NO171367C - Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider - Google Patents

Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider

Info

Publication number
NO171367C
NO171367C NO891208A NO891208A NO171367C NO 171367 C NO171367 C NO 171367C NO 891208 A NO891208 A NO 891208A NO 891208 A NO891208 A NO 891208A NO 171367 C NO171367 C NO 171367C
Authority
NO
Norway
Prior art keywords
didehydronucleosides
dideoxy
procedure
preparation
Prior art date
Application number
NO891208A
Other languages
English (en)
Norwegian (no)
Other versions
NO891208L (no
NO891208D0 (no
NO171367B (no
Inventor
Jr John E Starrett
Muzammil M Mansuri
John C Martin
Carl E Fuller
Henry G Howell
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO891208D0 publication Critical patent/NO891208D0/no
Publication of NO891208L publication Critical patent/NO891208L/no
Priority to NO913457A priority Critical patent/NO171314C/no
Priority to NO913459A priority patent/NO171316C/no
Priority to NO913456A priority patent/NO172345C/no
Priority to NO913458A priority patent/NO171315C/no
Publication of NO171367B publication Critical patent/NO171367B/no
Publication of NO171367C publication Critical patent/NO171367C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO891208A 1988-03-24 1989-03-20 Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider NO171367C (no)

Priority Applications (4)

Application Number Priority Date Filing Date Title
NO913457A NO171314C (no) 1988-03-24 1991-09-03 Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider
NO913459A NO171316C (no) 1988-03-24 1991-09-03 Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider r
NO913456A NO172345C (no) 1988-03-24 1991-09-03 Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider
NO913458A NO171315C (no) 1988-03-24 1991-09-03 Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/173,473 US4904770A (en) 1988-03-24 1988-03-24 Production of 2',3'-dideoxy-2',3'-didehydronucleosides

Publications (4)

Publication Number Publication Date
NO891208D0 NO891208D0 (no) 1989-03-20
NO891208L NO891208L (no) 1989-09-25
NO171367B NO171367B (no) 1992-11-23
NO171367C true NO171367C (no) 1993-03-03

Family

ID=22632190

Family Applications (1)

Application Number Title Priority Date Filing Date
NO891208A NO171367C (no) 1988-03-24 1989-03-20 Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider

Country Status (14)

Country Link
US (1) US4904770A (ko)
EP (1) EP0334368A3 (ko)
JP (1) JPH02149595A (ko)
KR (2) KR0140889B1 (ko)
AU (1) AU622439B2 (ko)
CA (1) CA1339448C (ko)
DK (1) DK146489A (ko)
EG (1) EG18661A (ko)
FI (1) FI93111C (ko)
IL (2) IL89693A (ko)
NO (1) NO171367C (ko)
NZ (1) NZ228390A (ko)
PT (1) PT90099B (ko)
ZA (1) ZA892166B (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455339A (en) * 1986-05-01 1995-10-03 University Of Georgia Research Foundation, Inc. Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
JPH02152976A (ja) * 1988-05-06 1990-06-12 Bristol Myers Co ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
US5200514A (en) * 1990-01-19 1993-04-06 University Of Georgia Research Foundation, Inc. Synthesis of 2'-deoxypyrimidine nucleosides
EP0493602A4 (en) * 1990-07-27 1993-01-20 Yuki Gosei Kogyo Co., Ltd. Process for producing 2',3'-dideoxy-2',3'-didehydronucleoside
US5166327A (en) * 1990-07-31 1992-11-24 Yuki Gosei Kogyo Co., Ltd. Process for producing 3'-deoxy-3-'-fluorothymidine
JP3042073B2 (ja) * 1991-06-19 2000-05-15 味の素株式会社 ヌクレオシド誘導体とその製造方法
HUT63852A (en) * 1991-06-21 1993-10-28 Acic Canada Inc Process for producing antiviral compounds and pharmaceutical compositions comprising same as active ingredient
FR2688003B1 (fr) * 1992-02-28 1995-06-30 Univ Limoges Derives de nucleosides, leur preparation et leurs applications biologiques.
US5506349A (en) * 1992-05-13 1996-04-09 Ribozyme Pharmaceuticals, Inc. Chemical synthesis of 2', 3'-dideoxycytidine
US5539099A (en) * 1993-11-15 1996-07-23 Bristol-Myers Squibb Company Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US6635753B1 (en) 1998-09-30 2003-10-21 Brantford Chemicals Inc. Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
IT1318463B1 (it) * 2000-04-12 2003-08-25 Archimica S P A Ora Clariant L Procedimento per la preparazione di 5'-acetilstavudina.
US6927291B2 (en) * 2001-03-01 2005-08-09 Pharmasset, Ltd. Method for the synthesis of 2′,3′-dideoxy-2′,3′-didehydronucleosides
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
EP1550665A1 (en) * 2003-12-26 2005-07-06 Ajinomoto Co., Inc. A process for the production of purine nucleoside compounds
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
EP2305696A3 (en) 2005-07-25 2011-10-12 Intermune, Inc. Macrocyclic inhibitors of Hepatitis C virus replication
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
CN101029068B (zh) * 2007-04-09 2010-06-23 陆咏 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法
PT2750768T (pt) 2011-08-30 2018-12-19 Astex Pharmaceuticals Inc Formulações de derivados de decitabina
WO2014172264A1 (en) * 2013-04-16 2014-10-23 Bristol-Myers Squibb Company Method for producing festinavir using 5-methyluridine as starting material
BR112018000054A2 (pt) 2015-07-02 2018-09-04 Otsuka Pharmaceutical Co., Ltd. composições farmacêuticas liofilizadas
WO2019025863A2 (en) 2017-08-03 2019-02-07 Otsuka Pharmaceutical Co., Ltd. MEDICAMENT COMPOUND AND METHODS OF PURIFICATION

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3539550A (en) * 1967-01-23 1970-11-10 Syntex Corp Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing

Also Published As

Publication number Publication date
IL89693A0 (en) 1989-09-28
KR0142109B1 (en) 1998-07-01
CA1339448C (en) 1997-09-09
NO891208L (no) 1989-09-25
KR0140889B1 (en) 1998-06-15
FI891338A0 (fi) 1989-03-21
DK146489D0 (da) 1989-03-22
FI891338A (fi) 1989-09-25
FI93111C (fi) 1995-02-27
NO891208D0 (no) 1989-03-20
JPH02149595A (ja) 1990-06-08
EP0334368A3 (en) 1991-12-27
FI93111B (fi) 1994-11-15
IL105573A (en) 1994-04-12
PT90099B (pt) 1994-07-29
NO171367B (no) 1992-11-23
AU3167389A (en) 1989-09-28
AU622439B2 (en) 1992-04-09
ZA892166B (en) 1992-02-26
EP0334368A2 (en) 1989-09-27
IL89693A (en) 1994-08-26
KR890014528A (ko) 1989-10-24
DK146489A (da) 1989-09-25
US4904770A (en) 1990-02-27
EG18661A (en) 1993-10-30
PT90099A (pt) 1989-11-10
NZ228390A (en) 1991-12-23

Similar Documents

Publication Publication Date Title
NO171367C (no) Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider
NO890269D0 (no) Fremgangsmaate for fremstilling av 1,4-disubstituerte-piperidinyl-forbindelser.
NO885454L (no) Fremgangsmaate for fremstilling av triklormonosilan.
NO894210L (no) Fremgangsmaate for fremstilling av kinolyloxazol-2-oner.
NO894649D0 (no) Fremgangsmaate for fremstilling av (s)-alfa-ethyl-2-oxo-1-pyrrolidinacetamid.
NO895032D0 (no) Fremgangsmaate for fremstilling av 2-benzotiazoliner.
NO890159D0 (no) Fremgangsmaate for fremstilling av 1-alkyl-5-nitroimidazoler.
NO891588D0 (no) Fremgangsmaate for fremstilling av fosfonoalkylpurinderivater.
NO895040D0 (no) Fremgangsmaate for fremstilling av polyhydroxybenzyloxypropanolaminer.
NO904108L (no) Fremstilling av 2,6-dioksypiperidinderivater.
NO172345C (no) Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider
NO171315C (no) Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider
NO171314C (no) Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider
NO171316C (no) Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider r
FI945699A (fi) 2',3'-dideoksi-2',3'-didehydronukleosidien valmistus
FI940103A0 (fi) 2',3'-deoksi-2',3'-didehydronukleosidien valmistus
FI945698A (fi) 2',3'-dideoksi-2',3'-dehydronukleosidien valmistus
FI945700A0 (fi) 2',3'-dideoksi-2',3'-didehydronukleosidien valmistus
NO172286C (no) Framgangsmaate for framstilling av 1,5-benzotiazepinderivater
NO922254D0 (no) Framgangsmaate for framstilling av 1,5-benzotiazepinderivater
NO890819L (no) Fremgangsmaate for fremstilling av hydroksybenzaldehyder.