TW202333708A

TW202333708A - 用於遞送治療劑之化合物及組合物

用於遞送治療劑之化合物及組合物 Download PDF

Info

Publication number: TW202333708A
Authority: TW; Taiwan
Prior art keywords: group; alkyl; lnp; alkenyl; lipid
Prior art date: 2021-12-10

Application number

TW111147301A

Other languages

English (en)

Chinese (zh)

Inventor

埈榮李

摩西卓拉西伯沙德

凱莉Ｅ班納圖

Original Assignee

美商現代公司

Priority date

2021-12-10

Filing date

2022-12-09

Publication date

2023-09-01

2022-12-09 Application filed by 美商現代公司 filed Critical 美商現代公司

2023-09-01 Publication of TW202333708A publication Critical patent/TW202333708A/zh

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239000000203 mixture Substances 0.000 title claims abstract description 171
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239000003814 drug Substances 0.000 title claims description 50
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150000002632 lipids Chemical class 0.000 claims abstract description 455
239000002105 nanoparticle Substances 0.000 claims abstract description 235
-1 cationic lipid Chemical class 0.000 claims abstract description 163
230000001225 therapeutic effect Effects 0.000 claims abstract description 133
230000000069 prophylactic effect Effects 0.000 claims abstract description 104
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210000000056 organ Anatomy 0.000 claims abstract description 22
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125000000217 alkyl group Chemical group 0.000 claims description 196
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238000000034 method Methods 0.000 claims description 67
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NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 29
125000001072 heteroaryl group Chemical group 0.000 claims description 26
PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
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RGICCULPCWNRAB-UHFFFAOYSA-N 2-[2-(2-hexoxyethoxy)ethoxy]ethanol Chemical compound CCCCCCOCCOCCOCCO RGICCULPCWNRAB-UHFFFAOYSA-N 0.000 claims description 8
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FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
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AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 4
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125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
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SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 claims description 3
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