KR100254746B1 - 미세입자,그의 제조 방법 및 진단에의 그의 이용 - Google Patents

미세입자,그의 제조 방법 및 진단에의 그의 이용

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Publication number
KR100254746B1
KR100254746B1 KR1019940704526A KR19940704526A KR100254746B1 KR 100254746 B1 KR100254746 B1 KR 100254746B1 KR 1019940704526 A KR1019940704526 A KR 1019940704526A KR 19940704526 A KR19940704526 A KR 19940704526A KR 100254746 B1 KR100254746 B1 KR 100254746B1
Authority
KR
South Korea
Prior art keywords
fine particles
medium
optionally
water
ultrasonic contrast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019940704526A
Other languages
English (en)
Korean (ko)
Other versions
KR950701823A (ko
Inventor
미카엘 슈타인
베르너 바이트쉬스
토마스 프리쯔쉬
디터 헬트만
요아힘 지게르트
폴크마르 울렌도르프
에스터 하마커
프랑크 뤼더스
Original Assignee
에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만
쉐링 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6461144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100254746(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만, 쉐링 악티엔게젤샤프트 filed Critical 에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만
Publication of KR950701823A publication Critical patent/KR950701823A/ko
Application granted granted Critical
Publication of KR100254746B1 publication Critical patent/KR100254746B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
KR1019940704526A 1992-06-13 1993-06-05 미세입자,그의 제조 방법 및 진단에의 그의 이용 Expired - Fee Related KR100254746B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4219723.6 1992-06-13
DE4219723A DE4219723A1 (de) 1992-06-13 1992-06-13 Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
PCT/EP1993/001425 WO1993025242A1 (de) 1992-06-13 1993-06-05 Mikropartikel, verfahren zu deren herstellung, sowie die verwendung dieser in der diagnostik

Publications (2)

Publication Number Publication Date
KR950701823A KR950701823A (ko) 1995-05-17
KR100254746B1 true KR100254746B1 (ko) 2000-08-01

Family

ID=6461144

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940704526A Expired - Fee Related KR100254746B1 (ko) 1992-06-13 1993-06-05 미세입자,그의 제조 방법 및 진단에의 그의 이용

Country Status (18)

Country Link
EP (1) EP0644777B2 (https=)
JP (1) JPH07507780A (https=)
KR (1) KR100254746B1 (https=)
CN (1) CN1064851C (https=)
AT (1) ATE163134T1 (https=)
AU (1) AU686103B2 (https=)
CA (1) CA2138010A1 (https=)
DE (2) DE4219723A1 (https=)
DK (1) DK0644777T4 (https=)
ES (1) ES2115060T5 (https=)
FI (1) FI945837A7 (https=)
GR (1) GR3026498T3 (https=)
HU (1) HU217121B (https=)
IL (1) IL105891A (https=)
NO (1) NO307646B1 (https=)
NZ (1) NZ253115A (https=)
TW (1) TW239079B (https=)
WO (1) WO1993025242A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (https=) 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
NZ244147A (en) † 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
DE19508049C2 (de) * 1995-02-23 1997-02-06 Schering Ag Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln
DE19510690A1 (de) 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
IL126073A (en) * 1996-03-05 2002-02-10 Acusphere Inc Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
GB9800813D0 (en) 1998-01-16 1998-03-11 Andaris Ltd Improved ultrasound contrast imaging method and apparatus
DE19925311B4 (de) * 1999-05-27 2004-06-09 Schering Ag Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln
DE10013850A1 (de) * 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
DE58908194D1 (de) * 1988-02-05 1994-09-22 Schering Ag Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika.
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
NZ244147A (en) * 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents

Also Published As

Publication number Publication date
DK0644777T4 (da) 2004-02-23
NO944805L (no) 1994-12-12
ES2115060T5 (es) 2004-06-16
EP0644777B2 (de) 2003-10-15
NO307646B1 (no) 2000-05-08
FI945837A0 (fi) 1994-12-12
IL105891A0 (en) 1993-10-20
EP0644777A1 (de) 1995-03-29
CA2138010A1 (en) 1993-12-23
DE59308146D1 (de) 1998-03-19
ES2115060T3 (es) 1998-06-16
FI945837L (fi) 1994-12-12
IL105891A (en) 1998-10-30
AU686103B2 (en) 1998-02-05
ATE163134T1 (de) 1998-02-15
DK0644777T3 (da) 1998-09-23
WO1993025242A1 (de) 1993-12-23
GR3026498T3 (en) 1998-07-31
CN1082924A (zh) 1994-03-02
DE4219723A1 (de) 1993-12-16
TW239079B (https=) 1995-01-21
KR950701823A (ko) 1995-05-17
JPH07507780A (ja) 1995-08-31
FI945837A7 (fi) 1994-12-12
NZ253115A (en) 1996-01-26
CN1064851C (zh) 2001-04-25
EP0644777B1 (de) 1998-02-11
HU217121B (hu) 1999-11-29
AU4323293A (en) 1994-01-04
HU9403566D0 (en) 1995-02-28
HUT69380A (en) 1995-09-28
NO944805D0 (no) 1994-12-12

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