KR100187327B1 - 상보시스템을 저해하거나 또는 면역할성을 억제하는 성분물 - Google Patents

상보시스템을 저해하거나 또는 면역할성을 억제하는 성분물 Download PDF

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Publication number
KR100187327B1
KR100187327B1 KR1019930701706A KR930701706A KR100187327B1 KR 100187327 B1 KR100187327 B1 KR 100187327B1 KR 1019930701706 A KR1019930701706 A KR 1019930701706A KR 930701706 A KR930701706 A KR 930701706A KR 100187327 B1 KR100187327 B1 KR 100187327B1
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KR
South Korea
Prior art keywords
group
cyclohexane
benzofuran
substituted
component
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Expired - Fee Related
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KR1019930701706A
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English (en)
Korean (ko)
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KR930702893A (ko
Inventor
로버트 디 신델라
바르톤 제이 브라드버리
테도로 예스 카우프만
스테펜 에이치 아이피
헨리 씨 쥬니어 미쉬
리츄
Original Assignee
알란 더블유 투크
티 쎌 싸이언스 인코퍼레이티드
마이클 알. 딘저슨
더 유니버시티 오브 미시시피
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Application filed by 알란 더블유 투크, 티 쎌 싸이언스 인코퍼레이티드, 마이클 알. 딘저슨, 더 유니버시티 오브 미시시피 filed Critical 알란 더블유 투크
Publication of KR930702893A publication Critical patent/KR930702893A/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1019930701706A 1990-12-06 1991-12-06 상보시스템을 저해하거나 또는 면역할성을 억제하는 성분물 Expired - Fee Related KR100187327B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US623,849 1990-12-06
US07/623,849 US5366986A (en) 1988-04-15 1990-12-06 Compounds which inhibit complement and/or suppress immune activity
PCT/US1991/009303 WO1992010096A1 (en) 1990-12-06 1991-12-06 Compounds that inhibit complement and/or suppress immune activity

Publications (2)

Publication Number Publication Date
KR930702893A KR930702893A (ko) 1993-11-29
KR100187327B1 true KR100187327B1 (ko) 1999-05-01

Family

ID=24499627

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930701706A Expired - Fee Related KR100187327B1 (ko) 1990-12-06 1991-12-06 상보시스템을 저해하거나 또는 면역할성을 억제하는 성분물

Country Status (7)

Country Link
US (2) US5366986A (cg-RX-API-DMAC7.html)
EP (1) EP0561989A1 (cg-RX-API-DMAC7.html)
JP (1) JPH06503829A (cg-RX-API-DMAC7.html)
KR (1) KR100187327B1 (cg-RX-API-DMAC7.html)
AU (1) AU663066B2 (cg-RX-API-DMAC7.html)
CA (1) CA2097826A1 (cg-RX-API-DMAC7.html)
WO (1) WO1992010096A1 (cg-RX-API-DMAC7.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
AU2191795A (en) * 1994-03-23 1995-10-09 Alexion Pharmaceuticals, Inc. Method for reducing immune and hemostatic dysfunctions during extracorporeal circulation
HK1000785A1 (en) * 1995-05-19 2006-06-30 Kyowa Hakko Kogyo Co., Ltd Oxygen-containing heterocyclic compounds
US6514996B2 (en) 1995-05-19 2003-02-04 Kyowa Hakko Kogyo Co., Ltd. Derivatives of benzofuran or benzodioxole
JPH11349488A (ja) * 1998-06-01 1999-12-21 Hisamitsu Pharmaceut Co Inc クラスタリンを含有する免疫抑制剤
US6673154B1 (en) * 2001-06-28 2004-01-06 Advanced Cardiovascular Systems, Inc. Stent mounting device to coat a stent
SE0202133D0 (sv) 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
US7160917B2 (en) * 2002-12-13 2007-01-09 Sanofi-Aventis Deutschland Gmbh Spirobenzofuran lactams and their derivatives, processes for their preparation and use thereof
DE10258650A1 (de) * 2002-12-13 2004-06-24 Aventis Pharma Deutschland Gmbh Neue Spirobenzofuranlactame und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben
SE0302755D0 (sv) * 2003-10-17 2003-10-17 Astrazeneca Ab Novel compounds
SE0303090D0 (sv) 2003-11-20 2003-11-20 Astrazeneca Ab Novel compounds
SE0303541D0 (sv) 2003-12-22 2003-12-22 Astrazeneca Ab New compounds
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
JP2006175744A (ja) * 2004-12-22 2006-07-06 Canon Inc 記録装置、及び記録方法
CN113185383B (zh) * 2021-04-28 2022-07-12 福州大学 一种以柠檬烯环氧化物为加氢受体的香芹酚制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128286A (en) * 1964-04-07 Process for preparing analogues
CH394240A (de) * 1960-02-12 1965-06-30 Hoffmann La Roche Verfahren zur Herstellung von spirozyklischen Ketoalkoholen
US4035509A (en) * 1974-04-22 1977-07-12 Syntex (U.S.A.) Inc. Methods and compositions for the use of 2-carboxy-5-oxo-5H-dibenzo[a,d]cycloheptenes, salts and esters thereof
JPS589114B2 (ja) * 1977-06-30 1983-02-18 大塚製薬株式会社 セスキテルペン類縁体、その製造法及び腎炎治療剤
FR2405941A1 (fr) * 1977-06-30 1979-05-11 Otsuka Pharma Co Ltd Nouveaux derives sesquiterpeniques utiles notamment comme inhibiteurs du systeme complementaire et leurs procedes de preparation
JPS5936913B2 (ja) * 1978-02-10 1984-09-06 大塚製薬株式会社 セスキテルペン誘導体
JPS5492680A (en) * 1977-12-29 1979-07-23 Otsuka Pharmaceut Co Ltd Novel microorganism
JPS6030289B2 (ja) * 1977-08-30 1985-07-16 大塚製薬株式会社 制ガン剤
US4268516A (en) * 1978-10-11 1981-05-19 Pfizer Inc. [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
JPS5630917A (en) * 1979-08-22 1981-03-28 Otsuka Pharmaceut Co Ltd Preventive and remedy for hepatitis
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US4301292A (en) * 1979-09-06 1981-11-17 Hoechst-Roussel Pharmaceuticals, Incorporated 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol
JPS5822193B2 (ja) * 1981-09-14 1983-05-07 大塚製薬株式会社 新規な微生物
JPS5822194B2 (ja) * 1981-09-14 1983-05-07 大塚製薬株式会社 新規な微生物
US4404221A (en) * 1981-10-19 1983-09-13 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use
US4517311A (en) * 1981-10-19 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions
US4426380A (en) * 1981-10-28 1984-01-17 Ciba-Geigy Corporation Benzofuran-2-ones and pharmaceutical compositions
IL69898A0 (en) * 1982-10-08 1984-01-31 Ciba Geigy Ag Furans
US4863958A (en) * 1984-06-20 1989-09-05 Merck Frosst Canada, Inc. Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis
JPS6133183A (ja) * 1984-07-25 1986-02-17 Mitsubishi Chem Ind Ltd ２，３−ジヒドロ−７−アミノベンゾフランの製造法
LU85544A1 (fr) * 1984-09-19 1986-04-03 Cird Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
US4623657A (en) * 1985-09-05 1986-11-18 Hoechst-Roussel Pharmaceuticals Inc. Spiro [benzofuran-2(3H),1'-cycloheptane]s and their therapeutic use
DE3777366D1 (de) * 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
US5366986A (en) * 1988-04-15 1994-11-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5173499A (en) * 1988-04-15 1992-12-22 T Cell Sciences, Inc. Compounds which inhibit complement and/or suppress immune activity
US5506247A (en) * 1988-04-15 1996-04-09 T Cell Sciences, Inc. Compounds that inhibit complement and/or suppress immune activity
CA2097825A1 (en) * 1990-12-06 1992-06-07 Henry C. Marsh, Jr. Synergistic compositions of soluble complement receptors and compounds that inhibit complement and/or suppress immune activity

Also Published As

Publication number Publication date
EP0561989A4 (cg-RX-API-DMAC7.html) 1994-03-09
US5656659A (en) 1997-08-12
EP0561989A1 (en) 1993-09-29
AU9127491A (en) 1992-07-08
WO1992010096A1 (en) 1992-06-25
AU663066B2 (en) 1995-09-28
CA2097826A1 (en) 1992-06-07
KR930702893A (ko) 1993-11-29
US5366986A (en) 1994-11-22
JPH06503829A (ja) 1994-04-28

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