KR100245654B1 - Attenuated, genetically engineered pseudorabies virus s-prv-155 and uses thereof - Google Patents
Attenuated, genetically engineered pseudorabies virus s-prv-155 and uses thereof Download PDFInfo
- Publication number
- KR100245654B1 KR100245654B1 KR1019930702619A KR930702619A KR100245654B1 KR 100245654 B1 KR100245654 B1 KR 100245654B1 KR 1019930702619 A KR1019930702619 A KR 1019930702619A KR 930702619 A KR930702619 A KR 930702619A KR 100245654 B1 KR100245654 B1 KR 100245654B1
- Authority
- KR
- South Korea
- Prior art keywords
- pseudorabies virus
- attenuated
- animal
- prv
- vaccine
- Prior art date
Links
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 title abstract 4
- 230000002238 attenuated effect Effects 0.000 title abstract 2
- 230000003053 immunization Effects 0.000 abstract 3
- 229960005486 vaccine Drugs 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/815—Viral vaccine for porcine species, e.g. swine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/663,413 US5240703A (en) | 1991-03-01 | 1991-03-01 | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
PCT/US1992/001634 WO1992015328A1 (en) | 1991-03-01 | 1992-02-28 | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
KR100245654B1 true KR100245654B1 (en) | 2000-03-02 |
Family
ID=24661700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019930702619A KR100245654B1 (en) | 1991-03-01 | 1993-09-01 | Attenuated, genetically engineered pseudorabies virus s-prv-155 and uses thereof |
Country Status (12)
Country | Link |
---|---|
US (3) | US5240703A (ko) |
EP (1) | EP0573614B1 (ko) |
JP (1) | JP3247376B2 (ko) |
KR (1) | KR100245654B1 (ko) |
AT (1) | ATE165978T1 (ko) |
AU (1) | AU1573292A (ko) |
DE (1) | DE69225471T2 (ko) |
DK (1) | DK0573614T3 (ko) |
ES (1) | ES2118815T3 (ko) |
GR (1) | GR3027623T3 (ko) |
HU (1) | HUT67138A (ko) |
WO (1) | WO1992015328A1 (ko) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5965138A (en) * | 1985-09-06 | 1999-10-12 | Syntro Corporation | Recombinant chimeric virus and uses thereof |
US5961982A (en) * | 1985-09-06 | 1999-10-05 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
US5928648A (en) * | 1985-09-06 | 1999-07-27 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
US5240703A (en) * | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
US5853733A (en) * | 1993-02-26 | 1998-12-29 | Syntro Corporation | Recombinant herpesvirus of turkeys and uses thereof |
DE69333751T2 (de) * | 1992-07-30 | 2005-12-29 | Akzo Nobel N.V. | Nicht-verbreitendes lebendes herpesvirusvakzin |
EP0619840A1 (en) * | 1992-10-06 | 1994-10-19 | Akzo Nobel N.V. | Pseudorabies virus vaccine |
US5738854A (en) * | 1992-10-06 | 1998-04-14 | Akzo Nobel N.V. | Pseudorabies virus vaccine |
US6875856B2 (en) * | 1993-09-24 | 2005-04-05 | Syntro Corporation | Recombinant infectious laryngotracheitis virus and uses thereof |
EP0659885A1 (en) * | 1993-12-21 | 1995-06-28 | Akzo Nobel N.V. | Vaccine against viruses associated with antibody-dependent-enhancement of viral infectivity |
US7153510B1 (en) * | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
DE69510207T3 (de) * | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
IL138075A0 (en) | 1998-02-27 | 2001-10-31 | Univ Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
EP1168918A4 (en) * | 1999-03-03 | 2002-08-21 | Univ Pennsylvania | VACCINE AND GENE THERAPY COMPOSITIONS AND METHOD FOR THEIR PRODUCTION AND USE |
JP2002542800A (ja) * | 1999-04-30 | 2002-12-17 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 変異体ヒトcd80および組成物およびその作製および使用法 |
DE60134408D1 (de) * | 2000-07-14 | 2008-07-24 | Univ Pennsylvania | Für akzessorische hiv proteine kodierende dna impfstoffe |
JP2004510714A (ja) * | 2000-10-04 | 2004-04-08 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア | フラビウイルス及びペスチウイルス由来のキャプシド蛋白質を使用する組成物及び方法 |
EP1390802A1 (en) * | 2001-04-27 | 2004-02-25 | Novartis AG | Automatic lens design and manufacturing system |
US8216585B2 (en) * | 2001-05-25 | 2012-07-10 | The Trustees Of The University Of Pennsylvania | Targeted particles and methods of using the same |
US7205398B2 (en) | 2002-05-24 | 2007-04-17 | Schering-Plough Animal Health Corporation | Eta-1 gene and methods for use |
NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
WO2004112706A2 (en) | 2003-06-13 | 2004-12-29 | The Trustees Of The University Of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
EP1664786B1 (en) * | 2003-09-09 | 2014-11-12 | Idexx Laboratories, Inc. | Detection of west nile virus infection and vaccination |
WO2007050095A2 (en) | 2004-11-19 | 2007-05-03 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
KR101421745B1 (ko) * | 2006-01-13 | 2014-07-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 코돈 최적화된 il―15를 사용하는 백신 및 면역치료제, 및 그의 사용 방법 |
WO2007082105A2 (en) | 2006-01-16 | 2007-07-19 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chlamydia vaccine |
CN105063064A (zh) | 2006-07-28 | 2015-11-18 | 宾夕法尼亚大学托管会 | 改进的疫苗及其使用方法 |
CA2720168C (en) | 2008-04-04 | 2024-04-30 | David B. Weiner | Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same |
US8852609B2 (en) * | 2008-04-04 | 2014-10-07 | The Trustees Of The University Of Pennsylvania | Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same |
WO2010050939A1 (en) | 2008-10-29 | 2010-05-06 | The Trustees Of The University Of Pennsylvania | Improved hcv vaccines and methods for using the same |
US8921536B2 (en) | 2008-10-29 | 2014-12-30 | The Trustees Of The University Of Pennsylvania | HCV vaccines and methods for using the same |
CA2653478A1 (en) * | 2009-01-23 | 2010-07-23 | Gregg Martin | Automated wash system for industrial vehicles |
US9050287B2 (en) | 2009-01-23 | 2015-06-09 | The Trustees Of The University Of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
KR20120093163A (ko) | 2009-09-14 | 2012-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Il-15 수용체 알파 및/또는 이를 인코딩하는 핵산 분자를 포함하는 백신 및 면역 치료제, 및 이를 이용하는 방법 |
KR102138780B1 (ko) | 2009-11-02 | 2020-07-29 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 구제역 바이러스(fmdv) 공통 단백질, 이를 위한 코딩 서열 및 이로부터 만들어진 백신 |
US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
KR101784177B1 (ko) | 2010-02-08 | 2017-10-11 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Rantes를 암호화하는 핵산 분자, 그리고 이를 포함하는 조성물 및 이의 사용 방법 |
AU2011325893B2 (en) | 2010-11-12 | 2016-01-14 | Inovio Pharmaceuticals, Inc | Consensus prostate antigens nucleic acid molecule encoding the same and vaccine and uses comprising the same |
JP6099573B2 (ja) | 2011-01-31 | 2017-03-22 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 新規なヘルペス抗原をコードする核酸分子、それを含むワクチン及びその使用方法 |
US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
PT2672992T (pt) | 2011-02-11 | 2020-07-27 | Univ Pennsylvania | Molécula de ácidos nucleicos codificando proteína nuclear do vírus da hepatite b e vacina compreendendo a mesma |
CA2841852C (en) | 2011-07-11 | 2020-06-30 | Inovio Pharmaceuticals, Inc. | Cross-protective arenavirus vaccines and their method of use |
EP3443982A1 (en) | 2011-10-12 | 2019-02-20 | The Trustees of the University of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
KR101679731B1 (ko) | 2011-10-24 | 2016-11-25 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 hcv 백신 및 이것을 사용하는 방법 |
EP3336096A1 (en) | 2011-12-12 | 2018-06-20 | The Trustees Of The University Of Pennsylvania | Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same |
US9750795B2 (en) | 2011-12-12 | 2017-09-05 | The Trustees Of The University Of Pennsylvania | Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections |
CN104619719A (zh) | 2012-04-10 | 2015-05-13 | 宾夕法尼亚大学理事会 | 人呼吸道合胞病毒共有抗原、由其制备的核酸构建体和疫苗及其使用方法 |
EA034056B1 (ru) | 2013-03-12 | 2019-12-23 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Усовершенствованные вакцины против вируса папилломы человека и способы их применения |
EA034110B1 (ru) | 2013-03-15 | 2019-12-27 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Противораковые вакцины и способы лечения с их применением |
KR20210088754A (ko) | 2013-03-15 | 2021-07-14 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 구제역 바이러스 (fmdv) 공통 단백질, 그에 대한 코딩 서열 및 그로부터 제조된 백신 |
EP2985288B1 (en) * | 2013-05-31 | 2019-11-13 | Pulike Biological Engineering, Inc. | Porcine pseudorabies virus, vaccine composition and preparation method and use thereof |
CN105087506B (zh) * | 2015-03-20 | 2020-06-30 | 普莱柯生物工程股份有限公司 | 一种猪伪狂犬病病毒致弱方法、及其致弱的病毒株、疫苗组合物和应用 |
CN106834236A (zh) * | 2016-02-23 | 2017-06-13 | 南京农业大学 | 猪伪狂犬病毒变异株TK、gE和gI基因缺失毒株及其应用 |
CN107815441B (zh) * | 2017-08-31 | 2020-05-12 | 浙江大学 | 一种ⅱ型伪狂犬病毒减毒株及其制备方法和应用 |
AU2018383658B2 (en) | 2017-12-13 | 2022-02-10 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
EP3737397B1 (en) | 2017-12-13 | 2022-11-30 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting prame and uses thereof |
EP3723812A4 (en) | 2017-12-13 | 2022-02-16 | Inovio Pharmaceuticals, Inc. | MUC16-TARGETING CANCER VACCINES AND THEIR USES |
MX2021005257A (es) * | 2018-11-06 | 2021-06-18 | Boehringer Ingelheim Vetmedica Gmbh | Composicion inmunogenica contra el subtipo h5 del virus de la influenza aviar. |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4769331A (en) * | 1981-09-16 | 1988-09-06 | University Patents, Inc. | Recombinant methods and materials |
NL8303501A (nl) * | 1983-10-12 | 1985-05-01 | Centraal Diergeneeskundig Inst | Deletiemutant van een herpesvirus en vaccin, dat dit virus bevat. |
US4514497B1 (en) * | 1983-12-30 | 1998-02-24 | Novagene Inc | Modified live pseudorabies viruses |
EP0162738A1 (en) * | 1984-04-09 | 1985-11-27 | MOLECULAR GENETICS RESEARCH & DEVELOPMENT LIMITED PARTNERSHIP | Production of pseudorabies virus subunit vaccines |
US5041370A (en) * | 1984-05-02 | 1991-08-20 | The Upjohn Company | Pseudorabies virus (PRV) gene, host cell, method for detecting animals infected with pseudorabies virus, and kit therefor |
US5041536A (en) * | 1984-05-02 | 1991-08-20 | The Upjohn Company | Pseudorabies virus (PRV) gene |
JP2559384B2 (ja) * | 1985-07-29 | 1996-12-04 | ジ・アップジョン・カンパニ− | ウイルスワクチン |
US5047237A (en) * | 1985-09-06 | 1991-09-10 | Prutech Research And Development Partnership | Attenuated pseudorabies virus having a deletion of at least a portion of a gene encoding an antigenic, nonessential protein, vaccine containing same and methods of identifying animals vaccinated with the vaccine |
US4877737A (en) * | 1985-09-06 | 1989-10-31 | Prutech Research And Development Partnership | Attenuated pseudorabies virus which has a deletion in at least a portion of a repeat sequence and vaccine containing same |
US5068192A (en) * | 1986-01-27 | 1991-11-26 | Prutech Research And Development Partnership | Attenuated pseudorabies virus which includes foreign DNA encoding an amino acid sequence |
WO1987004463A1 (en) * | 1986-01-27 | 1987-07-30 | Syntro Corporation | Attenuated herpesviruses, herpesviruses which include foreign dna encoding an amino acid sequence and vaccine containing same |
US4711850A (en) * | 1986-01-28 | 1987-12-08 | Novagene, Inc. | Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same |
US4753884A (en) * | 1986-01-28 | 1988-06-28 | Novagene, Inc. | Pseudorabies virus mutants, vaccines containing same, methods for the production of same and methods for the use of same |
US4999296A (en) * | 1986-04-29 | 1991-03-12 | Novagene, Inc. | Thymidine kinase negative insertion mutants of pseudorabies virus and methods for the production of same |
US5037742A (en) * | 1986-07-18 | 1991-08-06 | E. I. Du Pont De Nemours And Company | Pseudorabies virus recombinants and their use in the production of proteins |
JPH02500409A (ja) * | 1987-07-27 | 1990-02-15 | シントロ・コーポレイシヨン | 弱毒化ヘルペスウイルス、アミノ酸配列コード化外来dna含有ヘルペスウイルス並びに同上含有ワクチン |
US5004593A (en) * | 1989-04-17 | 1991-04-02 | Mayo Foundation For Medical Education And Research | Hexamethylmelamine formulation exhibiting reduced neurotoxicity |
US5240703A (en) * | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
-
1991
- 1991-03-01 US US07/663,413 patent/US5240703A/en not_active Expired - Lifetime
-
1992
- 1992-02-28 EP EP19920909287 patent/EP0573614B1/en not_active Expired - Lifetime
- 1992-02-28 HU HU9302369A patent/HUT67138A/hu unknown
- 1992-02-28 JP JP50824092A patent/JP3247376B2/ja not_active Expired - Fee Related
- 1992-02-28 WO PCT/US1992/001634 patent/WO1992015328A1/en active IP Right Grant
- 1992-02-28 ES ES92909287T patent/ES2118815T3/es not_active Expired - Lifetime
- 1992-02-28 DE DE1992625471 patent/DE69225471T2/de not_active Expired - Lifetime
- 1992-02-28 DK DK92909287T patent/DK0573614T3/da active
- 1992-02-28 AT AT92909287T patent/ATE165978T1/de active
- 1992-02-28 AU AU15732/92A patent/AU1573292A/en not_active Abandoned
-
1993
- 1993-04-30 US US08/055,530 patent/US5451499A/en not_active Expired - Lifetime
- 1993-09-01 KR KR1019930702619A patent/KR100245654B1/ko not_active IP Right Cessation
-
1995
- 1995-06-01 US US08/456,509 patent/US5736319A/en not_active Expired - Lifetime
-
1998
- 1998-08-11 GR GR980401801T patent/GR3027623T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06505392A (ja) | 1994-06-23 |
EP0573614B1 (en) | 1998-05-13 |
JP3247376B2 (ja) | 2002-01-15 |
AU1573292A (en) | 1992-10-06 |
WO1992015328A1 (en) | 1992-09-17 |
GR3027623T3 (en) | 1998-11-30 |
DE69225471T2 (de) | 1999-01-14 |
ES2118815T3 (es) | 1998-10-01 |
DE69225471D1 (de) | 1998-06-18 |
US5451499A (en) | 1995-09-19 |
EP0573614A1 (en) | 1993-12-15 |
HU9302369D0 (en) | 1994-01-28 |
EP0573614A4 (en) | 1994-09-14 |
US5736319A (en) | 1998-04-07 |
ATE165978T1 (de) | 1998-05-15 |
HUT67138A (en) | 1995-02-28 |
US5240703A (en) | 1993-08-31 |
DK0573614T3 (da) | 1999-01-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100245654B1 (en) | Attenuated, genetically engineered pseudorabies virus s-prv-155 and uses thereof | |
ZA934736B (en) | Deletion mutants as vaccines for cholera | |
HK32696A (en) | Virus vaccine | |
GR3035135T3 (en) | Poultry vaccine containing infections bronchitis virus serotype 4/91. | |
MX9709868A (es) | Uso de esporfozoitos o merozoitos de eimeria para preparar una vacuna contra la coccidiosis. | |
EP0536302A4 (en) | Improved adjuvants and vaccines | |
HU9202976D0 (en) | Vaccine acting against anaemy of chicken | |
ATE285791T1 (de) | Impfstoff, der acemannan als adjuvans enthält | |
GR3018529T3 (en) | Nematode vaccine. | |
HU9401400D0 (en) | New bacterium causing poultry disease and vaccine derived thereof | |
MY112772A (en) | Canine coronavirus vaccine from feline enteric coronavirus | |
PL301253A1 (en) | Vaccine for prevention of poultry capsule infective diseases, method of administering such vaccine and method of preparing same | |
IE853109L (en) | Vaccines against avian infectious bronchitis | |
EP0244760A3 (en) | Vaccine for the prevention of marek's disease | |
JPS5770823A (en) | Inactivated vaccine for chicken leucocytozoonosis | |
Cochran | Attenuated, genetically-engineered pseudorabies virus S-PRV-155 and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20101029 Year of fee payment: 12 |
|
LAPS | Lapse due to unpaid annual fee |