DK146489A - Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider - Google Patents
Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosiderInfo
- Publication number
- DK146489A DK146489A DK146489A DK146489A DK146489A DK 146489 A DK146489 A DK 146489A DK 146489 A DK146489 A DK 146489A DK 146489 A DK146489 A DK 146489A DK 146489 A DK146489 A DK 146489A
- Authority
- DK
- Denmark
- Prior art keywords
- didehydronucleosides
- dideoxy
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/173,473 US4904770A (en) | 1988-03-24 | 1988-03-24 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK146489D0 DK146489D0 (da) | 1989-03-22 |
| DK146489A true DK146489A (da) | 1989-09-25 |
Family
ID=22632190
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK146489A DK146489A (da) | 1988-03-24 | 1989-03-22 | Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4904770A (da) |
| EP (1) | EP0334368A3 (da) |
| JP (1) | JPH02149595A (da) |
| KR (2) | KR0140889B1 (da) |
| AU (1) | AU622439B2 (da) |
| CA (1) | CA1339448C (da) |
| DK (1) | DK146489A (da) |
| EG (1) | EG18661A (da) |
| FI (1) | FI93111C (da) |
| IL (2) | IL105573A (da) |
| NO (1) | NO171367C (da) |
| NZ (1) | NZ228390A (da) |
| PT (1) | PT90099B (da) |
| ZA (1) | ZA892166B (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455339A (en) * | 1986-05-01 | 1995-10-03 | University Of Georgia Research Foundation, Inc. | Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides |
| US5384396A (en) * | 1988-02-23 | 1995-01-24 | The University Of Georgia Research Foundation, Inc. | Process for the deoxygenation of nucleosides |
| JPH02152976A (ja) * | 1988-05-06 | 1990-06-12 | Bristol Myers Co | ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ |
| SE464168B (sv) * | 1989-07-19 | 1991-03-18 | Bo Fredrik Oeberg | Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt) |
| US5200514A (en) * | 1990-01-19 | 1993-04-06 | University Of Georgia Research Foundation, Inc. | Synthesis of 2'-deoxypyrimidine nucleosides |
| EP0493602A4 (en) * | 1990-07-27 | 1993-01-20 | Yuki Gosei Kogyo Co., Ltd. | Process for producing 2',3'-dideoxy-2',3'-didehydronucleoside |
| US5166327A (en) * | 1990-07-31 | 1992-11-24 | Yuki Gosei Kogyo Co., Ltd. | Process for producing 3'-deoxy-3-'-fluorothymidine |
| JP3042073B2 (ja) * | 1991-06-19 | 2000-05-15 | 味の素株式会社 | ヌクレオシド誘導体とその製造方法 |
| AU2181592A (en) * | 1991-06-21 | 1993-01-25 | Acic (Canada) Inc. | Novel anti-viral compounds and processes for production of anti-viral compounds |
| FR2688003B1 (fr) * | 1992-02-28 | 1995-06-30 | Univ Limoges | Derives de nucleosides, leur preparation et leurs applications biologiques. |
| US5506349A (en) * | 1992-05-13 | 1996-04-09 | Ribozyme Pharmaceuticals, Inc. | Chemical synthesis of 2', 3'-dideoxycytidine |
| US5539099A (en) * | 1993-11-15 | 1996-07-23 | Bristol-Myers Squibb Company | Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides |
| US5608049A (en) * | 1995-03-10 | 1997-03-04 | Bristol-Myers Squibb Company | Preparation of d4T from 5-methyluridine |
| US5608048A (en) * | 1995-06-05 | 1997-03-04 | Bristol-Myers Squibb Company | d4 T polymorphic Form 1 process |
| US6635753B1 (en) | 1998-09-30 | 2003-10-21 | Brantford Chemicals Inc. | Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof |
| US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| IT1318463B1 (it) * | 2000-04-12 | 2003-08-25 | Archimica S P A Ora Clariant L | Procedimento per la preparazione di 5'-acetilstavudina. |
| CN1505635A (zh) | 2001-03-01 | 2004-06-16 | 2′,3′-二脱氧-2＇,3＇-二脱氢核苷的合成方法 | |
| US7160537B2 (en) * | 2003-12-15 | 2007-01-09 | Siemens Medical Solutions Usa, Inc. | Method for preparing radiolabeled thymidine having low chromophoric byproducts |
| US20050131224A1 (en) * | 2003-12-15 | 2005-06-16 | Cti Pet Systems, Inc. | Method for preparing radiolabeled thymidine |
| EP1550665A1 (en) * | 2003-12-26 | 2005-07-06 | Ajinomoto Co., Inc. | A process for the production of purine nucleoside compounds |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| CN102816170A (zh) | 2005-07-25 | 2012-12-12 | 因特蒙公司 | C型肝炎病毒复制的新颖大环抑制剂 |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| CN101029068B (zh) * | 2007-04-09 | 2010-06-23 | 陆咏 | 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法 |
| CA2845585C (en) | 2011-08-30 | 2020-02-18 | Astex Pharmaceuticals, Inc. | Decitabine derivative formulations |
| EP2986602A1 (en) * | 2013-04-16 | 2016-02-24 | Bristol-Myers Squibb Company | Method for producing festinavir using 5-methyluridine as starting material |
| MX2018000016A (es) | 2015-07-02 | 2019-01-31 | Otsuka Pharma Co Ltd | Composiciones farmaceuticas liofilizadas. |
| AU2018310857A1 (en) | 2017-08-03 | 2020-02-13 | Otsuka Pharmaceutical Co., Ltd. | Drug compound and purification methods thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3322747A (en) * | 1965-04-01 | 1967-05-30 | Merck & Co Inc | Thionocarbonate nucleosides |
| US3539550A (en) * | 1967-01-23 | 1970-11-10 | Syntex Corp | Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides |
| US3792040A (en) * | 1970-03-19 | 1974-02-12 | Syntex Corp | Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing |
-
1988
- 1988-03-24 US US07/173,473 patent/US4904770A/en not_active Expired - Lifetime
-
1989
- 1989-03-15 CA CA000593738A patent/CA1339448C/en not_active Expired - Fee Related
- 1989-03-20 NZ NZ228390A patent/NZ228390A/en unknown
- 1989-03-20 NO NO891208A patent/NO171367C/no unknown
- 1989-03-21 IL IL10557389A patent/IL105573A/en not_active IP Right Cessation
- 1989-03-21 FI FI891338A patent/FI93111C/fi not_active IP Right Cessation
- 1989-03-21 IL IL8969389A patent/IL89693A/en not_active IP Right Cessation
- 1989-03-22 DK DK146489A patent/DK146489A/da not_active Application Discontinuation
- 1989-03-22 ZA ZA892166A patent/ZA892166B/xx unknown
- 1989-03-23 KR KR89003629A patent/KR0140889B1/ko not_active IP Right Cessation
- 1989-03-23 JP JP1071592A patent/JPH02149595A/ja active Pending
- 1989-03-23 AU AU31673/89A patent/AU622439B2/en not_active Ceased
- 1989-03-23 PT PT90099A patent/PT90099B/pt not_active IP Right Cessation
- 1989-03-23 EP EP19890105269 patent/EP0334368A3/en not_active Ceased
- 1989-03-23 EG EG144/89A patent/EG18661A/xx active
-
1997
- 1997-10-23 KR KR97054314A patent/KR0142109B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL89693A0 (en) | 1989-09-28 |
| NZ228390A (en) | 1991-12-23 |
| ZA892166B (en) | 1992-02-26 |
| DK146489D0 (da) | 1989-03-22 |
| EP0334368A2 (en) | 1989-09-27 |
| NO171367B (no) | 1992-11-23 |
| FI93111B (fi) | 1994-11-15 |
| FI891338A0 (fi) | 1989-03-21 |
| NO171367C (no) | 1993-03-03 |
| JPH02149595A (ja) | 1990-06-08 |
| KR0140889B1 (en) | 1998-06-15 |
| PT90099A (pt) | 1989-11-10 |
| IL89693A (en) | 1994-08-26 |
| EP0334368A3 (en) | 1991-12-27 |
| PT90099B (pt) | 1994-07-29 |
| AU622439B2 (en) | 1992-04-09 |
| NO891208D0 (no) | 1989-03-20 |
| AU3167389A (en) | 1989-09-28 |
| CA1339448C (en) | 1997-09-09 |
| IL105573A (en) | 1994-04-12 |
| EG18661A (en) | 1993-10-30 |
| FI891338A (fi) | 1989-09-25 |
| KR890014528A (ko) | 1989-10-24 |
| NO891208L (no) | 1989-09-25 |
| FI93111C (fi) | 1995-02-27 |
| KR0142109B1 (en) | 1998-07-01 |
| US4904770A (en) | 1990-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |