KR100243981B1 - 결정상태의 에토포사이드 4'-포스페이트 디에탄올레이트 - Google Patents

결정상태의 에토포사이드 4'-포스페이트 디에탄올레이트 Download PDF

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Publication number
KR100243981B1
KR100243981B1 KR1019920018032A KR920018032A KR100243981B1 KR 100243981 B1 KR100243981 B1 KR 100243981B1 KR 1019920018032 A KR1019920018032 A KR 1019920018032A KR 920018032 A KR920018032 A KR 920018032A KR 100243981 B1 KR100243981 B1 KR 100243981B1
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KR
South Korea
Prior art keywords
etoposide
phosphate
diethanolate
solution
crystalline
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Expired - Lifetime
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KR1019920018032A
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English (en)
Korean (ko)
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KR930007968A (ko
Inventor
데니스파브로
Original Assignee
스티븐 비. 데이비스
브리스톨-마이어스스퀴브컴파니
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Publication of KR930007968A publication Critical patent/KR930007968A/ko
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Publication of KR100243981B1 publication Critical patent/KR100243981B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019920018032A 1991-10-08 1992-10-01 결정상태의 에토포사이드 4'-포스페이트 디에탄올레이트 Expired - Lifetime KR100243981B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/773,056 US5648474A (en) 1991-10-08 1991-10-08 Crystalline etoposide 4'-phosphate diethanolate
US773056 1991-10-08

Publications (2)

Publication Number Publication Date
KR930007968A KR930007968A (ko) 1993-05-20
KR100243981B1 true KR100243981B1 (ko) 2000-02-01

Family

ID=25097069

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920018032A Expired - Lifetime KR100243981B1 (ko) 1991-10-08 1992-10-01 결정상태의 에토포사이드 4'-포스페이트 디에탄올레이트

Country Status (27)

Country Link
US (1) US5648474A (https=)
EP (1) EP0537555B1 (https=)
JP (1) JP3205816B2 (https=)
KR (1) KR100243981B1 (https=)
CN (1) CN1030610C (https=)
AT (1) ATE156832T1 (https=)
AU (1) AU650572B2 (https=)
CA (1) CA2079581C (https=)
CZ (1) CZ283735B6 (https=)
DE (1) DE69221573T2 (https=)
DK (1) DK0537555T3 (https=)
EG (1) EG20187A (https=)
ES (1) ES2109970T3 (https=)
FI (1) FI105034B (https=)
GR (1) GR3025176T3 (https=)
HU (2) HU213606B (https=)
IL (1) IL103262A (https=)
MX (1) MX9205777A (https=)
MY (1) MY108969A (https=)
NO (1) NO178342C (https=)
NZ (1) NZ244521A (https=)
PH (1) PH31666A (https=)
PL (1) PL168332B1 (https=)
RU (1) RU2042686C1 (https=)
SK (1) SK298692A3 (https=)
TW (1) TW239863B (https=)
ZA (1) ZA926903B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670578A (en) * 1983-08-29 1987-06-02 Merck & Co., Inc. Process for crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters
US4914222A (en) * 1983-08-29 1990-04-03 Merck & Co., Inc. Crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process
US4713246A (en) * 1984-03-19 1987-12-15 Bristol-Myers Company Etoposide oral dosage form
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
US4927638A (en) * 1986-10-08 1990-05-22 Bristol-Myers Company Etoposide solutions
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
DE68912721T2 (de) * 1988-11-16 1994-05-11 Nippon Kayaku Kk Kristallines Hydrochlorid von einer Etoposid-2-dimethylamino-Verbindung und Verfahren zur Herstellung davon.
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides

Also Published As

Publication number Publication date
SK278935B6 (sk) 1998-04-08
EP0537555B1 (en) 1997-08-13
ATE156832T1 (de) 1997-08-15
IL103262A0 (en) 1993-02-21
ES2109970T3 (es) 1998-02-01
CZ298692A3 (en) 1993-04-14
FI105034B (fi) 2000-05-31
HU9203119D0 (en) 1992-12-28
MY108969A (en) 1996-11-30
EG20187A (en) 1997-09-30
FI924359L (fi) 1993-04-09
AU2530192A (en) 1993-04-22
FI924359A0 (fi) 1992-09-29
NO178342C (no) 1996-03-06
PL296078A1 (en) 1993-04-19
NO923754L (no) 1993-04-13
DK0537555T3 (da) 1998-01-26
TW239863B (https=) 1995-02-01
NO178342B (no) 1995-11-27
JPH05194575A (ja) 1993-08-03
CA2079581A1 (en) 1993-04-09
US5648474A (en) 1997-07-15
CZ283735B6 (cs) 1998-06-17
ZA926903B (en) 1993-05-03
CN1030610C (zh) 1996-01-03
HU213606B (en) 1997-08-28
PL168332B1 (pl) 1996-02-29
AU650572B2 (en) 1994-06-23
DE69221573D1 (de) 1997-09-18
JP3205816B2 (ja) 2001-09-04
CN1071432A (zh) 1993-04-28
DE69221573T2 (de) 1998-02-26
RU2042686C1 (ru) 1995-08-27
SK298692A3 (en) 1998-04-08
IL103262A (en) 1997-06-10
HU211672A9 (en) 1995-12-28
NO923754D0 (no) 1992-09-28
NZ244521A (en) 1994-02-25
MX9205777A (es) 1993-04-01
GR3025176T3 (en) 1998-02-27
CA2079581C (en) 2002-11-12
EP0537555A1 (en) 1993-04-21
PH31666A (en) 1999-01-12
HUT62309A (en) 1993-04-28
KR930007968A (ko) 1993-05-20

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