KR0142109B1 - Production of 2:3:-dideoxy-2:3:-dihydronucleosides - Google Patents
Production of 2:3:-dideoxy-2:3:-dihydronucleosidesInfo
- Publication number
- KR0142109B1 KR0142109B1 KR97054314A KR19970054314A KR0142109B1 KR 0142109 B1 KR0142109 B1 KR 0142109B1 KR 97054314 A KR97054314 A KR 97054314A KR 19970054314 A KR19970054314 A KR 19970054314A KR 0142109 B1 KR0142109 B1 KR 0142109B1
- Authority
- KR
- South Korea
- Prior art keywords
- dihydronucleosides
- dideoxy
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/173,473 US4904770A (en) | 1988-03-24 | 1988-03-24 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR0142109B1 true KR0142109B1 (en) | 1998-07-01 |
Family
ID=22632190
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR89003629A KR0140889B1 (en) | 1988-03-24 | 1989-03-23 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
| KR97054314A KR0142109B1 (en) | 1988-03-24 | 1997-10-23 | Production of 2:3:-dideoxy-2:3:-dihydronucleosides |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR89003629A KR0140889B1 (en) | 1988-03-24 | 1989-03-23 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4904770A (ko) |
| EP (1) | EP0334368A3 (ko) |
| JP (1) | JPH02149595A (ko) |
| KR (2) | KR0140889B1 (ko) |
| AU (1) | AU622439B2 (ko) |
| CA (1) | CA1339448C (ko) |
| DK (1) | DK146489A (ko) |
| EG (1) | EG18661A (ko) |
| FI (1) | FI93111C (ko) |
| IL (2) | IL105573A (ko) |
| NO (1) | NO171367C (ko) |
| NZ (1) | NZ228390A (ko) |
| PT (1) | PT90099B (ko) |
| ZA (1) | ZA892166B (ko) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455339A (en) * | 1986-05-01 | 1995-10-03 | University Of Georgia Research Foundation, Inc. | Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides |
| US5384396A (en) * | 1988-02-23 | 1995-01-24 | The University Of Georgia Research Foundation, Inc. | Process for the deoxygenation of nucleosides |
| JPH02152976A (ja) * | 1988-05-06 | 1990-06-12 | Bristol Myers Co | ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ |
| SE464168B (sv) * | 1989-07-19 | 1991-03-18 | Bo Fredrik Oeberg | Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt) |
| US5200514A (en) * | 1990-01-19 | 1993-04-06 | University Of Georgia Research Foundation, Inc. | Synthesis of 2'-deoxypyrimidine nucleosides |
| WO1992002516A1 (fr) * | 1990-07-27 | 1992-02-20 | Japan Tobacco Inc. | Procede de production de 2',3'-didesoxy-2',3'-dideshydronucleoside |
| US5166327A (en) * | 1990-07-31 | 1992-11-24 | Yuki Gosei Kogyo Co., Ltd. | Process for producing 3'-deoxy-3-'-fluorothymidine |
| JP3042073B2 (ja) * | 1991-06-19 | 2000-05-15 | 味の素株式会社 | ヌクレオシド誘導体とその製造方法 |
| DE550714T1 (de) * | 1991-06-21 | 1995-06-14 | Acic Canada Inc | Antiviralverbindungen und Ihrer Verfahren zur Herstellung. |
| FR2688003B1 (fr) * | 1992-02-28 | 1995-06-30 | Univ Limoges | Derives de nucleosides, leur preparation et leurs applications biologiques. |
| US5506349A (en) * | 1992-05-13 | 1996-04-09 | Ribozyme Pharmaceuticals, Inc. | Chemical synthesis of 2', 3'-dideoxycytidine |
| US5539099A (en) * | 1993-11-15 | 1996-07-23 | Bristol-Myers Squibb Company | Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides |
| US5608049A (en) * | 1995-03-10 | 1997-03-04 | Bristol-Myers Squibb Company | Preparation of d4T from 5-methyluridine |
| US5608048A (en) * | 1995-06-05 | 1997-03-04 | Bristol-Myers Squibb Company | d4 T polymorphic Form 1 process |
| US6635753B1 (en) | 1998-09-30 | 2003-10-21 | Brantford Chemicals Inc. | Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| IT1318463B1 (it) * | 2000-04-12 | 2003-08-25 | Archimica S P A Ora Clariant L | Procedimento per la preparazione di 5'-acetilstavudina. |
| JP2004527504A (ja) * | 2001-03-01 | 2004-09-09 | フアーマセツト・リミテツド | ２’，３’−ジデオキシ−２’，３’−ジデヒドロヌクレオシドの合成法 |
| US20050131224A1 (en) * | 2003-12-15 | 2005-06-16 | Cti Pet Systems, Inc. | Method for preparing radiolabeled thymidine |
| US7160537B2 (en) * | 2003-12-15 | 2007-01-09 | Siemens Medical Solutions Usa, Inc. | Method for preparing radiolabeled thymidine having low chromophoric byproducts |
| US20050171126A1 (en) * | 2003-12-26 | 2005-08-04 | Ajinomoto Co., Inc. | Process for the production of purine nucleoside compounds |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| JP5249028B2 (ja) | 2005-07-25 | 2013-07-31 | インターミューン・インコーポレーテッド | Ｃ型肝炎ウイルス複製の新規大環状阻害剤 |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| CN101029068B (zh) * | 2007-04-09 | 2010-06-23 | 陆咏 | 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法 |
| KR102004559B1 (ko) | 2011-08-30 | 2019-07-26 | 아스텍스 파마수티컬스, 인크. | 데시타빈 유도체 제제 |
| US20160060252A1 (en) * | 2013-04-16 | 2016-03-03 | Bristol-Myers Squibb Company | 5-methyluridine method for producing festinavir |
| JP6768722B2 (ja) | 2015-07-02 | 2020-10-14 | 大塚製薬株式会社 | 凍結乾燥医薬組成物 |
| BR112020002280A2 (pt) | 2017-08-03 | 2020-07-28 | Otsuka Pharmaceutical Co., Ltd. | composto farmacológico e métodos purificação do mesmo |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3322747A (en) * | 1965-04-01 | 1967-05-30 | Merck & Co Inc | Thionocarbonate nucleosides |
| US3539550A (en) * | 1967-01-23 | 1970-11-10 | Syntex Corp | Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides |
| US3792040A (en) * | 1970-03-19 | 1974-02-12 | Syntex Corp | Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing |
-
1988
- 1988-03-24 US US07/173,473 patent/US4904770A/en not_active Expired - Lifetime
-
1989
- 1989-03-15 CA CA000593738A patent/CA1339448C/en not_active Expired - Fee Related
- 1989-03-20 NZ NZ228390A patent/NZ228390A/en unknown
- 1989-03-20 NO NO891208A patent/NO171367C/no unknown
- 1989-03-21 IL IL10557389A patent/IL105573A/en not_active IP Right Cessation
- 1989-03-21 IL IL8969389A patent/IL89693A/en not_active IP Right Cessation
- 1989-03-21 FI FI891338A patent/FI93111C/fi not_active IP Right Cessation
- 1989-03-22 ZA ZA892166A patent/ZA892166B/xx unknown
- 1989-03-22 DK DK146489A patent/DK146489A/da not_active Application Discontinuation
- 1989-03-23 KR KR89003629A patent/KR0140889B1/ko not_active IP Right Cessation
- 1989-03-23 EG EG144/89A patent/EG18661A/xx active
- 1989-03-23 EP EP19890105269 patent/EP0334368A3/en not_active Ceased
- 1989-03-23 PT PT90099A patent/PT90099B/pt not_active IP Right Cessation
- 1989-03-23 AU AU31673/89A patent/AU622439B2/en not_active Ceased
- 1989-03-23 JP JP1071592A patent/JPH02149595A/ja active Pending
-
1997
- 1997-10-23 KR KR97054314A patent/KR0142109B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ228390A (en) | 1991-12-23 |
| KR890014528A (ko) | 1989-10-24 |
| KR0140889B1 (en) | 1998-06-15 |
| CA1339448C (en) | 1997-09-09 |
| FI891338A (fi) | 1989-09-25 |
| FI891338A0 (fi) | 1989-03-21 |
| NO891208L (no) | 1989-09-25 |
| IL89693A0 (en) | 1989-09-28 |
| AU622439B2 (en) | 1992-04-09 |
| NO171367C (no) | 1993-03-03 |
| US4904770A (en) | 1990-02-27 |
| IL89693A (en) | 1994-08-26 |
| PT90099B (pt) | 1994-07-29 |
| EP0334368A3 (en) | 1991-12-27 |
| PT90099A (pt) | 1989-11-10 |
| EP0334368A2 (en) | 1989-09-27 |
| ZA892166B (en) | 1992-02-26 |
| FI93111C (fi) | 1995-02-27 |
| DK146489D0 (da) | 1989-03-22 |
| NO891208D0 (no) | 1989-03-20 |
| NO171367B (no) | 1992-11-23 |
| IL105573A (en) | 1994-04-12 |
| FI93111B (fi) | 1994-11-15 |
| AU3167389A (en) | 1989-09-28 |
| EG18661A (en) | 1993-10-30 |
| JPH02149595A (ja) | 1990-06-08 |
| DK146489A (da) | 1989-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| A201 | Request for examination | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| LAPS | Lapse due to unpaid annual fee |