌弘益科技有限公司 1’-乙酰氧基胡椒酚乙酸酯注射液
CN103432109B (zh) * 2013-09-01 2015-09-23 吴静 紫杉醇的药物组合物
US10561766B2 (en) 2015-09-15 2020-02-18 W. L. Gore & Associates, Inc. Drug composition and coating

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
NZ224497A (en) * 1987-05-18 1990-04-26 Janssen Pharmaceutica Nv Pharmaceutical composition comprising flunarizine
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
TW223634B (enrdf_load_stackoverflow) * 1991-03-18 1994-05-11 Kingston David G I
EP0580759B1 (en) * 1991-04-19 1999-05-26 The University Of Mississippi Methods and compositions for isolating taxanes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer Treat. Rep 71 (12) 1179-1184, 1987. *
J. Microencapsulation (1990), 7(2), 191-197 *

Also Published As

Publication number Publication date
ZA938844B (en) 1994-08-02
AU5553894A (en) 1994-06-22
IL126178A0 (en) 1999-05-09
NZ258044A (en) 1995-12-21
WO1994012198A1 (en) 1994-06-09
AU667142B2 (en) 1996-03-07
IL107776A0 (en) 1994-02-27
CN1096673A (zh) 1994-12-28
CN1095266A (zh) 1994-11-23
AU5196793A (en) 1994-06-09
CN1047305C (zh) 1999-12-15
IN176188B (enrdf_load_stackoverflow) 1996-02-24

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