|
US5422251A
(en)
|
1986-11-26 |
1995-06-06 |
Princeton University |
Triple-stranded nucleic acids
|
|
US5176996A
(en)
|
1988-12-20 |
1993-01-05 |
Baylor College Of Medicine |
Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
|
|
US5420032A
(en)
|
1991-12-23 |
1995-05-30 |
Universitge Laval |
Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
|
|
US5792632A
(en)
|
1992-05-05 |
1998-08-11 |
Institut Pasteur |
Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
|
|
DE4228458A1
(de)
|
1992-08-27 |
1994-06-01 |
Beiersdorf Ag |
Multicistronische Expressionseinheiten und deren Verwendung
|
|
US6013516A
(en)
|
1995-10-06 |
2000-01-11 |
The Salk Institute For Biological Studies |
Vector and method of use for nucleic acid delivery to non-dividing cells
|
|
DE19539493A1
(de)
|
1995-10-24 |
1997-04-30 |
Thomae Gmbh Dr K |
Starker homologer Promotor aus Hamster
|
|
GB9526131D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Recombinant chimeric receptors
|
|
CA2265460A1
(en)
|
1996-09-11 |
1998-03-19 |
The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services |
Aav4 vector and uses thereof
|
|
PL332875A1
(en)
|
1996-10-17 |
1999-10-25 |
Oxford Biomedica Ltd |
Retroviral vectors
|
|
EP0970227B1
(en)
|
1997-03-20 |
2008-01-09 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Recombinant antibodies and immunoconjugates targeted to cd-22 bearing cells and tumors
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
US6156303A
(en)
|
1997-06-11 |
2000-12-05 |
University Of Washington |
Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom
|
|
GB9720465D0
(en)
|
1997-09-25 |
1997-11-26 |
Oxford Biomedica Ltd |
Dual-virus vectors
|
|
US5994136A
(en)
|
1997-12-12 |
1999-11-30 |
Cell Genesys, Inc. |
Method and means for producing high titer, safe, recombinant lentivirus vectors
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US7070934B2
(en)
|
1999-01-12 |
2006-07-04 |
Sangamo Biosciences, Inc. |
Ligand-controlled regulation of endogenous gene expression
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US7030215B2
(en)
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
CA2394850C
(en)
|
1999-12-06 |
2012-02-07 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
KR20020086508A
(ko)
|
2000-02-08 |
2002-11-18 |
상가모 바이오사이언스 인코포레이티드 |
약물 발견용 세포
|
|
JP2002060786A
(ja)
|
2000-08-23 |
2002-02-26 |
Kao Corp |
硬質表面用殺菌防汚剤
|
|
US7575924B2
(en)
|
2000-11-13 |
2009-08-18 |
Research Development Foundation |
Methods and compositions relating to improved lentiviral vectors and their applications
|
|
US7067317B2
(en)
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
|
US20050267061A1
(en)
|
2004-04-08 |
2005-12-01 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating neuropathic and neurodegenerative conditions
|
|
ATE437221T1
(de)
|
2001-05-14 |
2009-08-15 |
Gbp Ip Llc |
Lentivirale vektoren kodierend für gerinnungsfaktoren für die gentherapie
|
|
EP1412493B1
(en)
|
2001-08-02 |
2011-10-05 |
Institut Clayton De La Recherche |
Methods and compositions relating to improved lentiviral vector production systems
|
|
US20040224385A1
(en)
|
2001-08-20 |
2004-11-11 |
Barbas Carlos F |
Zinc finger binding domains for cnn
|
|
CA2461351C
(en)
|
2001-09-26 |
2014-08-05 |
Ira H. Pastan |
Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells
|
|
EP1438075A4
(en)
|
2001-10-02 |
2006-04-19 |
Inst Clayton De La Rech |
METHOD AND COMPOSITIONS ASSOCIATED WITH LENTIVIRAL VECTORS WITH LIMITED EXPRESSION AND ITS APPLICATIONS
|
|
NZ532635A
(en)
|
2001-11-13 |
2007-05-31 |
Univ Pennsylvania |
A method of identifying unknown adeno-associated virus (AAV) sequences and a kit for the method
|
|
US7939059B2
(en)
|
2001-12-10 |
2011-05-10 |
California Institute Of Technology |
Method for the generation of antigen-specific lymphocytes
|
|
AU2002359284A1
(en)
|
2001-12-17 |
2003-06-30 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor
|
|
US7262054B2
(en)
|
2002-01-22 |
2007-08-28 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
|
SE0200198D0
(sv)
|
2002-01-23 |
2002-01-23 |
Astrazeneca Ab |
New use
|
|
US7361635B2
(en)
|
2002-08-29 |
2008-04-22 |
Sangamo Biosciences, Inc. |
Simultaneous modulation of multiple genes
|
|
DE60333487D1
(de)
|
2002-12-13 |
2010-09-02 |
Genetix Pharmaceuticals Inc |
Therapeutische retrovirus-vektoren für gentherapie
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
CN1856576B
(zh)
|
2003-09-30 |
2011-05-04 |
宾夕法尼亚州立大学托管会 |
腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用
|
|
US7982011B2
(en)
|
2003-11-25 |
2011-07-19 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Mutated anti-cd22 antibodies and immunoconjugates
|
|
US7972854B2
(en)
|
2004-02-05 |
2011-07-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
JP2008506359A
(ja)
|
2004-04-08 |
2008-03-06 |
サンガモ バイオサイエンシズ インコーポレイテッド |
ジンクフィンガータンパク質による神経因性疼痛の処置
|
|
WO2006110689A2
(en)
|
2005-04-07 |
2006-10-19 |
The Trustees Of The University Of Pennsylvania |
Method of increasing the function of an aav vector
|
|
CA2891996A1
(en)
|
2005-10-18 |
2007-04-26 |
Duke University |
Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity
|
|
EP2132322A4
(en)
|
2007-03-02 |
2013-02-20 |
Richmond Chemical Corp |
METHOD FOR INCREASING YIELD AND IMPROVING PURIFICATION OF PRODUCTS FROM REACTIONS WITH TRANSAMINASE
|
|
ES2708856T3
(es)
|
2007-08-03 |
2019-04-11 |
Pasteur Institut |
Vectores de transferencia de gen lentivírico y sus aplicaciones medicinales
|
|
US8728812B2
(en)
|
2008-04-22 |
2014-05-20 |
President And Fellows Of Harvard College |
Compositions and methods for promoting the generation of PDX1+ pancreatic cells
|
|
WO2010022395A2
(en)
|
2008-08-22 |
2010-02-25 |
President And Fellows Of Harvard College |
Methods of reprogramming cells
|
|
US8507274B2
(en)
|
2009-02-06 |
2013-08-13 |
President And Fellows Of Harvard College |
Compositions and methods for promoting the generation of definitive endoderm
|
|
EP2406284B9
(en)
|
2009-03-10 |
2017-03-01 |
Biogen MA Inc. |
Anti-bcma antibodies
|
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス， インコーポレイテッド |
新規のｄｎａ結合タンパク質及びその使用
|
|
WO2011146862A1
(en)
|
2010-05-21 |
2011-11-24 |
Bellicum Pharmaceuticals, Inc. |
Methods for inducing selective apoptosis
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
EP2694089B1
(en)
|
2011-04-05 |
2024-06-05 |
Cellectis |
New tale-protein scaffolds and uses thereof
|
|
CA2833820C
(en)
|
2011-05-27 |
2019-10-29 |
Glaxo Group Limited |
Bcma (cd269/tnfrsf17) -binding proteins
|
|
WO2013040557A2
(en)
|
2011-09-16 |
2013-03-21 |
The Trustees Of The University Of Pennsylvania |
Rna engineered t cells for the treatment of cancer
|
|
WO2013096955A1
(en)
|
2011-12-23 |
2013-06-27 |
Case Western Reserve University |
Targeted gene modification using hybrid recombinant adeno-associated virus
|
|
CN108285491B
(zh)
|
2012-02-29 |
2021-08-10 |
桑格摩生物科学股份有限公司 |
治疗亨廷顿氏病的方法和组合物
|
|
EA033110B1
(ru)
|
2012-04-11 |
2019-08-30 |
Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез |
Химерный рецептор антигена, направленный на антиген созревания b-клеток, кодирующая его нуклеиновая кислота, соответствующие экспрессионный вектор, клетка-хозяин, применения и способы
|
|
GB201212902D0
(en)
|
2012-07-20 |
2012-09-05 |
Univ Singapore |
Combinatoric encoding methods for microarrays
|
|
JP6694712B2
(ja)
|
2012-11-01 |
2020-05-20 |
マックス−デルブルック−セントラム フアー モレキュラーレ メデジン |
Ｃｄ２６９（ｂｃｍａ）に対する抗体
|
|
JP6556156B2
(ja)
|
2014-02-27 |
2019-08-07 |
ユーシーエル ビジネス ピーエルシー |
Ａｐｒｉｌバリアント
|
|
KR102632731B1
(ko)
|
2014-04-30 |
2024-02-01 |
막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트 |
Ｃｄ269에 대한 인간화 항체
|
|
GB201409858D0
(en)
|
2014-06-03 |
2014-07-16 |
Ucl Business Plc |
Human liver scaffolds
|
|
TWI750110B
(zh)
|
2014-07-21 |
2021-12-21 |
瑞士商諾華公司 |
使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症
|
|
MX2017001079A
(es)
|
2014-07-24 |
2017-09-12 |
Bluebird Bio Inc |
Receptores de antígeno quiméricos de antígeno de maduración de células b (bcma).
|
|
EP2990416B1
(en)
|
2014-08-29 |
2018-06-20 |
GEMoaB Monoclonals GmbH |
Universal chimeric antigen receptor expressing immune cells for targeting of diverse multiple antigens and method of manufacturing the same and use of the same for treatment of cancer, infections and autoimmune disorders
|
|
US11161907B2
(en)
|
2015-02-02 |
2021-11-02 |
Novartis Ag |
Car-expressing cells against multiple tumor antigens and uses thereof
|
|
KR20260048600A
(ko)
|
2015-03-27 |
2026-04-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
변형된 t 세포 및 이의 제조 및 사용 방법
|
|
EP3294342A4
(en)
|
2015-05-08 |
2018-11-07 |
President and Fellows of Harvard College |
Universal donor stem cells and related methods
|
|
CN108431209B
(zh)
|
2015-06-12 |
2023-02-10 |
新加坡科技研究局 |
肝脏干细胞的衍生和成熟肝细胞类型及其用途
|
|
EP3355937A4
(en)
|
2015-09-28 |
2019-04-17 |
Regents of the University of Minnesota |
CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS AS THERAPEUTIC INTERVENTIONS AT AUTO AND ALLO IMMUNITY
|
|
WO2017058753A1
(en)
|
2015-09-28 |
2017-04-06 |
Trustees Of Dartmouth College |
Chimeric antigen receptor, regulatory cells and methods of use
|
|
SG11201810640RA
(en)
|
2016-06-08 |
2018-12-28 |
Intrexon Corp |
Cd33 specific chimeric antigen receptors
|
|
EP4282877A3
(en)
|
2016-08-10 |
2024-02-21 |
Legend Biotech Ireland Limited |
Chimeric antigen receptors targeting bcma and methods of use thereof
|
|
CN110177869A
(zh)
|
2017-01-13 |
2019-08-27 |
加利福尼亚大学董事会 |
免疫改造的多能细胞
|
|
WO2018176390A1
(zh)
|
2017-03-31 |
2018-10-04 |
深圳市立昌机电设备有限公司 |
绕线机的安全防备方法及系统
|
|
AU2018269194B2
(en)
|
2017-05-15 |
2025-05-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Bicistronic chimeric antigen receptors and their uses
|
|
WO2019005886A1
(en)
|
2017-06-26 |
2019-01-03 |
The Broad Institute, Inc. |
CRISPR / CAS-CYTIDINE DEAMINASE COMPOSITIONS, SYSTEMS AND METHODS FOR TARGETED EDITING OF NUCLEIC ACIDS
|
|
AU2018290843B2
(en)
|
2017-06-26 |
2025-04-24 |
Massachusetts Institute Of Technology |
CRISPR/Cas-adenine deaminase based compositions, systems, and methods for targeted nucleic acid editing
|
|
US20200138865A1
(en)
|
2017-06-30 |
2020-05-07 |
The United States Of America,As Represented By The Secretary,Department Of Health And Human Services |
Anti-b-cell maturation antigen chimeric antigen receptors with human domains
|
|
WO2019126709A1
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Cas12b systems, methods, and compositions for targeted dna base editing
|
|
EP3728576A4
(en)
|
2017-12-22 |
2021-11-24 |
The Broad Institute, Inc. |
CAS12B SYSTEMS, METHODS AND COMPOSITIONS FOR SPECIFIC EDITING OF RNA BASES
|
|
WO2019126762A2
(en)
|
2017-12-22 |
2019-06-27 |
The Broad Institute, Inc. |
Cas12a systems, methods, and compositions for targeted rna base editing
|
|
AU2019214183B2
(en)
|
2018-02-01 |
2022-04-07 |
Innovent Biologics (Suzhou) Co., Ltd. |
Fully human anti-B cell maturation antigen (BCMA) single chain variable fragment, and application thereof
|
|
CN116082518A
(zh)
|
2018-02-01 |
2023-05-09 |
南京驯鹿生物技术股份有限公司 |
一种结合bcma的嵌合抗原受体（car）及其应用
|
|
US11266690B2
(en)
|
2018-02-01 |
2022-03-08 |
Nanjing Iaso Biotherapeutics Co., Ltd. |
Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
|
|
EP3793579A4
(en)
|
2018-05-16 |
2022-02-23 |
Washington University |
METHODS AND COMPOSITIONS FOR GENERATION OF ENDODERMAL LINEAGE AND BETA CELLS AND USES THEREOF
|
|
BR112021000637A2
(pt)
|
2018-07-17 |
2021-04-13 |
The Regents Of The University Of California |
Célula cardíaca hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença cardíaca, método para produzir uma população de células cardíacas hipoimunes, célula endotelial hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença vascular, método para produzir uma população de células endoteliais hipoimunes, neurônio dopaminérgico hipoimune isolado, método para tratar um paciente que sofre de uma doença ou afecção neurodegenerativa, método para produzir uma população de neurônios dopaminérgicos hipoimunes, célula de ilhota pancreática hipoimune isolada, método para tratar um paciente que sofre de diabetes, método para produzir uma população de células de ilhota pancreática hipoimunes, célula de epitélio pigmentado da retina (rpe) hipoimune isolada, método para tratar um paciente que sofre de uma afecção ocular, e método para produzir uma população de células de epitélio pigmentado da retina (rpe) hipoimunes
|
|
US20210308183A1
(en)
|
2018-07-17 |
2021-10-07 |
The Regents Of The University Of California |
Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells
|
|
EP3850088A4
(en)
|
2018-09-07 |
2023-07-19 |
Beam Therapeutics, Inc. |
Compositions and methods for improving base editing
|
|
US11295152B2
(en)
|
2019-03-01 |
2022-04-05 |
Basf Coatings Gmbh |
Method and system for object recognition via a computer vision application
|
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
|
WO2020181193A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
|
JP7657726B2
(ja)
|
2019-03-19 |
2025-04-07 |
ザ ブロード インスティテュート，インコーポレーテッド |
編集ヌクレオチド配列を編集するための方法および組成物
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
WO2021158921A2
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
EP4217490A2
(en)
|
2020-09-24 |
2023-08-02 |
The Broad Institute Inc. |
Prime editing guide rnas, compositions thereof, and methods of using the same
|
|
US20230383261A1
(en)
|
2020-10-14 |
2023-11-30 |
Sana Biotechnology, Inc. |
Hepatocyte-like cells
|
|
TW202246494A
(zh)
|
2021-01-26 |
2022-12-01 |
美商艾姆比斯藥品公司 |
基因改造肝細胞群
|