KR100205768B1 - Stereo-selective composition of 4-acetoxyazetidinone - Google Patents

Stereo-selective composition of 4-acetoxyazetidinone

Info

Publication number
KR100205768B1
KR100205768B1 KR1019960035355A KR19960035355A KR100205768B1 KR 100205768 B1 KR100205768 B1 KR 100205768B1 KR 1019960035355 A KR1019960035355 A KR 1019960035355A KR 19960035355 A KR19960035355 A KR 19960035355A KR 100205768 B1 KR100205768 B1 KR 100205768B1
Authority
KR
South Korea
Prior art keywords
acetoxyazetidinone
stereo
selective composition
selective
composition
Prior art date
Application number
KR1019960035355A
Other languages
English (en)
Inventor
Tae-Sup Hwang
Hee-An Kwon
Mi-Jung Lee
In-Hee Lee
Taek-Hyun Yun
Soo-Jin Lee
Chang-Yong Ahn
Original Assignee
Choongwae Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Choongwae Pharm Co filed Critical Choongwae Pharm Co
Priority to KR1019960035355A priority Critical patent/KR100205768B1/ko
Priority to KR1019970016153A priority patent/KR100205769B1/ko
Priority to KR1019970016152A priority patent/KR19980018088A/ko
Priority to AU27132/97A priority patent/AU2713297A/en
Priority to JP51060498A priority patent/JP4108130B2/ja
Priority to PCT/KR1997/000072 priority patent/WO1998007691A1/en
Priority to AU27131/97A priority patent/AU2713197A/en
Priority to PCT/KR1997/000071 priority patent/WO1998007690A1/en
Priority to JP10510605A priority patent/JP2000516628A/ja
Application granted granted Critical
Publication of KR100205768B1 publication Critical patent/KR100205768B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
KR1019960035355A 1996-08-24 1996-08-24 Stereo-selective composition of 4-acetoxyazetidinone KR100205768B1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
KR1019960035355A KR100205768B1 (en) 1996-08-24 1996-08-24 Stereo-selective composition of 4-acetoxyazetidinone
KR1019970016153A KR100205769B1 (ko) 1996-08-24 1997-04-29 트랜스아제티디논의 입체선택적 제조방법
KR1019970016152A KR19980018088A (ko) 1996-08-24 1997-04-29 4-아세톡시아제티디논의 입체선택적 제조방법
AU27132/97A AU2713297A (en) 1996-08-24 1997-04-30 Process for stereoselective preparation of trans-azetidinones
JP51060498A JP4108130B2 (ja) 1996-08-24 1997-04-30 ４―アセトキシアゼチジノンの立体選択的な製造方法
PCT/KR1997/000072 WO1998007691A1 (en) 1996-08-24 1997-04-30 Process for stereoselective preparation of trans-azetidinones
AU27131/97A AU2713197A (en) 1996-08-24 1997-04-30 Process for stereoselective preparation of 4-acetoxyazetidinones
PCT/KR1997/000071 WO1998007690A1 (en) 1996-08-24 1997-04-30 Process for stereoselective preparation of 4-acetoxyazetidinones
JP10510605A JP2000516628A (ja) 1996-08-24 1997-04-30 トランスアゼチジノンの立体選択的な製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019960035355A KR100205768B1 (en) 1996-08-24 1996-08-24 Stereo-selective composition of 4-acetoxyazetidinone

Publications (1)

Publication Number Publication Date
KR100205768B1 true KR100205768B1 (en) 1999-07-01

Family

ID=19470687

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1019960035355A KR100205768B1 (en) 1996-08-24 1996-08-24 Stereo-selective composition of 4-acetoxyazetidinone
KR1019970016152A KR19980018088A (ko) 1996-08-24 1997-04-29 4-아세톡시아제티디논의 입체선택적 제조방법
KR1019970016153A KR100205769B1 (ko) 1996-08-24 1997-04-29 트랜스아제티디논의 입체선택적 제조방법

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1019970016152A KR19980018088A (ko) 1996-08-24 1997-04-29 4-아세톡시아제티디논의 입체선택적 제조방법
KR1019970016153A KR100205769B1 (ko) 1996-08-24 1997-04-29 트랜스아제티디논의 입체선택적 제조방법

Country Status (4)

Country Link
JP (2) JP2000516628A (ko)
KR (3) KR100205768B1 (ko)
AU (2) AU2713197A (ko)
WO (2) WO1998007691A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
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KR101314955B1 (ko) 2011-02-21 2013-10-04 강원대학교산학협력단 페넴계 항생제 중간체의 제조방법

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KR20020087500A (ko) * 2000-12-23 2002-11-23 주식회사대웅제약 3-치환 아제티디논의 제조방법
CN100344616C (zh) * 2001-06-12 2007-10-24 维尔斯达医疗公司 用于治疗代谢失调的化合物
KR100654963B1 (ko) * 2004-08-24 2006-12-06 임광민 아미드 화합물의 제조방법
WO2007004028A2 (en) * 2005-06-30 2007-01-11 Ranbaxy Laboratories Limited Processes for the preparation of penems and its intermediate
CN101177416B (zh) * 2006-11-06 2011-06-08 上海医药工业研究院 (2’s,3’r,4s)-3-[2’-(n-取代氨甲基)-3’-羟基丁酰基]-4-取代噁唑烷-2-酮衍生物及其制备方法
CN101684110B (zh) * 2008-09-22 2014-02-12 浙江九洲药业股份有限公司 一种氮杂环丁酮衍生物的制备方法
US9637746B2 (en) 2008-12-15 2017-05-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
EP2566953B1 (en) 2010-05-07 2019-01-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
WO2012030980A1 (en) 2010-08-31 2012-03-08 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
CN102002066B (zh) * 2010-11-01 2013-10-02 山东鑫泉医药中间体有限公司 一种4―乙酰氧基―2―氮杂环丁酮的合成方法
CN102336696A (zh) * 2011-07-15 2012-02-01 浙江海翔川南药业有限公司 合成4-aa的中间体及其制备方法和用途
EP2753702B1 (en) 2011-09-09 2021-12-15 GreenLight Biosciences, Inc. Cell-free preparation of carbapenems
CN102432632A (zh) * 2011-09-16 2012-05-02 上海悦昂化学有限公司 一种（3r，4r）-3-[（1r）叔丁基二甲基硅氧乙基]-4-乙酰氧基-2-氮杂环丁酮的制备方法
DK3030671T3 (en) 2013-08-05 2019-01-21 Greenlight Biosciences Inc MODIFIED PROTEINS WITH A PROTEASE CLEANING PLACE
KR20230048162A (ko) 2015-03-30 2023-04-10 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
CN105153075A (zh) * 2015-08-31 2015-12-16 江苏瑞克医药科技有限公司 一种提高亚胺培南关键中间体2，3-环氧丁酸纯度的后处理方法
AU2017246458B2 (en) 2016-04-06 2022-08-11 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
CN106008585B (zh) * 2016-05-20 2018-07-17 上海应用技术学院 一种(3r,4r)-4-乙酰氧基-3-[(r)-1-叔丁基二甲基硅氧乙基]-2-氮杂环丁酮的合成工艺和装置
IL273887B (en) 2017-10-11 2022-09-01 Greenlight Biosciences Inc Methods and preparations for the production of nucleoside triphosphate and ribonucleic acid
CN113549102B (zh) * 2021-09-22 2021-12-17 凯莱英医药集团（天津）股份有限公司 脱除酰胺基团上的对甲氧基苯基保护基的方法
CN115385950B (zh) * 2022-10-27 2023-04-28 天津凯莱英医药科技发展有限公司 连续臭氧氧化制备4-乙酰氧基氮杂环丁酮的系统及方法

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GB8321004D0 (en) * 1983-08-04 1983-09-07 Erba Farmitalia Azetidinones
CA1256443A (en) * 1984-07-05 1989-06-27 Takehisa Ohashi Process for preparing 4-acetoxy-3- hydroxyethylazetidin-2-one derivatives
EP0279781A3 (de) * 1987-02-17 1989-07-26 Ciba-Geigy Ag Verfahren zur Herstellung von 4-Acetoxy-3-hydroxyethyl-azetidinon
JPH01211560A (ja) * 1988-02-18 1989-08-24 Sagami Chem Res Center β−ラクタム誘導体の製造方法
EP0371875B1 (en) * 1988-11-29 1994-12-28 Takasago International Corporation Process for preparing 4-acetoxyazetidinones
JPH02306973A (ja) * 1989-05-19 1990-12-20 Otsuka Pharmaceut Co Ltd カルボニル化合物の製造方法
EP0404586A3 (en) * 1989-06-21 1991-12-11 Merck & Co. Inc. Nitrogen deprotected 4-acyloxyazetidin-2-ones
US4952288A (en) * 1989-06-21 1990-08-28 Merck & Co., Inc. Process for the preparation of 4-acyloxyazetidin-2-one by electrochemical methods
JP3052580B2 (ja) * 1992-06-23 2000-06-12 住友化学工業株式会社 光学活性な４─アシロキシ─２─アゼチジノンの製造法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101314955B1 (ko) 2011-02-21 2013-10-04 강원대학교산학협력단 페넴계 항생제 중간체의 제조방법

Also Published As

Publication number Publication date
JP2000516934A (ja) 2000-12-19
KR100205769B1 (ko) 1999-07-01
JP2000516628A (ja) 2000-12-12
KR19980018088A (ko) 1998-06-05
WO1998007691A1 (en) 1998-02-26
WO1998007690A1 (en) 1998-02-26
AU2713197A (en) 1998-03-06
KR19980018089A (ko) 1998-06-05
AU2713297A (en) 1998-03-06
JP4108130B2 (ja) 2008-06-25

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