JPH07507780A - 微粒子，その製法並びにその診断学における使用 - Google Patents

微粒子，その製法並びにその診断学における使用

Info

Publication number
JPH07507780A
JPH07507780A JP6501098A JP50109894A JPH07507780A JP H07507780 A JPH07507780 A JP H07507780A JP 6501098 A JP6501098 A JP 6501098A JP 50109894 A JP50109894 A JP 50109894A JP H07507780 A JPH07507780 A JP H07507780A
Authority
JP
Japan
Prior art keywords
fine particles
contrast agent
water
gas
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP6501098A
Other languages
English (en)
Japanese (ja)
Inventor
シュタイン，ミヒャエル
ヴァイトシィース，ヴェルナー
フリッチュ，トーマス
ヘルトマン，ディーター
ジーゲルト，ヨアヒム
ウーレンドルフ，フォルクマール
ハーマヒャー，エシュター
リューダース，フランク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6461144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH07507780(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Publication of JPH07507780A publication Critical patent/JPH07507780A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
JP6501098A 1992-06-13 1993-06-05 微粒子，その製法並びにその診断学における使用 Ceased JPH07507780A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4219723A DE4219723A1 (de) 1992-06-13 1992-06-13 Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
DE4219723.6 1992-06-13
PCT/EP1993/001425 WO1993025242A1 (de) 1992-06-13 1993-06-05 Mikropartikel, verfahren zu deren herstellung, sowie die verwendung dieser in der diagnostik

Publications (1)

Publication Number Publication Date
JPH07507780A true JPH07507780A (ja) 1995-08-31

Family

ID=6461144

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6501098A Ceased JPH07507780A (ja) 1992-06-13 1993-06-05 微粒子，その製法並びにその診断学における使用

Country Status (18)

Country Link
EP (1) EP0644777B2 (https=)
JP (1) JPH07507780A (https=)
KR (1) KR100254746B1 (https=)
CN (1) CN1064851C (https=)
AT (1) ATE163134T1 (https=)
AU (1) AU686103B2 (https=)
CA (1) CA2138010A1 (https=)
DE (2) DE4219723A1 (https=)
DK (1) DK0644777T4 (https=)
ES (1) ES2115060T5 (https=)
FI (1) FI945837A7 (https=)
GR (1) GR3026498T3 (https=)
HU (1) HU217121B (https=)
IL (1) IL105891A (https=)
NO (1) NO307646B1 (https=)
NZ (1) NZ253115A (https=)
TW (1) TW239079B (https=)
WO (1) WO1993025242A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (https=) 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
NZ244147A (en) † 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
GB9318288D0 (en) * 1993-09-03 1993-10-20 Nycomed Imaging As Improvements in or relating to contrast agents
GB9417941D0 (en) * 1994-09-06 1994-10-26 Nycomed Imaging As Improvements in or relating to contrast agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
DE19508049C2 (de) * 1995-02-23 1997-02-06 Schering Ag Verwendung von Methylenmalondiesterderivaten zur Herstellung von gasenthaltenden Mikropartikeln
DE19510690A1 (de) 1995-03-14 1996-09-19 Schering Ag Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
IL126073A (en) * 1996-03-05 2002-02-10 Acusphere Inc Microencapsulated fluorinated gases for use as imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
GB9800813D0 (en) 1998-01-16 1998-03-11 Andaris Ltd Improved ultrasound contrast imaging method and apparatus
DE19925311B4 (de) * 1999-05-27 2004-06-09 Schering Ag Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln
DE10013850A1 (de) * 2000-03-15 2001-09-20 Schering Ag Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
DE58908194D1 (de) * 1988-02-05 1994-09-22 Schering Ag Ultraschallkontrastmittel, verfahren zu deren herstellung und deren verwendung als diagnostika und therapeutika.
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
NZ244147A (en) * 1991-09-03 1994-09-27 Hoechst Ag Echogenic particles which comprise a gas and at least one shaping substance, and their use as diagnostic agents

Also Published As

Publication number Publication date
DK0644777T4 (da) 2004-02-23
NO944805L (no) 1994-12-12
ES2115060T5 (es) 2004-06-16
EP0644777B2 (de) 2003-10-15
NO307646B1 (no) 2000-05-08
FI945837A0 (fi) 1994-12-12
IL105891A0 (en) 1993-10-20
EP0644777A1 (de) 1995-03-29
CA2138010A1 (en) 1993-12-23
KR100254746B1 (ko) 2000-08-01
DE59308146D1 (de) 1998-03-19
ES2115060T3 (es) 1998-06-16
FI945837L (fi) 1994-12-12
IL105891A (en) 1998-10-30
AU686103B2 (en) 1998-02-05
ATE163134T1 (de) 1998-02-15
DK0644777T3 (da) 1998-09-23
WO1993025242A1 (de) 1993-12-23
GR3026498T3 (en) 1998-07-31
CN1082924A (zh) 1994-03-02
DE4219723A1 (de) 1993-12-16
TW239079B (https=) 1995-01-21
KR950701823A (ko) 1995-05-17
FI945837A7 (fi) 1994-12-12
NZ253115A (en) 1996-01-26
CN1064851C (zh) 2001-04-25
EP0644777B1 (de) 1998-02-11
HU217121B (hu) 1999-11-29
AU4323293A (en) 1994-01-04
HU9403566D0 (en) 1995-02-28
HUT69380A (en) 1995-09-28
NO944805D0 (no) 1994-12-12

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Legal Events

Date Code Title Description
A313 Final decision of rejection without a dissenting response from the applicant

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Effective date: 20040120

A02 Decision of refusal

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Effective date: 20040210