JPWO2023107669A5 - - Google Patents

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Publication number
JPWO2023107669A5
JPWO2023107669A5 JP2024534287A JP2024534287A JPWO2023107669A5 JP WO2023107669 A5 JPWO2023107669 A5 JP WO2023107669A5 JP 2024534287 A JP2024534287 A JP 2024534287A JP 2024534287 A JP2024534287 A JP 2024534287A JP WO2023107669 A5 JPWO2023107669 A5 JP WO2023107669A5
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Japan
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alkenyl
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JP2024534287A
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English (en)
Japanese (ja)
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JP2025502627A5 (https=
JP2025502627A (ja
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Priority claimed from PCT/US2022/052347 external-priority patent/WO2023107669A1/en
Publication of JP2025502627A publication Critical patent/JP2025502627A/ja
Publication of JP2025502627A5 publication Critical patent/JP2025502627A5/ja
Publication of JPWO2023107669A5 publication Critical patent/JPWO2023107669A5/ja
Pending legal-status Critical Current

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JP2024534287A 2021-12-10 2022-12-09 治療剤の送達のための化合物及び組成物 Pending JP2025502627A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163288317P 2021-12-10 2021-12-10
US63/288,317 2021-12-10
PCT/US2022/052347 WO2023107669A1 (en) 2021-12-10 2022-12-09 Compounds and compositions for delivery of therapeutic agents

Publications (3)

Publication Number Publication Date
JP2025502627A JP2025502627A (ja) 2025-01-28
JP2025502627A5 JP2025502627A5 (https=) 2025-12-08
JPWO2023107669A5 true JPWO2023107669A5 (https=) 2025-12-08

Family

ID=85076438

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024534287A Pending JP2025502627A (ja) 2021-12-10 2022-12-09 治療剤の送達のための化合物及び組成物

Country Status (7)

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US (1) US20250144036A1 (https=)
EP (1) EP4444692A1 (https=)
JP (1) JP2025502627A (https=)
CN (1) CN118369308A (https=)
AR (1) AR127892A1 (https=)
TW (1) TW202333708A (https=)
WO (1) WO2023107669A1 (https=)

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EP4286012A3 (en) 2015-09-17 2024-05-29 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
HUE057877T2 (hu) 2015-12-22 2022-06-28 Modernatx Inc Vegyületek és készítmények terápiás szerek intracelluláris bejuttatására
WO2018170322A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Crystal forms of amino lipids
SMT202300097T1 (it) 2017-03-15 2023-05-12 Modernatx Inc Composto e composizioni per il rilascio intracellulare di agenti terapeutici
AU2020350759A1 (en) 2019-09-19 2022-03-31 Modernatx, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
CN116969850A (zh) * 2022-06-14 2023-10-31 苏州科锐迈德生物医药科技有限公司 碳酸酯-羧酸酯型脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂
WO2024067639A1 (zh) * 2022-09-30 2024-04-04 荣灿生物医药技术(上海)有限公司 一种转染效率高的可电离脂质化合物及其应用
CN116947669B (zh) * 2022-09-30 2024-04-12 荣灿生物医药技术(上海)有限公司 一种转染效率高的可电离脂质化合物及其应用
EP4727914A1 (en) * 2023-06-14 2026-04-22 ModernaTX, Inc. Compounds and compositions for delivery of therapeutic agents
CN121463960A (zh) * 2023-06-28 2026-02-03 上海瑞宏迪医药有限公司 一种含有阳离子脂质的药物组合物及其用途
CN121889371A (zh) * 2023-07-03 2026-04-17 科纳勒生物公司 脂质及其组合物
CN116891423B (zh) * 2023-07-07 2024-03-01 荣灿生物医药技术(上海)有限公司 脂质化合物、组合物及其制备方法和应用
CN121532376A (zh) * 2023-07-19 2026-02-13 正基基因科技有限公司 脂质和脂质纳米颗粒
CN119330848B (zh) * 2023-10-19 2025-07-08 仁景(苏州)生物科技有限公司 用于递送的脂质化合物及脂质纳米颗粒
KR20250064439A (ko) * 2023-11-02 2025-05-09 주식회사 삼양홀딩스 양이온성 지질 및 이의 제조방법
CN117658839A (zh) * 2023-11-22 2024-03-08 武汉大学 一种含羟基可电离脂质及其制备方法与应用
WO2025124541A1 (zh) * 2023-12-13 2025-06-19 上海瑞宏迪医药有限公司 一种阳离子脂质及其应用
CN119798203A (zh) * 2024-01-05 2025-04-11 仁景(苏州)生物科技有限公司 用于递送的脂质化合物和脂质纳米颗粒
CN119874554B (zh) * 2024-02-02 2025-08-19 仁景(苏州)生物科技有限公司 用于递送的脂质化合物和脂质纳米颗粒
CN117695410B (zh) * 2024-02-06 2024-05-03 中国人民解放军军事科学院军事医学研究院 CRISPR/Cas9纳米抗菌剂及其制备方法
CN119264001A (zh) * 2024-04-03 2025-01-07 上海蓝鹊生物医药有限公司 含氮链状化合物、制备方法、包含其的组合物和应用
CN118388360B (zh) * 2024-04-17 2025-04-04 北京悦康科创医药科技股份有限公司 含有苯环结构的长效脾靶向阳离子脂质化合物、包含其的组合物及用途
CN118852328A (zh) * 2024-07-02 2024-10-29 北京大学 肽基可离子化脂质合成及其应用
CN119019272A (zh) * 2024-08-14 2024-11-26 中国药科大学 可电离脂质、包含其的组合物及其用途
CN119039164B (zh) * 2024-08-29 2025-04-11 国药中生生物技术研究院有限公司 可离子化脂质化合物、包含其的脂质纳米颗粒、药物组合物、药物制剂及其应用
WO2026061393A1 (zh) * 2024-09-18 2026-03-26 北京剂泰生命科技有限公司 递送编码分泌型蛋白的核酸分子的脂质纳米颗粒及其用途
CN119661389A (zh) * 2024-10-15 2025-03-21 山东大学 一种基于反式-1,4-环己烷二甲醇的可电离脂质、脂质纳米颗粒及其制备方法与应用
CN121426694B (zh) * 2025-12-31 2026-04-03 中国科学技术大学苏州高等研究院 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用
CN121426693B (zh) * 2025-12-31 2026-04-03 中国科学技术大学苏州高等研究院 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用

Family Cites Families (10)

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Publication number Priority date Publication date Assignee Title
EP4286012A3 (en) 2015-09-17 2024-05-29 ModernaTX, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
PL3350333T3 (pl) 2015-09-17 2022-03-07 Modernatx, Inc. Polinukleotydy zawierające region stabilizujący ogon
AU2016336344A1 (en) 2015-10-05 2018-04-19 Modernatx, Inc. Methods for therapeutic administration of messenger ribonucleic acid drugs
IL307179A (en) * 2015-10-28 2023-11-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
HUE057877T2 (hu) 2015-12-22 2022-06-28 Modernatx Inc Vegyületek és készítmények terápiás szerek intracelluláris bejuttatására
SMT202300097T1 (it) 2017-03-15 2023-05-12 Modernatx Inc Composto e composizioni per il rilascio intracellulare di agenti terapeutici
US12077501B2 (en) 2017-06-14 2024-09-03 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
WO2021055849A1 (en) 2019-09-19 2021-03-25 Modernatx, Inc. Headgroup lipid compounds and compositions for intracellular delivery of therapeutic agents
AU2020350759A1 (en) * 2019-09-19 2022-03-31 Modernatx, Inc. Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents
BR112022004936A2 (pt) 2019-09-19 2022-06-14 Modernatx Inc Compostos lipídicos contendo carbonato e composições para distribuição intracelular de agentes terapêuticos

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