CN118369308A - 用于递送治疗剂的化合物和组合物 - Google Patents
用于递送治疗剂的化合物和组合物 Download PDFInfo
- Publication number
- CN118369308A CN118369308A CN202280081536.3A CN202280081536A CN118369308A CN 118369308 A CN118369308 A CN 118369308A CN 202280081536 A CN202280081536 A CN 202280081536A CN 118369308 A CN118369308 A CN 118369308A
- Authority
- CN
- China
- Prior art keywords
- group
- alkyl
- lnp
- lipid
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163288317P | 2021-12-10 | 2021-12-10 | |
| US63/288317 | 2021-12-10 | ||
| PCT/US2022/052347 WO2023107669A1 (en) | 2021-12-10 | 2022-12-09 | Compounds and compositions for delivery of therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118369308A true CN118369308A (zh) | 2024-07-19 |
Family
ID=85076438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280081536.3A Pending CN118369308A (zh) | 2021-12-10 | 2022-12-09 | 用于递送治疗剂的化合物和组合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250144036A1 (https=) |
| EP (1) | EP4444692A1 (https=) |
| JP (1) | JP2025502627A (https=) |
| CN (1) | CN118369308A (https=) |
| AR (1) | AR127892A1 (https=) |
| TW (1) | TW202333708A (https=) |
| WO (1) | WO2023107669A1 (https=) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116969850A (zh) * | 2022-06-14 | 2023-10-31 | 苏州科锐迈德生物医药科技有限公司 | 碳酸酯-羧酸酯型脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CN119019272A (zh) * | 2024-08-14 | 2024-11-26 | 中国药科大学 | 可电离脂质、包含其的组合物及其用途 |
| CN119039164A (zh) * | 2024-08-29 | 2024-11-29 | 国药中生生物技术研究院有限公司 | 可离子化脂质化合物、包含其的脂质纳米颗粒、药物组合物、药物制剂及其应用 |
| CN119330848A (zh) * | 2023-10-19 | 2025-01-21 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物及脂质纳米颗粒 |
| CN119661389A (zh) * | 2024-10-15 | 2025-03-21 | 山东大学 | 一种基于反式-1,4-环己烷二甲醇的可电离脂质、脂质纳米颗粒及其制备方法与应用 |
| CN121426694A (zh) * | 2025-12-31 | 2026-01-30 | 中国科学技术大学苏州高等研究院 | 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用 |
| CN121426693A (zh) * | 2025-12-31 | 2026-01-30 | 中国科学技术大学苏州高等研究院 | 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用 |
| WO2026061393A1 (zh) * | 2024-09-18 | 2026-03-26 | 北京剂泰生命科技有限公司 | 递送编码分泌型蛋白的核酸分子的脂质纳米颗粒及其用途 |
| WO2026081995A1 (zh) * | 2024-10-14 | 2026-04-23 | 北京剂泰生命科技有限公司 | 含有杂芳环结构的可电离脂质 |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| WO2024067639A1 (zh) * | 2022-09-30 | 2024-04-04 | 荣灿生物医药技术(上海)有限公司 | 一种转染效率高的可电离脂质化合物及其应用 |
| CN116947669B (zh) * | 2022-09-30 | 2024-04-12 | 荣灿生物医药技术(上海)有限公司 | 一种转染效率高的可电离脂质化合物及其应用 |
| WO2024259373A1 (en) * | 2023-06-14 | 2024-12-19 | Modernatx, Inc. | Compounds and compositions for delivery of therapeutic agents |
| EP4736848A1 (en) * | 2023-06-28 | 2026-05-06 | Shanghai Regenelead Therapies Co., Ltd. | Pharmaceutical composition containing cationic lipid and use thereof |
| CN121889371A (zh) * | 2023-07-03 | 2026-04-17 | 科纳勒生物公司 | 脂质及其组合物 |
| CN116891423B (zh) * | 2023-07-07 | 2024-03-01 | 荣灿生物医药技术(上海)有限公司 | 脂质化合物、组合物及其制备方法和应用 |
| KR20260046133A (ko) * | 2023-07-19 | 2026-04-06 | 젠에디트바이오 리미티드 | 지질 및 지질 나노입자 |
| KR20250064439A (ko) * | 2023-11-02 | 2025-05-09 | 주식회사 삼양홀딩스 | 양이온성 지질 및 이의 제조방법 |
| CN117658839A (zh) * | 2023-11-22 | 2024-03-08 | 武汉大学 | 一种含羟基可电离脂质及其制备方法与应用 |
| TW202527910A (zh) * | 2023-12-13 | 2025-07-16 | 大陸商上海瑞宏迪醫藥有限公司 | 一種陽離子脂質及其應用 |
| WO2025146125A1 (zh) * | 2024-01-05 | 2025-07-10 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物和脂质纳米颗粒 |
| WO2025161943A1 (zh) * | 2024-02-02 | 2025-08-07 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物和脂质纳米颗粒 |
| CN117695410B (zh) * | 2024-02-06 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | CRISPR/Cas9纳米抗菌剂及其制备方法 |
| CN119264001A (zh) * | 2024-04-03 | 2025-01-07 | 上海蓝鹊生物医药有限公司 | 含氮链状化合物、制备方法、包含其的组合物和应用 |
| CN118388360B (zh) * | 2024-04-17 | 2025-04-04 | 北京悦康科创医药科技股份有限公司 | 含有苯环结构的长效脾靶向阳离子脂质化合物、包含其的组合物及用途 |
| CN118852328A (zh) * | 2024-07-02 | 2024-10-29 | 北京大学 | 肽基可离子化脂质合成及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| EP3350333B2 (en) | 2015-09-17 | 2025-08-06 | ModernaTX, Inc. | Polynucleotides containing a stabilizing tail region |
| EP3359670B2 (en) | 2015-10-05 | 2024-02-14 | ModernaTX, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| HRP20230209T1 (hr) * | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| US20230000773A1 (en) | 2019-09-19 | 2023-01-05 | Modernatx, Inc. | Novel headgroup lipid compounds and compositions for intracellular delivery of therapeutic agents |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CA3155015A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
-
2022
- 2022-12-07 AR ARP220103357A patent/AR127892A1/es unknown
- 2022-12-09 CN CN202280081536.3A patent/CN118369308A/zh active Pending
- 2022-12-09 TW TW111147301A patent/TW202333708A/zh unknown
- 2022-12-09 JP JP2024534287A patent/JP2025502627A/ja active Pending
- 2022-12-09 US US18/716,220 patent/US20250144036A1/en active Pending
- 2022-12-09 WO PCT/US2022/052347 patent/WO2023107669A1/en not_active Ceased
- 2022-12-09 EP EP22847452.4A patent/EP4444692A1/en active Pending
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116969850A (zh) * | 2022-06-14 | 2023-10-31 | 苏州科锐迈德生物医药科技有限公司 | 碳酸酯-羧酸酯型脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| CN119330848A (zh) * | 2023-10-19 | 2025-01-21 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物及脂质纳米颗粒 |
| CN119330848B (zh) * | 2023-10-19 | 2025-07-08 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物及脂质纳米颗粒 |
| CN119019272A (zh) * | 2024-08-14 | 2024-11-26 | 中国药科大学 | 可电离脂质、包含其的组合物及其用途 |
| CN119039164A (zh) * | 2024-08-29 | 2024-11-29 | 国药中生生物技术研究院有限公司 | 可离子化脂质化合物、包含其的脂质纳米颗粒、药物组合物、药物制剂及其应用 |
| CN119039164B (zh) * | 2024-08-29 | 2025-04-11 | 国药中生生物技术研究院有限公司 | 可离子化脂质化合物、包含其的脂质纳米颗粒、药物组合物、药物制剂及其应用 |
| WO2026061393A1 (zh) * | 2024-09-18 | 2026-03-26 | 北京剂泰生命科技有限公司 | 递送编码分泌型蛋白的核酸分子的脂质纳米颗粒及其用途 |
| WO2026081995A1 (zh) * | 2024-10-14 | 2026-04-23 | 北京剂泰生命科技有限公司 | 含有杂芳环结构的可电离脂质 |
| WO2026081992A1 (zh) * | 2024-10-14 | 2026-04-23 | 北京剂泰生命科技有限公司 | 用于主动靶向递送的可电离脂质、其组合物和其应用 |
| CN119661389A (zh) * | 2024-10-15 | 2025-03-21 | 山东大学 | 一种基于反式-1,4-环己烷二甲醇的可电离脂质、脂质纳米颗粒及其制备方法与应用 |
| CN121426694A (zh) * | 2025-12-31 | 2026-01-30 | 中国科学技术大学苏州高等研究院 | 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用 |
| CN121426693A (zh) * | 2025-12-31 | 2026-01-30 | 中国科学技术大学苏州高等研究院 | 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025502627A (ja) | 2025-01-28 |
| US20250144036A1 (en) | 2025-05-08 |
| WO2023107669A1 (en) | 2023-06-15 |
| AR127892A1 (es) | 2024-03-06 |
| TW202333708A (zh) | 2023-09-01 |
| EP4444692A1 (en) | 2024-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN114728886B (zh) | 用于细胞内递送治疗剂的含碳酸酯的脂质化合物和组合物 | |
| CN118369308A (zh) | 用于递送治疗剂的化合物和组合物 | |
| JP7817473B2 (ja) | 治療薬の細胞内送達のための分岐状尾部脂質化合物及び組成物 | |
| JP7642620B2 (ja) | 治療剤の細胞内送達のための頭部基脂質化合物及び組成物 | |
| US20240226026A1 (en) | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents | |
| CN116133652A (zh) | 制备脂质纳米粒子的方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |