JPWO2022010889A5 - - Google Patents
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- Publication number
- JPWO2022010889A5 JPWO2022010889A5 JP2023500330A JP2023500330A JPWO2022010889A5 JP WO2022010889 A5 JPWO2022010889 A5 JP WO2022010889A5 JP 2023500330 A JP2023500330 A JP 2023500330A JP 2023500330 A JP2023500330 A JP 2023500330A JP WO2022010889 A5 JPWO2022010889 A5 JP WO2022010889A5
- Authority
- JP
- Japan
- Prior art keywords
- henipavirus
- protein
- molecule
- nucleic acid
- cathepsin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000035314 Henipavirus Species 0.000 claims description 86
- 210000004027 cell Anatomy 0.000 claims description 67
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 45
- 102000039446 nucleic acids Human genes 0.000 claims description 42
- 108020004707 nucleic acids Proteins 0.000 claims description 42
- 150000007523 nucleic acids Chemical class 0.000 claims description 42
- 239000008194 pharmaceutical composition Substances 0.000 claims description 37
- 108091006027 G proteins Proteins 0.000 claims description 27
- 102000030782 GTP binding Human genes 0.000 claims description 27
- 108091000058 GTP-Binding Proteins 0.000 claims description 27
- 102000005600 Cathepsins Human genes 0.000 claims description 22
- 108010084457 Cathepsins Proteins 0.000 claims description 22
- 210000004962 mammalian cell Anatomy 0.000 claims description 14
- 102000004169 proteins and genes Human genes 0.000 claims description 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 9
- 230000003612 virological effect Effects 0.000 claims description 9
- 102000004172 Cathepsin L Human genes 0.000 claims description 8
- 108090000624 Cathepsin L Proteins 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 102000004225 Cathepsin B Human genes 0.000 claims description 6
- 108090000712 Cathepsin B Proteins 0.000 claims description 6
- 101710160621 Fusion glycoprotein F0 Proteins 0.000 claims description 6
- 230000012202 endocytosis Effects 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 210000005260 human cell Anatomy 0.000 claims description 5
- 241000526636 Nipah henipavirus Species 0.000 claims description 4
- 108091005461 Nucleic proteins Proteins 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 3
- -1 22 or 25 amino acids Chemical class 0.000 claims description 2
- 102100023206 Neuromodulin Human genes 0.000 claims description 2
- 101710132548 Protein F1 Proteins 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 210000004102 animal cell Anatomy 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000002121 endocytic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004986 primary T-cell Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025170166A JP2025188163A (ja) | 2020-07-06 | 2025-10-08 | ウイルスフソソームを産生するための方法及び組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063048524P | 2020-07-06 | 2020-07-06 | |
| US63/048,524 | 2020-07-06 | ||
| PCT/US2021/040501 WO2022010889A1 (en) | 2020-07-06 | 2021-07-06 | Methods and compositions for producing viral fusosomes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025170166A Division JP2025188163A (ja) | 2020-07-06 | 2025-10-08 | ウイルスフソソームを産生するための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023534924A JP2023534924A (ja) | 2023-08-15 |
| JP2023534924A5 JP2023534924A5 (https=) | 2024-07-17 |
| JPWO2022010889A5 true JPWO2022010889A5 (https=) | 2024-07-17 |
Family
ID=79552689
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023500330A Pending JP2023534924A (ja) | 2020-07-06 | 2021-07-06 | ウイルスフソソームを産生するための方法及び組成物 |
| JP2025170166A Pending JP2025188163A (ja) | 2020-07-06 | 2025-10-08 | ウイルスフソソームを産生するための方法及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025170166A Pending JP2025188163A (ja) | 2020-07-06 | 2025-10-08 | ウイルスフソソームを産生するための方法及び組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240279685A1 (https=) |
| EP (1) | EP4175622A4 (https=) |
| JP (2) | JP2023534924A (https=) |
| KR (1) | KR20230044420A (https=) |
| CN (1) | CN116157116A (https=) |
| AU (1) | AU2021305060A1 (https=) |
| BR (1) | BR112023000151A2 (https=) |
| CA (1) | CA3188810A1 (https=) |
| IL (1) | IL299658A (https=) |
| MX (1) | MX2023000358A (https=) |
| WO (1) | WO2022010889A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018256925B2 (en) | 2017-04-28 | 2024-11-21 | Agrospheres, Inc. | Compositions and methods for the encapsulation and scalable delivery of agrochemicals |
| US11624061B2 (en) | 2017-04-28 | 2023-04-11 | Agrospheres, Inc. | Compositions and methods for enzyme immobilization |
| BR112020005803A2 (pt) | 2017-09-25 | 2020-12-01 | Agrospheres, Inc. | composições e métodos para produção e administração moduláveis de produtos biológicos |
| US12496274B2 (en) | 2018-11-14 | 2025-12-16 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート，インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| EP4185600A4 (en) | 2020-07-24 | 2024-12-04 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018266111B2 (en) * | 2017-05-08 | 2024-11-07 | Flagship Pioneering Innovations V, Inc. | Compositions for facilitating membrane fusion and uses thereof |
| US12496274B2 (en) * | 2018-11-14 | 2025-12-16 | Flagship Pioneering Innovations V, Inc. | Compositions and methods for compartment-specific cargo delivery |
-
2021
- 2021-07-06 IL IL299658A patent/IL299658A/en unknown
- 2021-07-06 US US18/004,403 patent/US20240279685A1/en active Pending
- 2021-07-06 WO PCT/US2021/040501 patent/WO2022010889A1/en not_active Ceased
- 2021-07-06 KR KR1020237003754A patent/KR20230044420A/ko active Pending
- 2021-07-06 AU AU2021305060A patent/AU2021305060A1/en active Pending
- 2021-07-06 CA CA3188810A patent/CA3188810A1/en active Pending
- 2021-07-06 JP JP2023500330A patent/JP2023534924A/ja active Pending
- 2021-07-06 CN CN202180054642.8A patent/CN116157116A/zh active Pending
- 2021-07-06 BR BR112023000151A patent/BR112023000151A2/pt unknown
- 2021-07-06 MX MX2023000358A patent/MX2023000358A/es unknown
- 2021-07-06 EP EP21838511.0A patent/EP4175622A4/en active Pending
-
2025
- 2025-10-08 JP JP2025170166A patent/JP2025188163A/ja active Pending
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