JPWO2024053578A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2024053578A5 JPWO2024053578A5 JP2024545636A JP2024545636A JPWO2024053578A5 JP WO2024053578 A5 JPWO2024053578 A5 JP WO2024053578A5 JP 2024545636 A JP2024545636 A JP 2024545636A JP 2024545636 A JP2024545636 A JP 2024545636A JP WO2024053578 A5 JPWO2024053578 A5 JP WO2024053578A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- nucleophile
- protecting group
- mass
- deprotecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 238000000034 method Methods 0.000 claims 7
- 239000012038 nucleophile Substances 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 230000002378 acidificating effect Effects 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 239000012535 impurity Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022142150 | 2022-09-07 | ||
| PCT/JP2023/032085 WO2024053578A1 (ja) | 2022-09-07 | 2023-09-01 | 核酸の製造方法、不純物の除去方法及び不純物が少ない核酸 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2024053578A1 JPWO2024053578A1 (https=) | 2024-03-14 |
| JPWO2024053578A5 true JPWO2024053578A5 (https=) | 2025-05-14 |
Family
ID=90191003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024545636A Pending JPWO2024053578A1 (https=) | 2022-09-07 | 2023-09-01 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250361540A1 (https=) |
| EP (1) | EP4585604A4 (https=) |
| JP (1) | JPWO2024053578A1 (https=) |
| CN (1) | CN119855824A (https=) |
| WO (1) | WO2024053578A1 (https=) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6036493A (ja) * | 1983-08-08 | 1985-02-25 | Nippon Zeon Co Ltd | 保護された核酸関連物質の分離法 |
| JPH07227284A (ja) | 1994-02-15 | 1995-08-29 | Takaaki Oishi | 合成ｄｎａの処理方法 |
| DK1149109T3 (da) * | 1999-02-05 | 2010-01-11 | Ge Healthcare Bio Sciences | Fremgangsmåde til afbeskyttelse af oligonukleotider |
| CN1643145A (zh) | 2002-03-21 | 2005-07-20 | 艾夫西亚生物科技公司 | 寡核苷酸及其类似物的纯化方法 |
| GB201115218D0 (en) | 2011-09-02 | 2011-10-19 | Glaxo Group Ltd | Novel process |
| US10947262B2 (en) | 2016-06-14 | 2021-03-16 | Biogen Ma Inc. | Hydrophobic interaction chromatography for purification of oligonucleotides |
| AU2020301419B2 (en) | 2019-06-25 | 2026-03-19 | Amgen Inc. | Purification methods for carbohydrate-linked oligonucleotides |
| WO2021045141A1 (ja) * | 2019-09-04 | 2021-03-11 | 神戸天然物化学株式会社 | オリゴヌクレオチドの脱保護方法 |
-
2023
- 2023-09-01 US US19/108,997 patent/US20250361540A1/en active Pending
- 2023-09-01 CN CN202380064067.9A patent/CN119855824A/zh active Pending
- 2023-09-01 WO PCT/JP2023/032085 patent/WO2024053578A1/ja not_active Ceased
- 2023-09-01 EP EP23863116.2A patent/EP4585604A4/en active Pending
- 2023-09-01 JP JP2024545636A patent/JPWO2024053578A1/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102514227B1 (ko) | 리튬 회수 방법 | |
| US5043075A (en) | Method of removing amines | |
| WO2022036862A1 (zh) | 一种氨解液及氨解方法 | |
| CN105568269A (zh) | 一种无氰镀金试剂亚硫酸金钠的制备方法 | |
| CN106459106A (zh) | 外消旋的或光学活性的α‑甘油磷酸胆碱的制备方法 | |
| CN113120941A (zh) | 从含钪镍钴氢氧化物中短流程提取高纯氧化钪的方法 | |
| JPWO2024053578A5 (https=) | ||
| RS67066B1 (sr) | Postupak za regeneraciju i prečišćavanje litijuma | |
| JP2018536640A5 (https=) | ||
| US9963422B2 (en) | Process for the synthesis of melphalan and the hydrochloride salt | |
| EP3666756B1 (en) | Method for preparing levetiracetam | |
| US20040063997A1 (en) | Process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride | |
| JP6947354B2 (ja) | リナグリプチンの製造法 | |
| FR2619098A1 (fr) | Procede de purification de saumures concentrees d'halogenures alcalins | |
| JPH11349495A (ja) | 水性酸溶液から金属化合物を除去する方法 | |
| JP3312459B2 (ja) | 光学活性アミンの単離方法 | |
| KR20160003007A (ko) | 플루오린화수소산과 질산의 혼합물을 정제하기 위한 역삼투 | |
| HU228593B1 (en) | Process for the purification of a salt of clavulanic acid | |
| EP0210934B1 (fr) | Procédé de séparation de terres rares et de l'uranium d'un concentré de tétrafluorure d'uranium et de leur valorisation | |
| NO312831B1 (no) | Fremgangsmåte ved fremstilling av 3-amin-1,2-propandiol | |
| ATE138353T1 (de) | Verfahren zur reinigung von phosphorsäure | |
| US20110144383A1 (en) | Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid | |
| CN117923999B (zh) | 一种伯胺的制备方法 | |
| KR20240055566A (ko) | 에스터 화합물의 인시츄 합성방법 | |
| SU923949A1 (ru) | Способ получения сульфата аммонияi |