JPWO2023283092A5 - - Google Patents
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- Publication number
- JPWO2023283092A5 JPWO2023283092A5 JP2024501179A JP2024501179A JPWO2023283092A5 JP WO2023283092 A5 JPWO2023283092 A5 JP WO2023283092A5 JP 2024501179 A JP2024501179 A JP 2024501179A JP 2024501179 A JP2024501179 A JP 2024501179A JP WO2023283092 A5 JPWO2023283092 A5 JP WO2023283092A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- polynucleotide
- seq
- prime editing
- editing composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163218744P | 2021-07-06 | 2021-07-06 | |
| US63/218,744 | 2021-07-06 | ||
| US202163219623P | 2021-07-08 | 2021-07-08 | |
| US63/219,623 | 2021-07-08 | ||
| PCT/US2022/035613 WO2023283092A1 (en) | 2021-07-06 | 2022-06-29 | Compositions and methods for efficient genome editing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024525665A JP2024525665A (ja) | 2024-07-12 |
| JPWO2023283092A5 true JPWO2023283092A5 (https=) | 2025-07-07 |
| JP2024525665A5 JP2024525665A5 (https=) | 2025-07-07 |
Family
ID=84800962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024501179A Pending JP2024525665A (ja) | 2021-07-06 | 2022-06-29 | 効率的なゲノム編集のための組成物及び方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240228988A1 (https=) |
| EP (1) | EP4367227A4 (https=) |
| JP (1) | JP2024525665A (https=) |
| AU (1) | AU2022306377A1 (https=) |
| CA (1) | CA3224970A1 (https=) |
| WO (1) | WO2023283092A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| CA3174483A1 (en) | 2020-03-04 | 2021-09-10 | Flagship Pioneering Innovations Vi, Llc | Improved methods and compositions for modulating a genome |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| JP2024533311A (ja) | 2021-09-08 | 2024-09-12 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | ゲノムを調節するための方法及び組成物 |
| KR20240099164A (ko) | 2021-09-08 | 2024-06-28 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | Pah-조절 조성물 및 방법 |
| JP2024534945A (ja) * | 2021-09-10 | 2024-09-26 | アジレント・テクノロジーズ・インク | 化学修飾を有するプライム編集のためのガイドｒｎａ |
| EP4444362A4 (en) | 2021-12-10 | 2026-04-01 | Flagship Pioneering Innovations Vi Llc | CFTR COMPOSITIONS AND MODULATION METHODS |
| WO2023225670A2 (en) | 2022-05-20 | 2023-11-23 | Tome Biosciences, Inc. | Ex vivo programmable gene insertion |
| WO2024020587A2 (en) | 2022-07-22 | 2024-01-25 | Tome Biosciences, Inc. | Pleiopluripotent stem cell programmable gene insertion |
| EP4665865A1 (en) | 2023-02-17 | 2025-12-24 | Anjarium Biosciences AG | Methods of making dna molecules and compositions and uses thereof |
| WO2024178144A1 (en) * | 2023-02-22 | 2024-08-29 | Prime Medicine, Inc. | Methods and compositions for editing nucleotide sequences |
| EP4720304A2 (en) * | 2023-05-31 | 2026-04-08 | University of Massachusetts | Improved modular prime editing with modified effectors and templates |
| WO2024259051A1 (en) * | 2023-06-14 | 2024-12-19 | The Children's Medical Center Corporation | Systems and methods for modifying a polynucleotide |
| WO2025038881A1 (en) * | 2023-08-16 | 2025-02-20 | Beam Therapeutics Inc. | Prime editing of single base mutations in sickle cell disease |
| WO2025076306A1 (en) * | 2023-10-06 | 2025-04-10 | University Of Massachusetts | Prime editors having improved prime editing efficiency |
| US20250354138A1 (en) | 2024-03-15 | 2025-11-20 | Beam Therapeutics Inc. | Prime editing of single base mutations in alpha-1 antitrypsin deficiency |
| WO2025226946A1 (en) * | 2024-04-24 | 2025-10-30 | Cedric Francois | Methods and compositions for the treatment of androgenic alopecia |
| WO2025231071A1 (en) * | 2024-05-01 | 2025-11-06 | Beam Therapeutics Inc. | Compositions and methods for cell conditioning |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019186348A1 (en) * | 2018-03-25 | 2019-10-03 | GeneTether, Inc | Modified nucleic acid editing systems for tethering donor dna |
| WO2020033083A1 (en) * | 2018-08-10 | 2020-02-13 | Cornell University | Optimized base editors enable efficient editing in cells, organoids and mice |
| KR20210121113A (ko) * | 2019-01-31 | 2021-10-07 | 빔 테라퓨틱스, 인크. | 비-표적 탈아미노화가 감소된 핵염기 편집기 및 핵염기 편집기를 특성규명하기 위한 분석 |
| CN116355966A (zh) * | 2019-02-02 | 2023-06-30 | 上海科技大学 | 一种融合蛋白在遗传编辑的用途 |
| JP7657726B2 (ja) * | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| WO2021042047A1 (en) * | 2019-08-30 | 2021-03-04 | The General Hospital Corporation | C-to-g transversion dna base editors |
| EP4081635A4 (en) * | 2019-12-26 | 2024-03-27 | Agency for Science, Technology and Research | Nucleobase editors |
-
2022
- 2022-06-29 WO PCT/US2022/035613 patent/WO2023283092A1/en not_active Ceased
- 2022-06-29 CA CA3224970A patent/CA3224970A1/en active Pending
- 2022-06-29 JP JP2024501179A patent/JP2024525665A/ja active Pending
- 2022-06-29 AU AU2022306377A patent/AU2022306377A1/en active Pending
- 2022-06-29 EP EP22838255.2A patent/EP4367227A4/en active Pending
-
2024
- 2024-01-04 US US18/404,456 patent/US20240228988A1/en active Pending
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